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成果及论文

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Biomaterials Science (2020)


Publications (# Equal contribution, *Corresponding author

2024

78. M. Xiang#, F. Yang#, P. Chen, J. Chen, J. Zhang, J. Yang, Y. Liu, Q. Zhang, J. Pi*, P. Yuan*, S.Q. Yao*, and L. Gao*, “Tumor Microenvironment-Responsive Self-Assembled Nanomedicine for Reversible Covalent Targeting of BCR-ABL Kinase”, Chinese Chemical Letters (2024), in revision.

77. J. Sun#, M. Gu#, L. Peng, J. Guo, P. Chen, Y. Wen, F. Feng, X. Chen, T. Liu, Y. Chen, X. Lu,* L. Gao,* S.Q. Yao,* and P. Yuan*, “A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H2O2-Triggered Targeted Protein Degradation in Cancer Therapy J. Am. Chem. Soc. (2024), accepted.

76. P. Chen#, J. Sun#, L. Wang#, M. Xiang, M. Gu, F. Miao, X. Wang, L. Duan, P. Yuan, Z.-M. Zhang*, X. Lu*, L. Gao*, S.Q. Yao*, “Cell-Active, Arginine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Non-Kinases”, XXXX (2024), submitted.

75. J. Sun#, L. Lou#, C-J Zhu#, P. Chen, G. Tang, M. Gu, S. Xia, X. Dong,* Z.-M. Zhang,* L. Gao,* S.Q. Yao,* Q. Xiao*,Chemical Evolution to Improve Bcr-Abl Kinase Inhibitors via Covalent and Pro-/Dual-drug Targeting Strategies, J. Adv. Res. (2024), S2090-1232(24)00392-8. DOI: 10.1016/j.jare.2024.09.008.

74. G. Tang,* X. Wang, H. Huang, M. Xu, X. Ma, F. Miao, X. Lu, C.-J. Zhang, L. Gao, Z.-M. Zhang,*  S. Q. Yao* Small Molecule-Induced Posttranslational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells”, J. Am. Chem. Soc. (2024), 146(34):23978-23988.

73. X. Wang, J. Sun, H. Huang, G. Tang, P. Chen, M. Xiang, L. Li, Z.-M. Zhang,* L. Gao,* S.Q. Yao*, “Kinase Inhibition via Small Molecule-Induced Intramolecular Protein Cross-Linking”, Angew Chem Int Ed (2024)e202404195.

72. G. Tang#, W. Wang#, C. Zhu#, H. Huang, P. Chen, X. Wang, M. Xu, J. Sun, C.-J. Zhang, Q. Xiao, L. GaoZ.-M. Zhang*,  S.Q. Yao*, “Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Development of Potential Targeted Covalent Inhibitors”, Angew Chem Int Ed (2024), e202316394, doi: 10.1002/anie.202316394.

71. Q.-H. Wan#, M. Gu#, W.-J. Shi*, Y.-X. Tang, Y. Lu, C. Xu, X.-S. Chen, X.-T. Wu, L. Gao*, D.-X. Han, and L. Niu*, “Meso-aryltellurium-BODIPY-based fluorescent turn-on probe for highly sensitive, selective and fast detection of GSH in living cells”, Talanta(2024), 267, 125251 

2023

70. E. O. J. Porta, L. Gao, P. W. Denny, P. G. Steel, K. Kalesh,* “Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages”,Microbiology Spectrum (2023), 11(6) : e0296023.

69. W. Wang#, X. Wang#, G. Tang*, C-J Zhu, M. Xiang, Q. Xiao, Z.-M. Zhang*, L. Gao*, S.Q. Yao*,Dual inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently”, Chem. Commun.(2023), 59(72):10789-10792. 

68. G. Tang, W. Wang, X. Wang, K. Ding, SoF. C. Ngan, S. K. Sze, L. Gao, P. Yuan,* X. Lu*, S.Q. Yao*, “Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry”, Eur. J. Med. Chem.  (2023), 259, 115671.

67. P. Chen#L. Lou # B. Sharma, M. Li, C. Xie, F. Yang , Y. Wu*, Q. Xiao *L. Gao*Recent advances on PKM2 modulators including inhibitors and activators in cancer applications",Current Medicinal Chemistry (2023), in pressDOI: 10.2174/0929867331666230714144851. 

66. L. Lou#, S. Zhou#, S. Tan#, M. Xiang, W. Wang, C. Yuan*, L. Gao* and Q. Xiao*, “Amplifying the Efficacy of ALA-based Prodrugs for Photodynamic Therapy Using Nanotechnology”, Frontiers in Pharmacology (2023), 14:1137707(IF5.988中科院2)

65. P. Chen#, G. Tang#, *, C. Zhu#, J. Sun, X. Wang, M. Xiang, H. Huang, W. Wang, L. Li, Z. Zhang*, L. Gao*, S.Q. Yao*, “ 2-Ethynylbenzaldehyde (EBA)-based, lysine-targeting irreversible covalent inhibitors for protein kinases and non-kinases”, J. Am Chem. Soc. (2023), 145 (7)3844-3849. (IF16.383, 中科院1Top Journal)

64. F. Yang#, X. Wang#, J. Sun#, S. Tan#, S. Zhou, W. Tu, X. Dong, Q. Xiao, F. Yang*, L. Gao*, Mesopore-Encaged Active MnOx in Nano-Silica Selectively Suppressed Lung Cancer Cell via Induced Autophagy Effect”,  Biomaterials Science (2023), 11(6):2056-2064. (IF 7.590, 中科院2)

63. W. Du#S. Du#, X. Dong#, H. Bai, J. Jiang, S. Hao, F. Yang, Q. Xiao, B. Zhang,J. Ge, L. Gao, L. Li*, S.Q. Yao*, W. Huang*,"Biodegradable Silica Nanocapsules Enable Efficient Nuclear-Targeted Delivery of Native Proteins for Cancer Therapy”, Biomaterials, 294, 122000


2022

62. J. Li#, H. Gao#, Y. Xiong#, L. Wang, H. Zhang, F. He, J. Zhao, S. Liu, L. Gao, Y. Guo*, W. Deng*, “Enhancing Cutaneous Wound Healing Based on Human Induced Neural Stem Cell-derived Exosomes”, Int J Nanomedicine (2022), 17, 5991-6006.

61. C. Yuan#, K. Ai#, M. Xiang, C. Xie, M. Zhao, M. Wu, H. Li, Y. Wu, Y. Cao, C. Li, X. Pei, Y. Zhong, H. K.W. Law, L. Gao, Q. Xiao*, X. Yang*, “Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling”, Cell Death & Disease (2022), 13(8):722. 

60. WJ Shi*, QH Wan, F. Yang, X Wang, YF Wei, XR Lin, JY Zhang, L Zheng, F Liu, L Gao*, “A novel TCF-aza-BODIPY-based near-infrared fluorescent probe for highly selective detection of hypochlorous acid in living cells”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (2022), 279(2022),121490.

59. C. Yu#, S. Wang#, C. Xu#, Y. Ding, G. Zhang, N. Yang, Q. Wu, Q. Xiao, L. Wang, B. Fang, C. Pu, J. Ge, L. Gao, L. Li*, S.Q. Yao*, “Two-photon small-molecule fluorogenic probes for visualizing endogenous nitroreductase activities from tumor tissues of a cancer patient”, Adv Healthc Mater(2022), e2200400. doi: 10.1002/adhm.202200400. 

58. P. Chen#, J. Sun#, C. Zhu#, G. Tang*, W. Wang, M. Xu, M. Xiang, C.-J. Zhang, Z.-M. Zhang*, L. Gao*, S. Q. Yao*, “Cell-active, reversible and irreversible covalent inhibitors that selectively target the catalytic lysine of BCR-ABL kinase”, Angew. Chem. Int. Ed. (2022), 61(26):e202203878. (IF 15.336, 中科院1Top期刊

57. J. Lan, S. Li, K. Lin, P. Zhou, W. Chen, L. Gao*, T. Zhu*, “Diastereoselective Synthesis of Spirocyclic indolines by Electrochemical Trifluoromethylation Triggered Dearomatization of indolesOrganic & Biomolecular Chemistry (2022)20, 3475-3479

56. J. Qin*, W. Wang, L. Gao, S.Q. Yao*, “Emerging Biosensing and Transducing Techniques for Potential Applications in Point-of-Care Diagnostics”, Chemical Science (2022), 13, 2857-2876.

2021

55. L. Wang#, J. Li#, Y. Xiong#, Y. Wu#, F. Yang#, Y. Guo, Z. Chen, L. Gao*, W. Deng*, Ultrashort peptides and hyaluronic acid based injectable composite hydrogels for sustained drug release and chronic diabetic wound healing", ACS Applied Materials & Interfaces (2021), 13(49), 58329-58339. (IF 9.229 in 2021中科院1Top journal)

54. F. Yang#, D. Zhang#, Q. Zhou#, M. Li, C. Xie, S. Li, X. Wang, W. Wang, Y. Guo, Q. Xiao*, Y. Wang*L. Gao*, “Peptides-modified polystyrene-based polymers as high-performance substrates for the growth and propagation of human embryonic stem cells”, Chinese Chemical Letters,33(2022),2901-2905(IF 6.779 in 2021, 中科院2)  

53. L. Gao*, W. Deng*, J. Shen*, Q. Xiao*, “Editorial: Recent Advances in Strategies and Tools for Efficient Drug Discovery and Delivery—Part II”, Current Medicinal Chemistry (2021), 28(31), 6304-6306.

52. Y.-F. Wei#, X. Wang#, W.-J. Shi*, R. Chen, L. Zheng, Z.-Z. Wang, K. Chen, and L. Gao*, “A novel methylenemalononitrile-BODIPY-based fluorescent probe for highly selective detection of hydrogen peroxide in living cells”, European Journal of Medicinal  Chemistry  (2021), 226,113828. (IF 6.514 in 2021中科院1Top Journal)

51. Q. Xiao*, X. Dong, F. Yang, S. Zhou, M. Xiang, L. Lou, S.Q. Yao*L. Gao*, “Engineered Cell-penetrating Peptides for Mitochondrion-targeted Drug Delivery in Cancer Therapy”, Chem. Eur. J. (2021), 27(59), 14721-14729. (IF 5.236 in 2021中科院2, Top Journal)

50. X. Dong, S. Y. Ong, C. Zhang, W. Chen, S. Du, Q. Xiao, L. Gao, S. Q. Yao*, “Broad-Spectrum Polymeric Nanoquencher as An Efficient Fluorescence Sensing Platform for Biomolecular Detection”, ACS Sensors (2021), 6(8), 3102-3111. 

49. Y. Liu, S. Lv, L. Peng, C. Xie, L. Gao, H. Sun, L. Lin, K. Ding,*Z. Li*, “Development and Application of Novel Electrophilic Warheads in Target Identification and Drug Discovery ”, Biochemical Pharmacology (2021), 190, 2114636.

48. Q. Xiao#, W. Du#, X. Dong, S. Du, S.Y. Ong, G. Tang, C. Zhang, F. Yang, L. Li*, L. Gao*, S.Q. Yao*, “Cell-penetrating mitochondria-targeting ligands for universal delivery of small molecules, proteins and nanomaterials”, Chem. Eur. J. (2021), 27(47), 12207-12214. (IF 5.236 in 2021中科院2, Top Journal)

47. W.J. Shi*, L., Feng, X. Wang, Y. Huang, Y.F. Wei, Y.Y. Huang, H.J. Ma, L. Zheng, L. Gao*,A near-infrared-emission aza-BODIPY-based fluorescent probe for fast, selective, and “turn-on”detection of HClO/ClO-”, Talanta (2021), 233,122581. (IF 6.057 in 2021中科院2, Top Journal)

46. M. Xiang#, Q. Zhou#, Z. Shi, X. Wang, M. Li, Y. Jia, S. Li, F. Yang, W. Wang, T. Chen, X. Xu, B. Sharma, Y. Nie, Q. Xiao*, L. Gao*, “A review of light sources and enhanced targeting for photodynamic therapy”, Current Medicinal Chemistry (2021), 28(31), 6437-6457. 

45. Y. Mo#, L. Duan#, Y. Yang, W. Liu, Y. Zhang, L. Zhou, S. Su, P.C. Lo, J. Cai, L. Gao, Q. Liu, X. Chen, C. Yang*, Q. Wang*, T. Chen*, “Nanoparticles Improved Resveratrol Brain Delivery and its Therapeutic Efficacy against Intracerebral Hemorrhage”, Nanoscale (2021), 13(6), 3827-3840.) 

44. Q. Xiao, B. Mai, Y. Nie, C. Yuan, M. Xiang, Z. Shi, J. Wu, W.A. Leung, C.S. Xu*, S.Q. Yao*, P. Wang*, L. Gao*, “In Vitro and In Vivo Demonstration of Ultra-Efficient and Broad-Spectrum Antibacterial Agents for Photodynamic Antibacterial Chemotherapy”, ACS Applied Materials & Interfaces (2021), 13(10):11588-11596. (IF 9.229 in 2021, 中科院1Top journal)

43. S. Xiong, J.S. Luo, Q. Wang, Z.J. Li, J.T. Li, Q. Liu, L. Gao, S. Fang, Y. Li, H. Pan, H. Wang, Y. Zhang, Q. Wang, X. Chen*, T. Chen* “Targeted Graphene Oxide for Drug Delivery as a Therapeutic Nanoplatform against Parkinson's Disease", Biomaterials Science (2021), 9(5), 1705-1715. 

42. L. Gao*, #, W. Wang#, X. Wang#, F. Yang, L. Xie, J. Shen, M.A. Brimble, Q. Xiao*, S. Q. Yao*, “Fluorescent probes for bioimaging of potential biomarkers in Parkinson’s disease”, Chem. Soc. Rev. (2021), 50(2), 1219-1250. (IF 54.564 in 2021, 中科院1Top journal) 


2020

41. L. Lu, Q. Zhang, Z. Wang, L. Gao*, J. Shen*, “Peptide-Modified Nanoparticles for Tumour Targeting and Molecular Imaging”, Current Medicinal Chemistry (2020), 28(31), 6411-6436. (IF 4.184) 

40. Y. Liu, D.M. Zhu, J. Luo, X. Chen, L. Gao, W. Liu*, T. Chen*, NIR-II-Activated Yolk-Shell Nanostructures as an Intelligent Platform for Parkinsonian Therapy”, ACS Applied Bio Materials (2020)3(10), 6876-6887.  

39. Y. Wu#, L. Wang#, Y. Xiong#, Q. Zhou, L. Li, G. Chen, Y. Ping, G. Davidson, P.A. Levkin*, L. Gao*, W. Deng*, “Cell-based high-throughput screening of cationic polymers for efficient DNA and siRNA delivery”, Acta Biomaterialia (2020), 115, 410-417. (IF 7.242 in 2020, 中科院1Top journal) 

38. B. Sharma#, L. Xie#, F. Yang#, W. Wang#, Q. Zhou, M. Xiang, S. Zhou, W. Lv, Y. Jia, L. Pokhrel, J. Shen, Q. Xiao*, L. Gao*, W. Deng*,“Recent advance on PTP1B inhibitors and their biomedical applications”, European Journal of Medicinal Chemistry (2020), 199:112376, doi:10.1016/j.ejmech.2020.112376(IF 5.572 in 2020, 中科院1区,Top Journal

37. Q. Xiao, H. Lin, J. Wu, X. Pang, Q. Zhou, Y. Jiang, P. Wang, A. W. Leung, H. Lee, S. Jiang, S.Q. Yao, L. Gao*, G. Liu*, C.-S. Xu*, “Pyridine Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy”, Journal of Medicinal Chemistry (2020), 63(9), 4896-4907(IF 6.205 in 2020, 中科院1Top journal

36. Y. Wu#, Y. Xiong#, L. Wang#, Q. Zhou, L. Li, P.A. Levkin, G. Davidson*, L. Gao*, W. Deng*, “Development of new self-assembled cationic amino liposomes for efficient gene delivery”, Biomaterials Science (2020), 8, 3021-3025. (Selected as back cover(IF 6.183 in 2020, 中科院2)

 

2019

35. J. Ding#, J. Chen#, L. Gao#, Z. Jiang, Y. Zhang, M. Li, Q. Xiao, S.S. Lee*, X. Chen*, “Engineered nanoplatforms for enhanced tumor penetration”, Nano Today (2019), 100800, DOI:10.1016/j.nantod.2019.100800. (Most downloaded paper since Dec of 2019 in Nano Today(IF 16.907 in 2020, 中科院1区,Top journal)

34. L. Gao*, S. S. Lee*, H. Sun*, J. Wang*, “Editorial: Recent Advances in Strategies and Tools for Efficient Drug Discovery and Delivery”, Current Medicinal Chemistry (2019), 26(13), 2232-2233. 

33. Q. Xiao#, W. Zhu#, W. Feng#, S. S. Lee, A.W. Leung, J. Shen*, L. Gao*, C. Xu*, “A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy”, Frontiers in Pharmacology (2019), 9:1534. DOI:10.3389/fphar.2018.01534.(ESI highly cited paper in 2020)

 

2018

32. J. Wang, L. Qiu, Y. You, L. Ma, Z. Zhu, L. Yang, J. Wang, X. Wang*, L. Liu, X. Liu, Y. Chang, J. Li, L. Gao*, and Y.-Q. Li*, “A novel in-capillary assay for dynamically monitoring fast binding between antibody and peptides using CE”, Journal of Separation Science 201841(24), 4544-4550. 

31. J. Wang, Z. Zhu, L. Qiu, J. Wang, X. Wang*, Q. Xiao, J. Xia, L. Liu, X. Liu, W. Feng, J. Wang, P. Miao*, L. Gao*, “A CE-FL based method for real time detection of in-capillary self-assembly of the nanoconjugates of polycysteine ligand and quantum dots”, Nanotechnology (2018), 29(27), 274001, DOI:10.1088/1361-6528/aabe5d. 

30. W. Feng, T. Huang, L. Gao, X. Yang, W. Deng, R. Zhou*, H. Liu*, “Textile supported silver nanoparticles as a highly efficient and recyclable heterogeneous catalyst for nitroaromatics reduction at room temperature”, RSC Advances (2018), 86288-6292.


2017

29. X. Ma #, L. Gao#, Y. Tang*, P. Miao*, “Gold nanoparticles- based DNA logic gate for miRNA inputs analysis coupling strand displacement reaction and hybridization chain reaction”, Particle & Particle Systems Characterization (2018), 35(2), 1700326-1-1700326-7, DOI: 10.1002/ppsc.201700326.

28. T. Liu, L. Gao, J. Zhao, Y. Cao, Y. Tang*, P. Miao*, “Polymyxin B-silver Nanoparticles colloidal system and the applications of lipopolysaccharide analysis”, Analyst (2018), 143(5), 1053-1058.

27. C. Guo*, J. Zhong, L. Gao, J. Gao, S. HuangEditorial: Thematic Issue: Nanostructures for Flexible Electronics and Drug Delivery, (2017), Journal of Nanomaterials, 2017, 3516952-1--3516952-2, DOI: 10.1155/2017/3516952

26. Q. Xiao, J. Wu, X. Pang, Y. Jiang, W. A. Leung, L. Gao, S. Jiang, C. Xu*, “Discovery and Development of Natural Products as Photosensitizers for Photodynamic Therapy”, Current Medicinal Chemistry (2018), 25(7), 839-860. 

25. J. Wang, J. Fan, L. Liu, S. Ding, X. Liu, L. Gao*, S. Chattopadhaya, P. Miao, J. Xia, L. Qiu*, P. Jiang*, “Developing a capillary electrophoresis based method for dynamically monitoring enzyme cleavage activity using quantum dots-peptide assembly”, Electrophoresis (2017), 38(19), 2530-2535. 


(Publications before joining SYSU in 2017)    

24. Y.S. Ong#, L. Gao#, K.A. Kalesh, Z. Yu*, J. Wang, C. Liu, Y. Li, H. Sun*, S.S. Lee*, “Recent Advances in Synthesis, Identification and Bioapplications of Bioactive peptides”, (2017), Current Topics in Medicinal Chemistry,17(2017), 2302-2318. 

23. W. Liao#, T.-T. Zhang #, L. Gao, S. S. Lee, J. Xu, H. Zhang, Z.G. Yang, Z. Liu,*, W. Li*, “Integration of Novel Materials and Advanced Genomic Technologies into New Vaccine Design”, (2017), Current Topics in Medicinal Chemistry, 17(2017), 2286-2301.

 

2016

22. P. Wang#, L. Gao#, H. Lei, S.S. Lee*, S.Q. Yao, H. Sun*. “A Versatile Microarray Immobilization Strategy Based on a Biorthogonal Reaction Between Tetrazine and Trans-cyclooctene”, Methods in Molecular Biology,1518 (2017), 67-80. 

21. J.H. Wang, C. Zhang, L. Liu, L. Qiu, S. Ding, M. Fu, L. Gao* and P. Jiang*,"A capillary electrophoresis method to explore the self-assembly of a novel polypeptide ligand with quantum dots”, (2016), Electrophoresis, 37(15-16), 2156-2162. 

20. L. Gao#, J. Chen#, Y. Hu*, H. Sun, Y. S. Ong, J. Zhang*, Z. Chai, S.S. Lee*, “Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-Drug Interactions”, (2016), Current Organic Chemistry, 20 (17), 1827-1834

19. J. Wang, J. Li, J.C. Li, F. Liu, Y. Gu, J. Fan, B. Dong, C. Wang, L. Qiu*, L. Gao*, S. S. Lee*, P. Jiang*, “Organic Chemistry Tool for Nanoparticles Monofunctinalization and Their Biomedical Applications”, (2016), Current Organic Chemistry, 20 (17), 1786-1796.

18. J.-E. Jee, J. Lim, Y. S. Ong, J. Oon, L. Gao, H.S. Choi, S.S. Lee, “An Efficient Strategy to Enhance Binding Affinity and Specificity of a Known Isozyme Inhibitor with Moderate Binding Affinity”, (2016), Organic & Biomolecular Chemistry, 14(28), 6833-6839.

17. F. Liu, J.H. Wang*, L. Liu, S. Ding, M. Fu, L. Deng* and L. Gao*, “Developing a fluorescence coupled capillary electrophoresis based method to probe interactions between QDs and colorectal cancer targeting peptides”, (2016), Electrophoresis, 37(15-16), 2170-2174. 

16. J. Wang*, #, L. Gao#, Y. M. Lee#, K.A. Kalesh, Y.S. Ong, J. Lim, J.-E. Jee, H. Sun, S.S. Lee*, Z-C Hua*, Q.S.  Lin *,Target identification of natural and traditional medicine with quantitative chemical proteomics approaches”, Pharmacology & Therapeutics, 162 (2016), 10-22. 

15. P. Miao*, Y. Tang, B. Wang, C. Jiang, L. Gao, B. Bo, J. Wang*, “Nuclease assisted target recycling and spherical nucleic acids gold nanoparticles recruitment for ultrasensitive detection of microRNA”, (2016), Electrochimica Acta,190, 396-401. 


2015

14. L. Gao, S.S. Lee, J. Chen, H. Sun*, Y. Zhao, Z. Chai, Y. Hu*, “High-throughput Screening of Substrate Specificity for Protein Tyrosine Phosphatases (PTPs) on Phosphopeptide Microarrays”, Methods in Molecular Biology, 1368 (2016), 181-196. 

13. Z. Yu #, B. Yan #, L. Gao, C. Dong, J. Zhong, M. D'Ortenzio, B. Nguyen, S.S. Lee, X. Hu*, F. Liang*,“Targeted delivery of Bleomycin: a comprehensive anticancer review”. Current Cancer Drug Target, (2016), 16 (6), 509-521. 

12. R. Peltier, G. Chen, H, Lei, M. Zhang, L. Gao, S.S. Lee, Z. Wang, H. Sun, “Rational Design of Peptide based Hydrogel Responsive to H2S”, Chem. Commun., 51 (97) (2015), 17273-17276. 

11. Z. Yu#, Q. Xu#, C.B. Dong, S.S. Lee, L. Gao*,Y. Li, M. D’Ortenzio, J. Wu*,” Self-assembling peptide nanofibrous hydrogel as a versatile drug delivery platform”, Current Pharmaceutical Design, 21(29) (2015), 4342-4354.

10. L. Gao#, Z. Yu#, D. Meng, F. Zheng, Y.S. Ong, P. Miao*, S.S. Lee*, L.P. Wen*, “Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin”, Protein and Peptide Letters, 22(2015), 762-766. 


2014

9. J. Chen#,*, X.J. Li#, L. Gao, Y. Hu*, W. Zhong, M. Xing*, A Facile Strategy for In-Situ Controlled Delivery of Doxorubicin With a pH-Sensitive Injectable Hydrogel”, Nano LIFE, 4 (2014), 1441001-1—1441001-13. 

8. D. Ling#, L. Gao #, J. Wang #, M. Shokouhimehr, J. Liu, Y. Yu, M. J. Hackett, P.K. So, B. Zheng, Z. Yao, J. Xia*, and T. Hyeon*, “A General Strategy for Site-directed Enzyme Immobilization using NiO Nanoparticle Decorated Mesoporous Silica”, Chemistry-A European Journal, 20 (2014), 7916–7921


2013

7. J. Wang#, P. Jiang#, L. Gao, Y. Yu, Y. Lu, L. Qiu, C. Wang, and J. Xia*, “Unique  Self-assembly Properties of a Bridge-Shaped Protein Dimer with Quantum Dots”, Journal of Nanoparticle Research, 15 (2013), 1914-1919.

6. L. Gao, H. Sun, M. Uttamchandani*, and S.Q. Yao*, “Phosphopeptide Microarrays for Comparative Proteomic Profiling of Cellular Lysates”, Methods in Molecular Biology,1002 (2013), 233-251.

 

Before 2013

5. L. Gao, M. Uttamchandani*, and S.Q. Yao*, “Comparative Proteomic Profiling of Mammalian Cell Lysates Using Phosphopeptide Microarrays”, Chem. Commun., 48 (2012), 2240-2242.

4. L. Gao, H. Sun, and S.Q. Yao*, “Activity-Based High-Throughput Determination of PTPs Substrate Specificity Using a Phosphopeptide Microarray”, Biopolymers, 94 (2010), 810–819. 

3. K.A. Kalesh, L.P. Tan, K. Liu, L. Gao, J. Wang, and S.Q. Yao*, “Peptide-based Activity-Based Probes (ABPs) for Target-Specific Profiling of Protein Tyrosine Phosphatases (PTPs)”, Chem. Commun., 46 (2010), 589-591. 

2. H. Sun, L.P. Tan, L. Gao, and S.Q. Yao*, “High-Throughput Screening of Catalytically Inactive Mutants of Protein Tyrosine Phosphatases (PTPs) in a Phosphopeptide Microarray”, Chem. Commun., [6] (2009), 677-679. 

1. H. Sun, C.H.S. Lu, H. Shi, L. Gao, and S.Q. Yao*, “Peptide Microarrays for High-throughput Studies of Ser/Thr Phosphatases”, Nature Protocols, 3 (2008), 1485-1493. 


专利


18.高理钱,顾明希,孙杰,王璇,熊媚媚,“一种靶向Bcr-Abl 的自组装纳米材料的制备方法及其用途”, 中国发明专利申请号2024113845419申请日2024 年09 月30 日

17. 高理钱,顾明希,孙杰,周士哲,陈鹏,向梦华,“一种靶向Bcr-Abl 的分子胶及其制备方法和用途”, 中国发明专利申请号2024113845620申请日2024 09 30

16. 高理钱,周士哲,肖奇才,娄亮,谈思佳,“一种靶向线粒体的乏氧响应前药及其制备方法与应用”,中国专利申请号: 202410422489.5,申请日:20240409日。

15. 高理钱,李孟础,张达,谈思佳,周士哲,谢程亮,肖奇才,杨芬,沈君,“靶向DAT蛋白的多肽及其应用”,中国发明专利申请号202210394456.5,申请日2022412

14. 高理钱,贾艳,李孟础,张达,谢程亮,肖奇才,王璇,孙杰, “一种具有抗氧化作用的活性六肽及其应用”,中国发明专利申请号202210356747.3,申请日202246

13. 肖奇才, 高理钱, 周士哲, "一种靶向线粒体的多肽及其制备方法与应用", 中国专利申请号202110846100.6, 申请日: 20210726公开日: 2021年11月09(已授权) 


12. 高理钱 石子寒,杨芬,肖奇才、谢刘幸、贾艳、李少云、张达, “靶向干扰素γ的多肽及其应用中国发明专利申请号:CN202011423132.7, 申请日2020129日,公开日2021年3月19日(已授权) 


11. 高理钱,谢刘幸,谈思佳,王璇,李孟础,杨芬,贾艳,肖奇才,沈君,靶向PKM2蛋白的抗肿瘤多肽及其引用中国发明专利申请号:CN202011355591.6, 申请日 20201127日,公开日2021年3月12日(已授权) 


10. 高理钱,贾艳,肖奇才,杨芬,谢程亮, “一种抗敏组合物及其制备方法和应用中国发明专利申请号CN202010926658.0, 申请日 202097


9. 高理钱,李少云,张达,石子寒,杨芬,肖奇才,周士哲,吕婉婷,李晗玥,靶向BRD4蛋白的抗肿瘤多肽及其应用”, 中国发明专利申请号: CN202010996282.0, 申请日2020922(已授权)


8. 高理钱,谢刘幸,李孟础,王璇,汪伟,肖奇才,杨芬,沈君,邓文斌,靶向GRB2 SH2 结合域的抗肿瘤多肽及其应用”,中国发明专利申请号:CN201911258905.8, 申请日 20191210


7.肖奇才,高理钱,周全明,石子寒,汪伟,向梦华,谢刘幸,杨芬,罗川朝。一种氟替卡松丙酸酯中间体的制备方法。中国发明专利申请号:CN202010150457.6,申请日20200306


6.肖奇才,尹国建,高理钱,向梦华。一种激光器。中国发明专利申请号:CN202010151860.0, 申请日20200306日,公开日 2020626


5.肖奇才,尹国建,高理钱,向梦华。一种激光器。中国实用新型专利申请号:CN202020273439.2, 申请日20200306日,授权公告日:2020109日,专利号ZL202020273439.2, 授权公告号CN211655311U (已授权)


4. 彭锦安,李方林,张琦珊,肖奇才,冯伟,高理钱, “一种米索前列醇酸的制备方法及其用途”, 中国发明专利申请号: 201810308887.9, 申请日 201849日,公开日 2018116


3. 彭锦安,李方林,张琦珊,罗玉婷,肖奇才,高理钱,“一种布洛芬杂质A的制备方法”,中国发明专利申请号: 201810751757.2, 申请日 2018710日,公开日20181113 


2. 彭锦安,李方林,张琦珊,肖奇才,冯伟,高理钱一种达格列净异构体杂质的制备方法。中国发明专利申请号201810335379.X, 申请日20180416,公开日20180724 


1. 温龙平,高理钱,孟 丹。"α-促黑激素的环状类似肽及其应用"。中国发明专利申请号CN200510083984.5,申请日:2005715日,公开日20051221号 (导师是第一作者)