中国药科大学中药学院天然药物化学系,副教授,硕士生导师。主要针对肿瘤发生和转移调控、神经退行性疾病开展天然药物化学及中药化学相关的研究,关注天然活性分子发现、结构修饰、改造和活性研究,以及新型纳米药物递药系统的构建和生物学评价等领域的研究。
项目
1、国家自然科学基金青年项目,81502950,基于STAT3信号通道的映三白草酮抗癌转移构效关系及作用机制研究,2016.01-2018.12,17.90万元,在研,主持
2、江苏省自然科学基金面上项目,BK2011628,三白草抗肿瘤活性成分及其构效关系研究,2011.12-2014.12,8.00万元,已结题,主持
3、中央高校基本科研业务费专项资金重点项目,2015ZD010,以天然抗肿瘤活性成分铁屎米酮类生物碱为底物的HDAC抑制剂的设计、合成及发现,2015.01- 2016.12,15.00万元,已结题,主持
代表文章(5篇)
1. Self-delivered and Self-monitored Chemo-Photodynamic Nanoparticles with Light-triggered Synergistic Anti-tumor Therapies by Downgrading HIF-1α and Depleting GSH [J] ACS Applied Materials & Interfaces, 12 (2020) 5680-5694. (IF 8.456)
2. Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer’s disease [J] Bioorganic Chemistry, 2020, 99: 103844.
3. Shaoyu Cui1, Hongli Jiang1, Lei Chen, Jian Xu, Wenzhuo Sun, Haopeng Sun, Zijian Xie, Yunhui Xu, Fubai Yang, Wenyuan Liu, Feng Feng*, Wei Qu*.Design, synthesis and evaluation of wound healing activity for β-sitosterols derivatives as potent Na+/K+-ATPase inhibitors. [J] Bioorganic Chemistry, 2020, 98: 103150.
4. Jing Sun, Lei Chen, Pan Jiang, Bingjing Duan, Ruyi Wang, Jian Xu, Wenyuan Liu, Yunhui Xue, Zijian Xie, Feng Feng*, Wei Qu*. Phenylethanoid glycosides of Callicarpa kwangtungensis Chun exert cardioprotective effect by weakening Na+-K+-ATPase/Src/ERK1/2 pathway and inhibiting apoptosis mediated by oxidative stress and inflammation [J] Journal of Ethnopharmacology, 2020, 258: 112881.
5. Xu Jian, Hui-Ling Zhu, Zhang Jie, Wen-Yuan Liu, Jian-Guang Luo, Ke Pan, Wen-Yuan Cao, Qi-Rui Bi, Feng Feng*, Wei Qu*. Littordials A-E, Novel Formyl-Phloroglucinol-β-caryophyllene Meroterpenoids from the Leaves of Psidium littorale [J] Organic Chemistry Frontiers, 2019. DOI: 10.1039/C9QO00174C