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成果及论文

出版专著

1.         Harnessing reactive oxygen species (ROS) for cancer treatment. Osama, Alsiddig; Zhang, Junmin; Fang, Jianguo* In: Rezaei, N. (Editor) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_255-1.

2.         The Biological Activities of Quinolizidine Alkaloids. Zhang, Junmin; Liu Ying–Qian*; Fang Jianguo* In: The Alkaloids: Chemistry and Biology, Hans-Joachim Knolker (Editor); Academic Press, Volume 89, 2023, pp. 1-37. https://doi.org/10.1016/bs.alkal.2022.06.001.

3.         Assay of selenol species in biological samples by the fluorescent probe Sel-green. Zhang, Baoxin; Fang, Jianguo* In: Methods in Enzymology–“Selenoproteins”, Eranthie Weerapana (Editor); Elsevie, Volume 622, 2022, pp. 259-273.

4.         Selective Neuronal Nitric Oxide Synthase Inhibitors. Ji, H.; Erdal, E. P.; Litzinger, E. A.; Seo, J.; Zhu, Y.; Xue, F.; Fang, J.; Huang, J.; Silverman, R. B.*  In: Frontiers in Medicinal Chemistry, Reitz, A. B.; Choudhary, M. I.; Atta-ur-Rahman, Editors; Bentham Science Publishers, Volume 4, 2009, pp. 842-882.

 

 

发表论文(部分)

最新:Hemin as a General Static Dark Quencher for Constructing Heme Oxygenase-1 Fluorescent Probe. Angew Chem Int Ed 2023 https://doi.org/10.1002/anie.202301598

1.       Puromycin Prodrug Activation by Thioredoxin Reductase Overcomes Its Promiscuous Cytotoxicity. J Med Chem 2023, 66, 3250.

2.       Naphthalimide Fluorescent Skeleton for Facile and Accurate Quantification of Glutathione. Anal Chem 2023, 95, 4301.

3.          Baylis-Hillman Adducts as a Versatile Module for Constructing Fluorogenic Release System. J Med Chem 2022, 65, 6056.

4.         Structural Modification of Aminophenylarsenoxides Generates Candidates for Leukemia Treatment via Thioredoxin Reductase Inhibition. J Med Chem 2021, 64, 16132.

5.       Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells. J Med Chem 2021, 64, 17979.

6.         Combination of chemotherapy and oxidative stress to enhance cancer cell apoptosis. Chem Sci 2020, 11, 3215.

7.         A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage. Nat Commun 2019, 10, 2745.

8.         Selective Activation of a Prodrug by Thioredoxin Reductase Providing a Strategy to Target Cancer Cells. Angew Chem Int Ed 2018, 57, 6141.

9.         A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease. Chem Sci 2017, 8, 2966.

10.         Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications. J Am Chem Soc 2015, 137, 757.

11.         Highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells. J Am Chem Soc 2014, 136, 226.

12.         S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007, 104, 18742.

13.     Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo. J Am Chem Soc 2006, 128, 1879.