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成果及论文

1. Song Liu; Lingli Bu; Yuming Zhang; Jiangyu Yan; Ling Li; Guorui Li*; Zhibin Song*; Jing Huang*; Subtle Structural Changes of  Dyes Lead to Distinctly Different Fluorescent Behaviors in Cellular Context: The Role of  G-Quadruplex DNA Interaction Using Coumarin Quinazolinone Conjugates as a Case Study, Analytical Chemistry, 2021.https://doi.org/10.1021/acs.analchem.1c00301

2. Song Liu; Han Su;Lingli Bu; Jiangyu Yan;Guorui Li ; Jing Huang; Fluorogenic Probes for Mitochondria and Lysosomes via Intramolecular Photoclick Reaction , Analyst , 2021, 146, 1369-1375. https://doi.org/10.1039/d0an01982h.

3. Juan Liao; Siyu Peng; Mei Long; Yaya Zhang; HuanMing Yang*; Yi Zhang*; Jing Huang*; Nano-Bio interactions of clay nanotubes with colon cancer cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 586, 124242. https://doi.org/10.1016/j.colsurfa.2019.124242

4. Mei Long; Bin Zhang; Siyu Peng; Juan Liao; Yi Zhang; Jie Wang, Mi Wang, Bo Qin, Jufang Huang, Jing Huang, Xiaoping Chen, Huaming Yang*, Interactions between two-dimensional nanoclay and blood cells in hemostasis, Materials Science and Engineering: C, 2019, 105, 110081-110090.https://doi.org/10.1016/j.msec.2019.110081

5. Tao Luo; Lingli Bu; Siyu Peng; Yaya Zhang; Zhi Zhou; Guorui Li*; Jing Huang*; One-step microwave-assisted preparation of oxygen-rich multifunctional carbon quantum dots and their application for Cu2+-curcumin detection, Talanta, 2019, 205, 120117-120125. https://doi.org/10.1016/j.talanta.2019.120117

6. Jihuan Yang; Yaya Zhang; Xuejiao Bai; Guorui Li*; Zhiming Xing; Cheng Zhong; Jia Zhou; Song Liu; Zhibin Song*; Jing Huang*; Coumarin-Quinazolinone conjugate with large two photon action cross-section assisted by intramolecular hydrogen bond for bioimaging, Sensors & Actuators: B. Chemical, 2019, 297, 126720-126729. https://doi.org/10.1016/j.snb.2019.126720

7. Lingli Bu; Tao Luo; Huanjun Peng; Ling Li; Dengying Long; Jingdong Peng*; Jing Huang*; One-step synthesis of N-doped carbon dots, and their applications in curcumin sensing, fluorescent inks, and super-resolution nanoscopy, Microchimica Acta, 2019, 186, 675-686. https://doi.org/10.1007/s00604-019-3762-5

8. Jing Huang*; Jing Zhang; Marina A. Bellani; Durga Pokharel; Julia Gichimu; Ryan C. James; Himabindu Gali; Chen Ling; Zhijiang Yan; Dongyi Xu; Junjie Chen; Amom Ruhikanta Meetei; Lei Li; Weidong Wang; Michael M. Seidman*; Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2, Cell Reports, 2019, 27(6), 1794-1808. https://doi.org/10.1016/j.celrep.2019.04.032

9. Lu Liu; Yaya Zhang; Jia Zhou; Jihuan Yang; Cheng Zhong; Yueshou Zhang; Yu Luo; Yang Fua; Jing Huang*; Zhibin Song*; Yiyuan Peng; Design of a quinazolinone-based environment-sensitive fluorescent dye: Solvatochromic fluorescence and application for one-photon and two-photon bioimaging, Dyes and Pigments, 2019, 165, 58-64. https://doi.org/10.1016/j.dyepig.2019.01.051

10.  Marina A Bellani; Jing Huang; Manikandan Paramasivam; Durga Pokharel, Julia Gichimu; Jing Zhang; Michae M. Seidman*; Imaging cellular responses to antigen tagged DNA damage , DNA Repair, 2018, 71, 183-189. https://doi.org/10.1016/j.dnarep.2018.08.023

11. Jing Huang; Himabindu Gali; Julia Gichimu; Marina A. Bellani; Durga Pokharel; Manikandan Paramasivam; Michael M. Seidman*; Single Molecule Analysis of Laser Localized Psoralen Adducts, Cation, 2017122, 55541-55547Inter. https://doi.org/10.3791/55541

12. Florian Rohleder; Jing Huang; Yutong Xue; Jochen Kuper; Adam Round; Michael Seidman*; Weidong Wang*; and Caroline Kisker*; FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks, Nucleic Acids Research, 2016, 44(7), 3219–3232. https://doi.org/10.1093/nar/gkw037

13.  Jing Huang; Himabindu Gali; Manikandan Paramasivam; Parameswary Muniandy; Julia Gichimu; Marina A; Bellani and Michael M. Seidman*; Single molecule analysis of laser localized interstrand crosslinks. Frontiers in Genetics, 2016, 7, 84-93. https://doi.org/10.3389/fgene.2016.00084

14.  Chen Ling; Jing Huang; Zhijiang Yan; Yongjiang Li; Mioko Ohzeki; Masamichi Ishiai; Dongyi Xu; Minoru Takata; Michael Seidman*; and Weidong Wang*; Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks, Cell Discovery, 2016, 2, 16047. https://doi.org/10.1038/celldisc.2016.47

15.  Taraswi Banerjee; Joshua A. Sommers; Jing Huang; Michael M. Seidman; Robert M. Brosh, Jr*; Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress, Current Biology, 2015, 25(21), 2830-2838. https://doi.org/10.1016/j.cub.2015.09.026

16.  Xiaolin Li; Evandro Fei Fang; Morten Scheibye-Knudsen; Honghua Cui; Lu Qiu; Jian Li; Yuping He; Jing Huang; Vilhelm A Bohr; Tzi Bun Ng*; Hongwei Guo*; Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis, Scientific Reports2014, 4, 6434. https://doi.org/10.1038/srep06434

17. Jing Huang; Shuo Liu; Marina A. Bellani; Arun Kalliat Thazhathveetil; Chen Ling; Johan P. de Winter; Yinsheng Wang; Weidong Wang; and Michael M. Seidman*; The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks, Molecular Cell, 2013, 52(3), 434–446.

18.  Daniel R. McNeill; Manikandan Paramasivam; Jakita Baldwin; Jing Huang; Vaddadi N. Vyjayanti; Michael M. Seidman and David M. Wilson III*; NEIL1responds and binds to psoralen-induced DNA interstrand crosslinks, Journal of Biological Chemistry, 2013, 288(18), 12426-12436. https://doi.org/10.1016/j.molcel.2013.09.021

19.  Venkateswarlu Popuri; Jing Huang; Mahesh Ramamoorthy; Takashi Tadokoro; Deborah L Croteau; Vilhelm A Bohr*; RECQL5 plays co-operative and complementary roles with WRN syndrome helicase, Nucleic Acids Research, 2013, 41(2), 881-899. https://doi.org/10.1093/nar/gkw1216

20.  Xiaolin Wang Jing Huang; Yangyang Zhou; Shengyong Yan; Xiaocheng Weng; Xiaojun Wu; Minggang Deng; Xiang Zhou*Conformational Switching of G-Quadruplex DNA by PhotoregulationAngewandte Chemie International Edition, 2010 , 49(31), 5305-539. https://doi.org/10.1002/anie.201002290

21.  Minghui Bai; Jing Huang; Xiaolong Zheng; Zhibin Song; Miru Tang; Wuxiang Mao; Libo Yuan; Jun Wu; Xiaocheng Weng;  Xiang 

Zhou*; Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives, Journal of the American Chemical Society, 2010 , 132(43), 15321-15327. https://doi.org/10.1021/ja106637e

22.  Yuhao Du; Jing Huang; Xiaocheng Weng; Xiang Zhou*; Specific recognition of DNA by small molecules.Current Medicinal Chemistry, 2010, 17(2), 173-189. https://doi.org/10.2174/092986710790112648

23.  Liang Xu; Dan Zhang; Jing Huang; Minggang Deng; Ming Zhang; Xiang Zhou *High fluorescence selectivity and visual detection of G-quadruplex structures by a novel dinuclear ruthenium complex, Chemical Communications, 2010, 46(5):743-745. https://doi.org/10.1039/b918045a

24.  Yuhao Du; Xiaocheng Weng; Jing Huang; Dan Zhang; Heng Ma; Dong Chen; Xiang Zhou*; Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA, Bioorganic & Medicinal Chemistry, 2010, 18(11), 4149-4153. https://doi.org/10.1016/j.bmc.2009.11.026

25.  Jing Huang; Ming Wang; Yangyang Zhou; Xiaocheng Weng; Liang Shuai; Xiang Zhou *; Deqing Zhang; Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission, Bioorganic & Medicinal Chemistry, 2009 , 17(22), 7743-7748. https://doi.org/10.1016/j.bmc.2009.09.040

26.  Jing Huang; Guorui LiZhiguo Wu;  Zhibin Song; Yangyang Zhou; Liang Shuai; Xiaocheng Weng; Xiang Zhou *; Guangfu Yang; Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex, Chemical Communications, 2009, 8, 902-904. https://doi.org/10.1039/b819789j

27.  Ming Zhang; Jing Huang; Minggang Deng; Xiaocheng Weng; Heng Ma; Xiang Zhou *; Sensitive and Visual Detection of Adenosine by a Rationally Designed FokI-Based Biosensing Strategy, Chemistry -An Asian Journal, 2009, 4(9),1420-1423. https://doi.org/10.1002/asia.200900200

28.  Lin Wu; Li Yang; Jing Huang; Lixia Zhang; Xiaocheng Weng; Xiaolian Zhang; Chao Shen; Xiang Zhou *; Congyi Zheng; Cationic Ester Porphyrins Cause High Levels of Phototoxicity in Tumor Cells and Induction of Apoptosis in HeLa CellsChemistry & Biodiversity, 2009 , 6(7), 1066-1076. https://doi.org/10.1002/cbdv.200800173

29.  Shaoru Wang; Dan Zhang; Fengling Luo; Lin Liu; Xiaocheng Weng; Jing Huang; Guorui Li; Xiaolian Zhang; Xiang Zhou *; Some cationic porphyrins: synthesis, stabilization of G-quadruplexes, and down-regulation of c-myc in Hep G2 cellsJournal of Porphyrins & Phthalocyanines, 2009, 13(8-9), 865-875. https://doi.org/10.1142/S1088424609001121

30.  Guorui Li; Jing Huang; Ming Zhang; Yangyang Zhou; Dan Zhang; Zhiguo Wu; Shaoru Wang; Xiaocheng Weng; Xiang Zhou *; Guangfu Yang; Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand, Chemical Communications, 2008, 38,4564-4566. https://doi.org/10.1039/b807916a

31.  Zhibin Song; Xiaocheng Weng; Liwei Weng; Jing Huang; Xiaolin Wang; Minghui Bai; Yangyang Zhou; Guangfu Yang; Xiang Zhou *; Synthesis and Oxidation-Induced DNA Cross-Linking Capabilities of Bis(catechol) Quaternary Ammonium Derivatives, Chemistry-A European Journal, 2008, 14(19), 5751-5754. https://doi.org/10.1002/chem.200800783

32.  Lixia Zhang; Jing Huang; Lige Ren; Minghui Bai; Lin Wu; Baoping Zhai; Xiang Zhou *; Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase, Bioorganic & Medicinal Chemistry, 2008, 16(1) 303-312. https://doi.org/10.1016/j.bmc.2007.09.037

33.  Boqiao Fu; Jing Huang; Lige Ren; Xiaocheng Weng; Yangyang Zhou; Yuhao Du; Xiaojun Wu; Xiang Zhou *; Guangfu Yang; Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands, Chemical Communications, 2007, 31, 3264-3266. https://doi.org/10.1039/b704599a

34.  An-Ming ZhangJing Huang; XiaoCheng Weng; JinXi Li; Lige Ren; ZhiBin Song; XiaoQin Xiong; Xiang Zhou *; XiaoPing Cao; Yan Zhou; A water-soluble, octacationic zinc phthalocyanine as molecular probe for nucleic acid secondary structure, Chemistry & Biodiversity, 2007, 4(2), 215-223. https://doi.org/10.1002/cbdv.200790026

35.  Lixia Zhang; Lige Ren; Minghui Bai; Liwei Weng; Jing Huang; Lin Wu; Minggang Deng; Xiang Zhou *; Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups, Bioorganic & Medicinal Chemistry, 2007, 15(22), 6920-6926. https://doi.org/10.1016/j.bmc.2007.07.053

36.  XiaoCheng Weng; Jing Huang; Song Wu; LiGe Ren; LiWei Weng; ShuGao Zhu; Xiang Zhou *; Specific recognition of loop DNA by dicationic PorphyrinsChemistry & Biodiversity, 2007, 4(7), 1501-1507. https://doi.org/10.1002/cbdv.200790129

37.  Lige Ren; Anming Zhang; Jing Huang; Ping Wang; Xiaocheng Weng; Lixia Zhang; Feng Liang; Zheng Tan; Xiang Zhou *; Quaternary ammonium zinc phthalocyanine: Inhibiting telomerase by stabilizing G quadruplexes and inducing G-quadruplex structure transition and formation, Chembiochem, 2007, 8(7), 775-780. https://doi.org/10.1002/cbic.200600554

38.  Xiaocheng Weng; Lige Ren; Liwei Weng; Jing Huang; Shugao Zhu;  Xiang Zhou*; Linhong Weng; Synthesis and biological studies of inducible DNA cross-linking agents, Angewandte Chemie International Edition, 2007, 46(42), 8020-8023. https://doi.org/10.1002/anie.200700844

 

 * corresponding author