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成果及论文


2024~

41. Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca2+ Homeostasis Regulation and Pancreas Autodigestion Inhibition

Yanan Wang#, Xinyuan Wang#, Xue Zhang, Baomei Zhang, Xinlei Meng, Deyao Qian, Yatao Xu,  Liangmin Yu*, Xuefeng Yan, Zhiyu He*

ACS Nano  (2024)In Press  通讯作者,IF:18.027   JCR 1区&中科院1区  TOP期刊


40. Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation

Keyang Li#Yanan Wang#, Yatao Xu, Guohua Shi,Sixian Wei, Xue Zhang, Baomei Zhang, Qiang Jia, Huanhua Xu*, Liangmin Yu, Jun Wu*, Zhiyu He*

Chinese Chemical Letters (2023)通讯作者,IF:8.455   JCR 1区 &中科院1区  TOP期刊


39. ROS-responsive dextran-phenylboronic acid-silibinin nanoparticles for targeting delivery of BAPTA-AM to effectively eliminate calcium overload-mediated inflammatory cascades and mitochondrial apoptosis: Alleviating acute liver injury

Yanan Wang, Huichao Wei, Keyang Li, Liru Liu, Yingfei Zhu, Xinyuan Wang, Jiahui Yan,  Liangmin Yu*, Xuefeng Yan, Zhiyu He* 

Chemical Engineering Journal 480 (2024) 148283, 通讯作者,IF:15.1   JCR 1区 &中科院1区  TOP期刊

2023

38. Marine biomaterials in biomedical nano/micro-systems

Yanan Wang, Long Chen, Yuanzheng Wang, Xinyuan Wang, Deyao Qian, Jiahui Yan, Zeyu Sun, Pengfei Cui*, Liangmin Yu, Jun Wu*, Zhiyu He* 

Journal of Nanobiotechnology 21 (2023) 408, 通讯作者,IF:10.2   JCR 1区 &中科院1区  TOP期刊


37.  Restoring cellular calcium homeostasis to rescue ER stress by 1,2-bis(2-aminophenoxy)  ethane-N,N,N,N-tetraacetic acid acetoxymethyl ester-loaded lipid-mPLGA hybrid-nanoparticles for acute kidney injury therapy

Jingwen Zhang, Jiahui Yan, Yanan Wang, Xueping Sun, Yuchao Gu*, Liangmin Yu, Changcheng Li, Jun Wu*, Zhiyu He* 

Chinese Chemical Letters (2023)通讯作者,IF:8.455   JCR 1区 &中科院1区  TOP期刊


36.  Rapidly inhibiting the inflammatory cytokine storms and restoring cellular homeostasis to alleviate sepsis by blocking pyroptosis and mitochondrial apoptosis pathways 

Jiahui Yan,  Jingwen Zhang, Yanan Wang, Hong Liu, Xueping Sun, Aixin Li, Liangmin Yu*, Xuefeng YanZhiyu He* 

Advanced Science (2023)2207448,通讯作者,IF:17.521   JCR 1区&中科院1区  TOP期刊


35.  Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment-Responsive BAPTA-AM/BAC Co-Delivery Nanosystem

Jiahui Yan, Yanan Wang, Jingwen Zhang, Xiaohu Liu, Liangmin Yu, Zhiyu He* 

Small (2023)202206936, 通讯作者,IF:15.153   JCR 1区&中科院1区  TOP期刊


34.  1,2-Bis(2-aminophenoxy)ethaneN,N,N,N′‐tetraacetic Acid Acetoxymethyl Ester Loaded Reactive Oxygen Species Responsive Hyaluronic Acid-Bilirubin Nanoparticles for Acute Kidney Injury Therapy via Alleviating Calcium Overload Mediated Endoplasmic Reticulum Stress

Yanan Wang, Minju Pu, Jiahui Yan, Jingwen Zhang, Huichao Wei, Liangmin Yu,Xuefeng Yan, Zhiyu He* 

ACS Nano 17 (2023)472-491 通讯作者,IF:18.027   JCR 1区&中科院1区  TOP期刊


2022~

33.  The Advancement of Gas-Generating Nanoplatforms in Biomedical Fields: Current Frontiers and Future Perspectives

Jiahui Yan, Yanan Wang, Xinyu Song, Xuefeng Yan, Yi Zhao*,  Liangmin Yu, Zhiyu He* 

Small Methods (2022) 2200139 通讯作者,IF:15.367   JCR 1区&中科院1区  TOP期刊


32.  Innovations and challenges of polyphenol-based smart drug delivery systems

Yanan Wang#, Jingwen Zhang#, Yi Zhao, Minju Pu, Xinyu Song, Liangmin Yu*, Xuefeng Yan, Jun Wu*Zhiyu He* 

Nano Research. (2022)  通讯作者 IF: 10.269    JCR 1&中科院1  TOP期刊


31. Cell-Selective Encapsulation within Metal–Organic Framework Shells via Precursor-Functionalized Aptamer Identification for Whole-Cell Cancer Vaccine

Huihui Yang, Yanfei Zhang, Leli Zeng, Wen Yin, Yuzhi Xu*, Jun Chen, Siyang Liu*, Xiaoyong Zou, Zhiyu He, Zong Dai*

Small Methods(2022)2101391 共同作者,IF:15.367   JCR 1区&中科院1区  TOP期刊


2021

30.  Kinetic control of Phytic acid/Lixisenatide/Fe (III) ternary nanoparticles assembly process for sustained peptide release

Yanan Wang#, Xinyu Song#, Liwei Zhuang#, Haifeng Lang, Liangmin Yu*, Xuefeng Yan, Zhiyu He*

 International Journal of Pharmaceutics  611 (2021) 121317通讯作者,IF: 6.51   JCR 1区&中科院2区  TOP期刊


29.  Dealing with MDR bacteria and biofilm in the post-antibiotic era: application of antimicrobial peptides-based nano-formulation

Xinyu Song#, Pengyan Liu#, Xiaohu Liu, Yanan Wang, Huichao Wei, Jingwen Zhang, Liangmin Yu*, Xuefeng Yan, Zhiyu He*

Materials Science and Engineering: C  128 (2021) 112318.  通讯作者 IF: 8.457   JCR 1区&中科院1区   TOP期刊


28.  Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications

Yi Zhao#, Minju Pu#, Yanan Wang,  Liangmin Yu*, Xinyu Song and Zhiyu He*

Journal of Controlled Release 336 (2021) 233-251.  通讯作者  IF: 11.467     JCR 1&中科院1    TOP期刊

 

27.  Recent advancements of nanomaterial-based therapeuti strategies toward sepsis: bacterial eradication, anti-inflammation and immunomodulation

Yi Zhao#, Minju Pu#, Jingwen Zhang, Yanan Wang, Xuefeng Yan, Liangmin Yu* and Zhiyu He*

Nanoscale  13 (2021) 10726-10747 通讯作者  IF: 8.307   JCR 1区&中科院1区  TOP期刊


26.  Sustained Release Systems for Delivery of Therapeutic Peptide/Protein

Tianqi Nie#, Wei Wang#, Xiaohu Liu#, Yanan Wang, Keyang Li, Xinyu Song, Jingwen Zhang, Liangmin Yu*Zhiyu He*

Biomacromolecules 22, no. 6 (2021)  2299-2324.   通讯作者     IF: 6.998  JCR 1区&中科院1区   TOP期刊


25. Nanomaterial-based stategies in antimicrobial application:Progress and Perspectives 

Yi Zhao#, Long Chen#, Yanan Wang#, Xinyu Song, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*

Nano Research. (2021)  通讯作者 IF: 10.269    JCR 1&中科院1  TOP期刊


24.  Recent advances of nanomedicine-based strategies in diabetes and complications management:Diagnostics,monitoring,and therapeutics

Yanan Wang, Chunhui Wang, Keyang Li, Xinyu Song, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*

Journal of Controlled Release 330 (2021) 618-640.   通讯作者  IF: 11.467  JCR 1&中科院1  TOP期刊


 

23.  Non-invasive delivery of levodopa-loaded nanoparticles to the brain via lymphatic vasculature to enhance treatment 

of Parkinson’s disease

Tianqi Nie#Zhiyu He#*, Jinchang Zhu, Kuntao Chen, Gregory P Howard, II Minn, Pengfei Zhao, Zaver M Bhujwalla, Hai-Quan Mao, Lixin Liu and Yongming Chen*

Nano Research 14 (2021) 2749-2761  共同第一作者&通讯作者 IF: 10.269    JCR 1&中科院1  TOP期刊




2020

22.  A Review on Antimicrobial Coatings for Biomaterial Implants and Medical Devices

Long Chen#, Xinyu Song#, Fei Xing#, Yanan Wang, Yuanzheng Wang, Zhiyu He*, and Li Sun*

Journal of Biomedical Nanotechnology 16, no. 6 (2020) 789-809.  通讯作者   IF: 4.48   JCR 1&中科院2


21.  Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood 

glycemic control in a mouse model of type II diabetes

Zaizhi Gui, Jinchang Zhu, Song Ye,  Jiao Chen, Yuanyuan Ling, Xueting Cai, Peng Cao, Zhiyu He*, and Chunping Hu*

International Journal of Pharmaceutics 577 (2020) 119071.  通讯作者   IF: 6.51   JCR 1&中科院2区 TOP期刊



20.  One-Pot Synthesis of PEGylated Lipoplexes to Facilitate Mucosal Permeation for Oral Insulin Gene Delivery

Tianqi Nie#Zhiyu He*, Jinchang Zhu, Lixin Liu, and Yongming Chen*

Advanced Therapeutics 3, no. 3 (2020) 2000016. 共同第一作者&通讯作者   IF: 5.003


19. A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and 

reduce cardiovascular complications in a mouse model of type II diabetes

Zhiyu He*, Tianqi Nie, Yizong Hu, Jinchang Zhu, Lixin Liu, Kam W. Leong, Yongming Chen*and Hai-Quan Mao*

Journal of Controlled Release 318 (2020) 86-97. 第一作者&通讯作者   IF: 11.467  JCR 1&中科院1   TOP期刊

 


18. A microfluidics-derived growth factor gradient in a scaffold regulates stem cell activities for tendon-to-bone interface 

healing

Lyu, Jingtong, Long Chen, Jiqiang Zhang, Xia Kang, Wenjie Wu, Hong Tang, Jun Wu*, Zhiyu He*, and Kanglai Tang*

Biomaterials Science 8 (2020) 3649-3663.   共同通讯作者.  IF: 7.59      JCR 1&中科院2  TOP期刊



17.  Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer 

drug delivery and in situ monitoring of drug release

Li, Yang, Yimin Niu, Jianhua Zhu, Cuicui Gao, Qunwei Xu, Zhiyu He, Dawei Chen, Ming Xu, and Yang Liu

Nanoscale 12, no. 4 (2020) 2673-2685.    IF: 8.307  JCR 1&中科院1    TOP期刊



16.  Programmed co-delivery of platinum nanodrugs and gemcitabine by a clustered nanocarrier for precision 

chemotherapy for NSCLC tumors

Huihui Shi, Ming Xu, Jianhua Zhu, Yang Li, Zhiyu He, Yuxia Zhang, Qunwei Xu, Yimin Niu, and Yang Liu

Journal of Materials Chemistry B  8, no. 2 (2020) 332-342.  IF: 7.571   JCR 1&中科院2

 


2019

15.  Elimination of Intracellular Calcium Overload by BAPTA-AM-Loaded Liposomes: A Promising Therapeutic Agent 

for Acute Liver Failure

Zailin Fu, Qiaomei Fan, Yang Zhou, Yi Zhao*, and Zhiyu He*

ACS Applied Materials & Interfaces 11, no. 43 (2019) 39574-39585.  通讯作者  IF:10.383 JCR 1&中科院1  TOP期刊


 

14.  Kinetic control in assembly of plasmid DNA/polycation complex nanoparticles

Yizong Hu, Zhiyu He, Yue Hao, Like Gong, Marion Pang, Gregory P. Howard, Hye-Hyun Ahn

ACS Nano 13, no. 9 (2019): 10161-10178.    IF: 18.027  JCR 1&中科院1  TOP期刊


 

13.  Surface Coating Approach to Overcome Mucosal Entrapment of DNA Nanoparticles for Oral Gene Delivery of

Glucagon-like Peptide 1

Tianqi Nie#Zhiyu He#*, Yang Zhou, Jinchang Zhu,  Lixin Liu, Kam W. Leong, Hai-Quan Mao, and Yongming Chen*

ACS Applied Materials & Interfaces 11, no. 33 (2019) 29593-29603. 共同第一作者&通讯作者   IF: 10.383  JCR 1&中科院1  TOP期刊



12.  Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse 

model of type II diabetes

Zhiyu He, Yizong Hu, Zaizhi Gui, Yang Zhou, Tianqi Nie, Zhijia Liu, Peng Cao*, Yongming Chen* and Hai-Quan Mao*

Journal of Controlled Release 301 (2019) 119-128. 第一作者   IF: 11.467   JCR 1&中科院1  TOP期刊

 


11.  The formation and characterization of antioxidant pickering emulsions: Effect of the interactions between gliadin

and chitosan

Li, Meng-Fan, Zhi-Yu He, Guo-Yan Li, Qing-Zhu Zeng, Dong-Xiao Su, Jing-Lin Zhang, Qin Wang, Yang Yuan, and Shan He

Food Hydrocolloids 90 (2019) 482-489.   IF: 11.504   JCR 1&中科院1区   TOP期刊



10.  Bone marrow mesenchymal stem cells and endothelial progenitor cells co-culture enhances large segment bone defect

repair

Peng, Jing, Long Chen, Kun Peng, Xuewen Chen, Jun Wu*, Zhiyu He*, and Zhou Xiang*

Journal of biomedical nanotechnology 15, no. 4 (2019) 742-755.  共同通讯作者   IF: 4.48   JCR 1&中科院2 



9.  Three-dimensional co-culture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells 

for bone regeneration

Long Chen, Jun Wu, Chengguang Wu, Fei Xing, Lang Li, Zhiyu He*, Kun Peng*, and Zhou Xiang*

Journal of biomedical nanotechnology 15, no. 4 (2019) 742-755.  共同通讯作者   IF: 4.48   JCR 1&中科院2

 


 

2018

8.  Hydrogen-bonded tannic acid-based anticancer nanoparticle for enhancement of oral chemotherapy

Le, Zhicheng, Yantao Chen, Honghua Han, Houkuan Tian, Pengfei Zhao, Chengbiao Yang, Zhiyu He et al. 

ACS Applied Materials & Interfaces 10, no. 49 (2018) 42186-42197.  IF: 10.383   JCR 1&中科院1   TOP期刊



7.  Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery

Zhiyu He, Yizong Hu, Tianqi Nie, Haoyu Tang, Jinchang Zhu, Kuntao Chen, Lixin Liu, Kam W. Leong*, Yongming Chen*, and Hai-Quan Mao*

Acta Biomaterialia 81 (2018) 195-207.   第一作者  IF: 10.633 JCR 1&中科院1  TOP期刊

 


6.  Uniform core-shell nanoparticles with thiolated hyaluronic acid coating to enhance oral delivery of insulin 

Houkuan Tian, Zhiyu He, Chengxin Sun, Chengbiao Yang, Pengfei Zhao, Lixin Liu, Kam W. Leong, Hai-Quan Mao, Zhijia Liu*, and Yongming Chen*

Advanced Healthcare Materials 7, no. 17 (2018) 1800285.   IF: 11.092.   JCR 1&中科院1   TOP期刊



5.  BAPTA-AM nanoparticle for the curing of acute kidney injury induced by ischemia/reperfusion

Zhiyu He, Haoyu Tang, Xinru You, Keqing Huang, Arvind Dhinakar, Yang Kang, Qiaoli Yu*, and Jun Wu*.

Journal of biomedical nanotechnology 14, no. 5 (2018): 868-883.  第一作者  IF: 4.48  JCR 1&中科院2



4.  Fine tuning of core-shell structure of hyaluronic acid/cell-penetrating peptides/siRNA nanoparticles for enhanced gene 

delivery to macrophages in antiatherosclerotic therapy

Zhao, Yi#Zhiyu He#, Hai Gao, Haoyu Tang, Jianhua He, Qing Guo, Wenli Zhang, and Jianping Liu*

Biomacromolecules 19, no. 7 (2018) 2944-2956.    共同第一作者  IF: 6.998  JCR 1&中科院1   TOP期刊

 


3.  Significant suppression of non-small-cell lung cancer by hyfrophobic poly (ester amide) nanoparticles with high

docetaxel loading

Chen, Xing, Lili Zhao, Yang Kang, Zhiyu He, Fei Xiong, Xiang Ling, and Jun Wu*.

Frontiers in Pharmacology 9 (2018) 118.  IF: 5.81   JCR 2&中科院2


 

2.  Scalable production of core–shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral 

delivery of insulin

Zhiyu He, Zhijia Liu, Houkuan Tian, Yizong Hu, Lixin Liu, Kam W. Leong*, Hai-Quan Mao*, and Yongming Chen*

Nanoscale 10, no. 7 (2018): 3307-3319.    第一作者  IF: 8.307  JCR 1&中科院1  TOP期刊



 

2017

1.  Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin

Zhiyu He, Jose Luis Santos, Houkuan Tian, Huahua Huang, Yizong Hu, Lixin Liu, Kam W. Leong*, Yongming Chen*, and Hai-Quan Mao*

 Biomaterials 130 (2017): 28-41.    第一作者   IF: 15.304     JCR 1&中科院1  TOP期刊