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徐健 副研究员    

中国药科大学中药学院中药制药系,副研究员,硕士生导师。2013年进入中国药科大学中药学院攻读博士学位,期间受CSC资助在美国Marshall University访学一年,2016年获得药物化学专业理学博士学位,同年进入中国药科大学从事师资博士后研究,2019年出站后转聘为讲师,2020年晋升为副研究员。

主要研究方向为:1、药用植物内生真菌次生代谢产物及其生物活性研究;2.发酵炮制法炮制机理、炮制工艺和质量标准研究;3.发酵类中药活性成分的发现及创新药物开发研究。目前以第一作者和通讯作者在Organic chemistry frontiersJournal of natural productsBioorganic chemistryTheranostics等国际知名期刊发表研究性SCI论文14篇,主持国家青年基金和中国博士后面上项目等纵向课题3项,横向课题1项,参与国家级和省部级课题8项,参编全国高等医药院校药学类规划教材《中药炮制学》。


近三年研究成果:

(1) Jian Xu, Hui-Lin Zhu, Jie Zhang, Wen-Yuan Liu, Jian-Guang Luo, Ke Pan, Wen-Yuan Cao, Qi-Rui Bi, Feng Feng,* and Wei Qu*. Littordials A-E, Novel Formyl-Phloroglucinol-β-caryophyllene Meroterpenoids from the Leaves of Psidium littorale. Organic Chemistry Frontiers. 2019, 6, 1667-1673. (IF 5.155)

(2) Mangmang Sang, Renjie Luo, Yidan Bai, Jun Dou, Zhongtao Zhang, Fulei Liu, Feng Feng, Jian Xu, Wenyuan Liu. Mitochondrial membrane anchored photosensitive nano-device for lipid hydroperoxides burst and inducing ferroptosis to surmount therapy-resistant cancer. Theranostics. 2019, 9(21): 6209-6223. (IF 8.579)

(3) Jian Xu, Hui-Lin Zhu, Jie Zhang, Tao Du, Er-Yan Guo, Wen-Yuan Liu, Jian-Guang Luo, Feng Ye, Feng Feng,* and Wei Qu.* Sesquiterpenoids from Chloranthus anhuiensis with neuroprotective effects in PC12 cells. Journal of Natural Products. 2018, 81, 13911398. (IF 4.257)

(4) Jie Zhang, Toshihiro Akihisa, Masahiro Kurita, Takashi Kikuchi, Wan-Fang Zhu, Feng Ye, Zhen-Huan Dong, Wen-Yuan Liu, Feng Feng,* and Jian Xu.* Melanogenesis-Inhibitory and Cytotoxic Activities of Triterpene Glycoside Constituents from the Bark of Albizia procera. Journal of Natural Products. 2018, 81(12), 2612-2620. (IF 4.257)

(5) Jian Xu, Yun-Wei Hu, Wei Qu, Ming-Hua Chen, Liang-Sheng Zhou, Qi-Rui Bi, Jian-Guang Luo, Wen-Yuan Liu, Feng Feng,* and Jie Zhang.* Cytotoxic and neuroprotective activities of constituents from Alternaria alternate, a fungal endophyte of Psidium littorale. Bioorganic Chemistry. 2019, 90: 103046. (IF 4.831)

(6) Eryan Guo, Yunwei Hu, Tao Du, Huilin Zhu, Lei Chen, Wei Qu, Jie Zhang, Ning Xie, Wenyuan Liu, Feng Feng, JianXu. Effects of Picrasma quassioides and its active constituents on Alzheimer's disease in vitro and in vivo. Bioorganic Chemistry. 2019, 92:103258. (IF 4.831).

(7) Hui-Lin Zhu, Yun-Wei Hu, Wei Qu, Jie Zhang, Er-Yan Guo, Xue-Yang Jiang, Wen-Yuan Liu, Feng Feng*, and Jian Xu*. Littordial F, a novel phloroglucinol meroterpenoid from the Leaves of Psidium littorale. Tetrahedron Letters, 2019, 60(28): 1868-1870. (IF 2.275).

(8) Jian Xu, Wei Qu, Wen-Yuan Cao, Yue Wang, Kai-Jun Zheng, Shi-Zheng Luo, Meng-Yuan Wu, Wen-Yuan Liu, Feng Feng,* and Jie Zhang.* Chemical Constituents from Tabernaemontana bufalina Lour. Chemistry & Biodiversity, 2019, 16, e1800491. (IF 2.039).

(9) Hui-Lin Zhu, Wei Qu, Jie Zhang, Er-Yan Guo, Tao Du, Wen-Yuan Liu, Feng Feng,* and Jian Xu.* Chemical constituents from Chloranthus anhuiensis and their Cytotoxic activities. Chemistry & Biodiversity, 2018, 15, e1800249. (IF 1.617).