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成果及论文

(1)     Yajie Liu*, Pengxing He*, Xubin Ma, Yingqi Tian, Yu Zhang, Yang Wang, Yingjie Jia, Hongmin Liu, Ying Liu, Yichao Xu; The combination of SLC7A11 inhibitor and oridonin synergistically inhibits cervical cancer cell growth by decreasing the NADPH/NADP+ ratio, Genes & Diseases, 2024, online, 101265.

(2)     Huiyun Wei; Yingying Zhang; Yilin Jia; Xunan Chen; Tengda Niu; Aniruddha Chatterjee; Pengxing He#; Guiqin Hou#; Heat shock protein 90: biological functions, diseases, and therapeutic targets, MedComm, 2024, 5(2): e470.

(3)     Linna Du; Han Yang; Yufei Ren; Yanli Ding; Yichao Xu; Xiaolin Zi; Hongmin Liu; Pengxing He#; Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced antitumor effects with ferroptosis inducers in NSCLC, Cell Death Disease, 2023, 14(11): 716.

(4)     Pengxing He; Jing Jing; Linna Du; Xuyang Zhang; Yufei Ren; Han Yang; Bin Yu; Hongmin Liu; Discovery of YS-363 as a highly potent, selective, and orally e ffi cacious EGFR inhibitor, Biomedicine Pharmacotherapy, 2023, 167: 115491.

(5)     Pengxing He; Linna Du; Qingqing Dai; Guobo Li; Bin Yu; Linlin Chang; Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors, Bioorganic Chemistry, 2023, 142:106970.

(6)     Xu-Yang Zhang, Pan Hao, Jun-Wei Wang, Wen Zhao#, Hong-Min Liu#, Peng-Xing He#. Inhibition of lysine-specific demethylase 1 enhances the sensitivity of the chemotherapeutic drug doxorubicin in gastric cancer cell. Molecular Biology Reports, 2023, 50: 507-516.

(7)     Pengxing He; Linna Du; Pan Hao; HanYang; Yufei Ren; Huiqin Kang; Yanli Ding; Wen Zhao; Yichao Xu; Hongmin Liu; Inhibition of lysine-specific demethylase 1 (LSD1) prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma, Genes & Diseases, 2022, 10(5): 1779-1782.

(8)     Zhi-lu Ma, Yan-li Ding, Jing Jing, Lin-na Du, Xu-yang Zhang, Hong-min Liu#Peng-xing He#. ATRA promotes PD-L1 expression to control gastric cancer immune surveillance. European Journal of Pharmacology, 2022, (920): 174822. 

(9)     Zhiru Wang, Wenting Kang, Ouwen Li, Fengyu Qi, Junwei Wang, Yinghua You, Pengxing He, Zhenhe Suo, Yichao Zheng, Hong-Min Liu. Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing. Acta Pharmaceutica Sinica B, 2021, 11(3): 694-707.

(10) Peng-xing He, Zhi-lu Ma, Huan Han, Xu-yang Zhang, Sheng-hui Niu, Lin-na Du, Yi-chao Zheng, Hong-min Liu. Expression of programmed death ligand 1 (PD-L1) is associated with metastasis and differentiation in gastric cancer. Life Sciences, 2020, 242: 117247.

(11) Pengxing He; Shenghui Niu; Shuai Wang; Xiaojing Shi; Siqi Feng; Linna Du; Xuyang Zhang; Zhilu Ma; Bin Yu; Hongmin Liu; Discovery of WS-157 as a highly potent, selective and orally active EGFR inhibitor, Acta Pharmaceutica Sinica B, 2019, 9(6): 1193-1203.

(12) Jie Zhang, Yafang Wang, Yanyan Shen, Pengxing He, Jian Ding, Yi Chen. G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1. Theranostics, 2018, 8(10): 2884-2895.

(13) Zheng YC, Yu B, Jiang GZ, Feng XJ, He PX, Chu XY, Zhao W, Liu HM. Irreversible LSD1 inhibitors: Application of tranylcypromine and its derivatives in cancer treatment. Current Topics in Medicinal Chemistry, 2016, 16(19): 2179-2188.

(14) Jie Zhang, Peng-xing He, Yong Xi, Mei-yu Geng, Yi Chen, Jian Ding. Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation. Oncotarget, 2015, 6(5): 2917-2927.

(15)  Peng-xing HE, Jie ZHANG, Yong-sheng CHE, Qiao-jun HE, Yi CHEN, Jian DING. G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation. Acta Pharmacologica Sinica, 2014. 35(12): 1546-1555.

(16)  Peng-xing HE, Jie ZHANG, Yong-sheng CHE, Qiao-jun HE, Yi CHEN, Jian DING. G226, a novel epipolythiodioxopiperazine derivative, induces autophagy and caspase-dependent apoptosis in human breast cancer cells in vitro. Acta Pharmacologica Sinica, 2014. 35(8): 1055-1064.