13. Xing, Z.; Liu, F.; Feng, J.; Yu, L.; Wu, Z.; Zhao, B.; Chen, B.; Ping, H.; Xu, Y.; Liu, A.; Zhao, Y.; Wang, C.; Wang, B.; Huang, X., Synergistic photobiocatalysis for enantioselective triple radical sorting. Nature 2024. DOI: 10.1038/s41586-024-08399-5

Highlighted by:

Nature发文！南大团队推动光酶领域到复杂多组分转化

12. Yu, J.; Hao, Y.; Huang, X., Repurposing type I aldolase for stereospecific radical coupling with light. Chem Catalysis 2024, 4 (11). DOI: 10.1016/j.checat.2024.101191

11. Xu, Y.; Liu, F.; Zhao, B.; Huang, X., Repurposing Naturally Occurring Enzymes Using Visible Light. Chin. J. Chem. 2024, 42, 3553-3558. DOI: 10.1002/cjoc.202400656

10. Chen, B.; Li, R.; Feng, J.; Zhao, B.; Zhang, J.; Yu, J.; Xu, Y.; Xing, Z.; Zhao, Y.; Wang, B.*; Huang, X.*, Modular Access to Chiral Amines via Imine Reductase-Based Photoenzymatic Catalysis. J. Am. Chem. Soc. 2024, DOI: 10.1021/jacs.4c03879. https://pubs.acs.org/doi/10.1021/jacs.4c03879

Highlighted by:  Synfacts

9. Yu, J.; Zhang, Q.; Zhao, B.; Wang, T.; Zheng, Y.; Wang, B.*; Zhang, Y.*; Huang, X.*, Repurposing Visible-Light-Excited Ene-Reductases for Diastereo- and Enantioselective Lactones Synthesis. Angew. Chem. Int. Ed. 2024, 63, e202402673.

      

8. Xu, Y.; Chen, H.; Yu, L.; Peng, X.; Zhang, J.; Xing, Z.; Bao, Y.; Liu, A.; Zhao, Y.; Tian, C.*; Liang, Y*.; Huang, X.* A light-driven enzymatic enantioselective radical acylation.  (former undergraduate, now PhD candidate) Nature 2024, 625, 74–78, DOI: 10.1038/s41586-023-06822-x

Highlighted by:

我国学者在新型光酶催化领域取得新进展 (nsfc.gov.cn)

南京大学黄小强/梁勇及合作者《Nature》发文：创制新光酶元件，引领光生物制造新方向-南京大学 (nju.edu.cn)

南大黄小强/梁勇/中科大田长麟团队合作Nature：光酶协同催化实现不对称自由基酰基化 (qq.com)

7. Bao, Y.; Xu, Y.; Huang, X.* Focused rational iterative site-specific mutagenesis (FRISM): A powerful method for enzyme engineering. Mol. Catal. 2024, 553, 113755. (invited review in honour of Prof. Manfred T. Reetz)

6. Zhang, J.; Zhang, Q.; Chen, B.; Yu, J.; Wang, B.*; Huang, X.* Photoenzymatic conversion of enamides to enantioenriched benzylic amines enabled by visible-light-induced single-electron reduction. ACS Catal. 2023, 15682-15690. (Bachelor thesis project)

                                                                             

5. Zhao, B.;  Feng, J.;  Yu, L.;  Xing, Z.;  Chen, B.;  Liu, A.;  Liu, F.;  Shi, F.;  Zhao, Y.;  Tian, C.*;  Wang, B.*; Huang, X.* Direct visible-light-excited flavoproteins for redox-neutral asymmetric radical hydroarylation, Nat. Catal. 2023, 6, 996-1004, DOI: 10.1038/s41929-023-01024-0 (undergraduate student)https://doi.org/10.1038/s41929-023-01024-0

Highlighted by

^{- 南京大学/厦门大学/中科大团队Nat. Catal.：可见光直接激发驱动的新光酶催化 (qq.com)}

4. Zeng, S.; Bao, Y.; Cao, A.; Huang, X.* Rational evolution of a fatty acid photodecarboxylase for highly selective photodecarboxylation of trans fatty acid, Univ. Chem. 2023, 38, 1-10. (undergraduate students)

3.  Ming, Y.; Chen, B.; Huang, X.* Recent advances in photoenzymatic synthesis, Synth. Biol. J. 2022, 3, 1-25.

2. Huang, X.;  Feng, J.;  Cui, J.;  Jiang, G.;  Harrison, W.;  Zang, X.;  Zhou, J.;  Wang, B*.; Zhao, H.* Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition, Nat. Catal. 2022, 5, 586–593.

Highlighted by 

- Nat. Catal. 2022, 5, 582–583.

- X-MOL: UIUC/厦门大学/深圳先进院/南京大学团队Nature Catalysis：利用光酶策略实现非天然的不对称生物合成 (qq.com)

- Researchers develop powerful strategy for creating new-to-nature enzymes | Chemical and Biomolecular Engineering | UIUC (illinois.edu)

1. Wesley, H.; Huang, X.;* Zhao, H.* Photobiocatalysis for abiological transformations, Acc. Chem. Res. 2022, 55,  1087–1096.

                                                    

 

Prior to NJU:

1.    Huang, X.;^† Wang, B.;^† Wang, Y.; Jiang, G.; Feng, J.; Zhao, H.* Photoenzymatic Enantioselective Intermolecular Radical Hydroalkylation, Nature 2020, 584, 69-74 (^†Co-first author) (C&EN, 2020, June 21, Synfacts 2020, 16, 1100)

2.    Huang, X.; Cao, M.; Zhao, H.* Integrating Biocatalysis with Chemocatalysis for Selective Transformations, Curr. Opion. Chem. Biol. 2020, 55, 161-170. (invited review)

3.    Huang, X.; Meggers, E.* Asymmetric Photocatalysis with Bis-Cyclometalated Rhodium Complexes, Acc. Chem. Res. 2019, 52, 833-847. (highly cited in field, Web of Science)

4.    Huang, X.; Zhang, Q.; Lin, J.; Harms, K.; Meggers, E.* Electricity Driven Asymmetric Lewis Acid Catalysis, Nat. Catal. 2019, 2, 34-40.

5.    Huang, X.; Lin, J.; Shen, T.; Harms, K.; Marchini, M.; Ceroni, P.; Meggers, E.* Asymmetric [3+2] Photocycloadditions of Cyclopropanes with Alkenes or Alkynes via Visible Light Excitation of Catalyst-Bound Substrates, Angew. Chem., Int. Ed. 2018, 57, 5454-5458. (selected as a Hot Paper, highlighted in Org. Chem. Highlights)

6.    Huang, X.; Li, X.; Xie, X.; Harms, K.; Riedel, R.; Meggers, E.* Catalytic Asymmetric Synthesis of a Nitrogen Heterocycle through Stereocontrolled Direct Photoreaction from Electronically Excited State, Nat. Commun. 2017, 8, 2245.

7.    Huang, X.; Quinn, T. R.; Harms, K.; Webster, R. D.; Zhang, L.; Wiest, O.; Meggers, E.* Direct Visible-Light-Excited Asymmetric Lewis Acid Catalysis of Intermolecular [2+2] Photocycloadditions, J. Am. Chem. Soc. 2017, 139, 9120-9123. (highlighted in Science 2017, 357, 265; Synfacts, 2017, 1061)

8.    Huang, X.; Webster, R. D.; Harms, K.; Meggers, E.* Asymmetric Catalysis with Organic Azides and Diazo Compounds Initiated by Photoinduced Electron Transfer, J. Am. Chem. Soc. 2016, 138, 12636-12642.

9.    Huang, X.; Li, X.; Zou, M.; Song, S.; Tang, C.; Yuan, Y.; Jiao, N.* From Ketones to Esters by a Cu-Catalyzed Highly Selective C(CO)–C(alkyl) Bond Cleavage: Aerobic Oxidation and Oxygenation with Air, J. Am. Chem. Soc. 2014, 136, 14858-14856.

10. Chen, F.;^† Huang, X.;^† Li, X.;^† Shen, T.; Zou, M.; Jiao, N.* Dehydrogenative N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild Conditions, Angew. Chem., Int. Ed. 2014, 53, 10495-10499. (^†Co-first author)

11. Huang, X.;^† Luo, S.;^† Burghaus, O.; Webster, R. D.; Harms, K.; Meggers, E.* Chem. Sci. 2017, 8, 7126-7131. (^†Co-first author)

12. Huo, H.;^† Huang, X.;^† Shen, X.; Harms, K.; Meggers, E.* Synlett 2016, 27, 749-753. (invited paper, ^†Co-first author)

13. Huang, X.; Li, X.; Jiao, N.* Chem. Sci. 2015, 6, 6355-6360.

14. Huang, X.; Li, X.; Zou, M.; Pan, J.; Jiao, N.* Org. Chem. Front. 2015, 2, 354-359.

15. Huang, X.; Jiao, N.* Org. Biomol. Chem. 2014, 12, 4324-4328.

16. Jung, H.; Hong, M.; Marchini, M.; Villa, M.; Steinlandt, P. S.; Huang, X.; Hemming, M.; Meggers, E.; Ceroni, P.;* Park, J.;* Baik, M.-H.* Chem. Sci. 2021, DOI: 10.1039/D1SC02745J.

17. Wang, Y.; Huang, X.; Hui, J.; Vo, L. M.; Zhao, H.* ACS Catal. 2020, 10, 9431–9437.

18. Kuang, Y.; Wang, K.; Shi, X.; Huang, X.; Meggers, E.; Wu, J. Angew. Chem. Int. Ed. 2019, 58, 11028-11032.

19. Zhu, B.; Shen, T.; Huang, X.; Zhu, Y.; Song, S.; Jiao, N. Angew. Chem., Int. Ed. 2019, 58, 11028-11032.

20. Grell, Y.; Hong, Y.; Huang, X.; Mochizuki, T.; Xie, X.; Harms, K.; Meggers, E. Organometallics 2019, 38, 3948-3954.

21. Liu, J.; Qiu, X.; Huang, X.; Luo, X.; Zhang, C.; Wei, J.; Pan, J.; Liang, Y.; Zhu, Y.; Qin, Q.; Song, S.; Jiao, N. Nat. Chem. 2019, 11, 71-77.

22. De Assis, F.; Huang, X.; Akiyama, M.; Pilli, R. A.; Meggers, E.* J. Org. Chem. 2018, 83, 10922-10932.

23. Ma, J.; Zhang, X.; Huang, X.; Luo, S.; Meggers, E.* Nat. Protoc. 2018, 13, 605-632.

24. Zhang, X.; Qin, J.; Huang, X.; Meggers, E.* Eur. J. Org. Chem. 2018, 571-577.

25. Zhang, X.; Qin, J.; Huang, X.; Meggers, E.* Org. Chem. Front. 2018, 5, 166-170.

26. Chen, S.; Huang, X.; Meggers, E.; Houk, K. N.* J. Am. Chem. Soc. 2017, 139, 17902-17907.

27. Ma, J.; Rosales, A. R.; Huang, X.; Harms, K.; Riedel, R.; Wiest, O.; Meggers, E.* J. Am. Chem. Soc. 2017, 139, 17245-17248.

28. Song, S.; Huang, X.; Liang, Y.-F.; Tang, C.; Li, X.; Jiao, N.* Green Chem. 2015, 17, 2727-2731.

29. Shen, T.; Huang, X.; Liang, Y.-F.; Jiao, N.* Org. Lett. 2015, 17, 6186-6189.

30. Zhu, Y.; Li, X.; Wang, X.; Huang, X.; Shen, T.; Zhang, Y.; Sun, X.; Zou, M.; Song, S.; Jiao, N.* Org. Lett. 2015, 17, 4702-4705.

31. Liang, Y.-F.; Wu, K.; Song, S.; Li, X.; Huang, X.; Jiao, N.* Org. Lett. 2015, 17, 876-879.

32. Li, Z.; Huang, X.; Chen, F.; Zhang, C.; Wang, X.; Jiao, N.* Org. Lett. 2015, 17, 584-587.

33. Chen, F.; Huang, X.; Cui, Y.; Jiao, N.* Chem. – Eur. J. 2013, 19, 11199-11202.