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成果及论文

一、代表性论著:

近五年在Nat Commun., Dev Cell., PNAS., Commun Biol., ACS Catalysis., ACS Nano., JCB, Glycobiology等杂志发表论文60余篇

Yu-He Tang, Ji-Xiong Leng, Ganglong Yang, Xiao-Dong Gao, Yi-Shi Liu, Morihisa Fujita; Production of CA125 with Tn antigens using a glycosylphosphatidylinositol anchoring system, The Journal of Biochemistry, 2024: mvae019. (期刊论文)

 

Meng-Hai Xiang, Tian-Tian Lu, Xiao-Dong Gao, Ning Wang; Efficient production and characterization of soluble active human β-1,2-N-acetylglucosaminyltransferase II in bacteria, Journal of bioscience and bioengineering, 2023, 136(3): 166-172. (期刊论文)

 

Xiuyuan Wang, Hanjie Li, Zibo Wang, Jingru Chen, Wenyan Chen, Xiaoman Zhou, Lina Zhang, Shiqian Xu, Xiao-Dong Gao, and Ganglong Yang; Site- and Structure-Specific Glycosylation Signatures of Bovine, Caprine, Porcine, and Human Milk-Derived Extracellular Vesicles, Journal of Agricultural and Food Chemistry, 2023, 71(51): 20826-20837. (期刊论文)

 

Ji-Xiang Jia, Sen-Lin Peng, Ndayambaje Yvan Kalisa, Qiang Chao, Zhifang Zhou, Xiao-Dong Gao & Ning Wang; A liposomal carbohydrate vaccine, adjuvanted with an NKT cell agonist, induces rapid and enhanced immune responses and antibody class switching, Journal of Nanobiotechnology, 2023, 21(1): 175. (期刊论文)

 

Hui-Lin Xu, Xiaoman Zhou, Shuai Chen, Si Xu, Zijie Li, Hideki Nakanishi & Xiao-Dong Gao; Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism, Communications Biology, 2023, 6(1): 259. (期刊论文)

 

Yi-Shi Liu, Yicheng Wang, Xiaoman Zhou, Linpei Zhang, Ganglong Yang, Xiao-Dong Gao, Yoshiko Murakami, Morihisa Fujita, Taroh Kinoshita; Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1. J Cell Biol 1 May 2023; 222 (5): e202208159. (期刊论文)

 

Shu-Ya Cao, Yi-Shi Liu, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita; A lipid scramblase TMEM41B is involved in the processing and transport of GPI-anchored proteins, The Journal of Biochemistry, 2023, 174(2): 109-123. (期刊论文)

 

Chun-Di Wang, Si Xu, Shuai Chen, Zheng-Hui Chen, Neta Dean, Ning Wang, Xiao-Dong Gao; An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP- N-acetylglucosamine transferase, Frontiers in Cell and Developmental Biology, 2022, 10: 1008078. (期刊论文)

 

Wang, Ning, Li, Sheng-Tao, Xiang, Meng-Hai, Gao, Xiao-Dong; Alg mannosyltransferases: From functional and structural analyses to the lipid-linked oligosaccharide pathway reconstitution, Biochim Biophys Acta Gen Subj, 2022, 0-130112. (期刊论文)

 

Yan Yang, Guoyu Liu, Feng Li, Lucas B. Carey, Changjin Sun, Kaiping Ling, Hiroyuki Tachikawa, Morihisa Fujita, Xiao-Dong Gao & Hideki Nakanishi; Receptor for advanced glycation end-products (RAGE) mediates phagocytosis in nonprofessional phagocytes, Communications Biology, 2022, 5(1): 824. (期刊论文)

 

Xiang, Meng-Hai, Xu, Xin-Xin, Wang, Chun-Di, Chen, Shuai, Xu, Si, Xu, Xiang-Yang, Dean, Neta, Wang, Ning, Gao, Xiao-Dong ;Topological and enzymatic analysis of human Alg2 mannosyltransferase reveals its role in lipid-linked oligosaccharide biosynthetic pathway., Commun Biol, 2022,5(1): 0-117. (期刊论文)

 

Chao Qiang, Li Tianlu, Jia Ji-xiang, Li Zijie, Peng Peng, Gao Xiao-Dong, Wang Ning ; Spore-Encapsulating Glycosyltransferase Catalysis Tandem Reactions: Facile Chemoenzymatic Synthesis of Complex Human Glycans, ACS Catalysis, 2022, 12(5): 3181-3188. (期刊论文)

 

Zhou Chen, Kangqing Fei, Yangfan Hu, Xiangyang Xu, Xiao-Dong Gao & Zijie Li; Identification of a Novel Alditol Oxidase from Thermopolyspora flexuosa with Potential Application in D-Glyceric Acid Production, Molecular Biotechnology, 2022, 64(7): 804-813. (期刊论文)

 

Yi-Fan Huang; Kazuhiro Aoki; Sachiko Akase; Mayumi Ishihara; Yi-Shi Liu; Ganglong Yang; Yasuhiko Kizuka; Shuji Mizumoto; Michael Tiemeyer; Xiao-Dong Gao; Kiyoko F. Aoki-Kinoshita; Morihisa Fujita; Global mapping of glycosylation pathways in human-derived cells, Developmental cell, 2021, 56(8): 1195-1209. e7. (期刊论文)

 

Ji-Xiong Leng, Wei-Wei Ren, Yuqing Li, Ganglong Yang, Xiao-Dong Gao, Morihisa Fujita; Cell engineering for the production of hybrid-type N-glycans in HEK293 cells, The journal of biochemistry, 2021, 170(1): 139-151. (期刊论文)

 

Jing Yang, Tetsuya Hirata, Yi-Shi Liu, Xin-Yu Guo, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita; Human SND2 mediates ER targeting of GPI-anchored proteins with low hydrophobic GPI attachment signals, FEBS letters, 2021, 595(11): 1542-1558.

 

Xin-Yu Guo, Yi-Shi Liu, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita; Calnexin mediates the maturation of GPI-anchors through ER retention, Journal of Biological Chemistry, 2020, 295(48): 16393-16410. (期刊论文)

 

Si-Si Liu, Yi-Shi Liu, Xin-Yu Guo, Yoshiko Murakami, Ganglong Yang, Xiao-Dong Gao, Taroh Kinoshita & Morihisa Fujita; A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins, Communications biology, 2021, 4(1): 777.

 

Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita; Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit, Molecules, 2021, 26(18): 5462. Journal of Biological Chemistry, 2020, 295(48): 16393-16410. (期刊论文)

 

Qiang Chao, Yi Ding, Zheng-Hui Chen, Meng-Hai Xiang, Ning Wang, Xiao-Dong Gao; Recent Progress in Chemo-Enzymatic Methods for the Synthesis of N-Glycans, Frontiers in Chemistry, 2020, 8: 513. (期刊论文)

 

Zhou Chen, Zijie Li, Fen Li, Ning Wang, Xiao-Dong Gao; Characterization of alditol oxidase from Streptomyces coelicolor and its application in the production of rare sugars, Enzyme and microbial technology, 2020, 133: 109456. (期刊论文)

 

Zhou Chen, Zijie Li, Fen Li, Mayan Wang, Ning Wang, Xiao-Dong Gao; Cascade synthesis of rare ketoses by whole cells based on L-rhamnulose-1-phosphate aldolase, Enzyme and microbial technology, 2020, 133: 109456. (期刊论文)

 

Zhou Chen, Zijie Li, Fen Li, Ning Wang, Xiao-Dong Gao; Characterization of alditol oxidase from Streptomyces coelicolor and its application in the production of rare sugars, Bioorganic & Medicinal Chemistry, 2020, 28(10): 115464. (期刊论文)

 

Li Sheng Tao, Lu Tian Tian, Xu Xin Xin, Ding Yi, Li Zijie, Kitajima Toshihiko, Dean Neta, Wang Ning, Gao Xiao Dong; Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans, Nature Communications, 2019, 10: 1813. (期刊论文)

 

Yiqun Du, Yufei Xia, Yongjuan Zou, Yuning Hu, Jiaqi Fu, Jie Wu, Xiao-Dong Gao, Guanghui Ma; Exploiting the Lymph-Node-Amplifying Effect for Potent Systemic and Gastrointestinal Immune Responses via Polymer/Lipid Nanoparticles, ACS nano, 2019, 13(12): 13809-13817. (期刊论文)

 

Feng Shini, Zhang Huijie, Xu Sha, Zhi Chunyi, Nakanishi Hideki, Gao Xiao Dong; Folate-conjugated, mesoporous silica functionalized boron nitride nanospheres for targeted delivery of doxorubicin, Materials Science and Engineering: C, 2019, 96: 552-560. (期刊论文)

 

二、论著之外的代表性研究成果和学术奖励:

参与撰写专著

(1) Morihisa Fujita, Gao XD, et al., Sugar Chains, 2015.

(2) Dean N., Gao XD, et al., Handbook of Glycosyltransferases and Related Genes, 2014.

(3) Gao, XD, et al., Molecular Imaging for Integrated Medical Therapy and Drug Development, 2009.

(4) 地神芳文、高暁冬、新間陽一;『糖鎖科学の新展開』: 酵母による糖転移酵素の発現とその利用, 2005.

 

专利

(1) 地神芳文千木良裕子高晓冬 ; O-フコース結合タンパク質合成系遺伝子が導入された酵母形質転換体, 2009-2-10, 日本特許第4258662 (JAPAN) (专利)

(2) 中西秀树高晓冬张海妮李子杰 ; 一种以酿酒酵母孢子为载体的固定化酶的制备方法, 2015-5-27, 中国, ZL 2013 1 0422568. 8 (专利)

(3) 王宁高晓冬贾继祥 ; 一种ALG1-CDGPMM2-CDG生物标记物的合成方法及其应用, 2021-6-24, 中国, CN202110705739.2 (专利)

(4) 高晓冬项梦海王宁陆天天 ; 一种提高重组N-乙酰葡糖胺转移酶II可溶性表达的方法, 2020-5-14, 中国, CN202010406876.1 (专利)

(5) 李子杰高晓冬李芬 ; 一种D型稀有己酮糖的制备方法, 2020-1-7, 中国, CN202010015442.9(专利)

(6) 高晓冬李子杰陈洲 ; 一种D-甘油醛的生产方法, 2020-1-7, 中国, CN202010014710.5 (专利)