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成果及论文

 代表论著:

1. Gao, Y.; Kuang, Y.; Guo,  Z.-F.; Guo, Z. H.; Krauss, I. J.; Xu, B.* “Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and A Supramolecular Hydrogel of Taxol Derivative” J. Am. Chem. Soc.2009131, 13576-13577.

2. Gao, Y.; Shi, J. F.; Yuan, D.; Xu, B.* “Imaging enzyme-triggered self-assembly of small molecules inside live cells” Nat. Commun., 2012, 3, 1033.

3. Yao, Q., Lin, F., Fan, X., Wang, Y., Liu, Y., Liu, Z., Jiang, X., Chen, P.*, Gao, Y.* “Synergistic Enzymatic and Bioorthogonal Reactions for Selective Prodrug Activation in Living Systems” Nat. Commun., 2018, 9, 5032.

4. Yao, Q., Huang, Z., Liu, D., Chen, J., Gao, Y.* “Enzyme-Instructed Supramolecular Self-Assembly with Anticancer Activity” Adv. Mater., 2019, 31, 1804814.

5. Yao, Q.#, Wang, C.#, Fu, M., Dai, L.*, Li, J.*, Gao, Y.* “Dynamic Detection of Active Enzyme Instructed Supramolecular Assemblies In Situ via Super-Resolution Microscopy” ACS Nano, 2020, 14, 4882-4889.

6. Huang, Z.#, Liu, Y.#, Wang, L., Ali, A., Yao, Q., Jiang, X.*, Gao, Y.* “Supramolecular Assemblies mimicking Neutrophil Extracellular Traps for MRSE Infection Control” Biomaterials, 2020, 253, 120124.

7. Yao, Q., Gao, S., Wu, C., Lin, T.*, Gao, Y.* “Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance” Biomaterials, 2021, 277, 121119.

8. Tian, F.#, Yang, M.#, Yao, Q., Song, J., He, J., Shi, X.*, Gao, Y.* “Kinetic Selectivity Dictates the Construction of Cancer Cell-Targeting Enzyme Instructed Supramolecular Assemblies” Nano Today, 2022, 47, 101658.

9. Chen, J.#, Zhang, P.#, Zhao, Y., Zhao, J., Wu, X., Zhang, R., Cha, R., Yao, Q., Gao, Y.* “Nitroreductase-Instructed Supramolecular Assemblies for Microbiome Regulation to Enhance Colorectal Cancer Treatments” Sci. Adv. 2022, 8, eadd2789.

10. Wu, C.#, Xie, J.#, Yao, Q.#, Song, Y., Yang, G., Zhao, J., Zhang, R., Wang, T., Jiang, X., Cai, X.*, Gao, Y.* “Intrahippocampal Supramolecular Assemblies Directed Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice” Adv. Mater. 2024, DOI: 10.1002/adma.202314310.

Peer-reviewed publications.

75. Wu, C.#, Xie, J.#, Yao, Q.#, Song, Y., Yang, G., Zhao, J., Zhang, R., Wang, T., Jiang, X., Cai, X.*, Gao, Y.* “Intrahippocampal Supramolecular Assemblies Directed Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice” Adv. Mater. 2024, DOI: 10.1002/adma.202314310.

74. Yao, Q.#, Lin, F.#, Lu, C., Zhang, R., Xu, H., Hu, X., Wu, Z., Gao, Y.*, Chen, P.* "A Dual-Mechanism Targeted Bioorthogonal Prodrug Therapy" Bioconjugate Chem. 2023, 34, 2255-2262. (ACS Editors' Choice)

73. Chen, J.#, Zhang, P.#, Wu, C., Yao, Q., Cha, R., Gao, Y.* "Reductase-Labile Peptidic Supramolecular Hydrogels Aided Oral Delivery of Probiotics" ACS Appl. Mater. Inter. 2023, 15, 31214-31223.

72. Qi, J.#, Hang, C.#, Gao, Y.*, Jiang, X.* "Fast Coating of Polydopamine Enables Scratch / Moisture Resistant Flexible Electronics" ACS Appl. Mater. Inter. 2023, 15, 25393-25402.

71. Zhao, J., Wu, X., Chen, J., Wu, C., Zhang, R., Yao, Q.*, Xie, J.*, Gao, Y.* "In situ supramolecular self-assembly for alleviating multidrug resistance in cancer" Supramol. Mater. 2023, 2, 100033.

70. Chen, J.#, Zhang, P.#, Zhao, Y., Zhao, J., Wu, X., Zhang, R., Cha, R., Yao, Q., Gao, Y.* "Nitroreductase-Instructed Supramolecular Assemblies for Microbiome Regulation to Enhance Colorectal Cancer Treatments" Sci. Adv. 2022, 8, eadd2789.

69. Tian, F.#, Yang, M.#, Yao, Q., Song, J., He, J., Shi, X.*, Gao, Y.* "Kinetic Selectivity Dictates the Construction of Cancer Cell-Targeting Enzyme Instructed Supramolecular Assemblies" Nano Today202247, 101658.

68. Zhao, Y., Yao, Q., Chen, J., Zhang, R., Song, J., Gao, Y.* "Intracellular fluorogenic supramolecular assemblies for self-report bioorthogonal prodrug activation" Biomater. Sci. 202210, 5662–5668.

67. Song, J., Wu, C., Zhao, Y., Yang, M., Yao, Q.*, Gao, Y.* “Bioorthogonal Disassembly of Tetrazine Bearing Supramolecular Assemblies Inside Living Cells” Small202218, 2104772.

66. Xie, J., Song, Y., Dai, Y., Xiao, G., Yao, Q., Xu, S., He, E., Li, X., Lu, Z., Wang, H., Gao, Y., Fan, Z., Ke, C., Zhang, X., Meng, D., Qi, Z., Cai, X.* “Implanted microelectrode arrays for evaluating inhibited seizure modulated by light-responsive hydrogel” J. Micromech. Microeng. 2021, 31, 105005.

65. Yao, Q., Gao, S., Wu, C., Lin, T.*, Gao, Y.* “Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance”. Biomaterials2021, 277, 121119. (ChemRxiv. Preprint. DOI: 10.26434/ chemrxiv.13159148.v1.)

64. Yao, Q., Wu, C., Chen, J., Zhao, Y., Gao, Y.* “Enzyme-Instructed Supramolecular Assemblies Promote Intracellular Boron Accumulation for Boron Neutron Capture Therapy.” Nanotechnology202132, 435602.

63. Ju, X. H.#, Song, J. L.#, Han, J. L., Shi, Y. H., Gao, Y.*, Duan, P. F.* “Photofluorochromic water-dispersible nanoparticles for single-photon-absorption upconversion cell imaging.” Nanotechnology202132, 475606.

62. Towaranonte, B., Gao, Y.* "Application of charge-coupled device (CCD) cameras in electrochemiluminescence: a minireview." Anal. Lett. 2022, 55, 186-202.

61. Yao, Q.#, Wu, G.#, Hao, H.#, Lu, H.*, Gao, Y.* “Redox-mediated reversible supramolecular assemblies driven by switch and interplay of peptide secondary structures.” Biomacromolecules202122, 2563-2572.

60. Chen, J., Zhao, Y., Yao, Q., Gao, Y.* “Pathological Environment Directed In Situ Peptidic Supramolecular Assemblies for Nanomedicines” Biomed. Mater. 202116, 022011.

59. Zhou, X.#, Liu, Y.#, Huang, Z., Yao, Q., He, F., Gao,Y.* “Gag Protein Oriented Supramolecular Nets as Potential HIV Traps.” Bioconjugate Chem202132, 106-110.

58. Mou, L.#, Qi, J.#, Tang, L. X., Dong, R. H., Xia, Y.*, Gao, Y.*, Jiang, X. Y.* “Highly Stretchable and Biocompatible Liquid Metal-Elastomer Conductors for Self-Healing Electronics.” Small202016, 2005336.

57. Liu, D., Yin, J., Liang, S., Shi, W., Jiang, X., Gao, Y.* “Enzyme Regulated Peptide-Liquid Metal Hybrid Hydrogels as Cell Amber for Single Cell Manipulation” ACS Appl. Mater. Inter202012, 45807-45813.

56. Cao, H. Y., Liu, Y.*, Sun, H. Y., Li. Z. L., Gao, Y., Deng, X., Shao, Y., Cong, Y.*, Jiang, X.* “Increasing the Assembly Efficacy of Peptidic β-Sheets for a Highly-Sensitive HIV Detection” Anal. Chem. 202092, 11089-11094.

55. Huang, Z.#, Liu, Y.#, Wang, L., Ali, A., Yao, Q., Jiang, X.*, Gao, Y.* “Supramolecular Assemblies mimicking Neutrophil Extracellular Traps for MRSE Infection Control.” Biomaterials2020253, 120124.

54. Yao, Q.#, Wang, C.#, Fu, M., Dai, L.*, Li, J.*, Gao, Y.* “Dynamic Detection of Active Enzyme Instructed Supramolecular Assemblies In Situ via Super-Resolution Microscopy.” ACS Nano202014, 4882-4889.

53. Liu, D., Miao, Z., Wu, C., He, F., Ren, P., Bai, S., Jiang, X., Gao, Y.* “Isothermal Kinase-Triggered Supramolecular Assemblies as Drug Sensitizers.” Chem. Sci.202011, 1132-1139.

52. Fu, W., Sabet,Z., Liu, J. You, M., Zhou, H., Wang, Y., Gao, Y., Li, J.,* Ma, X.,* Chen, C.* “Metal ions modulation of the self-assembly of short peptide conjugated nonsteroidal anti-inflammatory drugs (NSAIDs).” Nanoscale202012, 7960-7968.

51. Cao, H., Wang, Y., Gao, Y., Deng, X., Cong, Y., Liu, Y.*, Jiang, X.* “Molecular Design of Beta-Sheet Peptide for the Multi-Modal Analysis of Disease.” Angew. Chem. Int. Ed.201958, 1626-1631.

50. Yao, Q., Huang, Z., Liu, D., Chen, J., Gao, Y.* “Enzyme-Instructed Supramolecular Self-Assembly with Anticancer Activity” Adv. Mater.201931, 1804814.

49. Huang, Z., Yao, Q., Wei, S., Chen, J., Gao, Y.* “Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose.” Curr. Med. Chem., 2019, 26, 1351-1365.

48. Yao, Q., Lin, F., Fan, X., Wang, Y., Liu, Y., Liu, Z., Jiang, X., Chen, P.*, Gao, Y.* “Synergistic Enzymatic and Bioorthogonal Reactions for Selective Prodrug Activation in Living Systems” Nat. Commun., 20189, 5032.

47. Wei, S.#, Zhou, X.#, Huang, Z., Yao, Q., Gao, Y.* “Hydrogen Sulfide Induced Supramolecular Self-Assembly in Living Cells” Chem. Commun.201854, 9051-9054.

46. Huang, Z., Yao, Q., Chen, J., Gao, Y.* “Redox Supramolecular Self-Assemblies Nonlinearly Enhance Fluorescence to Identify Cancer Cells” Chem. Commun.201854, 5385-5388.

45. Yao, Q.#, Bao, Q.#, Li, X., Wang, H., Yang, Z., Shi, X.*, Gao, Y.*, Xu, B. “Determine Packing Model of a Supramolecular Nanofiber via Mass-per-Length Measurement and de novo Simulation” Nanoscale201810, 3990-3996.

44. Liu, Y.#, Qu, Z.#, Cao, H., Sun, H., Gao, Y.*, Jiang, X.* “pH Switchable Nano-Assembly for Imaging A Broad Range of Malignant Tumors” ACS Nano201711, 12446−12452.

43. Huang, P.*, Gao, Y.*, Lin, J., Hu, H., Liao, H., Yan, X., Tang, Y., Jin, A., Song, J., Niu, G., Zhang, G., Horkay, F., Chen, X.* “Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics” ACS Nano20159, 9517–9527.

42. Yuan, D., Shi, J., Du, X., Huang, Y., Gao, Y., Baoumb, A., Xu, B.* “The enzyme-instructed assembly of the core of yeast prion Sup35 to form supramolecular hydrogels” J. Mater. Chem. B20164, 1318-1323.

41. Gao, Y.*, Nieuwendaal, R., Dimitriadis, E. K., Hammouda, B., Douglas, J. F.*, Xu, B., Horkay, F.* “Supramolecular Self-assembly of a Model Hydrogelator: Characterization of Fiber Formation and Morphology.” Gels20162, 27.

40. Ling Y., Gao, Y., Shu C., Zhou Y., Zhong WY.*, Xu B. “Using a peptide segment to covalently conjugate doxorubicin and taxol for the study of drug combination effect.” RSC Adv.20155, 101475-101479.

39. Kuang,Y.; Long, M. J. C.; Zhou, J.; Shi, J. F.; Gao, Y.; Xu, C.; Hedstrom, L.; Xu, B.* "Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics." J. Biol. Chem.2014289, 29208.

38. Zhao, F.; Li, J.; Zhou, N.; Sakai, J.; Gao, Y.; Shi, J. F.; Goldman, B.; Browdy, H. M.; Luo, H. R.; Xu, B.* "De Novo Chemoattractants Form Supramolecular Hydrogels for Immunomodulating Neutrophils In Vivo." Bioconjugate Chem.201425, 2116-2122.

37. Zhao, F.; Heesters, B. A.; Chiu, I.; Gao, Y.; Shi, J. F.; Zhou, N.; Carroll, M. C.; Xu, B.* “L-Rhamnose-containing supramolecular nanofibrils as a potential immunosuppressive material” Org. Biomol. Chem.201412, 6816-6819.

36. Zhou, J.; Du, X. W.; Gao, Y.; Shi, J. F.; Xu, B.* “Aromatic-Aromatic Interactions Enhance Interfiber Contacts for Enzymatic Formation of A Spontaneously Aligned Supramolecular Hydrogel” J. Am. Chem. Soc.2014136, 2970-2973.

35. Kuang, Y.; Gao, Y.; Shi, J. F.; Li, J; Xu, B.* “The first supramolecular peptidic hydrogelator containing taurine” Chem. Commun.201450, 2772-2774.

34. Gao, Y.; Kuang, Y.; Du, X. W.; Zhou, J.; Chandran, P.; Horkay, F.; Xu, B.* “Imaging self-assembly dependent spatial distribution of small molecules in cellular environment” Langmuir201329, 15191-15200.

33. Gao, Y.Berciu, C.; Kuang, Y.; Shi, J. F.; Nicastro, D.; Xu, B.* “Probing Nanoscale Self-Assembly of Non-Fluorescent Small Molecules inside Live Mammalian Cells” ACS Nano20137, 9055-9063.

32. Li, J. Y.; Gao, Y.; Kuang, Y.; Shi, J. F.; Du, X. W.; Zhou, J.; Wang, H. M.; Yang, Z. M.; Xu, B.* “Dephosphorylation of D-peptide derivatives to form biofunctional, supramolecular nanofibers/hydrogels and their potential applications for intracellular imaging and intratumoral chemotherapy” J. Am. Chem. Soc.2013135, 9907–9914.

31. Li, J. Y.; Kuang, Y.; Shi, J. F.; Gao, Y.; Zhou, J.; Xu, B.* “The conjugation of non-steroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels” Beilstein J. Org. Chem., 20139, 908-917.

30. Zhang, Y.; Zhang, B.; Kuang, Y.; Gao, Y.; Shi, J.; Zhang, X. X.; Xu, B.* “A redox responsive, fluorescent supramolecular metallohydrogel consists of nanofibers with single-molecule width” J. Am. Chem. Soc.2013, 135, 5008-5011.

29. Li, J. Y.; Li, X. M.; Kuang, Y.; Gao, Y.; Du, X. W.; Shi, J. F.; Xu B.* “Self-delivery multifunctional anti-HIV hydrogels for sustained release” Adv. Healthcare Mater., 20132, 1586-1590.

28. Li, J. Y.; Kuang, Y.; Gao, Y.; Du, X. W.; Shi, J. F.; Xu, B.* “D-amino acids boost the selectivity and confer supramolecular hydrogels of a non-steroidal anti-inflammatory drug (NSAID)" J. Am. Chem. Soc. 2013135, 542-545.

27. Li, X. M.; Du, X. W.; Li, J. Y.; Gao, Y.; Pan, Y.; Zhou, N.; Xu, B.* "Introducing D-amino acid or simple glycoside into small peptides to enable supramolecular hydrogelators to resist proteolysis" Langmuir 201237, 13512-13517.

26. Gao, Y.; Shi, J. F.; Yuan, D.; Xu, B.* “Imaging enzyme-triggered self-assembly of small molecules inside live cells” Nat. Commun., 20123, 1033.

25. Gao, Y.; Long, M. J. C.; Shi, J. F.; Hedstrom, L.; Xu, B.* “Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules” Chem. Commun.201248, 8404-8406.

24. Li, X. M.; Du, X. W.; Gao, Y.; Shi, J. F.;  Kuang, Y.; Xu, B.* “Supramolecular hydrogels formed by the conjugates of nucleobases, Arg-Gly-Asp (RGD) peptides, and glucosamine” Soft Matter20128, 7402-7407.

23. Du, X. W.; Li, J. F.; Gao, Y.; Kuang, Y.; Xu, B.* “Catalytically dephosphorylate adenosine monophosphate (AMP) to form supramolecular nanofibers/hydrogels” Chem. Commun., 201248, 2098-2100.

22. Zhang, Y.; Li, N.; Delgado, J.; Gao, Y.; Kuang, Y.; Fraden, S.; Epstein, I. R.; Xu, B.* “Post-Self-Assembly Crosslinking of Molecular Nanofibers for Oscillatory Hydrogels” Langmuir201228, 3063-3066.

21. Shi, J. F.; Gao, Y.; Zhang, Y.; Pan, Y; Xu, B.* “Calcium Ions to Crosslink Supramolecular Nanofibers to Tune the Elasticity of Hydrogels over Orders of Magnitude” Langmuir201127, 14425-14431.

20. Kuang, Y.; Gao, Y.; Xu, B.* “Supramolecular hydrogelators of N-terminated dipeptides selectively inhibit cancer cells” Chem. Commun., 201147, 12625-12627.

19. Li, X. M.; Kuang, Y.; Shi, J. F.; Gao, Y.; Lin, H.C.; Xu, B.* “Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only of Nucleobase, Amino Acid, and Glycoside”, J. Am. Chem. Soc.2011133, 17513-17518.

18. Li, X. M.; Kuang, Y.; Lin, H.-C.; Gao, Y.; Shi, J. F.; Xu, B.* “Supramolecular Nanofibers and Hydrogels of Nucleopeptides”  Angew. Chem. Int. Ed.201150, 9365-9369.

17. Kuang, Y.; Gao, Y.; Shi, J.F.; Lin, H.C.; Xu, B.* "Supramolecular hydrogels based on the epitope of potassium ion channels" Chem. Commun., 201147, 8772-8774.

16. Zhao, F.; Weitzel, C.S; Gao, Y.; Browdy, H.M.; Shi, JF.; Lin, H.C.; Lovett, S.T.; Xu, B.* "beta-Galactosidase instructed formation of molecular nanofibers and a hydrogel" Nanoscale20113, 2859-2861.

15. Pan, Y.; Gao, Y.; Shi, J. F.; Wang, L.; Xu, B.* “A Versatile Supramolecular Hydrogel of Nitrilotriacetic acid (NTA) for Binding Metal Ions and Magnetorheological Response” J. Mater. Chem.201121, 6804-6806.

14. Shi, J. F.; Gao, Y.; Yang, Z. M.; Xu, B.* “Exceptionally Small Supramolecular Hydrogelators Based on Aromatic-Aromatic Interactions” Beilstein J. Org. Chem., 20117, 167–172.

13. Zhao, F.; Gao, Y.; Shi, J. F.; Browdy, H. M.; Xu, B.* “A Novel Anisotropic Supramolecular Hydrogel with High Stability over a Wide pH Range” Langmuir201127, 1510-1512.

12. Zhang, Y.; Kuang, Y.; Gao, Y.; Xu, B.* “Versatile Small Molecule Motifs for Self-assembly in Water and Formation of Biofunctional Supramolecular Hydrogels” Langmuir, 201127, 529-537.

11. Gao, Y.; Zhao, F.; Wang, L.; Zhang, Y.; Xu, B.* “Small Peptide Nanofibers as the Matrices of Molecular Hydrogels for Mimicking Enzymes and Enhancing the Activity of Enzymes” Chem. Soc. Rev2010, 39, 3425-3433.

10. Li, X. M.; Li, J. Y.; Gao, Y.; Kuang, Y.; Shi, J. F.; Xu, B.* “Molecular Nanofibers of Olsalazine Confer Supramolecular Hydrogels for Reductive Release of An Anti-inflammatory Agent “ J. Am. Chem. Soc. 2010132, 17707-17709.

9. Li, X. M.; Gao, Y.; Kuang, Y.; Xu, B.* “Enzymatic Formation of A Photoresponsive Supramolecular Hydrogel” Chem. Commun., 201046, 5364-5366.

8. Ma, M. L., Kuang, Y., Gao, Y., Zhang, Y., Gao, P., Xu, B.* “Aromatic-aromatic Interactions Induce the Self-Assembly of Pentapeptidic Derivatives in Water to Form Nanofibers and Supramolecular Hydrogels” J. Am. Chem. Soc., 2010132, 2719-2728.

7. Gao, Y.; Yang, Z. M.; Kuang, Y.; Ma, M. L.; Li, J. Y.; Zhao, F.; Xu, B.* “Enzyme-instructed Self-assembly of Peptide Derivatives to Form Nanofibers and Hydrogels” Biopolymers: Peptide Sci.201094, 19-31.

6. Gao, Y.; Kuang, Y.; Guo,  Z.-F.; Guo, Z. H.; Krauss, I. J.; Xu, B.* “Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and A Supramolecular Hydrogel of Taxol Derivative” J. Am. Chem. Soc.2009131, 13576-13577.

5. Liang, G.; Yang, Z. M., Zhang, R. J.; Li, L. H.; Fan, Y. J.; Kuang, Y.; Gao, Y.; Wang, T.; Lu, W. W.; Xu, B.* “A Supramolecular Hydrogel of A D-Amino acid Dipeptide for Controlled Drug Release in vivo” Langmuir200925, 8419-8422.

4. Wang, Q. G.; Yang, Z. M.; Gao, Y.; Ge, W. W.; Wang, L.; Xu, B.* "Enzymatic hydrogelation to immobilize an enzyme for high activity and stability" Soft Matter 20084, 550-553.

3. Gao, J. H.; Zhang, B.; Gao, Y.; Pan, Y.; Zhang, X. X.; Xu, B.* "Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures" J. Am. Chem. Soc. 2007129, 11928-11935.

2. Yang, Z. M.; Liang, G. L.; Ma, M. L.; Gao, Y.; Xu, B.* "In Vitro and In Vivo Enzymatic Formations of Supramolecular Hydrogels Based on Self-Assembled Nanofibers of a beta-Amino Acid Derivative" Small, 2007, 3, 558-562.

1. Yang, Z. M.; Liang, G. L.; Ma, M. L.; Gao, Y.; Xu, B.* “Conjugates of naphthalene and dipeptides produce molecular hydrogelators with high efficiency of hydrogelation and superhelical nanofibers” J. Mater. Chem.200717, 850-854.