一. 个人简介
中山大学“百人计划”高级引进人才，副教授、博导，药物化学学术带头人，学院药物化学教研室副主任，国家卫健委全球卫生人才后备库成员(国家卫健委2019)，海外高层次留学人才(广东2019)。2007年在中国科学技术大学生物化学与分子生物学系获得硕士学位，师从温龙平教授(“973”首席科学家); 2012年在新加坡国立大学化学系药物化学和化学生物学专业获得博士学位，师从国际知名的化学生物学领域的专家姚少钦教授和Mahesh Uttamchandani副教授。之后在香港大学，香港中文大学和新加坡科技局生物工程与纳米技术研究所从事博士后研究，于2016年4月在新加坡科技局生物工程与纳米技术研究所晋升研究科学家(Research Scientist)。2017年4月聘任为中山大学“百人计划”紧缺型高级人才，副教授、博导。
现主持国家自然科学基金面上项目、国家自然科学基金应急项目、国自然-广东省联合基金集成重点项目、广东省重点研发计划、深圳市科创委自由探索项目和中山大学“百人计划”项目等多个基金。近些年在Chem Soc Rev, Angew. Chem. Int. Ed., J. Am. Chem. Soc, Nano Today, Pharmacology & Therapeutics, J. Med. Chem., ACS Applied Materials & Interfaces, Chem. Commun., ACTA Biomaterialia, Eur. J. Med. Chem., Chem.-Eur. J., Biomaterials Science, Talanta 等国际主流期刊发表SCI论文近70篇，其中第一/共一/通讯作者共41篇，申请中国发明/实用新型专利15项，入选ESI高被引论文3篇。此外，自2012起还受邀担任Chinese Chemical Letters和其它6个国际期刊的Editorial board member, 国际期刊专刊客座主编(2期, Curr Med Chem)、客座编辑(Curr Med Chem 和Journal of Nanomaterials各1期)，和多个重要国际期刊的审稿人。同时也是国家基金委，广东省科技厅，深圳市科创委等项目评审专家。
联系方式：
E-mail:gaolq@mail.sysu.edu.cn
二.教育和工作经历
2000-2004, 安徽大学应用化学系， 学士，导师：杨家祥/沈玉华/许戈文 教授
2004-2007, 中国科技大学生命学院， 硕士，导师：温龙平 教授
2007-2012， 新加坡国立大学化学系， 博士，导师：Shao Q. YAO 教授 & Mahesh UTTAMCHANDANI 副教授
2012-2012, 香港大学化学系， 博士后，合作导师: Xiang LI 教授
2012-2013, 香港中文大学化学系， 博士后，合作导师: Jiang XIA 教授
2013-2016, 新加坡科技局生物工程与纳米技术研究所，博士后, 合作导师: Jackie Y. YING教授 & Su Seong LEE博士
2016-2017, 新加坡科技局生物工程与纳米技术研究所，研究科学家, 合作导师: Jackie Y. YING教授 & Su Seong LEE 博士
2017.04-至今，中山大学药学院（深圳）“百人计划”副教授、博导
三、Representative publications (# Equal contribution, * Corresponding author）
1. L. Gao*, #, W. Wang#, X. Wang#, F. Yang, L. Xie, J. Shen, M.A. Brimble, Q. Xiao*, S. Q. Yao*, “Fluorescent probes for bioimaging of potential biomarkers in Parkinson’s disease”, Chem Soc Rev (2021), 50(2), 1219-1250. (IF 60.615 in 2022, 中科院1区, Top journal)
2. P. Chen#, J. Sun#, C. Zhu#, G. Tang*, W. Wang, M. Xu, M. Xiang, C.-J. Zhang, Z.-M. Zhang*, L. Gao*, S. Q. Yao*, “Cell-active, reversible and irreversible covalent inhibitors that selectively target the catalytic lysine of BCR-ABL kinase”, Angew. Chem. Int. Ed. (2022), 61(26):e202203878. (IF 16.823 in 2022, 中科院1区，Top期刊)
3. P. Chen#, G. Tang#, *, C. Zhu#, J. Sun, X. Wang, M. Xiang, H. Huang, W. Wang, L. Li, Z. Zhang*, L. Gao*, S.Q. Yao*, “ 2-Ethynylbenzaldehyde (EBA)-based, lysine-targeting irreversible covalent inhibitors for protein kinases and non-kinases”, J. Am Chem. Soc. (2023),145 (7)，3844-3849. (IF16.383, 中科院1区，Top Journal).
4. Q. Xiao, B. Mai, Y. Nie, C. Yuan, M. Xiang, Z. Shi, J. Wu, W.A. Leung, C.S. Xu*, S.Q. Yao*, P. Wang*, L. Gao*, “In Vitro and In Vivo Demonstration of Ultra-Efficient and Broad-Spectrum Antibacterial Agents for Photodynamic Antibacterial Chemotherapy”, ACS Applied Materials & Interfaces (2021), 13(10):11588-11596. (IF 10.383 in 2022, 中科院1区，Top journal)
5. Q. Xiao, H. Lin, J. Wu, X. Pang, Q. Zhou, Y. Jiang, P. Wang, A. W. Leung, H. Lee, S. Jiang, S.Q. Yao, L. Gao*, G. Liu*, C.-S. Xu*,“Pyridine Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy”, Journal of Medicinal Chemistry (2020), 63(9), 4896-4907. (IF 8.039 in 2021, 中科院1区，Top journal)
6. L. Wang#, J. Li#, Y. Xiong#, Y. Wu#, F. Yang#, Y. Guo, Z. Chen, L. Gao*, W. Deng*, “Ultrashort peptides and hyaluronic acid based injectable composite hydrogels for sustained drug release and chronic diabetic wound healing", ACS Applied Materials & Interfaces (2021), 13(49), 58329-58339. (IF 10.383 in 2022, 中科院1区，Top journal)
7. Y. Wu, L. Wang, Y. Xiong, Q. Zhou, L. Li, G. Chen, Y. Ping, G. Davidson, P.A. Levkin*, L. Gao*, W. Deng*, “Cell-based high-throughput screening of cationic polymers for efficient DNA and siRNA delivery”, Acta Biomaterialia (2020), 115, 410-417. (IF 10.633 in 2022, 中科院1区，Top journal)
8. Y.-F. Wei#, X. Wang#, W.-J. Shi*, R. Chen, L. Zheng, Z.-Z. Wang, K. Chen, and L. Gao*, “A novel methylenemalononitrile-BODIPY-based fluorescent probe for highly selective detection of hydrogen peroxide in living cells”, European Journal of Medicinal Chemistry (2021), 226, 113828. (IF 7.088 in 2022, 中科院1区，Top Journal)
9. J. Ding#, J. Chen#, L. Gao#, Z. Jiang, Y. Zhang, M. Li, Q. Xiao, S.S. Lee*, X. Chen*, “Engineered nanoplatforms for enhanced tumor penetration”, Nano Today (2019), 100800, DOI:10.1016/j.nantod.2019.100800. (IF 18.962 in 2022, 中科院1区，Top journal) (Most downloaded paper since Dec of 2019 in Nano Today ) (自2019年12月发表至今引用次数已超200次)
10. F. Yang#, D. Zhang#, Q. Zhou#, M. Li, C. Xie, S. Li, X. Wang, W. Wang, Y. Guo, Q. Xiao*, Y. Wang*, L. Gao*, “Peptides-modified polystyrene-based polymers as high-performance substrates for the growth and propagation of human embryonic stem cells” Chinese Chemical Letters (2021), 33(2022), 2901-2905. (IF 8.455 in 2022, 中科院1区)
11. W.J. Shi*, L. Feng, X. Wang, Y. Huang, Y.F. Wei, Y.Y. Huang, H.J. Ma, W. Wang, M. Xiang, L. Gao*, “A near-infrared-emission aza-BODIPY-based fluorescent probe for fast, selective, and “turn-on” detection of HClO/ClO-”, Talanta (2021), 233:122581. (IF 6.556 in 2022，中科院1区, Top Journal)
12. Q. Xiao*, X. Dong, F. Yang, S. Zhou, M. Xiang, L. Lou, S.Q. Yao*, L. Gao*, “Engineered Cell-penetrating Peptides for Mitochondrion-targeted Drug Delivery in Cancer Therapy”, Chem. Eur. J. (2021), 27(59), 14721-14729. (IF 5.020 in 2022, 中科院2区, Top Journal)
13. F. Yang#, X. Wang#, J. Sun#, S. Tan#, S. Zhou, W. Tu, X. Dong, Q. Xiao, F. Yang*, L. Gao*, “Mesopore-Encaged Active MnOx in Nano-Silica Selectively Suppressed Lung Cancer Cell via Induced Autophagy Effect”, Biomaterials Science (2023),11(6), 2056-2064. (IF 7.590, 中科院2区)
14. Q. Xiao#, W. Du#, X. Dong, S. Du, S.Y. Ong, G. Tang, C. Zhang, F. Yang, L. Li*, L. Gao*, S.Q. Yao*, “Cell-penetrating mitochondria-targeting ligands for universal delivery of small molecules, proteins and nanomaterials”, Chem. Eur. J. (2021), 27(47), 12207-12214. (IF 5.020 in 2022，中科院2区, Top Journal)
15. B. Sharma, L. Xie, F. Yang, W. Wang, Q. Zhou, M. Xiang, S. Zhou, W. Lv, Y. Jia, L. Pokhrel, J. Shen, Q. Xiao*, L. Gao*, W. Deng*,“Recent advance on PTP1B inhibitors and their biomedical applications”, European Journal of Medicinal Chemistry (2020), 199:112376, doi:10.1016/j.ejmech.2020.112376. (IF 7.088 in 2022, 中科院1区，Top Journal)
16. Y. Wu, Y. Xiong, L. Wang, Q. Zhou, L. Li, P.A. Levkin, G. Davidson*, L. Gao*, W. Deng*, “Development of new self-assembled cationic amino liposomes for efficient gene delivery”, Biomaterials Science (2020), 8, 3021-3025. (IF 7.590 in 2022, 中科院2区) (Selected as back cover)
17. J. Wang*, #, L. Gao#, Y. M. Lee#, Y.S. Ong, J. Lim, J.-E. Jee, H. Sun, S.S. Lee*, Z-C Hua*, Q.S. Lin *, “Target identification of natural and traditional medicine with quantitative chemical proteomics approaches”, Pharmacology & Therapeutics, 162 (2016), 10-22. (IF 13.400 in 2022, 中科 院1区, Top journal) （自2016年发表至今引用次数已超60次）
18. D. Ling#, L. Gao #, J. Wang #, M. Shokouhimehr, J. Liu, Y. Yu, M. J. Hackett, P.K. So, B. Zheng, Z. Yao, J. Xia*, and T. Hyeon*, “A General Strategy for Site-directed Enzyme Immobilization using NiO Nanoparticle Decorated Mesoporous Silica”, Chem. Eur. J. (2014), 20, 7916–7921. (IF 5.020 in 2022, 中科院2区, Top Journal)
19. L. Gao, M. Uttamchandani*, and S.Q. Yao*, “Comparative Proteomic Profiling of Mammalian Cell Lysates Using Phosphopeptide Microarrays”, Chem. Commun., 48 (2012), 2240-2242. (IF 6.065 in 2022, 中科院2区，Top journal)
20. Q. Xiao#, W. Zhu#, W. Feng#, S. S. Lee, A.W. Leung, J. Shen*, L. Gao*, C. Xu*, “A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy”, Frontiers in Pharmacology (2019), 9:1534. DOI:10.3389/fphar.2018.01534 (IF 5.988 in 2022, 中科院2区) (ESI 高被引论文)