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成果及论文

近五年代表性论著 

1.    Qin Y, Zhang Z, Guo X, Li W, Xia W, Ge G, Li Y, Guan M, Gao A, Mao L, Wang H, P. K. Chu, Geng D, A Bone-Targeting Hydrogen Sulfide Delivery System for Treatment of Osteoporotic Fracture via Macrophage Reprogramming and Osteoblast-Osteoclast Coupling. Adv. Funct. Mater. 2024, 2418822.

2.     Liu X, Wang W, Zhu F, Xu H, Ge G, Liang X, Yang H, Xu Y, Xu W, Wei M, Zhou Q, Geng D. Osteoblastic ferroptosis inhibition by small-molecule promoting GPX4 activation for peri-prosthetic osteolysis therapy. J Nanobiotechnology. 2024 Dec 18;22(1):758.

3.     Wang W, Wang Q, Li W, Xu H, Liang X, Wang W, Li N, Yang H, Xu Y, Bai J, Yang S, Geng D. Targeting APJ drives BNIP3-PINK1-PARKIN induced mitophagy and improves systemic inflammatory bone loss. J Adv Res. 2024 Dec 25:S2090-1232(24)00611-8.

4.     Zhang H, Ge G, Zhang W, Sun H, Liang X, Xia Y, Du J, Wu Z, Bai J, Yang H, Yang X, Zhou J, Xu Y, Geng D. PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis. Adv Sci (Weinh). 2024 Sep;11(36):e2404080.

5.    Wang Q, Wang W, Peng X, Ge G, Li W, Zhu C, Chen X, Guo S, Li N, Yang H, Xu Y, Bai J, Pan G, Geng D, Engineering Peptide-Oligonucleotide Nano-Conjugates via Click Reaction as Self-Delivery System for Gene Therapy of Inflammatory Arthritis. Adv. Funct. Mater. 2024, 34, 2406503.

6.  Chen M, Qiao Y, Yu L, et al. A microenvironment responsive polyetheretherketone implant with antibacterial and osteoimmunomodulatory properties facilitates osseointegration. Bioact Mater. 2024;43:273-291.

7.     Yu L, Qiao Y, Ge G, Chen M, Yang P, Li W, Qin Y, Xia W, Zhu C, Pan G, Zhang P, Yang H, Wang C, Bai J, Geng D, Rational Design of Engineered Bionic Periosteum for Dynamic Immunoinduction, Smart Bactericidal, and Efficient Bone Regeneration. Adv. Funct. Mater. 2024, 34, 2401109.

8.     Ge G, Wang W, Wang Q, Wang M, Wang T, Yu L, Zhang X, Zhu C, Xu Y, Yang H, Bai J, Pan G, Geng D, Extracellular Vesicle Clicking on Osteoimplants Through Biomimetic Molecular Adhesion Enables Immune-Enhanced Osseointegration in Diabetics. Adv. Funct. Mater. 2024, 34, 2315849.

9.     Qiao Y, Yu L, Yang P, Chen M, Sun H, Wang L, Wu B, Oh CD, Yang H, Bai J, Geng D. Spatiotemporal Immunomodulation and Biphasic Osteo-Vascular Aligned Electrospun Membrane for Diabetic Periosteum Regeneration. Adv Sci (Weinh). 2023 Dec;10(36):e2302874.

10.   Wang W, Wang Q, Yu L, Ge G, Liu X, Gao A, Wang G, Wu Z, Bai J, Wang H, Chu PK, Geng D. Bio-orthogonal engineered peptide: A multi-functional strategy for the gene therapy of osteoporotic bone loss. Biomaterials. 2023 Nov;302:122352.

11.  Ge G, Guo Q, Zhou Y, Li W, Zhang W, Bai J, Wang Q, Tao H, Wang W, Wang Z, Gan M, Xu Y, Yang H, Li B, Geng D. GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases. Elife. 2023 Nov 6;12:e92142.

12.  Xia Y, Ge G, Xiao H, Wu M, Wang T, Gu C, Yang H, Geng D. REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis. Cell Death Dis. 2023 Sep 25;14(9):631.

13.  Bai J, Feng Y, Li W, Li W, Cheng Z, Rosenholm J, Yang H, Pan G, Zhang H, Geng D. Alternative Copper-Based Single-Atom Nanozyme with Superior Multienzyme Activities and NIR-II Responsiveness to Fight against Deep Tissue Infections. Research (Wash D C). 2023 June; 0031

14.  Zheng K, Bai J, Chen W, Xu Y, Yang H, Li W, Li P, Tong L, Wang H, P. K. Chu, Geng D, Multifunctional BPs/MT@PLGA-ALE Nanospheres for Treatment of Osteoporotic Fracture with Near-Infrared Irradiation. Adv. Funct. Mater. 2023, 33, 2214126.

15.   Qiu S, Wu X, Li Z, Xu X, Wang J, Du Y, Pan W, Huang R, Wu Y, Yang Z, Zhou Q, Zhou B, Gao X, Xu Y, Cui W, Gao F, Geng D. A Smart Nanoreactor Based on an O2-Economized Dual Energy Inhibition Strategy Armed with Dual Multi-stimuli-Responsive "Doorkeepers" for Enhanced CDT/PTT of Rheumatoid Arthritis. ACS Nano. 2022 Oct 25;16(10):17062-17079.

16.  Sun H, Zhang H, Wang T, Zheng K, Zhang W, Li W, Zhang W, Xu Y, Geng D. Biomechanical and Finite-Element Analysis of Femoral Pin-Site Fractures Following Navigation-Assisted Total Knee Arthroplasty. J Bone Joint Surg Am. 2022 Oct 5;104(19):1738-1749.

17.  Bai J, Ge G, Wang Q, Li W, Zheng K, Xu Y, Yang H, Pan G, Geng D. Engineering Stem Cell Recruitment and Osteoinduction via Bioadhesive Molecular Mimics to Improve Osteoporotic Bone-Implant Integration. Research (Wash D C). 2022 Sep 6;2022:9823784.

18.  Yang C, Tao H, Zhang H, Xia Y, Bai J, Ge G, Li W, Zhang W, Xiao L, Xu Y, Wang Z, Gu Y, Yang H, Liu Y, Geng D. TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss. Autophagy. 2022 Mar 24:1-

19.   Li M, Bai J, Tao H, Hao L, Yin W, Ren X, Gao A, Li N, Wang M, Fang S, Xu Y, Chen L, Yang H, Wang H, Pan G, Geng D. Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy. Bioact Mater. 2021 Jul 10;8:309-324.

20.   Zheng K, Bai J, Li N, Li M, Sun H, Zhang W, Ge G, Liang X, Tao H, Xue Y, Hao Y, Zhu C, Xu Y, Geng D. Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway. Bioact Mater. 2021 Mar 18;6(10):3343-3357.

21.  Bai J, Wang H, Chen H, Ge G, Wang M, Gao A, Tong L, Xu Y, Yang H, Pan G, Chu PK, Geng D. Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation. Biomaterials. 2020 Oct;255:120197.

22.  Liu Y, Du J, Peng P, Cheng R, Lin J, Xu C, Yang H, Cui W, Mao H, Li Y, Geng D. Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy. Bioact Mater. 2020 Aug 12;6(1):146-157.