博士，特聘副研究员，硕士生导师

上海市青年科技启明星（2022）、上海市“超级博士后”（2018）

         研究聚焦聚焦“如何基于强化荧光传感与生理环境耦合作用，精准获取多维度生物学信息”的关键科学问题，创新荧光传感机制、递送示踪策略、多模式协同方法，从细胞、组织乃至活体层面突破生物光学成像应用研究瓶颈，精准解析多维度生命过程：

1）“荧光反转”激活型、“反卡莎”比率型机制：通过光物理激发态势能面调控策略与分子砌块创制源头创新，发展高灵敏、内标比率型荧光探针，提升生物分子定量检测精准度；

2）逻辑运算荧光响应策略：基于染料电子离域调控与原位诱导材料解组装，开发序列激活的纳米探针体系，提升肿瘤靶向递送成像精准度；

3）限域环境分子激发态运动调控方法：阐明分子光物理激发态弛豫过程与材料微环境组装调控之间的关系，在限域环境中精准操控激发态分子内运动与相互作用，协同增强多模式成像，高时空分辨率反馈病理信息，形成并建立标准化荧光检测方法。

         已发表SCI论文50篇，申请中国发明专利7项，已授权5项。以第一/共一/通讯作者发表论文21篇，包括Nature Protocols (1篇)、Nature Communications (2篇)、Journal of the American Chemical Society (1篇)、Angewandte Chemie (4篇)、Chemical Science (3篇)、Science China Chemistry (1篇)、Coordination Chemistry Reviews (1篇)等，3篇论文为封面论文，3篇论文为ESI高被引论文。

研究生招收专业：精细合成化学与分子工程

邮箱：chenxuyan@ecust.edu.cn

ORCID：https://orcid.org/0000-0001-7130-769X

个人简历

2013年毕业于华东理工大学化学与分子工程学院，材料化学专业，学士；

2018年毕业于华东理工大学化学与分子工程学院，精细合成化学与分子工程专业，博士（导师：朱为宏教授、郭志前教授）；

2018-2021年华东理工大学，生物荧光传感研究方向，博士后（合作导师：田禾院士）。

2021年起加入华东理工大学材料生物学与动态化学前沿科学中心，任特聘副研究员。

代表性论著

1.        Yan; Guo; Chi; Fu; Abedi; Liu; Tian; Zhu*, Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. Nat. Commun. 2021, 12, 3869.

2.        Yan; Dai; Yao; Fu; Tian; Zhu; Guo*, Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat. Protoc. 2023, 18, 1316-1336.

3.        Shi#; Yan#; Guo*; Chi; Wei; Liu; Liu*; Tian; Zhu*, De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules. Nat. Commun. 2020, 11, 793.

4.        Yao; Ding; Yan*; Tao; Peng; Liu; Wang; Cohen Stuart; Guo*, Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed. 2023, 62, 202218983.

5.        Yan; Guo*; Liu; Shi; Tian; Zhu*, A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release. Chem. Sci. 2018, 9, 6176-6182.

6.        Yan; Guo*; Shen; Chen; Tian; Zhu*, Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy. Chem. Sci. 2018, 9, 4959-4969.

7.        Fu#; Yan#; Guo*; Zhang; Zhang*; Tian; Zhu*, Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J. Am. Chem. Soc. 2019, 141, 3171-3177.

8.        Yan; Zhang; Guo*, Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy. Coord. Chem. Rev. 2021, 427, 213556.

9.        Yan; Xu; Wu; Zhao; Zhao; Tang,; Guo*, Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy. Sci. China. Chem. 2021, 64, 2045-2052.

10.      Tao; Yan*; Wu; Li; Li; Xie; Cheng; Xu; Yang; Zhu; Guo*, Uniting dual-modal MRI/chemiluminescence nanotheranostics: spatially and sensitively self‐reporting photodynamic therapy in oral cancer. Adv. Funct. Mater. 2023, 202303240.

11.      Chang; Yan*; Shi; Li; Fu; Guo* , Rational design of shortwave infrared (SWIR) fluorescence probe: Cooperation of ICT and ESIPT processes for sensing endogenous cysteine. Chin. Chem. Lett. 2022, 33, 762-766.

12.      Ma#; Yan#; Guo*; Tan; Niu; Li; Zhu, Spatio-temporally reporting dose-dependent chemotherapy via uniting dual-modal MRI/NIR imaging. Angew. Chem. Int. Ed. 2020, 59, 21143-21150.

13.      Zhang#; Yan#; Wang; Guo*; Liu; Zhu, A sequential dual-lock strategy for photoactivatable chemiluminescent probes enabling bright duplex optical imaging. Angew. Chem. Int. Ed. 2020, 59, 9059-9066.

14.      Wu#; Yan#; Li; You; Yu*; Wu; Zheng; Liu; Guo; Tian; Zhu*, Circularly polarized fluorescence resonance energy transfer (C-FRET) for efficient chirality transmission within an intermolecular system. Angew. Chem. Int. Ed. 2021, 60, 24549-24557.

15.      Wang#; Yan#; Zhang; Guo*; Zhu, In vivo real-time tracking of tumor-specific biocatalysis in cascade nanotheranostics enables synergistic cancer treatment. Chem. Sci. 2020, 11, 3371-3377.

16.      Li#; Yan#; Zhang; Guo*; Zhu, Ratiometric and light-up near-infrared fluorescent DCM-based probe for real-time monitoring endogenous tyrosinase activity. Dyes. Pigm. 2019, 162, 802-807.

17.      Tao#; Yan#; Li; Dai; Cheng; Li*; Zhu; Guo*, Sequence-activated fluorescent nanotheranostics for real-time profiling pancreatic cancer. JACS Au 2022, 2, 246-257.