2024
193. Wang Xiaorong, Chen Shiqin, Xia Xue, Du Yufan, Wei Ya, Yang Wenqin, Zhang Yiwei, Song Yujun, Lei Ting, Huang Qianqian, Gao Huile*. Lysosome-targeting protein degradation through endocytosis pathway triggered by polyvalent nano-chimera for AD therapy. Adv Mater, 2025, 37: 2411061. (IF=27.4) https://doi.org/10.1002/adma.202411061
192. Xia Xue, Wei Ya, Huang Qianqian, Zhou Yang, Wang Xiaorong, Shi Yulong, Yang Xiaotong, Yang Wenqin, Zhang Yiwei, Lei Ting, Huang Yuan, Li Hanmei, Qin Meng*, Gao Huile*. Counteracting Alzheimer’s disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator. Acta Pharm Sin B, 2024, 14(12): 5464-5478. (IF=14.7) https://doi.org/10.1016/j.apsb.2024.05.017
191. Tong Fan, Wang Yufan, Xu Yanyan, Zhou Yang, He Siqin, Du Yufan, Yang Wenqin, Lei Ting, Song Yujun, Gong Tao, Gao Huile*. MMP-2-triggered, mitochondria-targeted PROTAC-PDT therapy of breast cancer and brain metastases inhibition. Nat Commun, 2024, 15: 10382. (IF=14.7) https://doi.org/10.1038/s41467-024-54854-2
190. Yang Wenqin, Shi Yulong, Zhang Yiwei, Yang Yating, Du Yufan, Yang Zixiao, Wang Xiaorong, Lei Ting, Xu Yanyan, Chen Yongke, Tong Fan, Wang Yazhen, Huang Qianqian, Hu Chuan, Gao Huile*. Intranasal carrier-free nanomodulator addresses both symptomatology and etiology of Alzheimer’s disease by restoring neuron plasticity and reprogramming lesion microenvironment. ACS Nano, 2024, 18(43): 29779–29793. (IF=15.8) https://doi.org/10.1021/acsnano.4c09449
189. 贺思琴，高会乐*。小分子纯药自组装递药系统用于抗肿瘤的研究进展。中国医药导刊，2024，26（04）：338-344。
188. Wang Qiguang, Liu Fei, Li Yue, Zhang Huan, Qi Xin, Wu Ke, Zhang Yi, You Shenglan, Liu Wenke, Hui Xuhui, Li Hanmei, Zhu Lei, Gao Huile*, Cheng Jian*. Choroid plexus CCL2-CCR2 signaling orchestrates macrophages recruitment and cerebrospinal fluid hypersecretion in hydrocephalus. Acta Pharm Sin B, 2024, 14(10): 4544-4559. (IF=14.7) https://doi.org/10.1016/j.apsb.2024.06.020
187. Liu Xueying#, Wang Hao#, Li Zhaofeng#, Li Jiamei, He Siqin, Hu Chuan, Song Yujun, Gao Huile*, Qin Yi*. Transformable self-delivered supramolecular nanomaterials combined with anti-PD-1 antibodies alleviate tumor immunosuppression to treat breast cancer with bone metastasis. J Nanobiotechnology, 2024, 22(1):566. (IF=10.6) https://doi.org/10.1186/s12951-024-02839-0
186. Li Yuan#, Tong Fan#, Wang Yufan, Wang Jing, Wu Manqi, Li Hanmei, Guo Hongyan*, Gao Huile*. In situ tumor vaccine with optimized nanoadjuvants and lymph node targeting capacity to treat ovarian cancer and metastases. Acta Pharm Sin B, 2024, 14(9):4102-4117. (IF=14.7) https://doi.org/10.1016/j.apsb.2024.06.003
185. Zhang Yao#, Zhang Mo#, Hu Xiaoxiao, Hao Han, Quan Cuilu, Ren Tiantian, Gao Huile*, Wang Jing*. Engineering a porphyrin COFs encapsulated by hyaluronic acid tumor-targeted nanoplatform for sequential chemo-photodynamic multimodal tumor therapy. Int J Biol Macromol, 2024, 279(3): 135328. (IF=7.7) https://doi.org/10.1016/j.ijbiomac.2024.135328
184. Jia Wenfeng, Gong Bokai, Chen Jiantao*, Yan Jia, Shi Yulong, Wang Hao*, Qin Meng, Gao Huile*. Dual-responsive shape-transformable charge-reversible nanoparticles combined with chemo-photodynamic-immunotherapy for the treatment of breast cancer and lung metastasis. Adv Funct Mater, 2024, 34(48), 2408581. (IF=18.5) https://doi.org/10.1002/adfm.202408581
183. Wang Yazhen, Yang Lianyi, Yan Chenxing, Du Yufan, Li Tinghua, Yang Wenqing, Lei Lei, He Bin, Gao Huile *, Nicholas A. Peppas, Cao Jun*. Supramolecular artificial Nano-AUTACs enable tumor-specific metabolism protein degradation for synergistic immunotherapy. Sci Adv, 2024, 10(25): eadn8079. (IF=11.7) https://doi.org/10.1126/sciadv.adn8079
182. Du Yufan, Yan Chenxing, Wang Yazhen, Xu Yanyan, Cun Xingli*, Gao Huile*. The implication and application of brain glymphatic system in mMultiple diseases. Adv Ther, 2024, 7(7), 2400088. (IF=3.7) https://doi.org/10.1002/adtp.202400088
181. Lin Ruyi, Yan Jia, Gong Bokai, Tong Fan, Song Yujun, Xia Xue, Hu Haili, Wang Yufan, Zhou Yang, Gong Tao, Shevtsov Maxim, Gao Huile*. Self-delivered transformable nanosystem capable of enhancing photodynamic effectiveness and multi-target ameliorating immunosuppression for treatment of breast cancer and lung metastasis. Adv Funct Mater, 2024, 34(42), 2405051. (IF=18.5) https://doi.org/10.1002/adfm.202405051
180. Yang Lianyi, Wang Yazhen, Song Yujun, Li Zeya, Lei Lei, Li Hanmei, He Bin, Cao Jun*, Gao Huile*. Metal coordination nanotheranostics mediated by nucleoside metabolic inhibitors potentiate STING pathway activation for cancer metalloimmunotherapy. J Control Release, 2024, 370: 354-366. (IF=10.5) https://doi.org/10.1016/j.jconrel.2024.04.042
179. Li Zhi, Li Wenpei, Jiang Shaoping, Hu Chuan, Huang Yuanyu, Shevtsov Maxim, Gao Huile*, Ruan Shaobo*. Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention. Chinese Chem Lett, 2024, 35(7):109150. (IF=9.4) https://doi.org/10.1016/j.cclet.2023.109150
178. Liu Jiaqi#, Liu Hongmei#, Huang Shan#, Peng Hong, Li Jiamei, Tu Kerong, Tan Sumin, Xie Rou, Lei Lei, Yue Qin*, Gao Huile*, Cai Lulu*. Multiple treatment of triple-negative breast cancer through gambogic acid-loaded mesoporous polydopamine. Small, 2024, 20(31), 2309583. (IF=13.0) https://doi.org/10.1002/smll.202309583
177. Yang Qianyu#, Wu Gang#, Yang Yefeng#, Zhou Yang, Song Jiali, Gao Huile*, Huang Weiyuan*. GSH-responsive shape-transformable nanotheranostics for dual-modal T1/T2 MRI-guided enhanced PDT of nasopharyngeal carcinoma. Adv Funct Mater, 2024, 34(37), 2402194. (IF=18.5) https://doi.org/10.1002/adfm.202402194
176. Song Yujun, Du Yufan, Hu Chuan, Lei Lei, Yang Lianyi, Wang Xiaorong, Jiang Chaoqing, Gao Huile*. Metformin-mediated immunosuppressive microenvironment remodeling in combination with chemotherapy via a spatial-specific multi-responsive carrier-free self-assembled nanoparticle. Adv Funct Mater, 2024, 34(25), 2316145. (IF=18.5) https://doi.org/10.1002/adfm.202316145
175. Li Xiaokun#, Li Jiamei#, He Siqin#, Luan Siyuan, Zhang Haowen, Yang Yushang, Chen Xiaoting, Chen Yilong, Zhou Jianfeng, Fang Pinhao, Xiao Xin, Liang Zhiwen, Zeng Xiaoxi, Gao Huile*, Yuan Yong*. Self-assembled acid-responsive nanosystem for synergistic anti-angiogenic/photothermal/ferroptosis therapy against esophageal cancer. Adv Healthcare Mater, 2024, 13(6), 2302787. (IF=10.0) https://doi.org/10.1002/adhm.202302787
174. Jiang Shaoping, Li Wenpei, Yang Jun, Zhang Tian, Zhang Yuquan, Xu Lin, Hu Bo, Li Zhi, Gao Huile*, Huang Yuanyu*, Ruan Shaobo*. Cathepsin B-responsive programmed brain targeted delivery system for chemo-immunotherapy combination therapy of glioblastoma. ACS Nano, 2024, 18(8): 6445–6462. (IF=15.8) https://doi.org/10.1021/acsnano.3c11958
173. Lei Ting#, Yang Zixiao#, Li Hanmei, Qin Meng*, Gao Huile*. Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease. Adv Drug Deliv Rev, 2024, 207:115219. （IF=15.2) https://doi.org/10.1016/j.addr.2024.115219
172. Lei Ting, Yang Zixiao, Jiang Chaoqing, Wang Xiaorong, Yang Wenqin, Yang Xiaotong, Xie Rou, Tong Fan, Xia Xue, Huang Qianqian, Du Yufan, Huang Yuan, Gao Huile*. Mannose-integrated nanoparticle hitchhike glucose transporter 1 recycling to overcome various barriers of oral delivery for alzheimer’s disease therapy. ACS Nano, 2024, 18(4):3234-3250. (IF=15.8) https://doi.org/10.1021/acsnano.3c09715
171. Zhang Yiwei, Xiao Wei, He Siqin, Xia Xue, Yang Wenqin, Yang Zhihang, Hu Haili, Wang Yushan, Wang Xiaorong, Li Hanmei, Huang Yuan, Huile Gao*. Lipid-mediated protein corona regulation with increased apolipoprotein A-I recruitment for glioma targeting. J Control Release, 2024, 368:42-51. (IF=10.5) https://doi.org/10.1016/j.jconrel.2024.02.020
170. Yang Peng#, Huang Qianqian#, Zhang Jianhua, Li Yiwen, Gao Huile*, Gu Zhipeng*. Natural polyphenolic nanodots for Alzheimer's disease treatment. Adv Mater, 2024, 36(3): 2308393. (IF=27.4) https://doi.org/10.1002/adma.202308393
169．He Siqin, Wang Lulu, Wu Dongxu, Tong Fan, Zhao Huan, Li Hanmei, Gong Tao, Gao Huile*, Zhou Yang*. Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy. Acta Pharm Sin B, 2024, 14(2): 765-780. (IF=14.7) https://doi.org/10.1016/j.apsb.2023.10.006
168. Huang Qianqian, Chen Yongke, Zhang Weiwei, Xia Xue, Li Hanmei, Qin Meng*, Gao, Huile*. Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases. J Control Release, 2024, 366:519-534. (IF=10.5) https://doi.org/10.1016/j.jconrel.2023.12.054
167. Hu Haili, Zhang Weiwei, Lei Lei, Tong Fan, Zhang Huilin, Zhang Yiwei, Yang Wenqin, Tang Yilu, Lin Ruyi, Xia Xue, Li Jiamei, Song Shiyong, Huile Gao*. Combination losartan with hyaluronic acid modified iethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis. Chinese Chem Lett, 2024, 35(3):108765. (IF=9.4) https://doi.org/10.1016/j.cclet.2023.108765
166. Tong Fan, Wang Yufan, Gao Huile*. Progress and challenges in the translation of cancer nanomedicines. Curr Opin Biotechnol, 2024, 85:103045. (IF=7.1) https://doi.org/10.1016/j.copbio.2023.103045
165. Wang Yazhen, Zhou Yang, Yang Lianyi, Lei Lei, He Bin, Cao Jun*, Gao Huile*. Challenges coexist with opportunities: spatial heterogeneity expression of PD-L1 in cancer therapy. Adv Sci, 2024,11(1):2303175. (IF=14.3) https://doi.org/10.1002/advs.202303175
2023
164. Wei Ya, Xia Xue, Li Hanmei, Gao Huile*. Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier. Expert Opin Drug Deliv, 2023, 20(12): 1713-1730. (IF=5.0) https://doi.org/10.1080/17425247.2023.2245332
163. Gong Bokai, Jia Wenfeng, Zhou Yang, Xu Yanyan, Wei Ya, Gao Huile*. Enhancing the treating efficacy of immunotherapy through the restructure of tumor microenvironment. Adv Nanobiomed Res, 2023, 3(12), 2300061. (IF=4.0) http://dx.doi.org/10.1002/anbr.202300061
162. Hu Chuan#, Wu Baoyu#, Wu Yihan, Shi Mingyi, Ma Jiaqi, Gao Huile*, Zhang Jinming*. Recent advances in nanotechnology for combating Alzheimer's disease. Mater. Chem. Front., 2023, 7(21): 5171-5186. (IF=6.0) https://doi.org/10.1039/D3QM00493G
161. 余晨曦，高会乐*。经皮给药技术用于脑靶向药物递送。 药学学报， 2023， 58(08): 2334-2340。https://doi.org/10.16438/j.0513-4870.2023-0433
160. Yang Qianyu#, Guo Yingkun#, Zhou Yang, Song Jiali, Song Yujun, Li Hanmei, Gao Huile *, Huang Weiyuan *. Multifunctional nanotheranostics for dual-modal imaging-guided precision therapy of nasopharyngeal carcinoma. Mol Pharm, 2023, 20(9): 4743-4757. (IF=4.5) https://doi.org/10.1021/acs.molpharmaceut.3c00491
159. Tong Fan, Hu Haili, Xu Yanyan, Zhou Yang, Xie Rou, Lei Ting, Du Yufan, Yang Wenqin, He Siqin, Huang Yuan, Gong Tao, Huile Gao*. Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages. Acta Pharm Sin B, 2023, 13(8): 3471-3488. (IF=14.7) https://doi.org/10.1016/j.apsb.2022.11.003
158. Li Zhaofeng#, Liu Peixin#, Chen Wei#, Liu Xueying, Tong Fan, Sun Junhui, Zhou Yang, Lei Ting, Yang Wenqin, Ma Dong*, Gao Huile*, Qin Yi*. Hypoxia-cleavable and specific targeted nanomedicine delivers epigenetic drugs for enhanced treatment of breast cancer and bone metastasis. J Nanobiotechnology, 2023, 21:221. (IF=10.6) https://doi.org/10.1186/s12951-023-01939-7
157. Huang Qianqian, Jiang Chaoqing, Xia Xue, Wang Yufan, Yan Chenxing, Wang Xiaorong, Lei Ting, Yang Xiaotong, Yang Wenqin, Cheng Guo *, and Gao Huile *. Pathological BBB crossing melanin-like nanoparticles as metal-ion chelator and neuroinflammation regulator against Alzheimer’s disease. Research, 2023, 2023: 0180. (IF=8.5)
http://doi.org/10.34133/research.0180
156. Tong Fan, Zhou Yang, Xu Yanyan, Chen Yuxiu, Yudintceva Natalia, Shevtsov Maxim, Gao Huile*. Supramolecular nanomedicines based on host-guest interactions of cyclodextrins. Exploration, 2023, 3(4): 20210111. http://doi.org/10.1002/EXP.20210111
155. Xie Rou, Wang Yufan, Tong Fan, Yang Wenqin, Lei Ting, Du Yufan, Wang Xiaorong, Yang Zixiao, Gong Tao, Shevtsov Maxim, Gao Huile*. Hsp70-targeting and size-tunable nanoparticles combine with PD-1 checkpoint blockade to treat glioma. Small, 2023, 19(37): 2300570. (IF= 13.0) https://doi.org/10.1002/smll.202300570
154. Hu Chuan#, Song Yujun#, Zhang Yiwei, He Siqin, Liu Xueying, Yang Xiaotong, Gong Tao, Huang Yuan, Gao Huile*. Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome. Acta Pharm Sin B, 2023, 13(5): 2176-2187. (IF=14.7) https://doi.org/10.1016/j.apsb.2023.02.009
153. Zhang Huilin, Zhang Yiwei, Hu Haili, Yang Wenqin, Xia Xue, Lei Lei, Lin Ruyi, Li Jiamei, Li Yuan*, Gao Huile*. In situ tumor vaccine for lymph nodes delivery and cancer therapy based on small size nanoadjuvant. Small, 2023, 19(33), 2301041. (IF=13.0) https://doi.org/10.1002/smll.202301041
152. Yang Qian*, Jiang Hong, Wang Yue, Leng Xiao, Wang Yantang, Tong Jie, Zhou Yang, Mo Chunfen, Peng Jinrong*, Gao Huile*. Plaque macrophage-targeting nanosystems with cooperative co-regulation of ROS and TRAF6 for stabilization of atherosclerotic plaques. Adv Funct Mater, 2023, 33(28), 2301053. (IF=18.5) https://doi.org/10.1002/adfm.202301053
151. Sepasi Tina, Ghadiri Tahereh, Ebrahimi-Kalan Abbas, Bani Farhad, Talebi Mehdi, Rahbarghazi Reza, Khodakarimi Sina, Beyrampour-Basmenj Hanieh, Seidi Khaled, Abbaspour-Ravasjani Soheil, Sadeghi Mohammad-Reza, Zarebkohan Amir*, Gao Huile*. CDX-modified chitosan nanoparticles remarkably reduce therapeutic dose of fingolimod in the EAE model of mice. Int J Pharm, 2023, 636:122815. (IF= 5.3) https://doi.org/10.1016/j.ijpharm.2023.122815
150. Zhou Yang, Zhang Yiwei, Jiang Chaoqing, Chen Yuxiu, Tong Fan, Yang Xiaotong, Wang Yazhen, Xia Xue, Gao Huile*. Rosmarinic acid-crosslinked supramolecular nanoassembly with self-regulated photodynamic and anti-metastasis properties for synergistic photoimmunotherapy. Small, 2023, 19(23), 2300594. (IF=13.0) https://onlinelibrary.wiley.com/doi/10.1002/smll.202300594
149. Li Jiaxin, Zhang Mengjiao, Shi Jinfeng, Wang Shengpeng, Zhong Xuemei, Wu Yihan, Qu Yan, Gao Huile*, Zhang Jinming*. pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide. Int J Pharm, 2023, 632:122572. (IF= 5.3) https://doi.org/10.1016/j.ijpharm.2022.122572
148. Liu Rui#, Luo Cong#, Pang Zhiqing#, Zhang Jinming#, Ruan Shaobo#, Wu Meiying#, Wang Lei#, Sun Tao#, Li Nan#, Han Liang#, Shi Jinjin#, Huang Yuanyu#, Guo Weisheng#, Peng Shaojun#, Zhou Wenhu#, Gao Huile*. Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment. Chin Chem Lett, 2023, 34(2):107518. (IF=9.4) https://doi.org/10.1016/j.cclet.2022.05.032
147. Yang Zhihang#, Du Yufan#, Lei Lei, Xia Xue, Wang Xiaorong, Tong Fan, Li Yuan*, Gao Huile*. Co-delivery of ibrutinib and hydroxychloroquine by albumin nanoparticles for enhanced chemotherapy of glioma. Int J Pharm, 2023, 630:122436. (IF= 5.3) https://doi.org/10.1016/j.ijpharm.2022.122436
2022
146. Xu Yanyan#, Xiong Jingyuan#, Sun Xiyang*, Gao Huile*. Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy. Acta Pharm Sin B, 2022, 12(12):4327-4347. (IF=14.5) https://doi.org/10.1016/j.apsb.2022.11.001
145. Lei Lei, Huang Dennis, Gao Huile*, He Bin, Cao Jun*, Peppas Nicholas A.*. Hydrogel-guided strategies to stimulate an effective immune response for vaccine-based cancer immunotherapy. Sci Adv, 2022, 8(47): adc8738. (IF= 13.6) https://www.science.org/doi/10.1126/sciadv.adc8738
144．Li Zhaofeng, Zhang Wei, Zhang Zhong, Gao Huile*, Qin Yi*. Cancer bone metastases and nanotechnology-based treatment strategies. Expert Opin Drug Deliv, 2022, 19(10): 1217-1232. (IF=6.6) https://doi.org/10.1080/17425247.2022.2093856
143. Li Jiamei, Zhou Yang, Liu Jiaqi, Yang Xiaotong, Zhang Kai, Lei Lei, Hu Haili, Zhang Huilin, Ouyang Liang*, Gao Huile*. Metal-phenolic networks with ferroptosis to deliver NIR-responsive CO for synergistic therapy. J Control Release, 2022, 352: 313-327. (IF= 10.8) https://doi.org/10.1016/j.jconrel.2022.10.025
142. Li Xiaokun#, Chen Lingmin#, Luan Siyuan, Zhou Jianfeng, Xiao Xin, Yang Yushang, Mao Chengyi, Fang Pinghao, Chen Longqi, Zeng Xiaoxi, Gao Huile*, Yuan Yong*. The development and progress of nanomedicine for esophageal cancer diagnosis and treatment. Seminars in Cancer Biology, 2022, 86: 873-885. (IF= 14.5) https://doi.org/10.1016/j.semcancer.2022.01.007
141. 胡川, 宋钰珺，高会乐*。肿瘤微环境响应性纳米递药系统用于肿瘤免疫治疗的研究进展. 药学进展，2022，46(07): 485-494。
140. He Jide, Liu Zenan, Zhu Xuehua, Xia Haizhui, Gao Huile *, Lu Jian*. Ultrasonic microbubble cavitation enhanced tissue permeability and drug diffusion in solid tumor therapy. Pharmaceutics, 2022, 14(8): 1642. (IF=5.4) https://doi.org/10.3390/pharmaceutics14081642
139. Jia Wenfeng#, Liu Rui#, Wang Yushan, Hu Chuan, Yu Wenqi, Zhou Yang, Wang Ling, Zhang Mengjiao, Gao Huile*, Gao Xiang*. Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer. Acta Pharm Sin B, 2022, 12(8):3354-3366. (IF=14.5) https://doi.org/10.1016/j.apsb.2022.03.010
138. Yang Xiaotong, Yang Wenqin, Xia Xue, Lei Ting, Yang Zhihang, Jia Wenfeng, Zhou Yang, Cheng Guo*, Gao Huile*. Intranasal delivery of BACE1 siRNA and rapamycin by dual targets modified nanoparticles for Alzheimer’s disease therapy. Small, 2022,18(30), 2203182. (IF= 13.3) https://doi.org/10.1002/smll.202203182
137. Xu Wenwen, Xu Mingyu, Xiao Yumeng, Yu Lu, Xie Huiru, Jiang Xuehua, Chen Meiwan, Gao Huile*, Wang Ling*. Changes in target ability of nanoparticles due to protein corona composition and disease state. Asian J Pharm Sci, 2022, 17(3): 401-411. (IF = 10.2) https://doi.org/10.1016/j.ajps.2022.03.002
136. Cheng Xinting, Pei Xibo*, Xie Wenjia, Chen Junyu, Li Yuanyuan, Wang Jian, Gao Huile*, Wan Qianbing*. pH-triggered size-tunable silver nanoparticles: targeted aggregation for effective bacterial infection therapy. Small, 2022, 18(22), 2200915. (IF=13.3) https://doi.org/10.1002/smll.202200915
135. Wu Yihan, Li Jingjing, Zhong Xuemei, Shi Jinfeng, Cheng Yanfen, He Chenglin, Li Jiaxin, Zou Liang, Fu Chaomei, Chen Meiwan, Zhang Jinming*, Gao Huile*. A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy. Asian J Pharm Sci, 2022, 17(2): 206-218. (IF = 10.2) https://doi.org/10.1016/j.ajps.2021.12.003
134. He Xueqin#, Wang Xiaorong#, Yang Lianyi, Yang Zhihang, Yu Wenqi, Wang Yazhen, Liu Rui, Chen Meiwan, Gao Huile*. Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection. Acta Pharm Sin B, 2022, 12(4), 1987-1999. (IF=14.5) https://doi.org/10.1016/j.apsb.2022.02.001
133. Zhou Yang, Tong Fan, Gu Weilong, He Siqin, Yang Xiaotong, Li Jiamei, Gao Yue-Dong*, Gao Huile*. Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors. Acta Pharm Sin B, 2022, 12(3): 1416-1431. (IF=14.5) https://doi.org/10.1016/j.apsb.2021.12.001
132. Liu Rui#, Jia Wenfeng#, Wang Yushan, Hu Chuan, Yu Wenqi, Huang Yuan, Wang Ling, Gao Huile*. Glymphatic system and subsidiary pathways drive nanoparticles away from the brain. Research, 2022, 9847612. （IF=11) https://doi.org/10.34133/2022/9847612
131. He Xueqin#, Xie Jiang#, Zhang Jing, Wang Xiaorong, Jia Xufeng, Yin Heng, Qiu Zhongqing, Yang Zhihang, Chen Jiao, Ji Zhiliang, Yu Wenqi, Chen Meiwan, Xu Wenming*, Gao Huile*. Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder. Adv Sci, 2022, 9(14), 2104286. (IF= 15.1) https://doi.org/10.1002/advs.202104286
130. Luan Siyuan#, Xie Rou#, Yang Yushang#, Xiao Xin, Zhou Jianfeng, Li Xiaokun, Fang Pinhao, Zeng Xiaoxi, Yu Xiangrong*, Chen Meiwan, Gao Huile*, Yuan Yong*. Acid-Responsive Aggregated Gold Nanoparticles for Radiosensitization and Synergistic Chemoradiotherapy in the Treatment of Esophageal Cancer. Small 2022,18(19), 2200115. (IF=13.3) https://doi.org/10.1002/smll.202200115
129. Zhou Yang, Liu Rui, Shevtsov Maxim, Gao Huile*. When imaging meets size-transformable nanosystems. Adv Drug Deliv Rev, 2022, 183:114176. (IF= 16.1) https://doi.org/10.1016/j.addr.2022.114176
128. He Siqin#, Gui Jiajia#, Xiong Kun, Chen Meiwan, Gao Huile*, Fu Yao*. A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases. J Nanobiotechnology, 2022, 20:101. (IF=10.2) https://doi.org/10.1186/s12951-022-01307-x
127. Song Yujun, Hu Chuan, Fu Yao*, Gao Huile*. Modulating the blood–brain tumor barrier for improving drug delivery efficiency and efficacy. VIEW, 2022, 3(1), 20200129.（IF=8.6） https://doi.org/10.1002/VIW.20200129
126. Farshbaf Masoud, Valizadeh Hadi, Panahi Yunes, Fatahi Yousef, Chen Meiwan, Zarebkohan Amir*, Gao Huile*. The impact of protein corona on the biological behavior of targeting nanomedicines. Int J Pharm, 2022, 614:121458. (IF= 5.8) https://doi.org/10.1016/j.ijpharm.2022.121458
125. Peng Shaojun*, Xiao Fengfeng, Chen Meiwan, Gao Huile*. Tumor microenvironment responsive nanomedicine for enhanced cancer immunotherapy. Adv Sci, 2022, 9(1), 2103836. (IF= 15.1) https://doi.org/10.1002/advs.202103836
124. Mei Heng, Cai Shengsheng, Huang Dennis, Gao Huile*, Cao Jun*, He Bin. Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification. Bioactive Mater, 2022, 8: 220-240.（IF= 18.9）https://doi.org/10.1016/j.bioactmat.2021.06.035
2021
123. Lei Ting, Yang Zhihang, Xia Xue, Chen Yuxiu, Yang Xiaotong, Xie Rou, Tong Fan, Wang Xiaolin, Gao Huile*. A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease. Acta Pharm Sin B, 2021, 11(12): 4032-4044.(IF=14.907) https://doi.org/10.1016/j.apsb.2021.04.022
122. Nemati Mahdieh, Bani Farhad, Sepasi Tina, Zamiri Reza Eghdam, Rasmi Yousef, Kahroba Houman, Rahbarghazi Reza, Sadeghi Mohammed Reza, Wang Yazhen, Zarebkohan Amir*, and Gao Huile*. Unraveling the effect of breast cancer patients’ plasma on the targeting ability of folic acid-modified chitosan nanoparticles. Mol Pharm, 2021, 18(12): 4341. (IF= 5.364) https://doi.org/10.1021/acs.molpharmaceut.1c00525
121. Yu Wenqi, Lin Ruyi, He Xueqin, Yang Xiaotong, Zhang Huilin, Hu Chuan, Liu Rui, Huang Yuan, Qin Yi*, Gao Huile*. Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis. Acta Pharm Sin B, 2021, 11(9): 2924-2936. (IF= 14.907) https://doi.org/10.1016/j.apsb.2021.04.006
120. Xia Xue, Zhou Yang, Gao Huile*. Prodrug strategy for enhanced therapy of central nervous system disease. Chem Comm, 2021, 57: 8842-8855. (IF= 6.065) https://doi.org/10.1039/D1CC02940A
119.Yu Wenqi#, Hu Chuan#, Gao Huile*. Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages. Adv Drug Deliv Rev, 2021, 178: 113909. (IF= 17.873) https://doi.org/10.1016/j.addr.2021.113909
118. Lin Congcong, Gao Huile*, Ouyang Liang*. Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure. J Control Release, 2021, 337: 494-504. (IF= 11.467) https://doi.org/10.1016/j.jconrel.2021.08.002
117. Qin Yi#, Tong Fan#, Zhang Wei#, Zhou Yang, He Siqin, Xie Rou, Lei Ting, Wang Yushan, Peng Shaojun, Li Zhaofeng, Leong Julian, Gao Huile*, Lu Ligong*. Self-delivered supramolecular nanomedicine with transformable shape for ferrocene-amplified photodynamic therapy of breast cancer and bone metastases. Adv Funct Mater, 2021, 31(42), 2104645. (IF=19.924) http://doi.org/10.1002/adfm.202104645
116. Xie Rou, Ruan Shaobo, Liu Jiaqi, Qin Lin, Yang Chuanyao, Tong Fan, Lei Ting, Shevtsov Maxim, Gao Huile*, Qin Yi*. Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance. Biomaterials, 2021, 275: 120891. (IF=15.304) https://doi.org/10.1016/j.biomaterials.2021.120891
115. Xiao Wei, Wang Yazhen, Zhang Huilin, Liu Yuwei, Xie Rou, He Xueqin, Zhou Yang, Liang Luqing, Gao Huile*. The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor. Biomaterials, 2021, 274: 120888. (IF=15.304) https://doi.org/10.1016/j.biomaterials.2021.120888
114. Hu Jiang, Yuan Xinwei, Wang Fei, Gao Huile*, Liu Xilin*, Zhang Wei*. The progress and perspective of strategies to improve tumor penetration of nanomedicines. Chin Chem Lett, 2021, 32(4): 1341-1347. (IF=8.455) https://doi.org/10.1016/j.cclet.2020.11.006
113. Wang Yazhen, Zhang Huilin, Xiao Wei, Liu Yuwei, Zhou Yang, He Xueqin, Xia Xue, Gong Tao, Wang Ling*, Gao Huile*. Unmasking CSF protein corona: effect on targeting capacity of nanoparticles. J Control Release, 2021, 333: 352-361. (IF= 11.467) https://doi.org/10.1016/j.jconrel.2021.04.001
112. 王雅蓁，龚涛，李圆*，高会乐*. 卵巢癌患者血浆蛋白冠的形成及其对纳米粒靶向性的影响. 药学学报, 2021, 56(2): 604-609.
111. Hu Chuan, Gao Huile*. A cleavable self-delivery nanoparticle for tumor photo-immunotherapy. Asian J Pharm Sci, 2021, 16(4): 133-135. (IF=9.273) https://doi.org/10.1016/j.ajps.2021.01.001
110. Qin Lin#, Zhang Huilin#, Zhou Yang, Umeshappa Channakeshava Sokke*, Gao Huile*. Nanovaccine-based strategies to overcome challenges in the whole vaccination cascade for tumor immunotherapy. Small, 2021, 17, 2006000. (IF= 15.153) http://doi.org/10.1002/smll.202006000
109. Ruan Shaobo, Zhou Yang, Jiang Xinguo, Gao Huile*. Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell Targeting, internalization, and drug Release. Adv Sci, 2021, 8(9): 2004025. (IF=17.521) https://doi.org/10.1002/advs.202004025
108. Jia Wenfeng#, Wang Yushan#, Liu Rui, Yu Xiangrong*, Gao Huile*. Shape transformable strategies for drug delivery. Adv Funct Mater, 2021, 31, 2009765. (IF=19.924) https://doi.org/10.1002/adfm.202009765
107. He Yanmei#, Lei Lei#, Cao Jun*, Yang Xiaotong, Cai Shengsheng, Tong Fan, Huang Dennis, Mei Heng, Luo Kui, Gao Huile*, He Bin, Peppas Nicholas A.*. A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting. Sci Adv, 2021, 7(6): eaba0776. (IF= 14.957) https://advances.sciencemag.org/content/7/6/eaba0776
106. Hu Chuan, He Xueqin, Chen Yuxiu, Yang Xiaotong, Qin Lin, Lei Ting, Zhou Yang, Gong Tao, Huang Yuan, Gao Huile*. Metformin mediated PD-L1 downregulation in combination with photodynamic-immunotherapy for treatment of breast cancer. Adv Funct Mater, 2021, 31(11), 2007149. (IF=19.924) https://doi.org/10.1002/adfm.202007149
105. Lin Ruyi#, Yu Wenqi#, Chen Xianchun*, Gao Huile*, Self-Propelled Micro/Nanomotors for Tumor Targeting Delivery and Therapy. Adv Healthc Mater, 2021, 10, 2001212.（IF=11.092）https://doi.org/10.1002/adhm.202001212
104. Yu Lu, Xu Mingyu, Xu Wenwen, Xiao Wei, Jiang Xuehua, Wang Ling*, Gao Huile*. Enhanced cancer-targeted drug delivery using precoated nanoparticles. Nano Lett, 2020, 20(12), 8903-8911.(IF=11.238) https://doi.org/10.1021/acs.nanolett.0c03982
103. Li Yuan, Gao Yan, Zhang Xi, Guo Hongyan*, Gao Huile*. Nanoparticle in precision medicine of for ovarian cancer: from chemotherapy to immunotherapy. Int J Pharm, 2020, 591:119986. (IF=4.213) https://doi.org/10.1016/j.ijpharm.2020.119986
102. Lin Congcong#, Tong Fan#, Liu Rui, Xie Rou, Lei Ting, Chen Yuxiu, Yang Zhihang, Gao Huile*, Yu Xiangrong*. GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy. Acta Pharm Sin B, 2020, 10(12):2348-2361. (IF=7.097) https://doi.org/10.1016/j.apsb.2020.10.009
101. Yu Wenqi#, Hu Chuan#, Gao Huile*, Intelligent Size-Changeable Nanoparticles for Enhanced Tumor Accumulation and Deep Penetration. ACS Appl Bio Mater, 2020, 3 (9), 5455-5462. https://doi.org/10.1021/acsabm.0c00917
100. Qin Lin#, Cao Jun#, Shao Kun#, Tong Fan, Yang Zhihang, Lei Ting, Wang Yazhen, Hu Chuan, Umeshappa Channakeshava Sokke, Gao Huile*, Nicholas A. Peppas. A tumor-to-lymph Procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis. Sci Adv, 2020, 6(37): eabb3116. (IF= 13.116) http://doi.org/10.1126/sciadv.abb3116
99. Zhang Wei, Wang Fei, Hu Chuan, Zhou Yang, Gao Huile*, Hu Jiang*. The progress and perspective of nanoparticle-enabled tumor metastasis treatment. Acta Pharm Sin B, 2020, 10(11): 2037-2053. (IF=7.091) https://doi.org/10.1016/j.apsb.2020.07.013
98. Hu Chuan, Lei Ting, Wang Yazhen, Cao Jun, Yang Xiaotong, Qin Lin, Liu Rui, Zhou Yang, Tong Fan, Umeshappa Sokke Channakeshava*, Gao Huile*. Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity. Biomaterials, 2020, 255, 120159. (IF=10.317) https://doi.org/10.1016/j.biomaterials.2020.120159
97. Zhou Yang, Yu Wenqi, Cao Jun*, Gao Huile*. Harnessing carbon monoxide-releasing platforms for cancer therapy. Biomaterials, 2020, 255, 120193. (IF=10.317) https://doi.org/10.1016/j.biomaterials.2020.120193
96. Cai lulu#, Yang Chuanyao#, Jia Wenfeng, Liu Yuwei, Xie Rou, Lei Ting, Yang Zhihang, He Xueqin, Tong Rongsheng*, Gao Huile*. Endo/Lysosome‐Escapable Delivery Depot for Improving BBB Transcytosis and Neuron Targeted Therapy of Alzheimer's Disease. Adv Funct Mater, 2020, 30(27), 1909999. (IF=16.836) https://doi.org/10.1002/adfm.201909999
95. Liu Rui#, An Yang#, Jia Wenfeng, Wang Yushan, Wu Yue, Zhen Yonghuan, Cao Jun*, Gao Huile*. Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer. J Control Release, 2020, 321, 589-601. (IF=7.727) https://doi.org/10.1016/j.jconrel.2020.02.043
94. Yang Xiaotong#, Chen Xianchun#, Lei Ting, Qin Lin, Zhou Yang, Hu Chuan, Liu Qingfeng*, Gao Huile*. The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration. Acta Pharm Sin B, 2020, 10(6):1094-1105. (IF=7.097) https://doi.org/10.1016/j.apsb.2020.02.011
93. Yu Wenqi, Shevtsov Maxim, Chen Xianchun*, Gao Huile*. Advances in aggregatable nanoparticles for tumor-targeted drug delivery. Chin Chem Lett, 2020, 31(6):1366-1374. (IF=4.632) https://doi.org/10.1016/j.cclet.2020.02.036
92. Zhou Yang, Chen Xianchun, Cao Jun*, Gao Huile*. Overcoming the Biologic Barriers in Tumor Microenvironment for Improving Drug Delivery and Efficacy. J Mater Chem B, 2020, 8 (31): 6765-6781. (IF=5.344) https://doi.org/10.1039/D0TB00649A
91. Yin Yanlong, Hu Ben, Yuan Xiao, Cai Li, Gao Huile*, Yang Qian*. Nanogel: a versatile nano-delivery system for biomedical applications. Pharmaceutics, 2020, 12(3): 290. (IF=4.421) https://doi.org/10.3390/pharmaceutics12030290
90. Yu Wenqi#, Liu Rui#, Zhou Yang, Gao Huile*. Size-Tunable Strategies for a Tumor Targeted Drug Delivery System. ACS Cent Sci, 2020, 6 (2), 100-116. (IF=12.685) https://doi.org/10.1021/acscentsci.9b01139
89. 胡川，高会乐。肿瘤微环境响应性与调节性递药系统研究进展。药学学报（Acta Pharmaceutica Sinica）, 2020, 55(7): 1520-1527.
88. Yin Yanlong#, Yuan Xiao#, Gao Huile*, Yang Qian*. Nanoformulations of small molecule protein tyrosine kinases inhibitors potentiate targeted cancer therapy. Int J Pharm, 2020, 573: 118785. (IF=4.213) https://doi.org/10.1016/j.ijpharm.2019.118785
2019
87. Li Chong#, Wang Jiancheng#,*, Wang Yiguang#, Gao Huile#, Wei Gang#, Huang Yongzhuo#, Yu Haijun#, Gan Yong#, Wang Yongjun#, Mei Lin#, Chen Huabing#, Hu Haiyan#, Zhang Zhiping#, Jin Yiguang#. Recent progress in drug delivery. Acta Pharm Sin B, 2019, 9(6): 1145-1162. (IF=7.097) http://doi.org/10.1016/j.apsb.2019.08.003
86. Luo Zhijian, Dai Yan, Gao Huile*. Development and application of hyaluronic acid in tumor targeting drug delivery. Acta Pharm SinB, 2019,9(6): 1099-1112. (IF=7.097) https://doi.org/10.1016/j.apsb.2019.06.004
85. Qin Lin, Gao Huile*.The application of nitric oxide delivery in nanoparticle-based tumor targeting drug delivery and treatment. Asian J Pharm Sci, 2019, 14(4): 380-390. (IF=3.968) https://doi.org/10.1016/j.ajps.2018.10.005
84. Ruan shaobo#, Xie Rou#, Qin Lin, Yu Meinan, Xiao Wei, Hu Chuan, Yu Wenqi, Qian Zhiyong, Ouyang Liang, He Qin, Gao Huile*. Aggregable nanoparticles-enabled chemotherapy and autophagy inhibition combined with anti-PD-L1 antibody for improved glioma treatment. Nano Lett., 2019, 19(11),8318-8332. (IF=11.238) https://doi.org/10.1021/acs.nanolett.9b03968
83. Yang Xiaotong, Hu Chuan, Tong Fan, Liu Rui, Zhou Yang, Qin Lin, Ouyang Liang, Gao Huile*. Tumor microenvironment-responsive dual drug dimer-loaded PEGylated bilirubin nanoparticles for improved drug delivery and enhanced immune-chemotherapy of breast cancer. Adv Funct Mater, 2019, 29(32),1901896. (IF=16.836) http://doi.org/10.1002/adfm.201901896
82. Liu Rui, Yu Meinan, Yang Xiaotong, UmeshappaS. Channakeshava, Hu Chuan, Yu Wenqi, Qin Lin, Huang Yuan,Gao Huile*.Linear chimeric triblock molecules self-assembled micelles with controllably transformable property to enhance tumor retention for chemo- photodynamic therapy of breast cancer. Adv Funct Mater, 2019, 29(23),1808462. (IF=16.836) http://doi.org/10.1002/adfm.201808462
81. Yu Wenqi, He Xueqin, Yang Zhihang, Yang Xiaotong, Xiao Wei, Liu Rui, Xie Rou, Qin Lin, Gao Huile*. Sequentially responsive biomimetic nanoparticles with optimal size incombination with checkpoint blockade for cascade synergetic treatment ofbreast cancer and lung metastasis. Biomaterials, 2019, 217, 119309. (IF=10.317) http://doi.org/10.1016/j.biomaterials.2019.119309
80. Yu Meinan, Su Dunyan, Yang Yuanyuan, Qin Lin, Hu Chuan, Liu Rui, Zhou Yang, Yang Chuanyao, Yang Xiaotong, Wang Guanlin*, Gao Huile*.D-T7 peptide-modified PEGylated bilirubin nanoparticles loaded with cediranib and paclitaxel for antiangiogenesis and chemotherapy of glioma. ACS Appl Mater Inter, 2019, 11(1):176-186.(IF=8.758) http://doi.org/10.1021/acsami.8b16219
79. Liu Rui, Hu Chuan, Yang Yuanyuan, Zhang Jingqing, Gao Huile*.Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment. Acta Pharm Sin B, 2019, 9(2):410-420. (IF=7.097) https://doi.org/10.1016/j.apsb.2018.09.001
2018
78. Gao Huile, GaoXiaoling, Edited.Brain Targeted Drug delivery system. Academic Press, 2018.9.28, Singapore.ISBN：978-0-12-814001-7
77. Xiao Wei, Gao Huile*. The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system. Int J Pharm, 2018, 552(1-2): 328-339.(IF=4.213)
76. Gao Huile*. Editorial (Thematic Issue: Novel Nanoparticles for Tumor Targeting Drug Delivery).Curr Drug Metab, 2018, 19(9): 722.(IF=2.659)
75. ShevtsovMaxim#*, Zhou Yang#, Khachatryan William,MulthoffGabriele, Gao Huile*. Recent advances in gold nanoformulations for cancer diagnosis and therapy.Curr Drug Metab, 2018, 19(9): 768-780.(IF=2.659)
74. Ruan Shaobo, Qin Lin, Xiao Wei, Hu Chuan, Zhou Yang, Wang Ranran, Sun Xing, Yu Wenqi, He Qin, Gao Huile*.Acid-responsive transferrin dissociation and GLUT mediated exocytosis for increasedblood-brain barrier transcytosis and programmed glioma targeting delivery. Adv Funct Mater, 2018, 28(30): 1802227. (IF=15.621)
73. Liu Rui#, Xiao Wei#, Hu Chuan, Xie Rou, Gao Huile*.Theranostic size-reducible and no donor conjugated gold nanocluster fabricated hyaluronic acid nanoparticle with optimal size for combinational treatment of breast cancer and lung metastasis. J Control Release, 2018, 278, 127-139. (IF=7.901)
72. Hu Chuan,CunXingli, Ruan Shaobo, Liu Rui, Xiao Wei, Yang Xiaotong, Yang Yuanyuan, Yang Chuanyao, Gao Huile*.Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy. Biomaterials, 2018, 168: 64-75. (IF=10.273)
71.Hu Chuan, Yang Xiaotong, Liu Rui,RuanShaobo, Zhou Yang, Xiao Wei, Yu Wenqi, Yang Chuanyao,Gao Huile*. Coadministration of iRGD with multistage responsive nanoparticles enhanced tumor targeting and penetration abilities for breast cancer therapy. ACS Appl Mater Inter, 2018, 10(26):22571-22579.(IF=8.456)
70. Zhang Huajin, Wu Tianmu, Yu Wenqi, RuanShaobo, He Qin, Gao Huile*. Ligand size and conformation affect the behavior of nanoparticles coated with in vitro and in vivo protein corona. ACS Appl Mater Inter, 2018, 10(10):9094-9103.(IF=8.456)
69. Xiao Wei#, XiongJingyuan#, Zhang Shuang, Xiong Yang, Zhang Huajin, Gao Huile*.Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability. Int J Pharm, 2018,538(1-2): 105-111. (IF=4.213)
2017
68. 阮少波，何勤，高会乐*. 豆荚蛋白酶响应的功能化金纳米粒用于皮下移植瘤靶向药物递送和治疗. 药学学报（Acta Pharmaceutica Sinica）, 2017, 52(11): 1756-1762.
67. Xiong Jingyuan, Gao Huile*. Matrix metalloproteases responsive nanomaterials for tumor targeting diagnosis and treatment. J Microencapsul, 2017,34(5):440-453. (IF=1.543)
66. Yang Shu, Gao Huile*. Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy.Pharmacol Res, 2017, 126: 97-108. (IF=5.574)
65. 高会乐, 蒋新国*.新型药物递释系统的研究进展. 药学学报（Acta PharmaceuticaSinica）, 2017, 52(2): 181-188.
64. Gao Huile*. Perspectives on dual targeting delivery systems for brain tumors. J Neuroimmune Pharmacol, 2017, 12(1): 6-16. (IF=3.339)
63. Ruan Shaobo, Xiao Wei, Hu Chuan, Zhang Huajin, Rao Jingdong, Wang Sihan, Wang Xiao, He Qin*, Gao Huile*. Ligand mediated and enzyme-directed precise targeting and retention for enhanced treatment of glioblastoma.ACS Appl Mater Inter, 2017, 9(24): 20348–20360.(IF=8.097)
62. Xiao Wei, Ruan Shaobo, Yu Wenqi, Wang Ranran, Hu Chuan, Liu Rui, Gao Huile*.Normalizing tumor vessels to increase the enzyme-induced retention and targeting of gold nanoparticle for breast cancer imaging and treatment. Mol Pharm, 2017,14(10), 3489-3498. (IF=4.556)
61. Xiao Wei#, Li Yuan#, Hu Chuan, Huang Yuan, He Qin, Gao Huile*. Melanin-originated carbonaceous dots for triple negative breast cancerdiagnosis by fluorescence and photoacoustic dual-mode imaging.JColloid Interf Sci, 2017, 497: 226-232.(IF=5.091)
2016
60. Gao Huile*.Editorial (Thematic Issue: Nanoparticles for Brain and Tumor Targeting Delivery).Curr Drug Metab, 2016, 17(8): 730.(IF=2.659)
59. Gao Huile*.Shaping tumor microenvironment for improving nanoparticles delivery. Curr Drug Metab, 2016, 17(8): 731-736. (IF=2.659)
58. Gao Huile*.Progress and perspectives on targeting nanoparticles for brain drug delivery. Acta Pharm Sin B, 2016,6(4): 268-286.(IF=6.014)
57. Jiang Xinguo,GaoHuile, Edited.Neurotoxicity of Nanomaterials and Nanomedicine. Academic Press, 2016.9.28, Singapore.
56. 高会乐, 蒋新国*.肿瘤靶向递药新策略的研究进展. 药学学报（Acta PharmaceuticaSinica）, 2016, 51(2): 272-280.
55. Gao Huile. Nanoparticles for brain targeting drug delivery. In Hari Singh Nalwa, Encyclopedia of nanoscience and nanotechnology, American Scientific Publishers, 2016, Valencia,chapter 9, 1-21.
54. Ruan Shaobo, Hu Chuan, Tang Xian, Cun Xingli, Xiao Wei, Shi Kairong, He Qin, Gao Huile*. Increased gold nanoparticle retention in brain tumors by in situ enzyme-induced aggregation. ACS Nano, 2016, 10(11): 10086-10098. (IF=13.709)
53. Cun Xingli, Ruan Shaobo, Chen Jiantao, Zhang Li, Li Jianping, He Qin*, Gao Huile*. A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan. Acta Biomater, 2016, 31C: 186-196. (IF=6.368)
52. Hu Guanlian#, Cun Xingli#, Ruan Shaobo, Shi Kairong, Wang Yang, Kuang Qifang, Hu Chuan, Xiao Wei, He Qin, Gao Huile*. Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles. Sci Rep, 2016,6:27669. (IF=4.259)
51. Hu Chuan#, Liu Yongmei#, Chen Jiantao, He Qin, Gao Huile*. A simple one-step synthesis of melanin-originated red shift emissive carbonaceous dots for bioimaging.JColloid Interf Sci, 2016, 480: 85-90. (IF=5.091)
2015
50. 袁端峰，何勤，高会乐*. 拉帕替尼白蛋白纳米粒冻干粉针的制备与表征. 华西药学杂志, 2015, 30(03): 279-281.
49. Gao Huile, Jiang Xinguo. Brain delivery using nanotechnology. In Di Liand Edward H. Kerns. Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects, John Wiley & Sons, Inc, 2015, New York, chapter 24, 521-534.
48. Zheng Min, Ruan Shaobo, Liu Shi, Sun Tingting, Qu Dan, Zhao Haifeng, XieZhigang*, Gao Huile*, Jing Xiabin, Sun Zaicheng*. Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano, 2015, 9 (11): 11455–11461. (IF=13.334)
47. Ruan Shaobo, Cao Xi, Cun Xingli, Hu Guanlian, Zhou Yi, Zhang Yanling, Lu Libao, He Qin, Gao Huile*. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release.Biomaterials, 2015, 60: 100-110. (IF=8.806)
46. Ruan Shaobo, Yuan Mingqing, Zhang Li, Hu Guanlian, Chen Jiantao, CunXingli, Zhang Qianyu, Yang Yuting, He Qin*, Gao Huile*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015, 37:425-435. (IF=8.806)高被引论文
45. Ruan Shaobo, He Qin, Gao Huile*. Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. Nanoscale, 2015, 7(21): 9487-9496. (IF=7.367)
44. Cun Xingli, Chen Jiantao, Ruan Shaobo, Zhang Li, Wan Jingyu, He Qin, Gao Huile*. A novel strategy through combining iRGD peptide with tumor microenvironment responsive and multistage nanoparticlesfor deep tumor penetration. ACS Appl Mater Inter, 2015, 7(49), 27458−27466. (IF=8.097)
43. Hu Guanlian, Chun Xinli, Wang Yang, He Qin, Gao Huile*. Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. Oncotarget, 2015, 6(38): 41258-41274. (IF=5.008)
42. Ruan Shaobo, Chen Jiantao, Cun Xingli, Long Yang, Tang Jie, Qian Jun, Shen Shun, Jiang Xinguo, Zhu Jianhua, He Qin*, Gao Huile*. Noninvasive in vivo diagnosis of brain gliomas using RGD-decorated fluorescent carbonaceous nanospheres. J Biomed Nanotech, 2015, 11(12): 2148-2157. (IF=3.929)
41. Gao Huile#, Cao Shijie#, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo. Preparation, characterization and anti-glioma effects of docetaxel-loaded, lipoprotein-like nanoparticles. J Biomed Nanotech,2015, 11(12):2137-2147. (IF=3.929)
40. Hu Guanlian, Wang Yang, He Qin*, Gao Huile*. Multistage drug delivery system based on microenvironment-responsive dendrimer-gelatin nanoparticles for deep tumor penetration.RSC Adv, 2015, 5: 85933-85937. (IF=3.289)
39. Ruan Shaobo, Zhang Li, Chen Jiantao, Cao Tingwei, Yang Yuting, Liu Yayuan, He Qin, Gao Fabao*, Gao Huile*. Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer. RSC Adv, 2015, 5:64303 - 64317. (IF=3.289)
38. Chen Jiantao, Cun Xingli, Ruan Shaobo, Wang Yang, Zhang Yanling, He Qin*, Gao Huile*. Glioma cell targeting doxorubicin delivery and redox-responsive release using angiopep-2 decorated carbonaceous nanodots.RSC Adv, 2015, 5: 57045 - 57049. (IF=3.289)
37. Chen Jiantao, Sun Huaqin, RuanShaobo, Wang Yang, Shen Shun, Xu Wenming, He Qin, Gao Huile*. In vitro and in vivo toxicology of bare and PEGylated fluorescent carbonaceous nanodots in mice and zebrafish: the potential relation with autophagy.RSC Adv, 2015, 5: 38547-38557. (IF=3.289)
36. Ruan Shaobo#, Qian Jun#, Shen Shun, Chen Jiantao, CunXingli, Zhu Jianhua, Jiang Xinguo, He Qin*, Gao Huile*. Non-invasive imaging of breast cancer using RGDyK functionalized fluorescent carbonaceous nanospheres. RSC Adv, 2015, 5: 25428-25436. (IF=3.289)
35. Hu Guanlian#, Zhang Huiqing#, Zhang Li, Ruan Shaobo, He Qin, Gao Huile*. Integrin-mediated active tumor targeting and tumor microenvironment response dendrimer-gelatin nanoparticles for drug delivery and tumor treatment. Int J Pharm, 2015, 496:1057-1068.(IF=3.994)
34. Gao Huile*, Zhang Qianyu, Yang Yuting, Jiang Xinguo, He Qin*. Tumor homing cell penetrating peptide decorated nanoparticles used for enhanced tumor targeting delivery and therapy. Int J Pharm, 2015, 478: 240-250.(IF=3.994)
33. Chen Jiantao#, Sun Huaqin#, Wang Weiliang, Xu Wenming, He Qin, Shen Shun, Qian Jun*, Gao Huile*.Polyethylene glycol modification reduces the cardiac toxicity of carbonaceous dots in mice and zebrafish model.Acta Pharmacol Sin, 2015, 36(11): 1349-1355.(IF=3.166)
2014
32. Gao Huile, Zhang Qianyu, Yu Zhiqiang, He Qin*. Cell-penetrating peptide-based intelligent liposomal systems for enhanced drug delivery. Curr Pharm Biotechnol, 2014, 15(3):210-219. (IF=2.511)
31. Gao Huile, He Qin*. The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior.Expert Opin Drug Deliv, 2014,11(3): 409-420. (IF=5.553)
30. Gao Huile, Yang Zhi, Cao Shijie, Xiong Yang, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment. Biomaterials, 2014, 35(7): 2374-2382. (IF=8.806)
29. Ruan Shaobo#, Qian Jun#, Shen Shun, Zhu Jianhua, Jiang Xinguo, He Qin, Gao Huile*. A simple one-step method to prepare fluorescent carbon dots and their potential application in non-invasive glioma imaging.Nanoscale, 2014, 6(17): 10040-10047. (IF=7.367)
28. Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Liu Qingfeng, Jiang Xinguo*. Study of the pharmacology mechanisms of dual targeting drug delivery system with tumor microenvironment assays. Acta Biomateria, 2014, 10(2): 858-867. (IF=6.368)高被引论文
27. Gao Huile, Hu Guanlian, Zhang Qianyu, Zhang Shuang, Jiang Xinguo, He Qin*. Pretreatment with chemotherapeutics for enhanced nanoparticles accumulation in tumor: the potential role of G2 cycle retention effect. Sci Rep, 2014,4: 4492. (IF=5.578)
26. Ruan Shaobo#, Qian Jun#, Shen Shun, Chen Jiantao, Zhu Jianhua, Jiang Xinguo, He Qin*, Yang Wuli*, Gao Huile*. Fluorescent carbonaceous nanodots for glioma imaging after angiopep-2 decoration. Bioconjug Chem, 2014, 25: 2252-2259. (IF=4.513)
25. Ruan Shaobo, Wan Jingyu, Fu Yao, Han Ke, Li Xiang, Chen Jiantao, Zhang Qianyu, Shen Shun, He Qin, Gao Huile*.PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem, 2014,25(6): 1061-1068. (IF=4.513)
24. Gao Huile, Zhang Shuang, Cao Shijie, Yang Zhi,Pang Zhiqing, Jiang Xinguo*. Angiopep-2 and activatable cell penetrating peptide dual-functionalized nanoparticles for systemic glioma targeted delivery.Mol Pharm, 2014, 11(8): 2755-2763. (IF=4.384)
23. Gao Huile, Xiong Yang, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo*. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration. Mol Pharm, 2014,11(3): 1042-1052. (IF=4.384)
22. Mei Ling, Zhang Qianyu, Yang Yuting, He Qin, Gao Huile*. Angiopep-2 and activatable cell penetrating peptide dual modified nanoparticles for enhanced tumor targeting and penetrating. Int J Pharm, 2014, 474: 95-102. (IF=3.65)
21. Gao Huile, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo, Pang Zhiqing*. In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide.Int J Pharm, 2014, 466(1-2): 8-17. (IF=3.65)
20. Gao Huile, Wang Yuchen, Chen Chen, Chen Jun, Wei Yan, Cao Shilei, Jiang Xinguo*. Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug. Int J Pharm, 2014; 461(1-2): 478– 488. (IF=3.65)
19. Qian Jun#, RuanShaobo#, Cao Xi, CunXingli, Chen Jiantao, Shen Shun, Jiang Xinguo, He Qin, Zhu Jianhua*, Gao Huile*. Fluorescent carbonaceous nanospheres as biological probe for noninvasive brain imaging. JColloid Interf Sci, 2014, 436: 227-233. (IF=5.091)
18. Qian Jun#, Chen Jiantao#, RuanShaobo, Shen Shun, He Qin, Jiang Xinguo, Zhu Jianhua*, Gao Huile*. Preparation and biological evaluation of photoluminescent carbonaceous nanospheres.J Colloid Interf Sci, 2014, 429: 77-82. (IF=5.091)
17. Ruan Shaobo, Zhu Biyue, Zhang Huajin, Chen Jiantao, Shen Shun, Qian Jun, He Qin, Gao Huile*. A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging. JColloid Interf Sci, 2014,422: 25-29. (IF=5.091)
16. Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles. J Drug Target, 2014, 22(5): 450-459. (IF=2.741)
15. Zhang Li, Zhang Shuang, RuanShaobo, Zhang Qianyu, He Qin,Gao Huile*. Lapatinib incorporated lipoprotein-like nanoparticles: preparation and breast cancer targeting mechanism. Acta Pharmacol Sin, 2014,35(6): 846-852. (IF=2.912)
2013 and before
14. Gao Huile, Jiang Xinguo*. Progress on the diagnosis and evaluation of brain tumors. Cancer Imaging, 2013, 13(4): 466-481. (IF=1.592)
13. Gao Huile, Pang Zhiqing, Jiang Xinguo*. Targeted delivery of nano-therapeutics for major disorders of the central nervous system. Pharm Res, 2013, 30: 2485-2498. (IF=3.952)
12. Gao Huile, Yang Zhi, Zhang Shuang, Cao Shijie, Pang Zhiqing, Yang Xiao, Jiang Xinguo*. Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. J Control Release, 2013, 172(3):921-928. (IF=7.877)
11. Gao Huile, Cao Shijie, Chen Chen,Cao Shilei, Yang Zhi, Xi Zhangjie, Pan Shuaiqi, Zhang Qizhi, Jiang Xinguo*. Incorporation of lapatinib into lipoprotein-like nanoparticles with enhanced water solubility and anti-breast cancer effect. Nanomedicine (Lond), 2013, 8(9): 1429-1442. (IF=5.005)
10. Gao Huile, Yang Zhi, Zhang Shuang, Cao Shijie, Pang Zhiqing*, Jiang Xinguo*. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep, 2013, 3: 2534. (IF=5.078)
9. Gao Huile#, Hu Yue#, Xiong Yang, Zhang Shuang, Yang Jiarong, Yu Lian*, Jiang Xinguo*. Glioma targeting and anti-glioma effect of interleukin 13 peptide and RGD peptide dual functionalized nanoparticles.Curr Pharm Biotechnol, 2013, 14: 1118-1126. (IF=2.511)
8. Gao Huile, Chen Chen, Xi Zhangjie, Chen Jun, Zhang Qizhi, Cao Shlei, Jiang Xinguo*. In Vivo Behavior and Safety of Lapatinib-Incorporated Lipid Nanoparticles. Curr Pharm Biotechnol, 2013, 14: 1062-1071. (IF=2.511)
7. Gao Huile#, Qian Jun#, Cao Shijie, Yang Zhi, Pang Zhiqing, Pan Shuaiqi, Fan Li, Xi Zhangjie, Jiang Xinguo, Zhang Qizhi*. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials, 2012, 33(20):5115-5123. (IF=8.806)高被引论文
6. Gao Huile#, Qian Jun#, Yang Zhi, Pang Zhiqing, Xi Zhangjie, Cao Shijie, Wang Yuchen, Pan Shuaiqi, Zhang Shuang, Wang Wei, Jiang Xinguo, Zhang Qizhi*. Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(epsilon-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials, 2012, 33(26): 6264-6272. (IF=8.806)
5. Gao Huile, Yang Zhi, Cao Shijie, Xi Zhangjie, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles. Nanotechnology, 2012,23(43):435101. (IF=3.842)
4. Gao Huile, Pang Zhiqing, Pan Shuaiqi, Cao Shijie, Yang Zhi, Chen Chen, Jiang Xinguo*. Anti glioma effect and safety of docetaxel-loaded nanoemulsion. Arch Pharm Res, 2012,35(2):333-341. (IF=1.538)
3. Gao Huile, Pan Shuaiqi, Yang Zhi, Cao Shijie, Chen Chen, Jiang Xinguo, Pang Zhiqing*, Hu Yu*. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein. Biomaterials, 2011, 32(33): 8669-8675. (IF=8.806)
2. Gao Huile, Pang Zhiqing, Lu Wei, Pan Shuaiqi, Jiang Xinguo*. Encapsulation of cationic peptides into polymersomes through in situ gelatinization. J Microencapsul, 2011, 28(6): 465-471. (IF=1.553)
1. Gao Huile, Pang Zhiqing, Fan Li, Hu Kaili, Wu Bingxian, Jiang Xinguo*. Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations. Acta Pharmacol Sin, 2010,31(2): 237-243. (IF=1.953)