VIP papers:
1.Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu. Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection. Nature Materials. 2022, 21, 598-607. (IF= 43.84)
2.Jiaguo Huang, Jingchao Li, Yan Lyu, Qingqing Miao, and Kanyi Pu. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nature Materials. 2019, 18, 1133-1143. (IF= 43.84)
3.Luling Wu#, Jiaguo Huang#, Kanyi Pu, Tony D. James. Dual-locked spectroscopic probes for sensing and therapy. Nature Reviews Chemistry, 2021, 5, 406-421. (IF= 34.03，共同一作)
2024
58. Shujuan Yi, Baoshuai Liang, Jiaguo Huang. Engineering Cyanine- and Hemicyanine-Based Probes for Optical Imaging of Kidney Diseases. ChemMedChem, 2024, DOI:10.1002/cmdc.202400227.
57. Yu M#, Meng Z#, Yi S#, Chen J, Xu W, Ruan B, Wang J, Han F*, Huang J*. A β-Galactosidase-Activated Fluorogenic Reporter for the Detection of Gastric Cancer In Vivo and in Urine. Anal Chem. 2024, 96(16), 6390-6397.
56. Liu Y#, Diao S#, Ruan B#, Zhou Y#, Yu M, Dong G, Xu W, Ning L, Zhou W, Jiang Y, Xie C*, Fan Q*, Huang J*. Molecular Engineering of Activatable NIR-II Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Inflammatory Bowel Disease. ACS nano. 2024, 18(11), 8437-8451.
55. An W, Xu W, Zhou Y, Huang C, Huang W*, Huang J*. Renal-clearable nanoprobes for optical imaging and early diagnosis of diseases. Biomater Sci. 2024, 12(6), 1357-1370. (Invited review)
2023
54. Zhou Y#, Zhu L#, Liu B, Xu W, Yang X, Liu Y, Ruan B, Yi S, Liang B, Dong G, Huang J*. Tailored Zwitterionic Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Acute Renal Failure. Angew. Chem. Int. Ed. 2023, 62 (52): e202315457.
53. Ruan B, Yu M, Zhou Y, Xu W, Liu Y, Liu B, Zhu L, Yi S, Jiang Y, Huang J*. Size-Transformable Superoxide-Triggered Nanoreporters for Crosstalk-Free Dual Fluorescence/Chemiluminescence Imaging and Urinalysis in Living Mice. Angew. Chem. Int. Ed. 2023, 62 (31): e202305812.
52. Huang W, Feng S, Liu J, Liang B, Zhou Y, Yu M, Liang J, Huang J, Lü X, Huang W. Configuration-Induced Multichromism of Phenanthridine Derivatives: A Type of Versatile Fluorescent Probe for Microenvironmental Monitoring. Angew. Chem. Int. Ed. 2023, 62 (9): e202219337.
2022
51. J Huang, S Xian, Y Liu, X Chen, K Pu, H Wang. A Renally Clearable Activatable Polymeric Nanoprobe for Early Detection of Hepatic Ischemia‐Reperfusion Injury. Adv. Mater. 2022, 34 (24), 2201357.
Before SYSU:
50. J Huang, X Chen, Y Jiang, C Zhang, S He, H Wang, K Pu. Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection. Nat. Mater. 2022, 21 (5), 598-607.
49. J Huang, K Pu. Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases. Chem. Sci. 2021, 12 (10), 3379-3392.
48. L Wu#, J Huang#, K Pu, TD James. Dual-locked spectroscopic probes for sensing and therapy. Nat. Rev. Chem. 2021, 5 (6), 406-421. （共同一作）
47. J Huang, K Pu. Activatable molecular probes for second near‐infrared fluorescence, chemiluminescence, and photoacoustic imaging. Angew. Chem. Int. Ed. 2020, 59 (29), 11717-11731.
46. J Huang, Y Jiang, J Li, S He, J Huang, K Pu. A Renal‐Clearable Macromolecular Reporter for Near‐Infrared Fluorescence Imaging of Bladder Cancer. Angew. Chem. Int. Ed. 2020, 59 (11), 4415-4420.
45. J Huang#, J Huang#, P Cheng, Y Jiang, K Pu. Near‐infrared chemiluminescent reporters for in vivo imaging of reactive oxygen and nitrogen species in kidneys. Adv. Funct. Mater. 2020, 30 (39), 2003628. （共同一作）
44. J Huang, J Li, Y Lyu, Q Miao, K Pu. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nat. Mater. 2019, 18 (10), 1133-1143.
43. J Huang, C Xie, X Zhang, Y Jiang, J Li, Q Fan, K Pu. Renal‐clearable molecular semiconductor for second near‐infrared fluorescence imaging of kidney dysfunction. Angew. Chem. Int. Ed. 2019, 58 (42), 15120-15127.
42. J Huang, Y Lyu, J Li, P Cheng, Y Jiang, K Pu. A Renal‐Clearable Duplex Optical Reporter for Real‐Time Imaging of Contrast‐Induced Acute Kidney Injury. Angew. Chem. Int. Ed. 2019, 131 (49), 17960-17968.
41. J Huang, C Brenna, AM Khan, C Daniele, R Rudolf, V Heuveline, N Gretz. A cationic near infrared fluorescent agent and ethyl-cinnamate tissue clearing protocol for vascular staining and imaging. Sci. Rep. 2019, 9 (1), 521.
40. J Huang. Drug-induced nephrotoxicity and drug metabolism in renal failure. Curr. Drug Metab. 2018, 19 (7), 558-558.
39. J Huang, S Weinfurter, C Daniele, R Perciaccante, R Federica, et al. Zwitterionic Near Infrared Fluorescent Agents for Noninvasive Real-time Transcutaneous Assessment of Kidney Function. Chem. Sci. 2017, 8 (4), 2652-2660.
38. H jiaguo, G Norbert. Light-Emitting Agents for Noninvasive Assessment of Kidney Function. Chemistryopen. 2017, 6 (4), 456-471.
37. J Huang, S Weinfurter, PC Pinto, M Pretze, B Krä nzlin, J Pill, R Federica, et al. Fluorescently labeled cyclodextrin derivatives as exogenous markers for real-time transcutaneous measurement of renal function. Bioconjug. Chem. 2016, 27 (10), 2513-2526.
36. J Huang, N Gretz, S Weinfurter. Filtration markers and determination methods for the assessment of kidney function. Eur. J. Pharmacol. 2016, 790, 92-98.
35. J Huang, M Tang, M Liu, M Zhou, Z Liu, Y Cao, M Zhu, S Liu, W Zeng. Development of a fast responsive and highly sensitive fluorescent probe for Cu2+ ion and imaging in living cells. Dyes Pigm. 2014, 107, 1-8.
34. J Huang, M Liu, X Ma, Q Dong, B Ye, W Wang, W Zeng. A highly selective turn-off fluorescent probe for Cu (II) based on a dansyl derivative and its application in living cell imaging. RSC Adv. 2014, 4 (44), 22964-22970.
33. H Jiaguo, L Zhiguo, Z Wenbin. Molecular probing and imaging of histone deacetylase inhibitors in cancer treatment. Anticancer Agents Med Chem. 2012, 12 (3), 182-186.
32. J Huang, W Zeng, M Zhou, F Gao. Progress of the dual-modality probes for molecular imaging. Acta Biophy. Sinica. 2011, 27, 301-311.
31. J Li, N Yu, D Cui, J Huang, Y Luo, K Pu. Activatable Semiconducting Polymer Pro‐nanomodulators for Deep‐Tissue Sono‐immunotherapy of Orthotopic Pancreatic Cancer. Angew. Chem. Int. Ed. 2023, 62 (30), e202305200.
30. X Wei, C Zhang, S He, J Huang, J Huang, SS Liew, Z Zeng, K Pu. A dual‐locked activatable phototheranostic probe for biomarker‐regulated photodynamic and photothermal cancer therapy. Angew. Chem. Int. Ed. 2022, 61 (26), e202202966.
29. J Li, Y Luo, Z Zeng, D Cui, J Huang, C Xu, L Li, K Pu, R Zhang. Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles. Nat. Commun. 2022, 13 (1), 4032.
28. Y Jiang, J Huang, C Xu, K Pu. Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer. Nat. Commun. 2021, 12 (1), 742.
27. C Zhang, Z Zeng, D Cui, S He, Y Jiang, J Li, J Huang, K Pu. Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy. Nat. Commun. 2021, 12 (1), 2934.
26. C Xu, Y Jiang, J Huang, J Huang, K Pu. Second near‐infrared light‐activatable polymeric nanoantagonist for photothermal immunometabolic cancer therapy. Adv. Mater. 2021, 33 (36), 2101410.
25. J Huang, Y Jiang, J Li, J Huang, K Pu. Molecular Chemiluminescent Probes with a Very Long Near‐Infrared Emission Wavelength for in Vivo Imaging. Angew. Chem. Int. Ed. 2021, 60 (8), 3999-4003.
24. Z Wang, J Huang, J Huang, B Yu, K Pu, FJ Xu. Chemiluminescence: From mechanism to applications in biological imaging and therapy. Aggregate. 2021, 2 (6), e140.
23. M Yang, J Huang, J Fan, J Du, K Pu, X Peng. Chemiluminescence for bioimaging and therapeutics: recent advances and challenges. Chem. Soc. Rev. 2020, 49 (19), 6800-6815.
22. Y Jiang, X Zhao, J Huang, J Li, PK Upputuri, H Sun, X Han, M Pramanik, et al. Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy. Nat. Commun. 2020, 11 (1), 1857.
21. S He, J Li, Y Lyu, J Huang, K Pu. Near-infrared fluorescent macromolecular reporters for real-time imaging and urinalysis of cancer immunotherapy. J. Am. Chem. Soc. 2020, 142 (15), 7075-7082.
20. J Zhang, L Ning, J Huang, C Zhang, K Pu. Activatable molecular agents for cancer theranostics. Chem. Sci. 2020, 11 (3), 618-630.
19. P Cheng, Q Miao, J Huang, J Li, K Pu. Multiplex optical urinalysis for early detection of drug-induced kidney injury. Anal. Chem. 2020, 92 (8), 6166-6172.
18. D Cui, J Huang, X Zhen, J Li, Y Jiang, K Pu. A semiconducting polymer nano‐prodrug for hypoxia‐activated photodynamic cancer therapy. Angew. Chem. Int. Ed. 2019, 131 (18), 5981-5985.
17. Y Jiang, PK Upputuri, C Xie, Z Zeng, A Sharma, X Zhen, J Li, J Huang, et al. Metabolizable semiconducting polymer nanoparticles for second near‐infrared photoacoustic imaging. Adv. Mater. 2019, 31 (11), 1808166.
16. J Li, D Cui, Y Jiang, J Huang, P Cheng, K Pu. Near‐infrared photoactivatable semiconducting polymer nanoblockaders for metastasis‐inhibited combination cancer therapy. Adv. Mater. 2019, 31 (46), 1905091.
15. Y Lyu, D Cui, J Huang, W Fan, Y Miao, K Pu. Near‐infrared afterglow semiconducting nano‐polycomplexes for the multiplex differentiation of cancer exosomes. Angew. Chem. Int. Ed. 2019, 58 (15), 4983-4987.
14. P Cheng, Q Miao, J Li, J Huang, C Xie, K Pu. Unimolecular chemo-fluoro-luminescent reporter for crosstalk-free duplex imaging of hepatotoxicity. J. Am. Chem. Soc. 2019, 141 (27), 10581-10584.
13. Y Jiang, J Huang, X Zhen, Z Zeng, J Li, C Xie, Q Miao, J Chen, P Chen, et al. A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nat. Commun. 2019, 10 (1), 2064.
12. J Li, J Huang, Y Lyu, J Huang, Y Jiang, C Xie, K Pu. Photoactivatable organic semiconducting pro-nanoenzymes. J. Am. Chem. Soc. 2019, 141 (9), 4073-4079.
11. J Li, D Cui, J Huang, S He, Z Yang, Y Zhang, Y Luo, K Pu. Organic semiconducting pro‐nanostimulants for near‐infrared photoactivatable cancer immunotherapy. Angew. Chem. Int. Ed. 2019, 58 (36), 12680-12687.
10. X Zhen, J Zhang, J Huang, C Xie, Q Miao, K Pu. Macrotheranostic probe with disease‐activated near‐infrared fluorescence, photoacoustic, and photothermal signals for imaging‐guided therapy. Angew. Chem. Int. Ed. 2018, 130 (26), 7930-7934.
9. H Wu, J Huang. Drug-induced nephrotoxicity: pathogenic mechanisms, biomarkers and prevention strategies. Curr. Drug Metab. 2018, 19 (7), 559-567.
8. J Li, X Zhen, Y Lyu, Y Jiang, J Huang, K Pu. Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics. Acs Nano. 2018, 12 (8), 8520-8530.
7. J Li, C Xie, J Huang, Y Jiang, Q Miao, K Pu. Semiconducting polymer nanoenzymes with photothermic activity for enhanced cancer therapy. Angew. Chem. Int. Ed. 2018, 57 (15), 3995-3998.
6. P Cheng, J Zhang, J Huang, Q Miao, C Xu, K Pu. Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis. Chem. Sci. 2018, 9 (30), 6340-6347.
5. H Wu, J Huang. Optimization of protein and peptide drugs based on the mechanisms of kidney clearance. Protein Pept. Lett. 2018, 25 (6), 514-521.
4. H Wu, J Huang. PEGylated Peptide-Based Imaging Agents for Targeted Molecular Imaging. Curr. Protein Pept. Sci. 2016, 17 (6), 582-595.
3. L Scarfe, A Rak-Raszewska, S Geraci, D Darssan, J Sharkey, J Huang, et al. Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Sci. Rep. 2015, 5 (1), 13601.
2. M Tang, J Huang, X Weng, L Yang, M Liu, M Zhou, X Wang, J Gao, W Yi, et al. Evaluation of a dansyl-based amino acid DNSBA as an imaging probe for apoptosis detection. Apoptosis. 2015, 20, 410-420.
1. Y Gu, D Huang, Z Liu, J Huang, W Zeng. Labeling strategies with F-18 for positron emission tomography imaging. Med. Chem. 2011, 7 (5), 334-344.