学术论文:
2021年，通讯/第一作者（含共同）：
1. YY. Nie, YX. Li, L. Liu, SY. Ren, YH. Tian*, F. Yang* (2021) Molecular mechanism underlying modulation of TRPV1 heat activation by polyols, JBC, in press. (* co-corresponding authors)
2. Y. Huang, SH. Yu, WX. Zhen, T. Cheng, D. Wang, JB. Lin, YH. Wu, YF. Wang, Y. Chen, LP. Shu, Yi Wang, XJ. Sun, Y. Zhou, F. Yang*, CH. Hsu*, PF. Xu* (2021) Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2, Theranostics, 11(14):6891-6904. (* co-corresponding authors)
2020年，通讯/第一作者（含共同）：
1. Xu L. §, Y. Han§, H. X. Chen, A. Aierken, H. Wen, W. Zheng, H. Wang, X. Lu, Z. Zhao, C. Ma, P. Liang, W. Yang*, S. Yang* and F. Yang* (2020) Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel, Nature Communications, 11(1): 3790. (* co-corresponding authors)
2. F. Yang* , L. Xu, BH. Lee, X. Xiao, Yarov-Yarovoy and J. Zheng* (2020) An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel, Advanced Science, 2020, 2000575. (* co-corresponding authors)
3. S. Yang§, X. Lu§, Y. Wang§, L. Xu§, X. Chen, F. Yang*, R. Lai* (2020) A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8, PNAS, 117(15):8633-8638. (* co-corresponding authors)
4. Zhu, A§. Aierken, A§. Yao, Z. Vu, S. Tian, Y*. Zheng, J*. Yang, S*., F. Yang*. (2020) A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel, Toxicon, 178(30):41-49. (* co-corresponding authors)
5. J. Xie, M. Ke, L. Xu, S. Lin, J. Huang, J. Zhang, F. Yang*, J. Wu* and Z. Yan* (2020) Structure of the human sodium leak channel NALCN in complex with FAM155A, Nature Communications, 11(1):5831. (* co-corresponding authors)
6. Zhang B., Q. Jin, L. Xu, N. Li, S. Chang, X. Zheng, J. Wang, Y. Chen, N. Gao*, X. Zhang*, F. Yang*, J. Guo* and S. Ye* (2020) Cooperative transport mechanism of human monocarboxylate transporter 2, Nature Communications, 11(1):2429. (* co-corresponding authors)
参与作者：
7. Chi, Z., Chen, S.,Xu, T., Zhen, W., Yu, W., Jiang, D., Guo, X., Wang, Z., Zhang, K., Li, M., Zhang, J., Fang, H., Yang, D., Ye, Q., Yang, X., Lin, H., F. Yang, Zhang, X., Wang, D. (2020) Histone Deacetylase 3 Couples Mitochondria to Drive IL-1beta-Dependent Inflammation by Configuring Fatty Acid Oxidation, Molecular Cell, S1097-2765 (20): 30578-5.
8. Hu, B., Zhang, Y., Deng, T., Gu, J., Liu, J., Yang, H., Xu, Y., Yan, Y., F. Yang, Zhang, H., Jin, Y., Zhou, J. (2020) PDPK1 regulates autophagosome biogenesis by binding to PIK3C3, Autophagy, Sep 10;1-18.
9. Wang, J. J§. Liu, F§. F. Yang, Wang, Y. Z. Qi, X. Li, Y. Hu, Q. Zhu, M. X*. Xu, T. L*. (2020) Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis, Nature Communications, 11(1):475.
10. Wang, YJ, Liu, MG., Wang, JH., Cao, W., Wu, C., Wang, ZY., Liu, L., F. Yang, Feng, ZH., Sun, L., Zhang, F., Shen, Y., Zhou, YD., Zhuo, M., Luo, JH., Xu, TL., Li, XY. (2020) Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity, Cell Reports, 33(6): 108369
11. Ying, Y., L. Lu, S. Banerjee, L. Xu, Q. Zhao, H. Wu, R. Li, X. Xu, H. Yu, D. Neculai, Y. Xi, F. Yang, J. Qin, and C. Li. (2020) KVarPredDB: a database for predicting pathogenicity of missense sequence variants of keratin genes associated with genodermatoses, Human Genomics, 14: 45.
2019年，通讯/第一作者（含共同）：
1. Luo, L., Wang, Y., Li, B., Xu, L., Kamau, P. M., J. Zheng*, F. Yang*, SL. Yang* and R. Lai* (2019) Molecular basis for heat desensitization of TRPV1 ion channels, Nature Communications, 10(1):2134. (* co-corresponding authors)
2. Li,B., Silva, J., Lu, X., Luo, L., Wang, Y., Xu, L., Aierken, A., Shynykul, Z., Kamau, P., Luo, A., Yang, J., Su, D., F. Yang*, Cui, J., SL. Yang* and R. Lai* (2019) Molecular game theory for a toxin-dominant food chain model, National Science Review, research article, 6: 1191-1200 (* co-corresponding authors)
3. Xu. L., F. Yang, Structural modeling of selectivity filter in transient receptor pontential melastatin 8 ion channel (2019) Journal of Zhejiang University (Medical Sciences), 48(1): 19-24
参与作者：
4. Sun, Q. Wang, H. Shu, L. Dong, N. F. Yang, Zhou, H. Chen, S. Zhang, R*. (2019) Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and bla IMP-4-Bearing Plasmids, Frontiers in Microbiology, 2019 10:2805.
5. Yin, Y., Dong, Y., Vu, S., F. Yang, Yarov-Yarovoy, V., Tian, Y., Zheng, J. (2019) Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers, British Journal of Pharmacology, 176(17):3364-3377.
6. Yu, P., Liu, Z., Yu, X., Ye, P., Liu, H., Xue, X., Yang, L., Li, Z., Wu, Y., Fang, C., Zhao, Y. J., F. Yang, Luo, J. H., Jiang, L. H., Zhang, L., Zhang, L., Yang, W. (2019), Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket, Cell Reports, 27(10): 3684-3695 e4
7. Dong, Y., Yin, Y., Vu, S., F. Yang, Yarov-Yarovoy, V., Tian, Y., Zheng, J. (2019) A distinct structural mechanism underlies TRPV1 activation by piperine, Biochemical and Biophysical Research Communications, 516(2):365-372.
2018年，通讯/第一作者（含共同）：
1. F. Yang§*, X. Xiao§, BH. Lee§, S. Vu, W. Yang, V. Yarov-Yarovoy and J. Zheng* (2018) The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel, Nature Communications, 9(1):2879. (* co-corresponding authors; § equal contribution)
2. Y. Han, B. Li, TT. Yin, C. Xu, R. Ombati, L. Luo, Y. Xia, J. Zheng, Y. Zhang, F. Yang*, GD. Wang*, SL. Yang* and R. Lai* (2018) Molecular mechanism of the tree shrew's insensitivity to spiciness, Plos Biology, 16(7): e2004921. (* co-corresponding authors)
2017年：
1. SL. Yang§, F. Yang§, B. Zhang§, BH. Lee, BW. Li, L. Luo, J. Zheng and R. Lai (2017) A bimodal activation mechanism underlies scorpion toxin-induced pain, Science Advances, 3(8): e1700810. (§ equal contribution)
2017年独立建立实验室之前：
1. F. Yang and J. Zheng (2017) Understand spiciness: mechanism of TRPV1 channel activation by capsaicin, Protein & Cell, doi:10.1007/s13238-016-0353-7
2. Ma. L§, F. Yang§, S. Vu and J. Zheng (2016) Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening, Scientific Reports, 6: 33827. (§ equal contribution)
3. F. Yang§, S. Vu§, Yarov-Yarovoy and J. Zheng (2016) Rational design and validation of a vanilloid-sensitive TRPV2 ion channel, Proceedings of the National Academy of Sciences, 113(26): E3657-66. (§ equal contribution) **Recommended by Faculty 1000
4. F. Yang§, X. Xiao§, W. Cheng, W. Yang, PL. Yu, ZZ. Song, V. Yarov-Yarovoy and J. Zheng (2015) Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel, Nature Chemical Biology, 11(7): 518-524. (§ equal contribution)
5. SL. Yang§, F. Yang§, NN. Wei§, J. Hong, BW. Li, L. Luo, MQ. Rong, V. Yarov-Yarovoy, J. Zheng, KW. Wang and R. Lai (2015) A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1, Nature Communications, 6:8279. (§ equal contribution)
6. YQ. Tang, JH. Zhou, F. Yang, J. Zheng and KW. Wang (2014) The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation, Biophysical Journal, 107(5): 1090-1104.
7. F. Yang and J. Zheng (2014) High temperature sensitivity is intrinsic to voltage-gated potassium channels, eLife, 3: e03255.
8. X. Cao, L. Ma, F. Yang, KW. Wang and J. Zheng (2014) Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold, Journal of General Physiology, 143(1): 75-90.
9. F. Yang§, L. Ma§, X. Cao§, KW. Wang and J. Zheng (2014) Divalent cations activate TRPV1 through promoting conformational change of the extracellular region, Journal of General Physiology, 143(1): 91-103. (§ equal contribution)
10. Ma, L., F. Yang, and J. Zheng (2014) Application of fluorescence resonance energy transfer in studies of biomolecules, Journal of Molecular Structure, 1077: 87-100.
11. L. Lei, F. Yang, DJ. Shi, YQ. Tang, J. Zheng and KW. Wang (2013) A TRPV4 channel C-terminal folding recognition domain critical for trafficking and function, Journal of Biological Chemistry, 288(15): 10427-10439.
12. X. Cao, F. Yang, J. Zheng and KW. Wang (2012) Intracellular proton-mediated activation of TRPV3 channels accounts for exfoliation effect of alpha hydroxyl acids on keratinocytes, Journal of Biological Chemistry, 287(31): 25905-25916.
13. Y. Cui, F. Yang, X. Cao, V. Yarov-Yarovoy, KW. Wang and J. Zheng (2012) Selective disruption of high-sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations, Journal of General Physiology, 139(4): 273-283. **Featured on the Cover.
14. W. Cheng§, F. Yang§, S. Liu, C. K. Colton, CB. Wang, Y. Cui, X. Cao, M.X. Zhu, CS. Sun, KW. Wang and J. Zheng (2012) Heteromeric heat-sensitive TRP channels exhibit distinct temperature and chemical response, Journal of Biological Chemistry, 287(10): 7279-7288. (§ equal contribution)
15. F. Zhang, S. Liu, F. Yang, J. Zheng and KW. Wang (2011) Identification of a tetrameric assembly domain in the c-terminus of heat-activated TRPV1 channels, Journal of Biological Chemistry, 286(17): 15308-15316.
16. F. Yang, Y. Cui, KW. Wang and J. Zheng (2010) Thermosensitive TRP channel pore turret is part of the temperature activation pathway, Proceedings of the National Academy of Sciences, 107(15): 7083-8 **Highlighted by Cell 141(3):377 and Faculty 1000
17. SS. Liang, F. Yang, C. Zhou, Y. Wang, S. Li, C. K. Sun, J. L. Puglisi, D. Bers, CS. Sun, and J. Zheng (2009) Temperature-dependent activation of neurons by continuous near-infrared laser, Cell Biochemistry and Biophysics, 53(1): 33–42
18. W. Cheng, F. Yang, C. L. Takanishi, and J. Zheng (2007) Thermosensitive TRPV channel subunits co-assemble into heteromeric channels with intermediate conductance and gating properties, Journal of General Physiology, 129(3): 191-207 **Featured on the Cover.
19. MZ. Wang, S. Qiu, YL. Hua, F. Yang, Y. Shen, JH. Luo (2005) Optimization of three-cube FRET assay and application in the analysis of subunit assembling of iGluR receptors in living cells, Acta Anatomica Sinica, 36(4): 447-451
20. S. Qiu, YL. Hua, F. Yang, YZ. Chen, and JH. Luo (2005) Subunit assembly of N-Methyl-D-aspartate receptors analyzed by fluorescence resonance energy transfer, Journal of Biological Chemistry, 280(26): 24923-24930
学术书籍
1. F. Yang and J. Zheng (2010) Fluorescence microscopy in thermoTRP channel research, TRP Channels, Edited by Michael X. Zhu, CRC Press, Chapter 15
2. J. Zheng and F. Yang (2013) Patch Fluorometry, Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester.
