一．代表性研究论文：
1. Shizhen He†, Jinhua Shang†, Yuqiu He, Fuan Wang*, Enzyme-free Dynamic DNA Reaction Networks for On-Demand Bioanalysis and Bioimaging. Acc. Chem. Res., 2024, 57, 533–544. DOI: 10.1021/acs.accounts.3c00676
2. Xue Gong†, Jiajia Zhang†, Pu Zhang, Ruomeng Li, Zhongwei Jiang, Lianzhe Hu, Xiaoqing Liu, Yi Wang*, Fuan Wang*, Scaling up of a self-confined catalytic hybridization circuit for robust microRNA imaging. Adv. Sci., 2024, 11, 2400517. DOI: 10.1002/advs.202400517
3. Ruomeng Li, Yuxuan Zhu, Xue Gong, Yanping Zhang, Chen Hong, Yeqing Wan, Xiaoqing Liu, Fuan Wang*, Self-Stacking Autocatalytic Molecular Circuit with Minimal Catalytic DNA Assembly. J. Am. Chem. Soc., 2023, 145, 2999–3007. DOI: 10.1021/jacs.2c11504 (HIGHLY CITED PAPER)
4. Yuqiu He†, Qing Wang†, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu, Fuan Wang*, A Smart Deoxyribozyme-Programmable Catalytic DNA Logic Circuit for High-Contrast MicroRNA Imaging. Angew. Chem. Int. Ed., 2023, 62, e202307418. DOI: 10.1002/anie.202307418
5. Jinhua Shang, Shanshan Yu, Ruomeng Li, Yuqiu He, Yushi Wang, Fuan Wang*, Bioorthogonal Disassembly of Hierarchical DNAzyme Nanogel for High-Performance Intracellular microRNA Imaging. Nano Lett., 2023, 23, 1386–1394. DOI: 10.1021/acs.nanolett.2c04658 (HIGHLY CITED PAPER)
6. Wenqian Yu†, Yingying Chen†, Mingzhu Yan, Zhen Xu, Junlin Sun, Yu Shen, Fuan Wang*, and Xiaoqing Liu*, Synergistic Immunostimulation for Tumor Sensitization with a Biomineralized DNA Sponge. Nano Today, 2023, 52, 101996. DOI: 10.1016/j.nantod.2023.101996
7. Shizhen He, Shanshan Yu, Ruomeng Li, Yingying Chen, Qing Wang, Yuqiu He, Xiaoqing Liu, Fuan Wang*, On-Site Nonenzymatic Orthogonal Activation of a Catalytic DNA Circuit for Self-Reinforced In Vivo MicroRNA Imaging. Angew. Chem. Int. Ed., 2022, 61, e202206529. DOI: 10.1002/anie.202206529 (VIP PAPER)
8. Huimin Wang†, Yuqiu He†, Jie Wei, Hong Wang, Kang Ma, Yangjie Zhou, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, Construction of an Autocatalytic Hybridization Assembly Circuit for Amplified In Vivo MicroRNA Imaging. Angew. Chem. Int. Ed., 2022, 61, e202115489. DOI: 10.1002/anie.202115489 (HOT PAPER, HIGHLY CITED PAPER)
9. Wenqian Yu, Junlin Sun, Xiuyuan Wang, Shuyi Yu, Mingzhu Yan, Fuan Wang*, Xiaoqing Liu*, Boosting Cancer Immunotherapy via the Convenient A2AR Inhibition Using a Tunable Nanocatalyst with Light-Enhanced Activity. Adv. Mater., 2022, 34, 2106967. DOI: 10.1002/adma.202106967
10. Yun Zhao, Ruoment Li, Junlin Sun, Zhiqiao Zou, Fuan Wang*, Xiaoqing Liu*, Multifunctional DNAzyme-Anchored Metal-Organic Framework for Efficient Suppression of Tumor Metastasis. ACS Nano, 2022, 16, 5404–5417. DOI: 10.1021/acsnano.1c09008
11. Yu Shang, Yingying Chen, Qing Wang, Yuqiu He, Shizhen He, Shanshan Yu, Xiaoqing Liu, Fuan Wang*, Construction of An Endogenously Activated Catalytic DNA Circuit for Highly Robust In Vivo MicroRNA Imaging. Nano Today, 2022, 45, 101553. DOI: 10.1016/j.nantod.2022.101553
12. Qing Wang, Kaiyue Tan, Hong Wang, Jinhua Shang, Yeqing Wan, Xiaoqing Liu, Xiaocheng Weng, Fuan Wang*, Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation. J. Am. Chem. Soc., 2021, 143, 6895–6904. DOI: 10.1021/jacs.1c00570
13. Jing Wang†, Shanshan Yu†, Qiong Wu, Xue Gong, Shizhen He, Jinhua Shang, Xiaoqing Liu, Fuan Wang*, A self-catabolic multifunctional DNAzyme nanosponge for programmable drug delivery and efficient gene silencing. Angew. Chem. Int. Ed., 2021, 60, 10766−10774. DOI: 10.1002/anie.202101474
14. Junlin Sun†, Feng Liu†, Wenqian Yu, Dandan Fu, Qunying Jiang, Fengye Mo, Xiuyuan Wang, Tianhui Shi, Fuan Wang*, Dai-Wen Pang*, Xiaoqing Liu*, Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy. Angew. Chem. Int. Ed., 2021, 60, 24275–24283. DOI: 10.1002/anie.202111093
15. Xue Gong, Haizhou Wang, Ruomeng Li, Jie Wei, Jing Wang, Jinhua Shang, Xiaoqing Liu*, Jing Liu, Fuan Wang*, A smart multi-antenna gene theranostic system based on the programmed assembly of hypoxia-related siRNA. Nat. Commun., 2021, 12, 3953. DOI: 10.1038/s41467-021-24191-9
16. Xue Gong, Ruomeng Li, Jing Wang, Jie Wei, Kang Ma, Xiaoqing Liu, Fuan Wang*, A Smart Theranostic Nanocapsule for Spatiotemporally Programmable Photo-genetherapy. Angew. Chem. Int. Ed., 2020, 59, 21648–21655. DOI: 10.1002/anie.202008413
17. Jie Wei, Huimin Wang, Qiong Wu, Xue Gong, Kang Ma, Xiaoqing Liu and Fuan Wang*, A Smart Autocatalytic DNAzyme Biocircuit for in vivo MRI-Guided MicroRNA Imaging. Angew. Chem. Int. Ed., 2020, 59, 5965–5971. DOI: 10.1002/anie.201911712 (HOT PAPER)
18. Jie Wei, Huimin Wang, Xue Gong, Qing Wang, Hong Wang, Yangjie Zhou, Fuan Wang*, A Proteinase-Free DNA Replication Machinery for in Vitro and in Vivo Amplified MicroRNA Imaging. Nucleic Acids Res., 2020, 48, e60. DOI: 10.1093/nar/gkaa250
19. Huimin Wang, Yuqi Chen, Hong Wang, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, DNAzyme-Loading MOFs for Self-Sufficient Gene Therapy. Angew. Chem. Int. Ed., 2019, 58, 7380–7384. DOI: 10.1002/anie.201902714 (HIGHLY CITED PAPER)
20. Jing Wang, Huimin Wang, Hong Wang, Shizhen He, Ruomeng Li, Zhao Deng, Xiaoqing Liu, Fuan Wang*, Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery. ACS Nano, 2019, 13, 5852−5863. DOI: 10.1021/acsnano.9b01589
21. Qiong Wu†, Gang Chen†, Keke Gong, Jing Wang, Xiaoxiao Ge, Xiaoqing Liu, Shaojun Guo*, Fuan Wang*, MnO2-Laden Black Phosphorus for MRI-Guided Synergistic PDT/PTT/Chemotherapy. Matter, 2019, 1, 496–512. DOI: 10.1016/j.matt.2019.03.007
二．已发表的科研论著：
武汉大学独立工作后
2024年
1. Shizhen He†, Jinhua Shang†, Yuqiu He, Fuan Wang*, Enzyme-free Dynamic DNA Reaction Networks for On-Demand Bioanalysis and Bioimaging. Acc. Chem. Res., 2024, 57(4), 533–544. DOI: 10.1021/acs.accounts.3c00676
2. Yuxuan Zhu†, Ruomeng Li†, Yifei Wang, Qingqing Zhang, Yuqiu He, Jinhua Shang, Xiaoqing Liu, Fuan Wang*, A methylation-gated DNAzyme circuit for spatially controlled imaging of microRNA in cells and animals. Anal. Chem., 2024, 96(23), 9666–9675. DOI: 10.1021/acs.analchem.4c01556
3. Yifei Wang, Jinhua Shang, Yuqiu He, Qingqing Zhang, Xiaoqing Liu, Fuan Wang* An intelligent redox-responsive DNA circuit for robust on-site profiling of glutathione-microRNA signaling pathway. Adv. Funct. Mater., 2024, 34(26), 2315993. DOI: 10.1002/adfm.202315993
4. Xue Gong†, Jiajia Zhang†, Pu Zhang, Ruomeng Li, Zhongwei Jiang, Lianzhe Hu, Xiaoqing Liu, Yi Wang*, Fuan Wang*, Scaling up of a self-confined catalytic hybridization circuit for robust microRNA imaging. Adv. Sci., 2024, 11(22), 2400517. DOI: 10.1002/advs.202400517
5. Zeyue Wang, Yu Shang, Yuxuan Zhu, Yuqiu He, Yingying Chen, Xiaoqing Liu, Fuan Wang*, A multiply guaranteed catalytic DNA circuit for cancer-cell selective imaging of miRNA and robust evaluation of drug resistance. Anal. Chem., 2024, 96(14), 5560–5569. DOI: 10.1021/acs.analchem.4c00018
6. Shanshan Yu†, Jing Wang†, Meijuan Liang, Yuxuan Zhu, Jinhua Shang, Yingying Chen, Xiaoqing Liu, Fuan Wang*, Rational engineering of a multifunctional DNA nanoassembly for enhanced antibacterial efficacy and accelerated wound healing. Adv. Healthc. Mater., 2024, 13(2), 2300694. DOI: 10.1002/adhm.202300694
7. Qingqing Zhang†, Shanshan Yu†, Jinhua Shang, Shizhen He, Xiaoqing Liu, Fuan Wang*, Spatiotemporally programmed disassembly of multifunctional integrated DNAzyme nanoplatfrom for amplified intracellular microRNA imaging. Small, 2024, 20(2), 2305672. DOI: 10.1002/smll.202305672
8. Meijuan Liang†, Gege Song†, Yeqing Wan, Yingying Chen, Fuan Wang*, Xiaoqing Liu*, Surface Engineering of Carbon Dots for Highly Sensitive α-Glucosidase Assay and Inhibition Evaluation. Chin. Chem. Lett., 2024, 35(3), 108573. DOI: 10.1016/j.cclet.2023.108573
9. Hui Wang†, Yingying Chen†, Yuqian Jiang, Yifei Wang, Ruomeng Li, Jinhua Shang, Fuan Wang*, Endogenous Glutathione-Activated Nucleic Acid Molecular Circuit-ry for Cell-Specific MicroRNA Imaging. Anal. Chem., 2024, 96, In Press. DOI: 10.1021/acs.analchem.4c02570
10. Xiuyuan Wang, Shusheng Yu, Yuqiu He, Fuan Wang, Xiaoqing Liu*, A Label-free Deoxyribozyme Sensor for m6A Demethylase Activity Detection. Chin. J. Chem., 2024, 42(9), 951–956. DOI: 10.1002/cjoc.202300633
11. Chenzhi Shi, Donglei Yang, Xiaowei Ma, Li Pan, Yuanchuan Shao, Gaurav Arya, Yonggang Ke, Chuan Zhang, Fuan Wang, Xiaolei Zuo, Min Li, Pengfei Wang*, A Programmable DNAzyme for the Sensitive Detection of Nucleic Acids. Angew. Chem. Int. Ed., 2024, 63(12), e202320179. DOI: 10.1002/anie.202320179
12. Yaqi Liu, Yulong Shi, Siyuan Wang, Sijia Liu, Min Shang, Bingyue Zhao, Hanghang Liu, Changying Yang, Fuan Wang, Chun Kit Kwok*, Huimin Wang*, Hook-Like DNAzyme-Activated Autocatalytic Biosensor for the Universal Detection of Pathogenic Bacteria. Anal. Chem., 2024, 96, In Press. DOI: 10.1021/acs.analchem.4c01757
13. Hong Wang*, Hanyan Zou, Fuan Wang, Multiply guaranteed DNA sensors for accurate target detection. ChemBioChem, 2024, 25, 202400266. In Press. DOI: 10.1002/cbic.202400266
2023年
14. Ruomeng Li, Yuxuan Zhu, Xue Gong, Yanping Zhang, Chen Hong, Yeqing Wan, Xiaoqing Liu, Fuan Wang*, Self-Stacking Autocatalytic Molecular Circuit with Minimal Catalytic DNA Assembly. J. Am. Chem. Soc., 2023, 145(5), 2999–3007. DOI: 10.1021/jacs.2c11504 (HIGHLY CITED PAPER)
15. Yuqiu He†, Qing Wang†, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu, Fuan Wang*, A Smart Deoxyribozyme-Programmable Catalytic DNA Logic Circuit for High-Contrast MicroRNA Imaging. Angew. Chem. Int. Ed., 2023, 62(33), e202307418. DOI: 10.1002/anie.202307418
16. Yingying Chen†, Mingzhu Yan†, Yushi Wang, Jinhua Shang, Shizhen He, Yuhui Gao, Chen Hong, Xiaoqing Liu*, Fuan Wang*, Construction of a Stimuli-Responsive DNAzyme-Braked DNA Nanomachine for the Amplified Imaging of miRNAs in Living Cells and Mice. CCS Chem., 2023, 5(7), 1697–1708. DOI: 10.31635/ccschem.022.202202171
17. Pei Dong†, Ruomeng Li†, Shizhen He†, Qingqing Zhang, Xiaoqing Liu, Fuan Wang*, The compact integration of a cascaded HCR circuit for highly reliable intracellular imaging of miRNA. Chem. Sci., 2023, 14(8), 2159–2167. DOI: 10.1039/d2sc05568f (HOT PAPER, HIGHLY CITED PAPER)
18. Ruomeng Li, Fengzhe Li, Yanping Zhang, Yuqiu He, Yushi Wang, Fuan Wang*, Miniature Hierarchical DNA Hybridization Circuit for Amplified Multiplexed MicroRNA Imaging. Anal. Chem., 2023, 95(7), 3848–3855. DOI: 10.1021/acs.analchem.2c05373
19. Chenxia Xie†, Ruomeng Li†, Xue Gong, Qingqing Zhang, Yanping Zhang, Zeyue Wang, Xiaoqing Liu, Fuan Wang*, Efficient intracellular microRNA imaging based on the localized and self-sustainable catalytic DNA assembly circuit. Anal. Chem., 2023, 95(27), 10398–10404. DOI: 10.1021/acs.analchem.3c01544
20. Xue Gong*†, Jiajia Zhang†, Pu Zhang, Yuqian Jiang, Lianzhe Hu, Zhongwei Jiang, Fuan Wang*, Yi Wang*, Engineering of a self-regulatory bidirectional DNA assembly circuit for amplified microRNA imaging. Anal. Chem., 2023, 95(51), 18731–18738. DOI: 10.1021/acs.analchem.3c02822
21. Jinhua Shang, Shanshan Yu, Ruomeng Li, Yuqiu He, Yushi Wang, Fuan Wang*, Bioorthogonal Disassembly of Hierarchical DNAzyme Nanogel for High-Performance Intracellular microRNA Imaging. Nano Lett., 2023, 23(4), 1386–1394. DOI: 10.1021/acs.nanolett.2c04658 (HIGHLY CITED PAPER)
22. Hong Wang†, Yushi Wang†, Yeqing Wan, Jinhua Shang, Qing Wang, Yuqian Jiang, Xiaoqing Liu, Fuan Wang*, A Cellular Membrane-Confined Concatenate DNA Circuit for Non-Invasive Cell Modulation with High Accuracy and Efficiency. Adv. Funct. Mater., 2023, 33(40), 2302708. DOI: 10.1002/adfm.202302708
23. Wenqian Yu†, Yingying Chen†, Mingzhu Yan, Zhen Xu, Junlin Sun, Yu Shen, Fuan Wang*, and Xiaoqing Liu*, Synergistic Immunostimulation for Tumor Sensitization with a Biomineralized DNA Sponge. Nano Today, 2023, 52, 101996. DOI: 10.1016/j.nantod.2023.101996
24. Jie Wei†, Mengdi Yu†, Kaiyue Tan, Jinhua Shang, Shizhen He, Chenxia Xie, Xiaoqing Liu, Fuan Wang*, Tailoring a Minimal Self-Replicate DNA Circuit for Highly Efficient Intracellular Imaging of microRNA. Small, 2023, 19(17), 2207961. DOI: 10.1002/smll.202207961
25. Wei Xu†, Feifei Hu†, Jiajing Li, Jinhua Shang, Xiaoqing Liu, Yan Zeng*, Qiong Wu*, Fuan Wang*, External stimulation-controlled dynamic DNA devices for biosensing and biomedical applications. Sci. China Chem., 2023, 66(11), 3105–3115. DOI: 10.1007/s11426-023-1783-5
26. Qing Wang, Zeyue Wang, Jinhua Shang, Bin Xiong,* Yingfu Li, Fuan Wang*, Chemical and Structural Modification of RNA-Cleaving DNAzymes for Efficient Biosensing and Biomedical Application. TrAC-Trends Anal. Chem., 2023, 159, 116910. DOI: 10.1016/j.trac.2022.116910
27. Qiong Wu,* Mengqing Xu, Jinhua Shang, Shizhen He, Xiaoqing Liu, Fuan Wang*, Stimuli-Responsive DNA Circuits for High-Performance Bioimaging Application. Adv. Sens. Res., 2023, 2(9), 2200102. DOI: 10.1002/adsr.202200102
28. Yudong Sun, Yifei Wang, Yaqi Liu, Huimin Wang,* Chanying Yang, Xiaoqing Liu, Fuan Wang*, Integration of Manganese Dioxide-based Nanomaterials for Biomedical Applications. Adv. Nanobiomed. Res., 2023, 3(1), 2200093. DOI: 10.1002/anbr.202200093
29. Siyuan Wang, Yaqi Liu, Jinhua Shang, Huimin Wang,* Changying Yang, Xiaoqing Liu, Fuan Wang*, Stimuli-Responsive RNA-Cleaving DNAzyme for Biomedical Application. Analysis & Sensing, 2023, 3(3), e202200065. DOI: 10.1002/anse.202200065
30. Qing Wang†, Yuqiu He†, Shizhen He, Shanshan Yu, Yuqian Jiang, Fuan Wang*, An Entropy-Driven DNA Nanomachine for MicroRNA Detection Using Personal Glucose Meter. Chem. Commun., 2023, 59(10), 1345–1348. DOI: 10.1039/d2cc06479k
31. Qingyang Si†, Yumeng Li†, Ziling Huang, Chuanyi Liu, Xiaomei Chen, Jie Wei*, Fuan Wang*, Construction of a simple dual-mode ATP-sensing system for reliable fish freshness evaluation. Anal. Chim. Acta, 2023, 1252, 341048. DOI: 10.1016/j.aca.2023.341048
32. Siyuan Wang, Jinhua Shang, Bingyue Zhao, Huimin Wang,* Changying Yang, Xiaoqing Liu, Fuan Wang*, Integration of Isothermal Enzyme-Free Nucleic Acid Circuits for High-Performance Biosensing Applications. ChemPlusChem, 2023, 88(10), e202300432. DOI: 10.1002/cplu.202300432
33. Jialing Hu, Zhiqiao Zou, Fengye Mo, Xue Lin, Yun Zhao, Tianhui Shi, Fuan Wang, Xiaoqing Liu*, Triggered amplification of gene theranostics with high accuracy and efficacy using metallo-nanoassemblies. Chem. Eng. J., 2023, 452 (2), 139323. DOI: 10.1016/j.cej.2022.139323
34. Gege Song, Zhiqiao Zou, Ailing Feng, Chenbiao Li, Meijuan Liang, Fuan Wang, Xiaoqing Liu*, Light-Up Aptameric Sensor of Serotonin for Point-of-Care Use. Anal. Chem., 2023, 95(23), 9076–9082. DOI: 10.1021/acs.analchem.3c01456
35. Benrui Weng, Yifei Wang, Siyuan Wang, Yaqi Liu, Nana Kang, Sijia Liu, Jiabing Ran, Zhangshuang Deng, Changying Yang, Decheng Wang, Huimin Wang*, Fuan Wang, An Intelligent Laser-Free Photodynamic Therapy Based on Endogenous miRNA-Amplified CRET Nanoplatform. Chem. Eur. J. 2023, 29(33), e202300861. DOI: 10.1002/chem.202300861
36. Nana Kang, Benrui Weng, Sijia Liu, Huiran Yang, Siyuan Wang, Yaqi Liu, Jiabing Ran, Hanghang Liu, Zhangshuang Deng, Changying Yang, Huimin Wang*, Fuan Wang, Chemiluminescence Resonance Energy Transfer-Based Multistage Nucleic Acid Amplification Circuit for MiRNA Detection with Low Background. Analyst, 2023, 148(12), 2683–2691. DOI: 10.1039/d3an00594a
37. Sijia Liu†, Benrui Weng†, Yaqi Liu, Siyuan Wang, Nana Kang, Jiabing Ran, Hanghang Liu, Shuo Huang, Zhangshuang Deng, Changying Yang, Huimin Wang*, Fuan Wang, Dual-Signal Cascaded Nucleic Acid Amplification Circuit-Loaded Metal-Organic Frameworks for Accurate and Robust imaging of Intracellular MicroRNA. Langmuir, 2023, 39(30), 10453–10463. DOI: 10.1021/acs.langmuir.3c00897
2022年
38. Huimin Wang†, Yuqiu He†, Jie Wei, Hong Wang, Kang Ma, Yangjie Zhou, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, Construction of an Autocatalytic Hybridization Assembly Circuit for Amplified In Vivo MicroRNA Imaging. Angew. Chem. Int. Ed., 2022, 61(19), e202115489. DOI: 10.1002/anie.202115489 (HOT PAPER, HIGHLY CITED PAPER)
39. Shizhen He, Shanshan Yu, Ruomeng Li, Yingying Chen, Qing Wang, Yuqiu He, Xiaoqing Liu, Fuan Wang*, On-Site Nonenzymatic Orthogonal Activation of a Catalytic DNA Circuit for Self-Reinforced In Vivo MicroRNA Imaging. Angew. Chem. Int. Ed., 2022, 61(45), e202206529. DOI: 10.1002/anie.202206529 (VIP PAPER)
40. Wenqian Yu, Junlin Sun, Xiuyuan Wang, Shuyi Yu, Mingzhu Yan, Fuan Wang*, Xiaoqing Liu*, Boosting Cancer Immunotherapy via the Convenient A2AR Inhibition Using a Tunable Nanocatalyst with Light-Enhanced Activity. Adv. Mater. 2022, 34(8), 2106967. DOI: 10.1002/adma.202106967
41. Jie Wei†, Jinhua Shang†, Shizhen He, Yu Ouyang, Itamar Willner,* Fuan Wang*, Construction of a Homogeneous Enzyme-Free Autocatalytic Nucleic Acid Machinery for High-Performance Intracellular Imaging of MicroRNA. CCS Chem., 2022, 4(11), 3549–3562. DOI: 10.31635/ccschem.021.202101545
42. Yun Zhao, Ruoment Li, Junlin Sun, Zhiqiao Zou, Fuan Wang*, Xiaoqing Liu*, Multifunctional DNAzyme-Anchored Metal-Organic Framework for Efficient Suppression of Tumor Metastasis. ACS Nano, 2022, 16(4), 5404–5417. DOI: 10.1021/acsnano.1c09008
43. Xue Gong†, Shizhen He†, Ruomeng Li†, Yingying Chen, Kaiyue Tan, Yeqing Wan, Xiaoqing Liu, Fuan Wang*, Monitoring and Modulating the Catalytic Hybridization Circuit for Self-Adaptive Bioorthogonal DNA Assembly. Chem. Sci., 2022, 13(35), 10428–10436. DOI: 10.1039/d2sc03757b
44. Zhiqiao Zou, Min Pan, Fengye Mo, Qunying Jiang, Ailing Feng, Yizhuo Zhou, Fuan Wang*, Xiaoqing Liu*, High-Fidelity ATP Imaging via an Isothermal Cascade Catalytic Amplifier. Chem. Sci., 2022, 13(41), 12198–12207. DOI: 10.1039/d2sc04560e
45. Fengzhe Li†, Yingying Chen†, Jinhua Shang, Qing Wang, Shizhen He, Xiwen Xing*, Fuan Wang*, An Isothermal Autocatalytic Hybridization Reaction Circuit for Sensitive Detection of DNA Methyltransferase and Inhibitors Assay. Anal. Chem., 2022, 94(10), 4495–4503. DOI: 10.1021/acs.analchem.2c00037
46. Yanping Zhang†, Ruomeng Li†, Shanshan Yu, Jinhua Shang, Yuqiu He, Yushi Wang, Xiaoqing Liu, Fuan Wang*, Sensitive Autocatalytic Hybridization Circuit for Reliable In Situ Intracellular Polynucleotide Kinase Imaging. Anal. Chem., 2022, 94(40), 13951-13957. DOI: 10.1021/acs.analchem.2c03169
47. Yu Shang, Yingying Chen, Qing Wang, Yuqiu He, Shizhen He, Shanshan Yu, Xiaoqing Liu, Fuan Wang*, Construction of An Endogenously Activated Catalytic DNA Circuit for Highly Robust In Vivo MicroRNA Imaging. Nano Today, 2022, 45, 101553. DOI: 10.1016/j.nantod.2022.101553
48. Qiong Wu†, Lei Yang†, Lingling Xie, Jinhua Shang, Shizhen He, Jing Liu,* Fuan Wang*, Modular Assembly of a Concatenated DNA Circuit for In Vivo Amplified Aptasensing. Small, 2022, 18(21), 2200983. DOI: 10.1002/smll.202200983
49. Shanshan Yu, Jinhua Shang, Shizhen He, Qing Wang, Ruomeng Li, Yingying Chen, Xiaoqing Liu, Fuan Wang*, Multiply guaranteed and successively amplified activation of a catalytic DNA machine for highly efficient intracellular imaging of microRNA. Small, 2022, 18(32), 2203341. DOI: 10.1002/smll.202203341
50. Kaiyue Tan†, Qingqing Zhang†, Qing Wang, Xue Gong, Shanshan Yu, Ruomeng Li, Xiaoqing Liu*, Fuan Wang*, Functional Zeolitic Imidazolate Framework for Robust L-Deoxyribozyme-based Therapy. Small, 2022, 18(47), 2204858. DOI: 10.1002/smll.202204858
51. Yuhui Gao†, Yingying Chen†, Jinhua Shang, Shanshan Yu, Shizhen He, Ran Cui*, Fuan Wang*, Enzyme-Free Autocatalysis-Driven Feedback DNA Circuits for Amplified Aptasensing of Living Cells. ACS Appl. Mater. Interfaces, 2022, 14(4), 5080–5089. DOI: 10.1021/acsami.1c22767
52. Yushi Wang†, Yingying Chen†, Yeqing Wan, Chen Hong, Jinhua Shang, Fengzhe Li, Xiaoqing Liu, Fuan Wang*, An Autocatalytic DNA Circuit Based on Hybridization Chain Assembly for Intracellular Imaging of Polynucleotide Kinase. ACS Appl. Mater. Interfaces, 2022, 14(28), 31727–31736. DOI: 10.1021/acsami.2c08523
53. Zhen Xu, Tianhui Shi, Fengye Mo, Wenqian Yu, Yu Shen, Qunying Jiang, Fuan Wang, Xiaoqing Liu*, Programmable Assembly of Multivalent DNA-Protein Superstructures for Tumor Imaging and Targeted Therapy. Angew. Chem. Int. Ed., 2022, 61(44), e202211505. DOI: 10.1002/anie.202211505
54. Dan Luo†, Xue Lin†, Yun Zhao, Jialing Hu, Fengye Mo, Gege Song, Zhiqiao Zou, Fuan Wang, Xiaoqing Liu*, A Dynamic DNA Nanosponge for Triggered Amplification of Gene-Photodynamic Modulation. Chem. Sci., 2022, 13(18), 5155–5163. DOI: 10.1039/d2sc00459c
55. Huiran Yang, Benrui Weng, Sijia Liu, Nana Kang, Jiabing Ran, Zhangshuang Deng, Huimin Wang*, Changying Yang*, Fuan Wang, Acid-improved DNAzyme-based chemiluminescence miRNA assay coupled with enzyme-free concatenated DNA circuit. Biosens. Bioelectron., 2022, 204, 114060. DOI: 10.1016/j.bios.2022.114060
2021年
56. Qing Wang, Kaiyue Tan, Hong Wang, Jinhua Shang, Yeqing Wan, Xiaoqing Liu, Xiaocheng Weng, Fuan Wang*, Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation. J. Am. Chem. Soc. 2021, 143(18), 6895–6904. DOI: 10.1021/jacs.1c00570
57. Jing Wang†, Shanshan Yu†, Qiong Wu, Xue Gong, Shizhen He, Jinhua Shang, Xiaoqing Liu, Fuan Wang*, A self-catabolic multifunctional DNAzyme nanosponge for programmable drug delivery and efficient gene silencing. Angew. Chem. Int. Ed., 2021, 60(19), 10766−10774. DOI: 10.1002/anie.202101474
58. Junlin Sun†, Feng Liu†, Wenqian Yu, Dandan Fu, Qunying Jiang, Fengye Mo, Xiuyuan Wang, Tianhui Shi, Fuan Wang*, Dai-Wen Pang*, Xiaoqing Liu*, Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy. Angew. Chem. Int. Ed., 2021, 60(45), 24275–24283. DOI: 10.1002/anie.202111093
59. Xue Gong, Haizhou Wang, Ruomeng Li, Jie Wei, Jing Wang, Jinhua Shang, Xiaoqing Liu*, Jing Liu, Fuan Wang*, A smart multi-antenna gene theranostic system based on the programmed assembly of hypoxia-related siRNA. Nat. Commun., 2021, 12, 3953. DOI: 10.1038/s41467-021-24191-9
60. Chen Hong, Qing Wang, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu, Fuan Wang* Intelligent Demethylase-Driven DNAzyme Sensor for Highly Reliable Metal Ions Imaging in Living Cells. Chem. Sci., 2021, 12(46), 15339–15346. DOI: 10.1039/d1sc05370a
61. Yingying Chen, Xue Gong, Yuhui Gao, Yu Shang, Jinhua Shang, Shanshan Yu, Ruomeng Li, Shizhen He, Xiaoqing Liu, Fuan Wang*, Bioorthogonal Regulation of DNA Circuit for Smart Intracellular MicroRNA Imaging. Chem. Sci., 2021, 12(47), 15710–15718. DOI: 10.1039/d1sc05214d
62. Jinhua Shang†, Chunxiao Li†, Fengzhe Li, Qing Wang, Bifeng Yuan, Fuan Wang*, Construction of enzyme-free initiator-replicated hybridization chain reaction circuit for amplified methyltransferase evaluation and inhibitors assay. Anal. Chem., 2021, 93(4), 2403−2410. DOI: 10.1021/acs.analchem.0c04356
63. Yeqing Wan, Gaiping Li, Lina Zou, Hong Wang, Qing Wang, Kaiyue Tan, Xiaoqing Liu, Fuan Wang*, A Deoxyribozyme-initiated Self-catalytic DNA Machine for Amplified Live-cell Imaging of MicroRNA. Anal. Chem., 2021, 93(31), 11052–11059. DOI: 10.1021/acs.analchem.1c02596
64. Jinhua Shang, Shanshan Yu, Yingying Chen, Yuhui Gao, Chen Hong, Fengzhe Li, Fuan Wang*, Real-time Investigation of Intracellular Polynucleotide Kinase Using A Cascaded Amplification Circuit. Anal. Chem., 2021, 93(46), 15559–15566. DOI: 10.1021/acs.analchem.1c04033
65. Ruomeng Li†, Xue Gong†, Chen Hong, Hong Wang, Yingying Chen, Kaiyue Tan, Xiaoqing Liu,* Fuan Wang*, An efficient photochemotherapy nanoplatform based on the endogenous biosynthesis of photosensitizer in macrophage-derived extracellular vesicles. Biomaterials, 2021, 279, 121234. DOI: 10.1016/j.biomaterials.2021.121234
66. Qing Wang†, Yuqiu He†, Fuan Wang*, Recent Advances of Multifunctional Deoxyribozyme for Biomedical Analysis. Chem. Res. Chin. Univ., 2021, 42(11), 3334–3356. DOI: 10.7503/cjcu20210449
67. Zhen Xu†, Li Zhang†, Min Pan, Qunying Jiang, Yunjie Huang, Fuan Wang, Xiaoqing Liu*, A Bionanozyme with Ultrahigh Activity Enables Spatiotemporally Controlled Reactive Oxygen Species Generation for Cancer Therapy. Adv. Funct. Mater., 2021, 31(40), 2104100. DOI: 10.1002/adfm.202104100
68. Shuang Li†, Qunying Jiang†, Yahua Liu, Wenxiao Wang, Wenqian Yu, Fuan Wang, Xiaoqing Liu*, Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer Specific Therapy. Anal. Chem., 2021, 93(32), 11275–11283. DOI: 10.1021/acs.analchem.1c02264
69. Yizhuo Zhou, Lina Zou, Gaiping Li, Tianhui Shi, Shuyi Yu, Fuan Wang, Xiaoqing Liu*, A Cooperatively Activatable DNA Nanoprobe for Cancer Cell-Selective Imaging of ATP. Anal. Chem., 2021, 93(41), 13960–13966. DOI: 10.1021/acs.analchem.1c03284
70. Qunying Jiang, Lei Fan, Junlin Sun, Jialing Hu, Man He, Bin Hu, Fuan Wang, Xiaoqing Liu*, Modulation of Oxidative Stress in Cancer Cells with A Biomineralized Converter. ACS Mater. Lett. 2021, 3(12), 1778–1785. DOI: 10.1021/acsmaterialslett.1c00470
71. Wenxiao Wang†, Yu Shen†, Fuan Wang, Ying Liu*, Xiaoqing Liu*, Bio-Inspired Dynamic Biomolecule Assembling for Fine Regulation of Protein Activity. Chem. Commun., 2021, 57(85), 11205–11208. DOI: 10.1039/d1cc03926a
72. Ping Dong†, Wenxiao Wang†, Min Pan, Wenqian Yu, Yahua Liu, Tianhui Shi, Jialing Hu, Yizhuo Zhou, Shuyi Yu, Fuan Wang, Xiaoqing Liu*, Cascaded Amplifier Nanoreactor for Efficient Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2021, 13(14), 16075–16083. DOI: 10.1021/acsami.1c01683
73. Tianhui Shi, Jialing Hu, Wenxiao Wang, Qunying Jiang, Zhen Xu, Shuyi Yu, Fuan Wang, Xiaoqing Liu*, Multiple Blockades of HGF/Met Signaling Pathway for Metastasis Suppression Using Nanoinhibitors. ACS Appl. Mater. Interfaces, 2021, 13(26), 30350–30358. DOI: 10.1021/acsami.1c07010
74. Huimin Wang†, Dan Luo†, Hong Wang, Fuan Wang, Xiaoqing Liu*, Construction of Smart Stimuli-responsive DNA Nanostructures for Biomedical Applications. Chem. Eur. J. 2021, 27(12), 3929–3943. DOI: 10.1002/chem.202003145
2020年
75. Jie Wei, Huimin Wang, Qiong Wu, Xue Gong, Kang Ma, Xiaoqing Liu and Fuan Wang*, A Smart Autocatalytic DNAzyme Biocircuit for in vivo MRI-Guided MicroRNA Imaging. Angew. Chem. Int. Ed., 2020, 59(15), 5965–5971. DOI: 10.1002/anie.201911712 (HOT PAPER, HIGHLY CITED PAPER)
76. Xue Gong, Ruomeng Li, Jing Wang, Jie Wei, Kang Ma, Xiaoqing Liu, Fuan Wang*, A Smart Theranostic Nanocapsule for Spatiotemporally Programmable Photo-genetherapy. Angew. Chem. Int. Ed., 2020, 59(48), 21648–21655. DOI: 10.1002/anie.202008413
77. Jie Wei, Huimin Wang, Xue Gong, Qing Wang, Hong Wang, Yangjie Zhou, Fuan Wang*, A Proteinase-Free DNA Replication Machinery for in Vitro and in Vivo Amplified MicroRNA Imaging. Nucleic Acids Res., 2020, 48(10), e60. DOI: 10.1093/nar/gkaa250
78. Jie Feng†, Wenqian Yu†, Zhen Xu, Fuan Wang*, Intelligent ZIF-8-Gated Polydopamine nanoplatform for in vivo Cooperatively Enhanced Combinational Phototherapy. Chem. Sci., 2020, 11(6), 1649–1656. DOI: 10.1039/c9sc06337d.
79. Yangjie Zhou†, Shanshan Yu†, Jinhua Shang, Yingying Chen, Qing Wang, Xiaoqing Liu and Fuan Wang*, Construction of an Exonuclease III-propelled Integrated DNAzyme Amplifier for Highly Efficient MicroRNA Detection and Intracellular Imaging with Ultralow Background. Anal. Chem., 2020, 92(22), 15069–15078. DOI: 10.1021/acs.analchem.0c03073
80. Meijuan Liang†, Minyi Zhang†, Shanshan Yu, Qiong Wu, Kang Ma, Yingying Chen, Xiaoqing Liu, Chunsen Li,* Fuan Wang*, Silver–Laden Black Phosphorus Nanosheets for an Efficient in Vivo Antimicrobial Application. Small, 2020, 16(13), 1905938. DOI: 10.1002/smll.201905938
81. Meijuan Liang, Yanbing Wang, Kang Ma, Shanshan Yu, Yingying Chen, Zhao Deng, Yi Liu, Fuan Wang*, Engineering Inorganic Nanoflares with Elaborate Enzymatic Specificity and Efficiency for Versatile Biofilm Eradication. Small, 2020, 16(41), 2002348. DOI: 10.1002/smll.202002348
82. Keke Gong†, Qiong Wu†, Hong Wang, Shizhen He, Jinhua Shang, Fuan Wang*, Autocatalytic DNAzyme Assembly for Amplified Intracellular Imaging. Chem. Commun., 2020, 56(77), 11410–11413. DOI: 10.1039/d0cc05257d (HOT PAPER)
83. Jinhua Shang, Jie Wei, Qing Wang, Jing Wang, Yangjie Zhou, Shanshan Yu, Xiaoqing Liu, Fuan Wang*, Adaption of an autonomously cascade DNA circuit for amplified detection and intracellular imaging of polynucleotide kinase with ultralow background. Biosens. Bioelectron., 2020, 152, 111994. DOI: 10.1016/j.bios.2019.111994
84. Kang Ma†, Pei Dong†, Meijuan Liang, Shanshan Yu, Yingying Chen, Fuan Wang*, Facile Assembly of Multifunctional Antibacterial Nanoplatform Leveraging Synergistic Sensitization between Silver Nanostructure and Vancomycin. ACS Appl. Mater. Interfaces, 2020, 12(6), 6955–6965. DOI: 10.1021/acsami.9b22043
85. Jie Feng†, Wenqian Yu†, Zhen Xu, Jialing Hu, Jing Liu, Fuan Wang* Multifunctional siRNA-Laden Hybrid Nanoplatform for Non-Invasive PA/IR Dual-Modal Imaging-Guided Enhanced Photogenetherapy. ACS Appl. Mater. Interfaces, 2020, 12(20), 22613–22623. DOI: 10.1021/acsami.0c04533
86. Huimin Wang†, Yuqi Chen†, Jinhua Shang, Hong Wang, Kang Ma, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, Multifunctional Hypoxia-Involved Gene Silencing Nanoplatform for Sensitizing Photochemotherapy. ACS Appl. Mater. Interfaces, 2020, 12(31), 34588–34598. DOI: 10.1021/acsami.0c08315
87. Keke Gong†, Fengze Li†, Hong Wang, Fuan Wang*, Amplified microRNA analysis based on isothermal enzyme-free nucleic acid amplification. J. Anal. Sci., 2020, 36(5), 677–682. DOI: 10.13526/j.issn.1006-6144.2020.05.000
88. Jialing Hu, Fuan Wang, Feng Liu, Wentong Sun, Qunying Jiang, Yahua Liu, Yun Zhao, Xiaoqing Liu*, Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy. Nano Research, 2020, 13(4), 1111–1121. DOI: 10.1007/s12274-020-2753-5
89. Wenqian Yu, Junlin Sun, Feng Liu, Shuyi Yu, Zhen Xu, Fuan Wang, Xiaoqing Liu*, Enhanced Immunostimulatory Activity of CpG Immunomodulator by the Assembly of Polymer DNA Wires and Spheres. ACS Appl. Mater. Interfaces, 2020, 12(15), 17167–17176. DOI: 10.1021/acsami.9b21075
2019年
90. Huimin Wang, Yuqi Chen, Hong Wang, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, DNAzyme-Loading MOFs for Self-Sufficient Gene Therapy. Angew. Chem. Int. Ed., 2019, 58, 7380–7384. DOI: 10.1002/anie.201902714 (HIGHLY CITED PAPER)
91. Qiong Wu†, Gang Chen†, Keke Gong, Jing Wang, Xiaoxiao Ge, Xiaoqing Liu, Shaojun Guo*, Fuan Wang*, MnO2-Laden Black Phosphorus for MRI-Guided Synergistic PDT/PTT/Chemotherapy. Matter, 2019, 1(2), 496–512. DOI: 10.1016/j.matt.2019.03.007
92. Jing Wang, Huimin Wang, Hong Wang, Shizhen He, Ruomeng Li, Zhao Deng, Xiaoqing Liu, Fuan Wang*, Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery. ACS Nano, 2019, 13(5), 5852−5863. DOI: 10.1021/acsnano.9b01589
93. Xue Gong, Jie Wei, Jing Liu, Ruomeng Li, Xiaoqing Liu, Fuan Wang*. Programmable Intracellular DNA Biocomputing Circuits for Reliable Cell Recognitions. Chem. Sci., 2019, 10(10), 2989–2997. DOI: 10.1039/c8sc05217d
94. Hong Wang, Huimin Wang, Qiong Wu, Meijuan Liang, Xiaoqing Liu, Fuan Wang*, DNAzyme-amplified DNA Circuit for Highly Accurate MicroRNA Detection and Intracellular Imaging. Chem. Sci., 2019, 10(41), 9597–9604. DOI: 10.1039/c9sc03552d
95. Qiong Wu, Hong Wang, Keke Gong, Jinhua Shang, Xiaoqing Liu, Fuan Wang*, Construction of an Autonomous Nonlinear Hybridization Chain Reaction for Extracellular Vesicles-Associated microRNAs Discrimination. Anal. Chem., 2019, 91(15), 10172–10179. DOI: 10.1021/acs.analchem.9b02181
96. Yangjie Zhou, Lei Yang, Jie Wei, Kang Ma, Xue Gong, Jinghua Shang, Shanshan Yu, Fuan Wang*, An autonomous nonenzymatic concatenated DNA circuit for amplified imaging of intracellular ATP. Anal. Chem., 2019, 91(23), 15229−15234. DOI: 10.1021/acs.analchem.9b04126
97. Lei Yang†, Qiong Wu†, Yuqi Chen, Xiaoqing Liu, Fuan Wang*, Xiang Zhou, Amplified MicroRNA Detection and Intracellular Imaging based on an Autonomous and Catalytic Assembly of DNAzyme. ACS Sensors, 2019, 4(1), 110–117. DOI: 10.1021/acssensors.8b01000
98. Kaiyue Tan, Yingying Chen, Kang Ma, Qing Wang, Xiaoqing Liu, Fuan Wang*, Spatiotemporally Tracking the Programmable Mitochondrial Membrane Potential Evolutions by a Robust Molecular Rotor. Small, 2019, 15(40), 1903266. DOI: 10.1002/smll.201903266
99. Lana Zou, Qiong Wu, Yangjie Zhou, Xue Gong, Xiaoqing Liu, Fuan Wang*, DNAzyme-Powered Cross-Catalytic Circuit for Amplified Intracellular Imaging. Chem. Commun., 2019, 55(46), 6519–6522. DOI: 10.1039/c9cc02637a
100. Lingyu Wu, Min Pan, Yuqi Chen, Haiyan Huang, Xiaoe Zhang, Fuan Wang*, Xiang Zhou*, Construction of DNAzyme-based Logic Gates for Amplified MicroRNA Detection and Cancer Recognition. Analyst, 2019, 144(24), 7278−7282. DOI: 10.1039/c9an01977d
101. Junlin Sun, Feng Liu, Wenqian Yu, Qunying Jiang, Jialing Hu, Yahua Liu, Fuan Wang, Xiaoqing Liu*. Highly Sensitive Glutathione Assay and Intracellular Imaging with Functionalized Semiconductor Quantum Dots. Nanoscale, 2019, 11, 5014–5020. DOI: 10.1039/c8nr09801h
102. Haomiao Su, Jinglei Xu, Qi Wang, Fuan Wang, Xiang Zhou*, High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis. Nat. Commun., 2019, 10, 5390. DOI: 10.1038/s41467-019-13310-2
103. Yahua Liu, Min Pan, Wenxiao Wang, Qunying Jiang, Fuan Wang, Dai-Wen Pang, Xiaoqing Liu*, Plasmonic and Photothermal Immunoassay via Enzyme-Triggered Crystal Growth on Gold Nanostars. Anal. Chem., 2019, 91, 2086–2092. DOI: 10.1021/acs.analchem.8b04517
104. Jie Feng, Zhen Xu, Ping Dong, Wenqian Yu, Feng Liu, Qunying Jiang, Fuan Wang, Xiaoqing Liu*, Stimuli-Responsive Multifunctional Metal-Organic Framework Nanoparticles for Enhanced Chemo-Photothermal Therapy. J. Mater. Chem. B, 2019, 7, 994–1004. DOI: 10.1039/c8tb02815j
105. Yahua Liu, Ping Dong, Qunying Jiang, Fuan Wang, Dai-Wen Pang, Xiaoqing Liu*, Assembly-enhanced fluorescence from metal nanoclusters and quantum dots for highly sensitive biosensing. Sens. Actuators B Chem., 2019, 279, 334–341. DOI: 10.1016/j.snb.2018.10.016
106. Min Pan, Zhen Xu, Qunying Jiang, Jie Feng, Junlin Sun, Fuan Wang, Xiaoqing Liu*, Interfacial engineering of carbon dots with benzenediboronic acid for fluorescent biosensing. Nanoscale Adv., 2019, 1, 765–771. DOI: 10.1039/c8na00166a
2018年
107. Jie Wei, Xue Gong, Qing Wang, Min Pan, Xiaoqing Liu, Jing Liu, Fan Xia, Fuan Wang*, Construction of an autonomously concatenated hybridization chain reaction for signal amplification and intracellular imaging. Chem. Sci., 2018, 9, 52–61. DOI: 10.1039/c7sc03939e (HIGHLY CITED PAPER, COVER PAPER)
108. Huimin Wang, Chunxiao Li, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, Construction of an enzyme-free concatenated DNA circuit for signal amplification and intracellular imaging. Chem. Sci., 2018, 9, 5842–5849. DOI: 10.1039/c8sc01981a (HIGHLY CITED PAPER)
109. Chunxiao Li†, Huimin Wang†, Jinhua Shang, Xiaoqing Liu, Bi-Feng Yuan, Fuan Wang*, Highly sensitive assay of methyltransferase activity based on an autonomous concatenated DNA circuit. ACS Sensors, 2018, 3, 2359−2366. DOI: 10.1021/acssensors.8b00738
110. Qiong Wu, Meijuan Liang, Simin Zhang, Xiaoqing Liu, Fuan Wang*, Development of functional black phosphorus nanosheets with remarkable catalytic and antibacterial performance. Nanoscale, 2018, 10, 10428–10435. DOI: 10.1039/c8nr01715h.
111. Min Pan†, Meijuan Liang†, Junlin Sun, Xiaoqing Liu*, Fuan Wang*, Lighting Up Fluorescent Silver Clusters via Target-Catalyzed Hairpin Assembly for Amplified Biosensing. Langmuir, 2018, 34, 14851−14857. DOI: 10.1021/acs.langmuir.8b01576
112. Meijuan Liang, Min Pan, Jialing Hu, Fuan Wang, Xiaoqing Liu*, Electrochemical Biosensor for MicroRNA Detection Based on Cascade Hybridization Chain Reaction. ChemElectroChem, 2018, 5, 1380–1386. DOI: 10.1002/celc.201800255
113. Jie Feng, Zhen Xu, Feng Liu, Yun Zhao, Wenqian Yu, Min Pan, Fuan Wang, Xiaoqing Liu*, Versatile Catalytic Deoxyribozyme Vehicles for Multimodal Imaging-Guided Efficient Gene Regulation and Photothermal Therapy. ACS Nano, 2018, 12, 12888–12901. DOI: 10.1021/acsnano.8b08101
2017年
114. Qing Wang, Min Pan, Jie Wei, Xiaoqing Liu, Fuan Wang*, Evaluation of DNA Methyltransferase Activity and Inhibition via Isothermal Enzyme-Free Concatenated Hybridization Chain Reaction. ACS Sensors, 2017, 2, 932–939. DOI: 10.1021/acssensors.7b00168
115. Jing Wang, Min Pan, Jie Wei, Xiaoqing Liu, Fuan Wang*, A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays. Chem. Commun., 2017, 53, 12878–12881. DOI: 10.1039/c7cc07057h (COVER PAPER)
2016年
116. Yuqi Chen, Yanyan Song, Zhiyong He, Zijing Wang, Wenting Liu, Fuan Wang, Xiaolian Zhang, and Xiang Zhou*, pH-controlled DNAzymes: Rational design and their applications in DNA-machinery devices. Nano Research, 2016, 9, 3084–3092. DOI: 10. 1007/s12274-016-1191-x
博士后期间发表论文
117. Masayuki Endo, Yuki Suzuki, Tomoko Emura, Kumi Hidaka, Fuan Wang, Itamar Willner, Hiroshi Sugiyama. Single-Molecule Visualization of the Zn2+-Dependent DNAzyme Functions. Angew. Chem. Int. Ed. 2015, 54, 10550–10554. DOI: 10.1002/anie.201504656
118. Wei-Ching Liao, Chun-Hua Lu, Raimo Hartmann, Fuan Wang, Yang Sung Sohn, Wolfgang J. Parak,* Itamar Willner,* Adenosine Triphosphate-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Cross-Linked Microcapsules. ACS Nano 2015, 9, 9078–9086. DOI: 10.1021/nn503223e
119. Sivan Lilienthal, Zohar Shpilt, Fuan Wang, Ron Orbach, Itamar Willner*. Programmed DNAzyme-Triggered Dissolution of DNA-Based Hydrogels: Means for Controlled Release of Biocatalysts and for the Activation of Enzyme Cascades. ACS Appl. Mater. Interfaces. 2015, 7, 8923–8931. DOI: 10.1021/acsami.5b02156
120. Lina Freage, Alexander Trifonov, Ran Tel-Vered, Eyal Golub, Fuan Wang, John S. McCaskill, Itamar Willner*. Addressing, amplifying and switching DNAzyme functions by electrochemically-triggered release of metal ions. Chem. Sci. 2015, 6, 3544-3549. DOI: 10.1039/c5sc00744e
121. Fuan Wang, Xiaoqing Liu, Itamar Willner*. DNA Switches: From Principles to Applications. Angew. Chem. Int. Ed. 2015, 54, 1098-1129. DOI: 10.1002/anie.201404652
122. Weiwei Guo, Chun-Hua Lu, Ron Orbach, Fuan Wang, Xiu-Juan Qi, Alessandro Cecconello, Dror Seliktar, Itamar Willner*. pH Stimulated DNA Hydrogels Exhibiting Shape-Memory Properties. Adv. Mater. 2015, 27, 73–78. DOI: 10.1002/adma.201403702
123. Lina Freage, Fuan Wang, Itamar Willner*. Multiplexed Analysis of Genes and of Metal Ions Using Enzyme/DNAzyme Amplification Machineries. Anal. Chem. 2014, 86, 11326–11333. DOI: 10.1021/ac5030667
124. Natalie Enkin, Fuan Wang, Etery Sharon, Itamer Willner*. Multiplexed Analysis of Genes Using Nucleic Acid-Stabilized Ag Nanocluster Quantum Dots. ACS Nano 2014, 8, 11666–11673. DOI: 10.1021/nn504983j
125. Yuwei Hu, Fuan Wang, Chun-Hua Lu, Julia Girsh, Eyal Golub, Itamar Willner*. Switchable Enzyme/DNAzyme Cascades by the Reconfiguration of DNA Nanostructures. Chem. Eur. J. 2014, 20, 16203–16209. DOI: 10.1002/chem.201404122
126. Zhanxia Zhang, Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Gated Mesoporous SiO2 Nanoparticles using K+-Stabilized G-Quadruplexes. Adv. Funct. Mater. 2014, 36, 5662–5670). DOI: 10.1002/adfm.201400939 (selected as the Cover of the issue 36 on 2014.)
127. Zhanxia Zhang, Fuan Wang, Dora Balogh, Itamar Willner*. pH-Controlled Release of Substrates from Mesoporous SiO2 Nanoparticles Gated By Metal Ion-Dependent DNAzymes. J. Mater. Chem. B 2014, 2, 4449–4455. DOI: 10.1039/c4tb00558a
128. Ron Orbach, Fuan Wang, Oleg Lioubashevski, Raphael D. Levine, Françoise Remacle, Itamar Willner*. A Full-Adder Based on Reconfigurable DNA-Hairpin Inputs and DNAzyme Computing Modules. Chem. Sci. 2014, 5, 3381–3387. DOI: 10.1039/c4sc00914b (selected as the Back Cover of the issue 5 on 2014.)
129. Fuan Wang, Chun-Hua Lu Itamar Willner*. From Cascaded Catalytic Nucleic Acids to Enzyme-DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations and Assembly of Complex Structures. Chem. Rev. 2014, 114, 2881–2941. DOI: 10.1021/cr400354z (selected as the Cover of the issue 5 on 2014.)
130. Fuan Wang, Chun-Hua Lu, Xiaoqing Liu, Lina Freage, Itamar Willner*. Amplified and Multiplexed Detection of DNA Using the Dendritic Rolling Circle Amplified Synthesis of DNAzyme Reporter Units. Anal. Chem. 2014, 86, 1614–1621. DOI: 10.1021/ac4033033
131. Ron Orbach, Weiwei Guo, Fuan Wang, Oleg Lioubashevski, Itamar Willner*. Self-Assembly of Luminescent Ag Nanocluster Nanowires. Langmuir 2013, 29, 13066–13071. DOI: 10.1021/la402888b
132. Zhanxia Zhang, Dora Balogh, Fuan Wang, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Biocatalytic Release of an Anticancer Drug from Nucleic-Acids-Capped Mesoporous SiO2 Using DNA or Molecular Biomarkers as Triggering Stimuli. ACS Nano 2013, 7, 8455–8468. DOI: 10.1021/nn403772j
133. Fuan Wang, Lina Freage, Ron Orbach, Itamar Willner*. Autonomous Replication of Nucleic Acids by Polymerization/Nicking Enzyme/DNAzyme Cascades for the Amplified Detection of DNA and the Aptamer-Cocaine Complex. Anal. Chem. 2013, 85, 8196–8203. DOI: 10.1021/ac4013094 Highlight by HispanicBusiness
134. Xiaoqing Liu, Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar Willner*. Graphene Oxide/Nucleic Acid-Stabilized Silver Nanoclusters: Functional Hybrid Materials for Optical Aptamer Sensing and Multi-plexed Analysis of Pathogenic DNAs. J. Am. Chem. Soc. 2013, 135, 11832–11839. DOI: 10.1021/ja403485r
135. Fuan Wang, Xiaoqing Liu, Chun-Hua Lu, Itamar Willner. Cysteine-Mediated Aggregation of Au Nanoparticles: A Process for the Sensitive Detection of H2O2 and the Development of Oxidase-Based Biosensors. ACS Nano 2013, 7, 7278–7286. DOI: 10.1021/nn402810x
136. Fuan Wang, Bilha Willner, Itamar Willner* DNA Nanotechnology with One-Dimensional Self-Assembled Nanostructures. Curr. Opin. Biotechnol. 2013, 24, 562–574. DOI: 10.1016/j.copbio.2013.02.005
137. Zhanxia Zhang, Dora Balogh, Fuan Wang, Ran Tel-Vered, Naomi Levy, Sohn Yang Sung, Rachel Nechushtai, Itamar Willner*. Light-Induced and Redox-Triggered Uptake and Release of Substrates to and from Mesoporous SiO2 Nanoparticles. J. Mater. Chem. B 2013, 1, 3159–3166. DOI: 10.1039/c3tb20292e
138. Zhanxia Zhang, Dora Balogh, Fuan Wang, Itamar Willner*. Smart Mesoporous SiO2 Nanoparticles for the DNAzyme-Induced Multiplexed Release of Substrates. J. Am. Chem. Soc. 2013, 135, 1934–1940. DOI: 10.10021/ja311385y
139. Fuan Wang, Xiaoqing Liu, Itamar Willner* Integration of Photoswitchable Proteins, Photosynthetic Reaction Centers and Semiconductor/Biomolecule Hybrids with Electrode Supports for Optobioelectronic Applications. Adv. Mater. 2013, 25, 349–377. DOI: 10.1002/adma.201201772
140. Xiaoqing Liu, Fuan Wang, Angelica Niazov-Elkan, Weiwei Guo, Itamar Willner*. Probing Biocatalytic Transformations with Luminescent DNA/Silver Nanoclusters. Nano Lett. 2013, 13, 309–314. DOI: 10.1021/nl304283c
141. Xiaoqing Liu, Angelica Niazov-Elkan, Fuan Wang, Itamar Willner*. Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines. Nano Lett. 2013, 13, 219–225. DOI: 10.1021/nl303894h
142. Johann Elbaz†, Fuan Wang†, Raphael D. Levine, Francoise Remacle, Itamar Willner*. Programmable Functional Logic Circuits Driven by Modular DNAzyme Libraries. Nano Lett. 2012, 12, 6049−6054. DOI: 10.1021/nl300051g († Equal contributor) (selected as the Cover of the issue 12 on 2012.)
143. Fuan Wang, Ron Orbach, Itamar Willner* Detection of Metal Ions (Cu2+, Hg2+) and of Cocaine Using a Ligation DNAzyme Machinery. Chem. Eur. J. 2012, 18, 16030–16036. DOI: 10.1002/chem.201201479
144. Ron Orbach, Lena Mostinski, Fuan Wang, Itamar Willner* Nucleic Acid-Driven DNA Machineries Synthesizing Mg2+-Dependent DNAzymes: An Interplay Between DNA Sensing and Logic Gate Operations. Chem. Eur. J. 2012, 18, 14689–14694. DOI: 10.1002/chem.201201995
145. Fuan Wang, Johann Elbaz, Itamar Willner*. Enzyme-Free Amplified Detection of DNA by an Autonomous Ligation and Replication DNAzyme Machinery. J. Am. Chem. Soc. 2012, 134, 5504–5507. DOI: 10.1021/ja300616w
146. Chunhua Lu†, Fuan Wang†, Itamar Willner* Zn2+-Ligation DNAzyme-Driven Enzymatic and Non-Enzymatic Cascades for the Amplified Detection of DNA. J. Am. Chem. Soc. 2012, 134, 10651–10658. († Equal contributor), DOI: 10.1021/ja3037838
147. Chunhua Lu†, Fuan Wang†, Itamar Willner* Amplified Optical Aptasensors through the Endonuclease-Stimulated Regeneration of the Analyte. Chem. Sci. 2012, 3, 2616–2622. († Equal contributor), DOI: 10.1039/c2sc20426f
148. Johann Elbaz, Zhengang Wang, Fuan Wang, Itamar Willner*. Programmed Dynamic Topologies in DNA Catenanes. Angew. Chem. Int. Ed. 2012, 51, 2349–2353. DOI: 10.1002/anie.201107591 (Selected as the Inside Cover of the issue 10 on 2012.)
149. Simcha Shimron†, Fuan Wang†, Ron Orbach, Itamar Willner* Amplified Detection of DNA through the Enzyme-Free Autonomous Assembly of Hemin/G-Quadruplex DNAzyme Nanowires. Anal. Chem. 2012, 84, 1042–1048. DOI: 10.1021/ac202643y († Equal contributor)
150. Fuan Wang, Johann Elbaz, Ron Orbach, Nimrod Magen, Itamar Willner*. Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires. J. Am. Chem. Soc. 2011, 133, 17149–17151. DOI: 10.1021/ja2076789 Highlight by Life Science Weekly on December 20, 2011
151. Fuan Wang, Johann Elbaz, Carsten Teller, Itamar Willner*. Amplified Detection of DNA through the Autocatalytic, Catabolic Generation of the Analyte by a DNAzyme. Angew. Chem. Int. Ed. 2011, 50, 295–299. DOI: 10.1002/anie.201005246
152. Johann Elbaz, Oleg Lioubashevski, Fuan Wang, Françoise Remacle, Raphael D. Levine, Itamar Willner*. DNA computing circuits using libraries of DNAzyme subunits. Nat. Nanotechnol. 2010, 5, 417–422. DOI: 10.1038/nnano.2010.88 Highlight by New Scientist
硕博连读期间发表论文
153. Ming Zhou, Fuan Wang, Shaojun Dong *. Boolean logic gates based on oxygen-controlled biofuel cell in "one pot". Electrochim. Acta 2011, 56, 4112–4118. DOI: 10.1016/j.electacta.2011.01.113
154. Xiaoqing Liu, Fuan Wang, Shuang Han, Lihong Shi, Guobao Xu*. Self-Assembly of gold nanoparticles/electroactive polyelectrolyte multilayer films for tunable electrocatalysis. Electroanalysis 2010, 22, 963–968. DOI: 10.1002/elan.200900479
155. Li Wang, Fuan Wang, Li Shang, Chengzhou Zhu, Wen Ren, Shaojun Dong*. AuAg bimetallic nanoparticles film fabricated based on H2O2-mediated silver reduction and its application. Talanta 2010, 82, 113–117. DOI: 10.1016/j.talanta.2010.04.009
156. Xiaoqing Liu, Haijuan Li, Fuan Wang, Yuling Wang, Shuyun Zhu, Guobao Xu*. Functionalized single-walled carbon nanohorns for electrochemical biosensing. Biosens. Bioelectron. 2010, 25, 2194–2199. DOI: 10.1016/j.bios.2010.02.027
157. Fuan Wang, Xiaoqing Liu, Gaiping Li, Dan Li, Shaojun Dong*. Selective Electrodissolution of Inorganic Ions/DNA Multilayer Film for Tunable DNA Release. J. Mater. Chem. 2009, 19, 286–291. DOI: 10.1039/B812940A
158. Jianlong Wang, Fuan Wang, Shaojun Dong*. Methylene Blue as an Indicator for Sensitive Electrochemical Detection of Adenosine Based on Aptamer Switch. J. Electroanal. Chem. 2009, 626, 1–5. DOI: 10.1016/j.jelechem.2008.08.008
159. Yan Du, Bingling Li, Fuan Wang, Shaojun Dong*. Au Nanoparticles Grafted Sandwich Platform Used Amplified Small Molecule Electrochemical Aptasensor. Biosens. Bioelectron. 2009, 24, 1979–1983. DOI: 10.1016/j.bios.2008.10.019
160. Liu Deng, Lihua Zhang, Li Shang, Shaojun Guo, Dan Wen, Fuan Wang, Shaojun Dong*. Electrochemiluminescence Detection of NADH, Ethanol Based on Partial Sulfonation of Sol-gel Network with Gold Nanoparticles. Biosens. Bioelectron. 2009, 24, 2273–2276. DOI: 10.1016/j.bios.2008.10.031
161. Ming Zhou, Yuling Wang, Yueming Zhai, Junfeng Zhai, Wen Ren, Fuan Wang, Shaojun Dong*. Controlled Synthesis of Large-Area and Patterned Electrochemically Reduced Graphene Oxide Films. Chem. Eur. J. 2009, 15, 6116–6120. DOI: 10.1002/chem.200900596
162. Fuan Wang, Jianlong Wang, Yueming Zhai, Dan Li, Gaiping Li, Shaojun Dong*. Layer-by-layer Assembly of Biologically Inert Inorganic Ions/DNA Multilayer Films for Tunable DNA Release by Chelation. J. Controlled Release 2008, 132, 65–73. DOI: 10.1016/j.jconrel.2008.08.016
163. Fuan Wang, Dan Li, Gaiping Li, Xiaoqing Liu, Shaojun Dong*. Electrodissolution of Inorganic ions/DNA Multilayer Film for Tunable DNA Release. Biomacromolecules 2008, 9, 2645–2652. DOI: 10.1021/bm800766t
164. Fuan Wang, Jianlong Wang, Xiaoqing Liu, Shaojun Dong*. Nanoparticle-amplified Surface Plasmon Resonance Study of Protein Conformational Change at Interface. Talanta 2008, 77, 628–634. DOI: 10.1016/j.talanta.2008.06.042
165. Liu Deng, Fuan Wang, Hongjun Chen, Li Shang, Liang Wang, Tie Wang, Shaojun Dong*. A Biofuel Cell with Enhanced Performance by Multilayer Biocatalyst Immobilized on Highly Ordered Macroporous Electrode. Biosens. Bioelectron. 2008, 24, 329–333. DOI: 10.1016/j.bios.2008.04.006
166. Jianlong Wang, Fuan Wang, Hongjun Chen, Xiaohua Liu, Shaojun Dong*. Electrochemical Surface Plasmon Resonance Detection of Enzymatic Reaction in Bilayer Lipid Membranes. Talanta 2008, 75, 666–670. DOI: 10.1016/j.talanta.2007.11.062
167. Lihua Zhang, Fuan Wang, Shaojun Dong*. Layer-by-layer Assembly of Functional Silica and Au Nanoparticles for Fabricating Electrogenerated Chemiluminescence Sensor. Electrochim. Acta 2008, 53, 6423–6427. DOI: 10.1016/j.electacta.2008.04.059
168. Liu Deng, Yizhe Wang, Li Shang, Dan Wen, Fuan Wang, Shaojun Dong*. A Sensitive NADH and Glucose Biosensor Tuned by Visible Light Based on Thionine Bridged Carbon Nanotubes and Gold Nanoparticles Multilayer. Biosens. Bioelectron. 2008, 24, 951–957. DOI: 10.1016/j.bios.2008.07.066
169. Fuan Wang, Jianlong Wang, Hongjun Chen, Shaojun Dong*. Assembly Process of CuHCF/MPA Multilayers on Gold Nanoparticles Modified Electrode and Characterization by Electrochemical SPR. J. Electroanal. Chem. 2007, 600, 265–274. DOI: 10.1016/j.jelechem.2006.10.008
170. Jianlong Wang, Fuan Wang, Xiangqin Zou, Zhiai Xu, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry for Detection of Small Molecules Using Catalyzed Deposition of Metal Ions on Gold Substrate. Electrochem. Commun. 2007, 9, 343–347. DOI: 10.1016/j.elecom.2006.09.011
171. Jianlong Wang, Fuan Wang, Zhiai Xu, Yizhe Wang, Shaojun Dong*. Surface Plasmon Resonance and Electrochemistry Characterization of Layer-by-Layer Self-Assembled DNA and Zr4+ Thin Films and Their Interaction with Cytochrome c. Talanta 2007, 74, 104–109. DOI: 10.1016/j.talanta.2007.05.033
172. Na Gao, Zhiai Xu, Fuan Wang, Shaojun Dong*. Sensitive Biomimetic Sensor Based on Molecular Imprinting at Functionalized Indium Tin Oxide Electrodes. Electroanalysis 2007, 19, 1655–1660. DOI: 10.1002/elan.200703919
173. Liu Deng, Ying Liu, Guocheng Yang, Li Shang, Dan Wen, Fuan Wang, Zhiai Xu, Shaojun Dong*. Molecular "Wiring" Glucose Oxidase in Supramolecular Architecture. Biomacromolecules 2007, 8, 2063–2071. DOI: 10.1021/bm061049l
174. Jianlong Wang, Yong Shao, Yongdong Jin, Fuan Wang, Shaojun Dong*. Electrochemical Thinning of Thick Gold Film with Controlled Thickness for SPR Sensing. Anal. Chem. 2005, 77, 5760–5765. DOI: 10.1021/ac0507035
三．参与编写的书目：
1. Hong Wang, Huimin Wang, Fuan Wang*. "Chapter 10: High-performance biosensing based on autonomous enzyme-free DNA circuit." in "DNA Nanotechnology: From Structure to Functionality" for Top. Curr. Chem. Edited by Chunhai Fan and Yonggang Ke. Springer Press.
2. Yuqiu He, Zeyue Wang, Yuqian Jiang, Fuan Wang*. "Chapter 10: Intelligent Sense-on-Demand DNA Circuits for Amplified Bioimaging in Living Cells." in "DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine" Edited by Zhou Nie. 2023 John Wiley & Sons, Ltd.
3. Fuan Wang, Bilha Willner, Itamar Willner*. "Chapter 2: DNA-Based Machines." in "Molecular Machines and Motors: Recent Advances and Perspectives" for Top. Curr. Chem. Edited by Alberto Credi, Silvi Serena and Margherita Venturi. Springer Press.
4. Fuan Wang, Chun-Hua Lu, Itamar Willner*. "Chapter 2: DNA Switches and Machines." in "DNA in Supramolecular Chemistry and Nanotechnology" Edited by Eugen Stulz Guido H. Clever. 2015 John Wiley & Sons, Ltd.
四．申请获批的专利：
1. Fuan Wang, Jie Wei, “A nucleic acid analysis method based on cascade hybridization chain reaction.” CN Patent No. CN201710937113.8 Oct. 10, 2017.
2. Fuan Wang, Jie Wei, Fengzhe Li, “A nucleic acid analysis method based on isothermally cross-catalyzed DNAzyme reaction.” CN Patent No. CN201911291884.X Dec. 16, 2019.
3. Fuan Wang, Qing Wang, Fengzhe Li, “A kind of DNAzyme molecular probe and its application.” CN Patent No. CN202110366516.8 Oct. 20, 2022.