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蒋学阳 博士 师资博士后    

2019年获中国药科大学理学博士学位。主要探究神经保护调节剂在神经退行性疾病的药物化学研究,关注动物药中活性蛋白成分在疾病中的应用。

主要研究成果(论文与专利):

[1]. Jiang, X.-Y.; Chen, T.-K.; Zhou, J.-T.; He, S.-Y.; Yang, H.-Y.; Chen, Y.; Qu, W.; Feng, F.; Sun, H.-P. Dual GSK-3 beta/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery. ACS Medicinal Chemistry Letters 2018, 9, 171-176. (Cover Article)

[2]. Jiang, X.-Y.; Zhou, J.-T.; Lin, Q.-H.; Gong, G.-Y.; Sun, H.-P.; Liu, W.; Guo, Q.; Feng, F.; Qu, W. Anti-angiogenic and anticancer effects of baicalein derivatives based on transgenic zebrafish model. Bioorganic & Medicinal Chemistry 2018, 26, 4481-4492.

[3]. Jiang, X.-Y.; Zhou, J.-T.; Zhou, Y.; Sun, H.-P.; Xu, J.; Feng, F.; Qu, W. Convenient Method of Synthesizing Aryloxyalkyl Esters from Phenolic Esters Using Halogenated Alcohols. Molecules (Basel, Switzerland) 2018, 23.

[4]. Jiang, X.-Y.; Li, X.-C.; Liu, W.-Y.; Xu, Y.-H.; Feng, F.; Qu, W. An efficient, scalable approach to hydrolyze flavonoid glucuronides via activation of glycoside bond. Tetrahedron 2017, 73, 1895-1903.

[5]. Zhou, J.; Jiang, X.-Y.; He, S.; Jiang, H.; Feng, F.; Liu, W.; Qu, W.; Sun, H. Rational design of multi-target-directed ligands: strategies and emerging paradigms. Journal of Medicinal Chemistry 2019, DOI: 10.1021/acs.jmedchem.9b00017.

[6]. Wang, Y., Jiang, X.-Y., Feng, F., Liu, W. Y*., Sun, H. P*. Degradation of proteins by PROTACs and other strategies, Acta Pharmaceutica Sinica B 2020, 10, 207-238.

(1). 柳文媛,蒋学阳,曲玮,李凌超,林清华,徐健。一种以葡萄糖醛酸苷为原料制备其相应苷元的方法。授权号:CN 104693163 B

(2)柳文媛,曲玮,蒋学阳,冯锋,郝艳峰,周越,李凌超。一种制备芳香胺类化合物的方法。公开号:CN 106631820 A

(3). 孙昊鹏,蒋学阳,王洋。靶向泛素化降解GSK-3β蛋白的化合物及其应用。申请号:201910374391.6