肖扬 特聘研究员:
Jingyi Hu, Rong Zhang, Hailan Zou, Lingxiang Xie, Zhiguang Zhou and Yang Xiao*.Latent Autoimmune Diabetes in Adults (LADA): From Immunopathogenesis to Immunotherapy.FRONTIERS IN ENDOCRINOLOGY.2022 Jul 21;13:917169. doi: 10.3389/fendo.2022.917169. eCollection 2022
Rong Zhang#,Yang Xiao#*,Jianru Yan,Wen Yang,Xiaomei WU,Zubing Mei*,Zhiguang Zhou.Effects of Berberine Plus Inulin on Diabetes Care in Patients With Latent Autoimmune Diabetes in Adults: Protocol for a Randomized Controlled Trial.FRONTIERS IN ENDOCRINOLOGY.
2022 Jun 15;13:876657.doi: 10.3389/fendo.2022.876657. eCollection 2022
Yuqing Liu, Xin Cheng, Hongli Li , Shan Hui, Zheyu Zhang, Yang Xiao*, Weijun Peng*.Non-Coding RNAs as Novel Regulators of Neuroinflammation in Alzheimer's Disease.Frontiers in Immunology.2022 Jun 2;13:908076. doi: 10.3389/fimmu.2022.908076. eCollection 2022.PMID: 35720333 PMCID: PMC9201920
Huijie Yang,Weiwen Zhang,Jin Ding,Jingyi Hu,Yi Sun,Weijun Peng,Yi Chu,Lingxiang Xie,Zubing Mei,Zhuo Shao*and Yang Xiao*.
A novel genomic instabilityderived lncRNA signature to predict prognosis and immune characteristics of pancreaticductal adenocarcinoma. Frontiers in Immunology.2022 Sep 15;13:970588.doi: 10.3389/fimmu.2022.970588. eCollection 2022
Shanshan Liu,*, Chang Liu, Zhuowei Hu, and Yang Xiao*.Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on 'The chemokine CCL1 triggers an AMFR‒SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis'.Journal of Molecular Cell Biology.2022 Feb 24;14(1):mjab080. doi: 10.1093/jmcb/mjab080
Li Y, Li T*, Zhou Z, Xiao Y*. Emerging roles of Galectin-3 in diabetes and diabetes complications: A snapshot. Rev Endocr Metab Disord. 2022;23(3):569-577. doi:10.1007/s11154-021-09704-7
Hu JY, Zou HL, Li YH, Nie DY, Chao C, Liu JH, Ding J, Zhou ZG, Xiao Y*. Serum fibroblast growth factor 19 (FGF19) levels are associated with atherogenic dyslipidemia in patients with type 2 diabetes. Chin Med J (Engl). 2021;134(18):2243-2245. Published 2021 Sep 1. doi:10.1097/CM9.0000000000001574
Liu SS#, Liu C#, Lv XX, Cui B, Yan J, Li YX, Li K, Hua F, Zhang XW, Yu JJ, Yu JM, Wang F, Shang S, Li PP, Zhou ZG, Xiao Y*, Hu ZW*. The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis [published correction appears in Immunity. 2021 Oct 12;54(10):2433-2435]. Immunity. 2021;54(9):2042-2056.e8. doi:10.1016/j.immuni.2021.06.008
Li C#, Xiao Y#*, Hu J, et al. Associations Between Diabetes and Idiopathic Pulmonary Fibrosis: a Study-level Pooled Analysis of 26 Million People. J Clin Endocrinol Metab. 2021;106(11):3367-3380. doi:10.1210/clinem/dgab553
Xiao Y#, Wang H, Tang Y, et al. Increased risk of diabetes in cancer survivors: a pooled analysis of 13 population-based cohort studies. ESMO Open. 2021;6(4):100218. doi:10.1016/j.esmoop.2021.100218
Xiao Y#, Shu L#, Wu X, et al. Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages. JCI Insight. 2021;6(7):e141814. Published 2021 Apr 8. doi:10.1172/jci.insight.141814
Jingyi Hu#, Yingxin Tang#, Hui Liu, Yanhua Li, Xia Li, Gan Huang, Yang Xiao*, Zhiguang Zhou*.Decreased Serum Fibroblast Growth Factor 19 Level is a Risk Factor for Type 1 Diabetes.Annals of Translational Medicine. 2021 Mar;9(5):376.doi: 10.21037/atm-20-5203
Xing Y, Lin Q, Tong Y, Zhou W, Huang J, Wang Y, Huang G, Li Y, Xiang Z, Zhou Z, Li T, Xiao Y*. Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China. Front Endocrinol (Lausanne). 2020;11:581902. Published 2020 Dec 18. doi:10.3389/fendo.2020.581902
Yao Yu, Qiuqiu Lin, Dewei Ye, Yanfei Wang, Binbin He, Yanhua Li, Gan Huang, Zhiguang Zhou, Yang Xiao*.Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes.2020 Oct 22;20(1):158.(卷: 20 期: 1)doi: 10.1186/s12902-020-00597-2
Hailan Zou, Lili Liu, Jia Guo, Hongjuan Wang, Siyun Liu, Yixuan Xing, Chao Deng, Yang Xiao*.Sodium-glucose cotransporter inhibitors as add-on therapy in addition to insulin for type 1 diabetes mellitus: A meta-analysis of randomized controlled trials.JOURNAL OF DIABETES INVESTIGATION.2021 Apr;12(4):546-556. doi: 10.1111/jdi.13387. Epub 2020 Sep 19
Qiuqiu Lin, Wenzhi Zhou, Yanfei Wang, Juan Huang, Xiaoyan Hui, Zhiguang Zhou, Yang Xiao*.Abnormal peripheral neutrophil transcriptome in newly diagnosed type 2 diabetes patients.JOURNAL OF DIABETES RESEARCH.2020 Apr 22;2020:9519072.(卷: 2020文献号: 9519072)doi: 10.1155/2020/9519072.
Yue Tong, Lin Yang, Feng Shao, Xiang Yan, Xia Li, Gan Huang, Yang Xiao*, Zhiguang Zhou*.Distinct secretion pattern of serum proinsulin in different types of diabetes.ANNALS OF TRANSLATIONAL MEDICINE.2020 Apr;8(7):452.(卷: 8 期: 7;文献号: 452)doi: 10.21037/atm.2020.03.189
Hu J, Liu Z, Tong Y, Mei Z, Xu A, Zhou P, Chen X, Tang W, Zhou Z* , Xiao Y*. Fibroblast Growth Factor 19 Levels Predict Subclinical Atherosclerosis in Men With Type 2 Diabetes. Front Endocrinol (Lausanne). 2020;11:282. Published 2020 May 22. doi:10.3389/fendo.2020.00282
Huang J#, Xiao Y#, Zheng P#, et al. Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes. Diabetes Metab Res Rev. 2019;35(1):e3064. doi:10.1002/dmrr.3064
Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao*, Zhiguang Zhou*, Zubing Mei.Incretin-based therapies for patients with type 1 diabetes: a meta-analysis.ENDOCRINE CONNECTIONS.2019 Mar;8(3):277-288.(卷: 8 期: 3 页: 277-288)doi: 10.1530/EC-18-0546
Yang Xiao#, Xiaoyu Xiao#, Aimin Xu, Xiaoyan Chen, Weili Tang, Zhiguang Zhou*.Circulating adipocyte fatty acid-binding protein levels predict the development of subclinical atherosclerosis in type 2 diabetes.JOURNAL OF DIABETES AND ITS COMPLICATIONS.
2018 Dec;32(12):1100-1104.(卷: 32 期: 12 页: 1100-1104.DOI: 10.1016/j.jdiacomp.2018.09.001 出版年: DEC 2018文献类型:Article)
Yang Xiao#, Xia Li, Chen Chao, Gan Huang, Weili Tang, Shiping Liu, Zhiguo Xie, Zhiguang Zhou*.Severe Insulin Resistance Due to Insulin Antibodies.Journal of Diabetes.2018 Jul;10(7):611-613.(卷: 10 期: 7 页: 611-613.DOI: 10.1111/1753-0407.12657.出版年: JUL 2018文献类型:Letter)
Xiao Y#, Liu L#, Xu A, et al. Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol. 2015;14:72. Published 2015 Jun 6. doi:10.1186/s12933-015-0229-9
Wang Y#, Xiao Y#, Zhong L#, et al. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes. 2014;63(12):4239-4248. doi:10.2337/db14-0480
Xiao Y#, Xu A, Law LS, et al. Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes. J Clin Endocrinol Metab. 2012;97(1):E54-E58. doi:10.1210/jc.2011-1930
刘姗姗 特聘教授:
1. Shan-shan Liu*, Chang Liu*, Xiao-xi Lv, Bing Cui, Jun Yan, Yun-xuan Li, Ke Li, Fang Hua, Xiao-wei Zhang, Jiao-jiao Yu, Jin-mei Yu, Feng Wang, Shuang Shang, Ping-ping Li, Zhi-guang Zhou, Yang Xiao#, and Zhuo-wei Hu#. The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021. 54, 2042–2056. DOI:https://doi.org/10.1016/j.immuni.2021.06.008
2. Shan-shan Liu*, Xiao-xi Lv*, Chang Liu, Jie Qi, Yun-xuan Li, Xu-peng Wei, Ke Li, Fang Hua, Bing Cui, Xiao-wei Zhang, Jiao-jiao Yu, Jin-mei Yu, Feng Wang, Shuang Shang, Chen-xi Zhao, Xue-ying Hou, Zhi-gang Yao, Ping-ping Li, Xia Li, Bo Huang, and Zhuo-wei Hu. Targeting degradation of the transcription factor C/EBPb reduces lung fibrosis by restoring activity of the ubiquitin-editing enzyme A20 in macrophages. Immunity. 2019. 51, 522–534. DOI: 10.1016/j.immuni.2019.06.014
3. Shan-shan Liu*, Jie Qi*, Zu-dong Teng, Fu-tao Tian, Xiao-xi Lv, Ke Li, Ya-jie Song, Wei-dong Xie, Zhuo-wei Hu# and Xia Li#. Resistomycin attenuates triple-negative breast cancer progression by inhibition of E3 ligase Pellino-1 activity and inducing SNAIL/SLUG degradation. Signal Transduct Target Ther. 2020, 5:133. DOI: 10.1038/s41392-020-00255-y
4. Shan-shan Liu#*, Xiao-xi Lv*, Xu-peng Wei, Chang Liu, Qiao Li, Jia-li Min, Fang Hua, Xiao-wei Zhang, Ke Li, Ping-ping Li, Yang Xiao, Zhuo-wei Hu, Bing Cui#. TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target. Acta Pharm Sin B. 2021, 11(10): 3105-3119. DOI: 10.1016/j.apsb.2021.06.017
5. Shan-shan Liu#*, Chang Liu, Zhuo-wei Hu, Yang Xiao#. Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on ‘The chemokine CCL1 triggers an AMFR–SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis’. J Mol Cell Biol. 2022, 14(1). DOI: 10.1093/jmcb/mjab080
6. Jia-li Min, Qiao Li, Suo-si Liu, Qian-rong Wang, Min Yin, Yan Zhang, Jun Yan, Bing Cui and Shan-shan Liu. TRAF6 suppresses the development of pulmonary fibrosis by attenuating the activation of fibroblasts. Front Pharmacol. 2022, 13:911945. DOI: 10.3389/fphar.2022.911945
7. Shan-shan Liu, Yan-feng Wang, Li-sha Ma, Bei-bei Zheng, Lin Li, Wei-dong Xie, Xia Li. 1-Oxoeudesm-11(13)-eno-12,8a-lactone induces G2/M arrest and apoptosis of human glioblastoma cells in vitro. Acta Pharmacol Sin. 2013. 34, 271-8. DOI: 10.1038/aps.2012.137
8. Shan-shan Liu, Di Wu, Lin Li, Xiao Sun, Wei-dong Xie, Xia Li. NF-κB activation was involved in reactive oxygen species-mediated apoptosis and autophagy in 1-oxoeudesm-11(13)-eno-12,8α-lactone-treated human lung cancer cells. Arch Pharm Res. 2014. 37, 1039-52. DOI: 10.1007/s12272-013-0270-8
9. Xiao-xi Lv*; Shan-shan Liu*; Ke Li; Bing Cui; Chang Liu; Zhuo-wei Hu. Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice. Oncotarget. 2017.8(43), 74720~74735. DOI: 10.18632/oncotarget.20353
10. Xu-peng Wei, Wan-yu Wang, Yun-xuan Li, Chang Liu, Xiao-xi Lv, Yan-yan Zhao, Shan-shan Liu. [The cell cycle inhibitor p21 promote mouse lung fibrosis by activating alveolar macrophages]. Acta Pharmaceutica Sinica, 2020, 55(8): 1792-1800. (Chinese)
11. Wan-yu Wang, Xiao-xi Lv, Zhuo-wei Hu, Shan-shan Liu. [Research progress of chemokines and their receptors in breast cancer]. Acta Pharmaceutica Sinica, 2021, 56(6): 1521-1531. (Chinese)
彭伟军 副研究员:
论文名称 |
发表时间 |
Use of Jianpi Jiedu Herbs in Patients with Advanced Colorectal Cancer: A Systematic Review and Meta-Analysis |
2018年1月 |
Integrated meta-analysis, network pharmacology, and molecular docking to investigate the efficacy and potential pharmacological mechanism of Kai-Xin-San on Alzheimer's disease |
2018年4月 |
Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury |
2018年8月 |
Association of gut microbiota composition and function with a senescence-accelerated mouse model of Alzheimer's Disease using 16S rRNA gene and metagenomic sequencing analysis |
2018年10月 |
Jianpi Jiedu decoction, a traditional Chinese medicine formula, inhibits tumorigenesis, metastasis, and angiogenesis through the mTOR/HIF-1α/VEGF pathway |
2018年12月 |
Meta-Analysis of Xihuang Pill Efficacy When Combined with Chemotherapy for Treatment of Breast Cancer |
2019年3月 |
Kangai Injection, a Traditional Chinese Medicine, Improves Efficacy and Reduces Toxicity of Chemotherapy in Advanced Colorectal Cancer Patients: A Systematic Review and Meta-Analysis |
2019年7月 |
Integrated 16S rRNA Sequencing, Metagenomics, and Metabolomics to Characterize Gut Microbial Composition, Function, and Fecal Metabolic Phenotype in Non-obese Type 2 Diabetic Goto-Kakizaki Rats |
2020年1月 |
Integrated network pharmacology analysis and serum metabolomics to reveal the cognitive improvement effect of Bushen Tiansui formula on Alzheimer's disease |
2020年3月 |
Plasma and cerebrospinal fluid pharmacokinetics of hydroxysafflor yellow A in patients with traumatic brain injury after intravenous administration of Xuebijing using LC-MS/MS method |
2020年5月 |
Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (−)-epigallocatechin-3-gallate in human colon cancer cells |
2020年6月 |
Integrated Metabolomic and Lipidomic Analysis Reveals the Neuroprotective Mechanisms of Bushen Tiansui Formula in an A β 1-42-Induced Rat Model of Alzheimer's Disease |
2020年7月 |
Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (-)-epigallocatechin-3-gallate in human colon cancer cells |
2020年8月 |
A Network Pharmacology Analysis of the Active Components of the Traditional Chinese Medicine Zuojinwan in Patients with Gastric Cancer |
2020年8月 |
Bushen-Tiansui Formula Improves Cognitive Functions in an A β 1-42 Fibril-Infused Rat Model of Alzheimer's Disease |
2020年9月 |
Quercetin-loaded selenium nanoparticles inhibit amyloid-β aggregation and exhibit antioxidant activity |
2020年10月 |
Protective Effect of Quercetin against H 2 O 2-Induced Oxidative Damage in PC-12 Cells: Comprehensive Analysis of a lncRNA-Associated ceRNA Network |
2020年12月 |
Genome-wide analysis of hippocampal transfer RNA-derived small RNAs identifies new potential therapeutic targets of Bushen Tiansui formula against Alzheimer's disease |
2020年12月 |
Identification and Validation of Six Autophagy-related Long Non-coding RNAs as Prognostic Signature in Colorectal Cancer |
2021年1月 |
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker |
2021年1月 |
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker |
2021年2月 |
Genome-wide analysis of hippocampal transfer RNA-derived small RNAs identifies new potential therapeutic targets of Bushen Tiansui formula against Alzheimer's disease |
2021年3月 |
Corrigendum to "Antioxidant Effect of Polygonatum sibiricum Polysaccharides in D-Galactose-Induced Heart Aging Mice" |
2021年6月 |
Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis |
2021年7月 |
TBX5-AS1, an enhancer RNA, is a potential novel prognostic biomarker for lung adenocarcinoma |
2021年7月 |
Development and Validation of a TNF Family-Based Signature for Predicting Prognosis, Tumor Immune Characteristics, and Immunotherapy Response in Colorectal Cancer Patient. |
2021年9月 |
Characterization of Immune-Related Long Non-coding RNAs to Construct a Novel Signature and Predict the Prognosis and Immune Landscape of Soft Tissue Sarcoma |
2021年9月 |
Antioxidant Effect of Polygonatum sibiricum Polysaccharides in D-Galactose-Induced Heart Aging Mice |
2021年10月 |
Genome Instability-Related miRNAs Predict Survival, Immune Landscape, and Immunotherapy Responses in Gastric Cancer |
2021年11月 |
Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network |
2021年12月 |
Systematic Pan-Cancer Analysis of KLRB1 with Prognostic Value and Immunological Activity across Human Tumors |
2022年1月 |
Involvement of Abnormal Gut Microbiota Composition and Function in Doxorubicin-Induced Cardiotoxicity |
2022年 2月 |
LncRNAs as the Regulators of Brain Function and Therapeutic Targets for Alzheimer's Disease. |
2022年7月 |
Non-Coding RNAs as Novel Regulators of Neuroinflammation in Alzheimer's Disease |
2022年7月 |