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成果及论文

After 2021

1. Kun Zhu, Isaac J. Celwyn, Dongyin Guan, Yang Xiao, Xiang Wang, Wenxiang Hu, Chunjie Jiang, Lan Cheng, Rafael Casellas, Mitchell A. Lazar. An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver. Molecular Cell. 2023 Oct 5;83(19):3457-3469.e7.

2.Cuihua Wang^#, Xianju Wang^#, WenxiangHu^*. Molecular and cellular regulation of thermogenic fat. Frontiers in Endocrinology. 2023.

‍ 3. Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A Lazar. Hepatocyte SREBP signaling mediates clock communication within the liver. The Journal of clinical investigation. 2023, 133(8):e163018.

4. Yang Xiao, Kirill Batmanov, Wenxiang Hu, Kun Zhu, Alexander Y. Tom, Dongyin Guan, Chunjie Jiang, Lan Cheng, Sam J. McCright, Eric C. Yang, Matthew R. Lanza, Yifan Liu, David A. Hill, Mitchell A. Lazar*. Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis[J]. Science translational medicine. 2023, 15(682): eadc9653.

5. Jian Ma^*, Chunjie Jiang, Xuebin Fu, Jun Chen, Wenxiang Hu, Lin Yuan. Novel insights into the pathophysiology of diabetes-related complications: Implications for improved therapeutic strategies. Frontiers in Endocrinology. 2023 Mar 1, 14: 456.

6. Wenxiang Hu*, Mitchell Lazar*. Modelling metabolic diseases and drug response using stem cells and organoids. Nature Reviews Endocrinology. 2022 Sep 7:1-16.

7. Wenxiang Hu*^#, Chunjie Jiang^#, Mindy Kim, Yang Xiao, Hannah J. Richter, Dongyin Guan, Kun Zhu,Brianna M Krusen, Arielle N. Roberts, Jessica Miller, David J. Steger, Mitchell A. Lazar*. Isoform-specific functions of PPARg in gene regulation and metabolism. Genes & Development. 2022 Mar 1;36(5-6):300-312.

8. Li Lin#, Miao lei#, Jiaman Lin#, Wenxiang Hu*. Advances and applications in liver organoid technology. SCIENTIA SINICA Vitae. 2021, 2(83).

9. Wenxiang Hu#*, Chunjie Jiang#, Mindy Kim, Wenjian Yang, Kun Zhu, Dongyin Guan, Wenjian Lv, Yang Xiao, Jessica R Wilson, Daniel J Rader, Ching-Hon Pui, Mary V. Relling, Mitchell A. Lazar*. Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. Cell Metabolism. 2021. (Highlighted by Nature Review Endocrinology)

Before 2021

1. Wenxiang Hu#, Chunjie Jiang#, Dongyin Guan, Pieterjan Dierickx, Rong Zhang, Arden Moscati, Girish N. Nadkarni, David J. Steger, Ruth J.F. Loos, Cheng Hu, Weiping Jia, Raymond E. Soccio, and Mitchell A. Lazar*. Patient adipose stem cell-derived adipocytes reveal genetic variation that predicts anti-diabetic drug response. Cell Stem Cell. 2019 Feb 7;24(2):299-308. (Cover story, Preview by Cell Stem Cell, Highlighted by Nature medicine and Nature Review Endocrinology)

2. Wenxiang Hu#, Binlong Qiu#, Wuqiang Guan#, Qinying Wang, Min Wang, Wei Li, Longfei Gao, Lu Shen, Yin Huang, Gangcai Xie, Hanzhi Zhao, Ying Jin, Beisha Tang, Yongchun Yu, Jian Zhao*, and Gang Pei*. Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell. 2015 Aug 6;17(2):204-12. ( Preview by Cell Stem Cell, Highlighted by Nature methods, Recommended by F1000)

3. Lin Cheng#, Wenxiang Hu#, Binlong Qiu#, Jian Zhao#*, Yongchun Yu, Wuqiang Guan, Min Wang, Wuzhou Yang and Gang Pei*. Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Research. 2014 doi: 10.1038/cr.2014.32.

4. Wenxiang Hu, Jian Zhao* and Gang Pei*. Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming. J Biol Chem. 2013 Aug 9; 288(32):22972-84.

5. Dongyin Guan, Ying Xiong, Trang Minh Trinh, Yang Xiao, Wenxiang Hu, Chunjie Jiang, Pieterjan Dierickx, Cholsoon Jang, Joshua D.Rabinowitz, Mitchell A. Lazar*. The Hepatocyte Clock and Feeding Interdependently Control Chrono-Homeostasis of Multiple Liver Cell Types. Science. 2020 369 (6509), 1388-1394.

6. Kiara K Benson, Wenxiang Hu, Angela H Weller, Alexis H Bennett, Eric R Chen, Sumeet A Khetarpal, Satoshi Yoshino, William P Bone, Lin Wang, Joshua D Rabinowitz, Benjamin F Voight, Raymond E Soccio*. Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene. PNAS. 2019 116 (46), 23232-23242.

7. Dongyin Guan, Ying Xiong, Patricia C. Borck, Cholsoon Jang, Paschalis-Thomas Doulias, Romeo Papazyan, Bin Fang, Chunjie Jiang, Yuxiang Zhang, Erika R. Briggs, Wenxiang Hu, David Steger, Harry Ischiropoulos, Joshua D. Rabinowitz, and Mitchell A. Lazar*. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes . Cell. 2018 174, 1–12

8. Wu-Zhou Yang#, Ting-Ting Liu#, Jun-Wei Cao, Xuan-Fu Chen, Xiao Liu, Min Wang, Xin Su, Shu-Qing Zhang, Bin-Long Qiu, Wen-Xiang Hu, Lin-Yun Liu, Lan Ma, Yong-Chun Yu*. Fear erasure facilitated by immature inhibitory neuron transplantation. Neuron. 2016 92 (6), 1352-1367

9. Lin Cheng#, Longfei Gao#, Wuqiang Guan, Jianxin Mao, Wenxiang Hu, Binlong Qiu, Jian Zhao, Yongchun Yu and Gang Pei*. Direct conversion of astrocytes into neuronal cells by drug cocktail. Cell Research. 2015; 25:1269–1272

10. Le-nan Zhuang, Wen-xiang Hu, Ming-liang Zhang, Shun-mei Xin, Wei-ping Jia, Jian Zhao*, and Gang Pei*. Beta-arrestin-1 protein represses diet-induced obesity. J Biol Chem. 2011 Aug 12; 286(32):28396-402.

11. Le-nan Zhuang, Wen-xiang Hu, Shun-mei Xin, Jian Zhao*, Gang Pei*. Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma). J Biol Chem. 2011 Aug 12; 286(32):28403-13

12. Rui Yue, Jiuhong Kang, Cong Zhao, Wenxiang Hu, Yawei Tang, Xiaosong Liu and Gang Pei*. β-arrestin1 regulates zebrafish hematopoiesis through binding to yy1 and relieving polycomb group repression. Cell. 2009 Oct 30;139(3):535-46.