王璇于2019年6月在中国海洋大学获得学士学位，2019年9月保研进入中山大学药学院(深圳)高理钱老师课题组开始研究生期间的学习，现为中山大学2019级在读硕士、博士(2021)连读研究生。

E-mail: wangx637@mail2.sysu.edu.cn

Publications (After joining SYSU) (# Equal contribution, * Corresponding author)

1. L. Gao*, #, W. Wang#, X. Wang#, F. Yang, L. Xie, J. Shen, M.A. Brimble, Q. Xiao*, S. Q. Yao*, “Fluorescent probes for bioimaging of potential biomarkers in Parkinson’s disease”, Chem Soc Rev (2021), 50(2), 1219-1250.

2. M. Xiang#, Q. Zhou#, Z. Shi, X. Wang, M. Li, Y. Jia, S. Li, F. Yang, W. Wang, T. Chen, X. Xu, B. Sharma, Y. Nie, Q. Xiao*, L. Gao*, “A review of light sources and enhanced targeting for photodynamic therapy”, Current Medicinal Chemistry (2021), 28(31), 6437-6457.

3. W.J. Shi*, L., Feng, X. Wang, Y. Huang, Y.F. Wei, Y.Y. Huang, H.J. Ma, W. Wang, M. Xiang，L. Gao*, “A near-infrared-emission aza-BODIPY-based fluorescent probe for fast, selective, and “turn-on” detection of HClO/ClO^-”, Talanta (2021), 233,122581.

4. Y.-F. Wei#, X. Wang#, W.-J. Shi*, R. Chen, L. Zheng, Z.-Z. Wang, K. Chen, and L. Gao*, “A novel methylenemalononitrile-BODIPY-based fluorescent probe for highly selective detection of hydrogen peroxide in living cells”, European Journal of Medicinal Chemistry (2021), 226,113828.

5.  F. Yang#, D. Zhang#, Q. Zhou#, M. Li, C. Xie, S. Li, X. Wang, W. Wang, Y. Guo, Q. Xiao*, Y. Wang *, L. Gao*, “Peptides-modified polystyrene-based polymers as high-performance substrates for the growth and propagation of human embryonic stem cells”,  Chinese Chemical Letters (2021), DOI:10.1016/j.cclet.2021.10.028.

6. WJ Shi*, QH Wan, F. Yang, X Wang, YF Wei, XR Lin, JY Zhang, L Zheng, F Liu, L Gao*, “A novel TCF-aza-BODIPY-based near-infrared fluorescent probe for highly selective detection of hypochlorous acid in living cells”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (2022), 279(2022),121490.

7. F. Yang#, X. Wang#, J. Sun#, S. Tan#, S. Zhou, W. Tu, X. Dong, Q. Xiao, F. Yang*, L. Gao*, “Mesopore-Encaged Active MnOx in Nano-Silica Selectively Suppressed Lung Cancer Cell via Induced Autophagy Effect”, Biomaterials Science (2022), 11(6):2056-2064.

8.  P. Chen#, G. Tang#, *, C. Zhu#, J. Sun, X. Wang, M. Xiang, H. Huang, W. Wang, L. Li, Z. Zhang*, L. Gao*, S.Q. Yao*, “ 2-Ethynylbenzaldehyde (EBA)-based, lysine-targeting irreversible covalent inhibitors for protein kinases and non-kinases”, J. Am Chem. Soc. (2023),145 (7)，3844-3849. (IF16.383, 中科院1区，Top Journal).

9.W. Wang#, X. Wang#, G. Tang*, C-J Zhu, M. Xiang, Q. Xiao, Z.-M. Zhang*, L. Gao*, S.Q. Yao*, “Dual inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently”, Chem. Commun.(2023), 59(72):10789-10792. 

10. P. Chen#, J. Sun#, L. Wang#, M. Xiang, M. Gu, F. Miao, X. Wang, L. Duan, P. Yuan, Z.-M. Zhang*, X. Lu*, L. Gao*, S.Q. Yao*, “Cell-Active, Arginine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Non-Kinases”, XXXX (2023), submitted.

11.X. Wang, J. Sun, H. Huang, G. Tang, P. Chen, M. Xiang, L. Li, Z.-M. Zhang,* L. Gao,* S.Q. Yao*, “Kinase Inhibition via Small Molecule-Induced Intramolecular Protein Cross-Linking”, XXXX (2024), submitted.

Patents 

1. 高理钱，谢刘幸，李孟础，王璇，汪伟，肖奇才，杨芬，沈君，邓文斌。“靶向GRB2 SH2结合域的抗肿瘤多肽及其应用”, 中国发明专利申请号：CN201911258905.8, 申请日 2019年12月10日

2.高理钱，谢刘幸，谈思佳，王璇，李孟础，杨芬，贾艳，肖奇才，沈君，“靶向PKM2蛋白的抗肿瘤多肽及其引用”，中国发明专利申请号: CN202011355591.6, 申请日 2020年11月27日

3.高理钱，贾艳，李孟础，张达，谢程亮，肖奇才，王璇，孙杰, “一种具有抗氧化作用的活性六肽及其应用”，中国发明专利申请号202210356747.3，申请日2022年4月6号