课题组可提供以下化合物（专利产品）：绿色化学发光鲁米诺系列 CAS:2813348-14-8; CAS:2813348-19-3; CAS:2813348-15-9; CAS:2813348-17-1，持续更新中...
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Patents
申请发明专利12项，获授权发明专利10项，PCT 一件; 成功转让专利3项，总金额100万。
10. 一种鲁米诺醚化衍生物及其制备方法与应用，发明人：刘芳，邓涛，黄欣欣，王绮玲; 专利号：ZL 10.2023113179343
9.一种糖肽类抗生素荧光探针化合物及其制备方法与应用，发明人：刘芳, 邓涛, 邹小妹, 周迎春, 刘昌辉, 张诗惠, 高永, 钟艳花; 专利号：ZL 2023107403106
8. 一种鲁米诺酯化衍生物及其制备方法与应用，发明人：刘芳，邓涛，陈福乾，刘昌辉; 专利号：ZL 202111647995.7
7. 一种氢化试卤灵衍生物及其制备方法与应用，发明人：刘芳，邓涛，陈福乾，夏晓彤；专利号：ZL 202211329790.9
6. 荧光探针化合物及其制备方法和应用，发明人：邓涛，刘芳，胡世友; 专利号：ZL 201811508750.4
5. 一种鲁米诺衍生物及其制备方法与应用，发明人：刘芳，邓涛，陈福乾; 专利号：ZL 202210468815.7
4. 一种二氢喹啉类荧光探针及其制备方法与应用，发明人：邓涛，刘芳，吴亚兰，黄文怡; 专利号：ZL 202011278753.0
3. 一种羟基自由基比率式荧光探针及其制备方法和应用，发明人：刘芳，邓涛，王小娟; 专利号：ZL 201911393823.4
2. 一种伯氨喹类药物的比色检测方法，发明人：刘芳，邓涛，伍盛鋆，吴亚兰; 专利号：ZL 201910212683.X
1. 一种羟基自由基的比色检测方法及其应用，发明人： 刘芳，邓涛，胡世友; 专利号：ZL 201811201942.0
PCT 专利: PCT/CN2023/070769
Others
5. 2024广东省大学生生物化学实验技能大赛，三等奖。指导老师：刘芳，王建刚
4. 2023广东省大学生生物化学实验技能大赛，一等奖。指导老师：刘芳
3. 2023第六届“高创杯”广东高校科技成果转化路演大赛-高教赛道生物医药组 三等奖，核心成员：刘芳，邓涛等。
2. 2022首届"我是发明人"创新大赛，铜奖，核心成员：刘芳，邓涛，陈福乾，夏晓彤
1. 2022第十一届全国药物分析大会，优秀墙报三等奖。
Publications:
# equal contribution, * corresponding author
After joining GZUCM
32. Chengxi Guo, Yufang Wu, Qiling Wang, Xiaoqi Li, Tao Deng, Xiaotong Xia, Lei Li*, Huan Li, Chaozhan Lin, Chenchen Zhu*, Fang Liu, *
Super-resolution Imaging Lysosome Vesicles and Establishing a Gallbladder-Visualizable Zebrafish Model via a Fluorescence Probe. Talanta, 2024, 279: 126656. https://doi.org/10.1016/j.talanta.2024.126656
31. Tao Deng, Jinjin Shao, Zhongguo Xie, Qiling Wang, Xinxin Huang, Zhichao Zhou, Jialiang Guo, Lei Li*, Fang Liu* .Triphenylphosphine-bonded Coumaranone Dyes Realize Dual Color Imaging of Mitochondria and Nucleoli. Spectrochim. Acta A. 2024, 317: 124434. https://doi.org/10.1016/j.saa.2024.124434
30. Rui Zhou, Kaiwen Huang, Simin Chen, Meiqi Wang, Fang Liu, Fangle Liu*, Chaozhan Lin*, Chenchen Zhu*. Zhilining Formula alleviates DSS-induced colitis through suppressing inflammation and gut barrier dysfunction via the AHR/NF-κBp65 axis. Phytomedicine. 2024, 129：155571. https://doi.org/10.1016/j.phymed.2024.155571.
29. Xiaomei Zou, Yanting Lin, Shihui Zhang, Tao Deng, Ximing Xu, Yingchun Zhou*, Zhihui Liu, Weiguo Lu, Qingzhong Hu, Chaozhan Lin, Chenchen Zhu*, Fang Liu*. Fluorescence detecting glycopeptide antibiotics via a dynamic molecular switch. Analytica Chimica Acta, 2024,1294, 342309. https://doi.org/10.1016/j.aca.2024.342309.
28. Zhichao Zhou, Fuqian Chen, Xiaotong Xia, Dong Ye, Rong Zhou*, Lei Li, Tao Deng, Zhenhua Ding*, Fang Liu*, Developing a Fluorescence Substrate for HRP-based Diagnostic Assays with Superiorities over the Commercial ADHP，Chin. Chem. Lett. 2024, 35, 108970. https://doi.org/10.1016/j.cclet.2023.108970
27. Siyu Zhang, Yujie Sun, Zhongyue Bai, Yifan Wang, Guangjian Zhao, Fengli Yao, Yacong Yang, Yu Hu, Xionghao Li, Fang Liu, Peng Wang* and Ximing Xu*，Gardenin B, A Natural Inhibitor for USP7: In vitro Evaluation and In silico Identification, Lett. Drug Des. Discov. 2024, 21: 2352 - 2358. https://www.eurekaselect.com/article/132350
26. Fuqian Chen#, Xiaotong Xia#, Dong Yea, Ting Li, Xinxin Huang, Chun Cai, Chenchen Zhu, Chaozhan Lin, Tao Deng*, Fang Liu*A Green-emitting Luminol Analogue as the Next Generation Chemiluminescent Substrate in Biochemical Analysis. Analytical Chemistry, 2023, 95, 5773–5779. https://doi.org/10.1021/acs.analchem.3c00073，highlight as cover story；分析人公众号推文：https://mp.weixin.qq.com/s/ki1Tbj9cs3J4CtvNpKsi-Q；网易崛步化学推文：https://www.163.com/dy/article/I097VEQK0552CB7Q.html
25. Jiayan Zhu, Ting Li, Shihui Zhang, Xiaomei Zou, Yingchun Zhou*, Weiguo Lu, Zhihui Liu, Tao Deng*, Fang Liu*. Discovering a Dihydrofluorescein Analogue as a Promising Fluorescence Substrate to HRP. Chemosensors. 2023, 11：152. https://www.mdpi.com/2227-9040/11/2/152/pdf
24. Xiaotong Xia, Shuru Liu, Wenming Liu, Qiuying Xu, Ximing Xu, Fang Liu*, Tao Deng*. Probe and Dye Design through Copper-mediated Reactions of N-arylhydroxylamines.Org. Biomol. Chem. 2022,20, 9234-9240.https://doi.org/10.1039/D2OB01595A
22. Tao Deng #, Jing Zhao#, Danfeng Peng, Xinqian He, Xin-an Huang, Chaozhan Lin, Chenchen Zhu, Lei Wang*, Fang Liu* Probing Serum Albumin Binding Site of Fenamates and Photochemical Protein Labeling with a Fluorescence Dye. Org. Biomol. Chem. 2022, 20, 5076-5085. https://doi.org/10.1039/D2OB00717G
21. Fuqian Chen, Ying Zhang, Ting Li, Danfeng Peng, Zhiwen Qi, Jianping Song, Tao Deng*, Fang Liu* Discovering Ester and Ether Derivatives of Luminol as Advanced Chemiluminescence Probes. Chin. Chem. Lett. 2023, 34，107496. https://doi.org/10.1016/j.cclet.2022.05.010
20. Fuqian Chen, Wenming Liu, Huan Li, Tao Deng, Bengang Xing*, Fang Liu*. Rhodamine Fluorophores for STED Super-resolution Biological Imaging. Analysis & Sensing, 2022, 2: e202100066. invited review article, Free PDF: https://doi.org/10.1002/anse.202100066
19. Siyu Zhang,Yifan Wang, Lu Liu, Guangjian Zhao,Yujie Sun, Juan Wang, Fang Liu, Peng Wang*, Ximing Xu*, Virtual Screening Inhibitors of Ubiquitin-specific Protease 7 combining Pharmacophore Modeling and Molecular Docking. Molecular informatics. 2022, Doi: 10.1002/minf.202100273
18. SiyuZhang, YifanWang, YujieSun, GuangjianZhao, JuanWang, LuLiu, FangLiu, PengWang*, XimingXu*, 4′,7-Di-O-methylnaringenin (DMNG), a naringenin derivative, activates p53 signal pathway through down-regulating MDM2. Journal of Functional Foods. 2022, 89: 104962.
17. Tao Deng#, Zhiwen Qi#, Yalan Wu, Jing Zhao, Lei Wang, Danfeng Peng ,Ying Zhang, Xin-an Huang, Fang Liu*. A Photosensitizing Perylenediimide Dye Lights up Cell Nucleolus through Visible Light-mediated Intracellular Translocation. Dyes and Pigments. 2021, 196: 109722. https://doi.org/10.1016/j.dyepig.2021.109722；https://authors.elsevier.com/a/1dgkr_3H92sIbi (PDF file）
16. Weijia Peng, Zeyu Zhu, Yang Yang, Jiawei Hou, Junfeng Lu, Chen Chen, Fang Liu, Rongbiao Pi*. N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells. Brain Research Bulletin 2021, 174: 250–259. https://www.sciencedirect.com/science/article/pii/S036192302100188X
15. C Liu, J Liu, J. Gu, F. Liu, J. Li, B.Yang, Y. Zheng, J. Li, S. Wu, Q. Wu, X. Zhang, L. Li, H. Yang, L. Wang,* X. Li*. Combination Effect of Three Main Constituents From Sarcandra glabra Inhibits Oxidative Stress in the Mice Following Acute Lung Injury: A Role of MAPK-NF-κB Pathway. Front Pharmacol. 2020, 11: 580064. https://www.frontiersin.org/articles/10.3389/fphar.2020.580064/full
14. Ruoyu Zhang*, Fang Liu*, Ye Tian, Wei Cao, Ruibing Wang. Nanotechnology in Traditional Medicines and Natural Products. Frontiers in Chemistry, 2021, 9, doi: 10.3389/fchem.2021.633419. Editoral review article.
Our article collection of this special issue is finished successfully. Please refer to https://www.frontiersin.org/research-topics/12061/nanotechnology-in-traditional-medicines-and-natural-products
13. Yalan Wu#, Wenyi Huang#, Danfeng Peng, Xin-an Huang, Jiangyong Gu, Shengjun Wu, Tao Deng*, Fang Liu*. Synthesis of Dihydroquinolines as Scaffolds for Fluorescence Sensing of Hydroxyl Radical. Organic Letters. 2021, 23, 135-139. Highlight as Back Cover , Highlighted by CBG 资讯&分析人。链接 ：https://www.chembeango.com/zixun/54021；https://pubs.acs.org/doi/10.1021/acs.orglett.0c03852
12. Yalan Wu#, Danfeng Peng#, Zhiwen Qi , Jing Zhao, Wenyi Huang, Ying Zhang, Changhui Liu, Tao Deng*, Fang Liu* . Magnetic Nanoparticle-based Ligand Replacement Strategy for Chemical Luminescence Determination of Cholesterol. Frontiers in Chemistry, 2020, 8, 601636. Free PDF: https://doi.org/10.3389/fchem.2020.601636
11.Anna S. Kim, Stavros Melemenidis, Anna Karin Gustavsson, Dania Abid, Yalan Wu, Fang Liu, Dimitre Hristov and Emil Schüler
10. Yalan Wu, Qingping Zeng, Zhiwen Qi, Tao Deng*, Fang Liu*. Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors, Frontiers in Chemistry, 2020, 8, 472. invited review. https://www.frontiersin.org/articles/10.3389/fchem.2020.00472/full
9. Tao Deng#, Xiaojuan Wang#, Shengjun Wu, Shiyou Hu, Wei Liu, Tongkai Chen, Zhiqiang Yu, Qin Xu* and Fang Liu*. A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish.
Chemical Communications, 2020, 56, 4432-4435. https://doi.org/10.1039/D0CC00382D
8. ShengjunWu, Yuge Li, Tao Deng,* Xiaojuan Wang, Shiyou Hu, Guiyuan Peng, Xin-an Huang, Yanwu Ling * and Fang Liu*. A new fluorescence probe for sensing of biothiols and screening of acetylcholinesterase inhibitors. Org. Biomol.Chem. 2020, 18, 2468-2474 https://doi.org/10.1039/D0OB00020E
7. Liang Zhao#, Fuqian Chen#, Wenyi Huang, Huayu Bao, Yingjie Hu, Xin-an Huang, Tao Deng*, Fang Liu*. A Fluorescence Turn-on Assay for Simple and Sensitive Determination of Hemin and Blood Stains. Sensors & Actuators, B: Chemical. 2020, 304, 127392. https://www.sciencedirect.com/science/article/pii/S0925400519315916
6. Tao Deng, Huayu Bao, Wenyi Huang, Xiaojuan Wang, Shiyou Hu, Shengjun Wu, Liang Zhao, Chun Cai, Yingjie Hu*, Fang Liu*
Easy access of dihydrofluoresceins as advanced fluorescence turn-on probes for oxidative stress. Dyes and Pigments, 2020, 173: 107915.https://doi.org/10.1016/j.dyepig.2019.107915.
5. Tao Deng#, Shiyou Hu #, Liang Zhao, Shengjun Wu, Wei Liu , Tongkai Chen, Tingdan Fu, He Wang, Huifang Shi,Xin-an Huang*, Fang Liu*. A ratiometric fluorescent probe for sensitive determination of the important glycopeptide antibiotic vancomycin. Analytical and Bioanalytical Chemistry, 2019, 411, 8103–8111,https://link.springer.com/article/10.1007/s00216-019-02190-6
4. Sha Xiong#, Wei Liu#, Dongli Li#, Xiaojia Chen, Fang Liu, Dongsheng Yuan, Huafeng Pan, Qi Wang, Shuhuan Fang*, Tongkai Chen*. Oral delivery of Puerarin nanocrystals to improve brain accumulation and anti-Parkinsonian efficacy. Molecular Pharmaceutics, 2019, 16: 1444-1455.
3. Yalan Wu#,, Shengjun Wu#,, Xin‐an Huang, Qingping Zeng, Tao Deng*, Fang Liu* Optimized Griess reaction for UV‐vis and Naked‐eye Determination of Anti‐malarial Primaquine. Journal of Visualized Experiments, 2019, J. Vis. Exp. (152), e60136, doi:10.3791/60136. invited video protocol. please find the video at https://www.jove.com/video/60136/optimized-griess-reaction-for-uv-vis-naked-eye-determination-anti
2.Tao Deng, Shengjun Wu,Yalan Wu, Shiyou Hu, Huayu Bao, Xin-an Huang, Qin Xu, Zhaoli Yang, Jianping Song*, Fang Liu*.An unexpected Griess reaction on the important anti-malarial drug primaquine and its application for drug determination. Journal of Pharmaceutical and Biomedical Analysis (JPBA). 2019, 171, 8-14. PDF download https://doi.org/10.1016/j.jpba.2019.03.063
1. Tao Deng, Shiyou Hu, Xin-an Huang, Jianping Song, Qin Xu, Yi Wang, Fang Liu* A Novel Strategy for Colorimetric Detection of Hydroxyl Radicals Based on a Modified Griess Test. Talanta, 2019;195:152-157. 链接：https://doi.org/10.1016/j.talanta.2018.11.044
Before GZUCM (2017.12)
28. J. Lou F. Liu C. Lindsay O. Chaudhuri S. C. Heilshorn Y. Xia*. Dynamic Hyaluronan Hydrogels with Temporally Modulated High Injectability and Stability Using a Biocompatible Catalyst. Adv. Mater.2018. https://doi.org/10.1002/adma.201705215
27. Lyu, L.;Liu, F.*; Wang, X.; Hu, M.; Mu, J.; Cheong, H.; Liu, G.; Xing, B.*, Stimulus-Responsive Short Peptide Nanogels for Controlled Intracellular Drug Release and for Overcoming Tumor Resistance. Chem –Asian J.2017, 9, 14627-14634.(Co-corresponding author)
26. Liu, F.; Lou, J.; Hristov, D., X-Ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitization. Nanoscale2017, 9, 14627-14634.
25. Ai, X.; Lyu, L.; Zhang, Y.; Tang, Y.; Mu, J.; Liu, F.; Zhou, Y.; Zuo, Z.; Liu, G.; Xing, B., Remote Regulation of Membrane Channel Activity by Site-Specific Localization of Lanthanide-Doped Upconversion Nanocrystals. AngewChemInt Edit2017, 3031-3035.
24. Wu, X.; Liu, F.; Wells, K. L.; Tan, S. L.; Webster, R. D.; Tan, H. S.; Zhang, D.; Xing, B.; Yeow, E. K., Interplay of Hole Transfer and Host–Guest Interaction in a Molecular Dyad and Triad: Ensemble and Single‐Molecule Spectroscopy and Sensing Applications. Chem–Eur. J.2015, 21, 3387-3398.
23. Lu, S.; Liu, F.; Xing, B.; Yeow, E. K., Nontoxic colloidal particles impede antibiotic resistance of swarming bacteria by disrupting collective motion and speed. Phys Rev E 2015, 92 (6), 062706.
22. Cai, Z.; Jing, X.; Tian, X.; Jiang, J.; Liu, F.; Wang, X., Direct and indirect in vitro plant regeneration and the effect of brassinolide on callus differentiation of PopuluseuphraticaOliv. S Afr J Bot 2015, 97, 143-148.
21. X. Li, J. Mu, F. Liu, E. W. P. Tan, B. Khezri, R. D. Webster,E. K. L. Yeow,* and B. Xing* Human Transport Protein Carrier for Controlled Photoactivation of Antitumor Prodrug and Real-Time Intracellular Tumor Imaging.Bioconjugate Chem. 2015, 26, 955-961.
20. F. Liu*, J. Mu, B. Xing*, Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin. Current Pharmaceutical Design2015, 21, 1866. (Co-corresponding author)
19. J. Mu, F. Liu*, M. S. Rajab, M. Shi, S. Li, C. Goh, L. Lu, Q. Xu, B. Liu, L. G. Ng, B. Xing*, Small Molecule FRET Reporter for Real-time Visualization of Cell-Surface Proteolytic Enzyme Functions. Angew. Chem. Int. Ed, 2014, 53, 14357. (Co-corresponding author).
18. F. Liu, J. Mu, X. Wu, S. Bhattacharjya, E.K.L. Yeow*, B. Xing*, Peptide-PeryleneDiimide Functionalized Magnetic Nano-platforms for Fluorescence Turn-on Detection and Clearance of Bacterial Lipopolysaccharide., Chem. Commun. 2014, 50, 6200. Featured as front inside cover.
17. F. Liu, J. Mu, B. Xing*, pH Responsive Small Molecule Peptide Nanogels: Strategies toward Overcoming Tumor Resistance and Controlled Intracellular Drug Redistribution. Abstract of ICMAT 2013, and Manuscript.
16. J. Li, F. Liu, Q. Shao, Y. Min, M. Costa, E. K. L. Yeow,* and B. Xing* Enzyme-Responsive Cell-Penetrating Peptides Conjugated Mesoporous Silica Quantum Dots Nanocarriers for Controlled Release of Nucleus-Targeted Drug Molecules and Real-Time Intracellular Fluorescence Imaging of Tumor Cells. Adv. Healthc. Mater.2014, 3, 1230. Featured as cover paper.
15. Min, Y.; Li, J.; Liu, F.; Padmanabhan, P.; Yeow, E.K.L*; Xing, B*. Recent Advance of Biological Molecular Imaging Based on Lanthanide-Doped Upconversion-Luminescent Nanomaterials. Nanomaterials, 2014, 4, 129.
14. X. Wu, F. Liu, K. L. Wells, S. L. J. Tan, R. D. Webster, H-S. Tan, B. Xing* and E. K. L. Yeow* Interplay of Hole Transfer and Host-Guest Interaction in Molecular Dyad and Triad: Ensemble and Single-Molecule Spectroscopy and Sensing Applications. Chem. Eur. J.2014, 21, 3387
13. Yang, Y.; Liu, F.; Liu, X.; Xing, B*. NIR Light Controlled Photorelease of siRNA and Its Targeted Intracellular Delivery Based on Upconversion Nanoparticles. Nanoscale 2013, 5, 231.
12. G. Zhou*, F. Liu, J. Wan, J. Wang, D. Wang, P. Wei, P. Ouyang. Design, Synthesis and Evaluation of a Cellular Stable and Detectable Biotinylated Fumagillin Probe and Investigation of Cell Permeability of Fumagillin and Its Analogues to Endothelial and Cancer Cells. Eur. J. Med. Chem. 2013, 70, 631.
11. Y. Min, J. Li, F. Liu, E. K. L. Yeow*, B. Xing*. Near-Infrared Light Mediated Photoactivation of Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging via Upconversion Nanoparticles.Angew. Chem. Int. Ed. 2013, 52, 1.
10. S. Lu, W. Bi, F. Liu, X. Wu, B. Xing and E. K. L. Yeow*, Loss of Collective Motion in Swarming Bacteria Undergoing Stress. Phys. Rev. Lett. 2013.111, 208101.
9. G. Zhou*, Z. Weng, X. Shao, F. Liu, X. Nie, J. Liu, C. Wang, K. Guo. Discovery and SAR Studies of Methionine-Proline Anilides as Dengue Virus NS2B-NS3 Protease Inhibitors. Bioorg. Med. Chem. Lett. 2013, 23, 6549.
8. F. Liu, A. Y. Ni, Y. Lim, H. Mohanram, S. Bhattacharjya* and B. Xing*. Lipopolysaccharide Neutralizing Peptide−Porphyrin Conjugates for Effective Photoinactivation and Intracellular Imaging of Gram-Negative Bacteria Strains. Bioconjugate Chem. 2012, 23, 1639.
7. J. Teguh, F. Liu, B. Xing*, and E. K. L. Yeow*. Surface-Enhanced Raman Scattering (SERS) of Nitrothiophenol Isomers Chemisorbed on TiO2. Chem. Asian J. 2012, 7, 975.
6. Q. Zhang, F. Liu, K. T. Nguyen , X. Ma , X. Wang , B. Xing , Y. Zhao*. Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery. Adv. Funct. Mater. 2012, 22, 5144.
5. Yang, Y.; Aw, J.; Chen, K.; Liu, F.; Padmanabhan, P.; Hou, Y. L.; Cheng, Z.; Xing, B.* Enzyme Responsive Multifunctional Magnetic Nanoparticles for Tumor Intracellular Drug Delivery and Imaging. Chem. Asian J. 2011, 6, 1381.
4. Zhang, W., XU, J.: Liu F.; Li, C.; Jie Y.; Chen, S.; Li, Z.; Liu J.; Chen, L.; Zhou, G.* Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A. Chin. J. Chem. 2010, 28, 1417
3. Liu, F.; Wan, J.; Chen, S.; Lu, X.; Wang, X.Y.; Zhou, G*. Synthesis and in vitro Tests of Two Biotinylated Fumagillin Derivatives. World Sci-Tech R & D (a Chinese Journal), 2010, 32, 699.
2. Liu, F.; Li, Y. A Primary Investigation into the Phyllotaxy Related Asymmetry on the Organs of Althea Rosea and BrassiaChinensis. Journal of Life Sciences. 2010, 4, 14 (a Chinese Journal).
1. Liu, F.; Li, Y. A Primary Study on the Tricotyledon Mutant of Dianthus plumarius. Highlights of Sciencepaper Online. 2010, 3, 2000. (a Chinese Journal)