4184
成果及论文
- Xie, J.; Dougan, M.; Jaikhani, N.; Ingram, J.; Fang, T.; Kummer, L.; Monin, N.; Pishesha, N.; Rickelt, S.; Hynes, R.; Ploegh, H. 2019. Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. PNAS 116 (16), 7624-7631. [highlighted by Fierce Biotech]
- Fang, T.; Ran, L.; Guzman, J.; Cho, J.; Kamm, R.; Ploegh, H. 2019. Tumor microenvironment remodeling by a chemokine fusion with PD-L1 Blocking VHH. Mol. Pharmaceutics 16, 2838-2844.
- Fang, T.; Burger, D.; Gmeiner, C.; Cho, J.; Ploegh, H.; Lichtman, J. 2018. Volumetric fluorescence immunostaining for ultrastructure-preserved correlative light and electron microscopy. Nature Methods 15 (12), 1029. [highlighted by BRAIN Initiative 2.0, Harvard, Simons Foundation]
- Antos, J. M.; Ingram, J.; Fang, T.; Pishesha, N.; Ploegh, H. L. Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation. Current Protocols in Protein Science, 15.3. 1-15.3. 19.
- Fang, T.; Duarte, J. N.; Ling, J.-J.; Li, Z.-Y.; Guzman, J. S. Ploegh, H. L. 2016. Structurally-defined αMHC-II nanobody-drug conjugates: Therapeutic and imaging platforms for B-cell lymphoma. Angew. Chem. Int. Ed.
55, 2416–2420.
- Li, Z.-Y.; Theile, C. S. Chen, G.-Y.; Bilate, A. M.; Duarte, J. N.; Avalos, A. M.; Fang, T.; Barberena, R.; Sato,
S.; Ploegh, H. L. 2015. Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies
and Antibody Fragments. Angew. Chem. Int. Ed. 127, 11872-11876.
- Li, X.-R.; Fang, T.; Boons, G. J. 2014. The preparation of well-defined antibody-drug conjugates through glycan remodeling and strain promoted azide-alkyne cycloadditions. Angew. Chem. Int. Ed. 126: 7307–
7310. [highlighted by Faculty 1000]
- Fang, T.; Van-Elssen, C. H. M. J.; Duarte, J. N.; Guzman, J. S. Ploegh, H. L. 2017. Targeted antigen delivery by an anti-Class II MHC nanobody elicited focused αMUC1-Tn immunity. Chem. Sci., 8, 5591-5597.
- Chahal, J., Fang, T., Woodham, A.; Khan, O.; Ling, J. J.; Anderson, D.; Ploegh, H. L. 2017. An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model. Sci. Rep. 7 (1), 252. [highlighted by MIT News]
- Duarte J. N., Cragnolini J. J., Swee L. K., Bilate A. M., Bader J., Ingram J. R., Rashidfarrokhi A., Fang T., Schiepers A., Hanke L., Ploegh H. L. 2016. Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs. J. Immunol. 197(12), 4838-4847.
- Fang, T.; Gu, Y.; Huang, W.; Boons, G. J. 2016. Mechanism of Glycosylation of Anomeric Sulfonium Ions. J. Am. Chem. Soc. 138, 3002-3011.
- Gagarinov, I. A.; Fang, T.; Liu, L.; Srivastava, A. D.; Boons, G. J. 2015. Synthesis of Staphylococcus aureus Type 5 Trisaccharide Repeating Unit: Solving the Problem of Lactamization. Org. Lett. 17(4), 928-931.
- Fang, T.; Mo, K. F.; Boons, G. J. 2012. Stereoselective assembly of complex oligosaccharides using anomeric sulfonium ions as glycosyl donors. J. Am. Chem. Soc. 134, 7545–7552.
- Mo, K. F.; Fang, T.; Stalnaker, S. H.; Kirby, P. S.; Liu, M.; Wells, L.; Pierce, M.; Live, D. H.; Boons, G. J. 2011. Synthetic, structural, and biosynthetic studies of an unusual phospho-glycopeptide derived from α-dystroglycan. J. Am. Chem. Soc. 133, 14418–14430.
