2022 Publications
1) Mengyang Shen, Yuanshuang Xu, Xinying Zhang,* and Xuesen Fan.* Synthesis of spirocyclopropylpyrazole derivatives via the cascade reaction of alkylidenecyclopropanes with pyrazolidinones and trifluoroethanol. Org. Chem. Front. 2022, 9(5), 1410-1416.
2) Qianting Zhou, Xia Song, Xinying Zhang,* Xuesen Fan.* Synthesis of Spiro[benzo[d][1,3]oxazine-4,4'-isoquinoline]s via [4+1+1] Annulation of N-Aryl Amidines with Diazo Homophthalimides and O2. Org. Lett. 2022, 24(6), 1280-1285.
3) Caiyun Yu, Yuanshuang Xu, Xinying Zhang*, and Xuesen Fan.* Synthesis of N-Arylindoles from 2-Alkenylanilines and Diazonaphthalen-2(1H)-ones through Simultaneous Indole Construction and Aryl Introduction. J. Org. Chem. 2022, 87 (11), 7392-7404.
4) Xia Song, Kelin Wang, Lian Xue, Haibo Yu, Xinying Zhang*, Richmond Lee*, Xuesen Fan.* Coupling partner-dependent unsymmetrical C-H functionalization of N-phenoxyacetamides leading to sophisticated spirocyclic scaffolds. Org. Chem. Front. 2022, 9(17), 4583-4590.
5) Guang Chen, Xinyuan Cai, Xinying Zhang*, and Xuesen Fan.* Condition-Dependent Selective Synthesis of Indolo[1,2-c]quinazolines and Indolo[3,2-c]quinolines from and Sulfoxonium Ylides. J. Org. Chem. 2022, 87 (15), 9815-9828.
6) Chunhua Ma, Yue Wang, Guang Chen, Jingyi Li, Yuqin Jiang, Xinying Zhang*, Xuesen Fan.* Divergent construction of 3-(indol-2-yl)succinimide/maleimide and fused benzodiazepine skeletons from 2-(1H-indol-1-yl)anilines and maleimides. Org. Chem. Front. 2022, 9 (17), 4663-4669.
7) Na Li, Xinying Zhang*, Xuesen Fan.* Synthesis of pyrazolidinone fused cinnolinesviathe cascade reactions of 1-phenylpyrazolidinones with vinylene carbonate. Tetrahedron Lett. 2022, 103, 153984.
8) Xinyuan Cai, Xia Song, Qiuhui Zhu, Xinying Zhang*, Xuesen Fan.* Concise Synthesis of Spirocyclic Dihydrophthalazines through Spiroannulation Reactions of Aryl Azomethine Imines with Cyclic Diazo Compounds. J. Org. Chem. 2022, 87 (16), 11048-11062.
9) Mengyang Shen, Hao Li,; Xinying Zhang, Xuesen Fan.* Rh(III)-catalyzed simultaneous [3+3]/[5+1] annulation of 1-arylpyrazolidinones with gem-difluorocyclopropenes leading to fluorinated pyridopyrimidinone derivatives. Org. Chem. Front. 2022, 9, 5976-5982
10) Bin Li,* Nana Shen, Kelin Wang, Xuesen Fan, and Xinying Zhang.* Rh(III)-Catalyzed Reaction of 2-Aryl-3-acyl-1H-indoles with α-Diazo Carbonyl Compounds: Synthesis of 5-Carbonyl Substituted Benzo[a]carbazoles via [5+1] Annulation. Asian J. Org. Chem. 2022, 11 (3), e202100710.
2021 Publications
1) Yuanshuang Xu, Caiyun Yu, Xinying Zhang,* and Xuesen Fan.* Selective Synthesis of Dihydrophenanthridine and Phenanthridine Derivatives from the Cascade Reactions of o-Arylanilines with Alkynoates through C-H/N-H/C-C Bond Cleavage. J. Org. Chem., 2021, 86 (8), 5805-5819.
2) Linghua Zhang, Jie Zhao, Yuqin Jiang, Xinying Zhang,* Xuesen Fan.* Synthesis of tetracyclic indenopyrazolopyrazolones through cascade reactions of aryl azomethine imines with propargyl alcohols. Org. Chem. Front. 2021, 8 (14), 3734-3739.
3) Muhua Wang, Linghua Zhang, Xi Chen, Xinying Zhang,* Xuesen Fan.* An unusual reaction mode of 1-phenylpyrazolidinones toward diazonaphthalen-2(1H)-ones featuring cascade C(sp(2))-H and C(sp(3))-H bond cleavage. Org. Chem. Front. 2021, 8 (13), 3238-3243.
4) Qianting Zhou, Xia Song, Xinying Zhang,* Xuesen Fan.* Synthesis of 3-spirooxindole 3H-indoles through Rh(III)-catalyzed [4+1] redox-neutral spirocyclization of N-aryl amidines with diazo oxindoles. Org. Chem. Front. 2021, 8 (15), 4131-4137.
5) Yujie Yang, Na Li, Jie Zhao, Yuqin Jiang, Xinying Zhang,* and Xuesen Fan.* Selective Synthesis of 3-(α-Fluorovinyl)indoles and 3-Acylindoles via the Cascade Reactions of 1-Phenylpyrazolidinones with α, α-Difluoromethylene Alkynes. Adv. Synth. Catal. 2021, 363 (14), 3600-3606.
6) Bing Hu, Guang Chen, Jie Zhao, Lian Xue, Yuqin Jiang, Xinying Zhang,* and Xuesen Fan.* Synthesis of Succinimide Spiro-Fused Sultams from the Reaction of N-(Phenylsulfonyl)acetamides with Maleimides via C(sp2)–H Activation. J. Org. Chem., 2021, 86 (15), 10330–10342.
7) Fang Wang, Qianting Zhou, Xinying Zhang,* and Xuesen Fan.* Direct α-Alkenylation of Cyclic Amines with Maleimides through Fe(III)-Catalyzed C(sp3)-H/C(sp2)-H Cross Dehydrogenative Coupling. J. Org. Chem., 2021, 86(17), 11708-11722.
8) Xia Song, Xinyuan Cai, Xinying Zhang,* and Xuesen Fan.* Synthesis of N-acylbenzimidazoles through [4+1] annulation of N-aryl pivalimidamides with dioxazolones. Org. Chem. Front. 2021, 8 (22), 6265-6272.
9) Guang Chen, Yue Wang, Jie Zhao, Xinying Zhang,* and Xuesen Fan.* Synthesis of Hydroxysuccinimide Substituted Indolin-3-ones via One-Pot Cascade Reaction of o-Alkynylnitrobenzenes with Maleimides under Au(III)-Cu(II) Relay/Synergetic Catalysis. J. Org. Chem., 2021, 86(21), 14652-14662.
10) Mengyang Shen, Jie Zhao, Yuanshuang Xu, Xinying Zhang,* and Xuesen Fan.* Synthesis of Dihydroquinolinone Derivatives via the Cascade Reaction of o-Silylaryl Triflates with Pyrazolidinones. J. Org. Chem., 2021, 86(21), 15203-15216.
11) Yuanshuang Xu, Caiyun Yu, Xinying Zhang,* and Xuesen Fan.* Synthesis of Indolyl-Tethered Spiro[cyclobutane-1,1'-indenes] through Cascade Reactions of 1-(Pyridin-2-yl)-1H-indoles with Alkynyl Cyclobutanol. Org. Lett. 2021, 23 (21), 8510-8515.
12) Yan He,* Zhi Zheng, Jintao Yang, Xinying Zhang, Xuesen Fan.* Recent advances in the functionalization of saturated cyclic amines. Org. Chem. Front. 2021, 8(16), 4582-4606.
13) Yan He,* Jintao Yang, Xinying Zhang and Xuesen Fan.* Selective cleavage and reconstruction of C–N/C–C bonds in saturated cyclic amines: tunable synthesis of lactams and functionalized acyclic amines. Org. Chem. Front. 2021, 8(18), 5118-5123.
14) Bin Li,* Nana Shen, Yujie Yang, Xinying Zhang, and Xuesen Fan.* Tunable Synthesis of Indeno[1,2-c]furans and 3-Benzoylindenones via FeCl3-CatalyzedCarbene/Alkyne Metathesis Reaction of o-Alkynylbenzoyl Diazoacetates. Org. Lett. 2021, 23(2), 388–393.
2020 Publications
1) Xia Song, Bao Nguyen Do Doan, Xinying Zhang, Richmond Lee* and Xuesen Fan*. Complementary C–H Functionalization Mode of Benzoylacetonitriles: Computer-Augmented Study of a Regio- and Stereoselective Synthesis of Functionalized Benzofulvenes. Org. Lett., 2020, 22(1), 46-51.
2) Fang Wang, Xinying Zhang*, Yan He, Xuesen Fan*.Synthesis of β-Dicarbonylated Tetrahydropiperidines via Direct Oxidative Cross-Coupling between Different C(sp3)–H Bonds.J. Org. Chem. 2020, 85, 2220-2230.
3) Guang Chen, Bin Li, Bing Hu, Xinying Zhang,* Xuesen Fan*. FeCl3-catalyzed C-3 functionalization of imidazo[1,2-a]pyridines with diazoacetonitrile under oxidant- and ligand-free conditions. Tetrahedron Lett., 2020, doi: 10.1016/j.tetlet.2020.151774.
4) Yuanshuang Xu, Mengyang Shen, Xinying Zhang*, and Xuesen Fan*. Selective Synthesis of Pyrazolo[1,2-a]pyrazolones and 2-Acylindoles via Rh(III)-Catalyzed Tunable Redox-Neutral Coupling of 1-Phenylpyrazolidinones with Alkynyl Cyclobutanols. Org. Lett., 2020, 22, 4697-4702.
5) Xi Chen, Muhua Wang, Xinying Zhang*, Xuesen Fan*. A novel synthesis of diversely functionalized 1,2,4-triones through the homo- and cross-coupling reactions of β-keto sulfoxonium ylides. Tetrahedron Letters, 2020, 61 151912.
6) Linghua Zhang, Yuanshuang Xu, Xiaopeng Zhang, Xinying Zhang*, Xuesen Fan*. Synthesis of pyrazolone fused benzodiazepines via Rh(III)-catalyzed [4+3] annulation of 1-phenylpyrazolidinones with propargyl alcohols. Org. Chem. Front., 2020, 7, 2284-2290.
7) Bin Li,* Nana Shen, Yujie Yang, Xinying Zhang, Xuesen Fan*. Synthesis of naphtho[1',2':4,5]imidazo[1,2-a]pyridines via Rh(iii)-catalyzed C-H functionalization of 2-arylimidazo[1,2-a]pyridines with cyclic 2-diazo-1,3-diketones featuring with a ring opening and reannulation. Org. Chem. Front. 2020, 7, 919-925.
8) Shenghai Guo,* Yangfan Liu, Yaping Wang, Xinying Zhang,* Xuesen Fan*. Construction of Bridged Carbocycles and Heterocycles via Rh(III)-Catalyzed C-H Alkylation/Michael Addition of 2-Arylindoles with Quinone Monoacetals. J. Org. Chem. 2020, 85, 8910-8922.
9) Shenghai Guo,* Yangfan Liu, Xinying Zhang, Xuesen Fan*.Iridium-Catalyzed Oxidative Annulation of 2-Arylindoles with Benzoquinone Leading to Indolo[1,2-f]phenanthridin-6-ols. Adv. Synth. Catal. 2020, 362, 3011-3020.
10) Shenghai Guo,* Lincong Sun, Xuzhuo Li, Xinying Zhang, Xuesen Fan*.Selective Synthesis of Indazolo[2,3-a]quinolines via Rh(III)-Catalyzed Oxidant-Free [4+2] or [5+1] Annulation of 2-Aryl-2H-indazoles with α-Diazo Carbonyl Compounds. Adv. Synth. Catal. 2020, 362, 913-926.
11) Ruixue Jia, Bin Li,* Xinying Zhang, Xuesen Fan*. Selective Synthesis of 2-Indolyl-3-oxoindolines or 2-(2-Aminophenyl)quinolines through Cu(II)- or Bi(III)-Catalyzed Tunable Dimerizations of 2-Alkynylanilines. Org. Lett. 2020, 22(17), 6810-6815.
12) Cai Gao, Qianting Zhou, Li Yang, Xinying Zhang* and Xuesen Fan*. Synthesis of alpha-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions.J. Org. Chem. 2020, 85(21), 13710-13720.
13) Xia Song, Qianting Zhou, Jie Zhao, Yuqin Jiang, Xiaopeng Zhang, Xinying Zhang,* Xuesen Fan*. Synthesis of 1,3-Benzodiazepines through [5 + 2] Annulation of N-Aryl Amidines with Propargylic Esters. Org. Lett. 2020, 22(24), 9506-9512.
14) Yan He,* Zhi Zheng, Qimeng Liu, Xinying Zhang, Xuesen Fan*. Solvent-Regulated Coupling of 2-Alkynylbenzaldehydes with Cyclic Amines: Selective Synthesis of Fused N-Heterocycles and Functionalized Naphthalene Derivatives. Org. Lett. 2020, 22(22), 9053-9058.
15) Yan He,* Jintao Yang, Qimeng Liu, Xinying Zhang, Xuesen Fan*. Synthesis of beta-Methylsulfonylated N-Heterocycles from Saturated Cyclic Amines with the Insertion of Sulfur Dioxide. J. Org. Chem. 2020, 85(23), 15600-15609.
16) Bin Li,* Chenhao Guo, Nana Shen, Xinying Zhang, Xuesen Fan*. Synthesis of maleimide fused benzocarbazoles and imidazo[1,2-a]pyridines via rhodium(iii)-catalyzed [4+2] oxidative cycloaddition. Organic Chemistry Frontiers, Org. Chem. Front. 2020, 7(22), 3698-3704.
2019 Publications
1). Fang Wang, Xinying Zhang, Yan He, Xuesen Fan*. Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the ring contraction and deformylative functionalization of piperidine derivatives. Org. Biomol. Chem., 2019, 17 (1), 156-164.
2). Xi Chen, Muhua Wang, Xinying Zhang*, and Xuesen Fan*. Rh(III)-Catalyzed Cascade Reactions of Sulfoxonium Ylides with α-Diazocarbonyl Compounds: An Access to Highly Functionalized Naphthalenones. Org. Lett., 2019, 21(8),2541-2545.
3). Tian Feng, Yan He,* Xinying Zhang, Xuesen Fan.* Synthesis of Functionalized Cyclobutane-Fused Naphthalene Derivatives via Cascade Reactions of Allenynes with tert-Butyl Nitrite. Adv. Synth. Catal., 2019, 361 (6), 1271-1276.
4). Ruixue Jia, Bin Li, Rong Liang, Xinying Zhang*, and Xuesen Fan*. Tunable Synthesis of Indolo[3,2-c]quinolines or 3-(2-Aminophenyl)quinolines via Aerobic/Anaerobic Dimerization of 2-Alkynylanilines. Org. Lett., 2019, 21 (13), 4996-5001.
5). Cai Gao, Bin Li, Xueyang Geng, Qianting Zhou, Xinying Zhang* and Xuesen Fan.* Two birds with one stone: one-pot simultaneous synthesis of 2,2,2-trifluoroethylphenanthridines and benzochromenones featuring the utilization of the byproduct of Togni’s reagent. Green Chem., 2019, 21(18), 5113-5117.
6). Chenhao Guo, Bin Li, Huilai Liu, Xiaopeng Zhang, Xinying Zhang* and Xuesen Fan.* Synthesis of Fused or Spiro Polyheterocyclic Compounds via the Dehydrogenative Annulation Reactions of 2-Arylindazoles with Maleimides.Org. Lett., 2019, 21(18), 7189-7193.
7). Yuanshuang Xu, Linghua Zhang, Mengyang Liu, Xiaopeng Zhang, Xinying Zhang* and Xuesen Fan.* Synthesis of benzoazepine derivatives via Rh(III)-catalyzed inert C(sp2)-H functionalization and [4 + 3] annulations. Org. Biomol. Chem. 2019, 17 (38), 8706-8710.
8). Fang Wang, Xinying Zhang, Yan He, Xuesen Fan*. A novel synthesis of 3-hydroxypiperidin-2-ones via site-selective difunctionalization of piperidine derivatives. Tetrahedron Lett., 2019, 60(42), 151155-151158.
9). Shenghai Guo,* Lincong Sun, Yangfan Liu, Nana Ma,* Xinying Zhang, Xuesen Fan.* Rh(III)-Catalyzed Oxidative Spirocyclization of Isoquinolones with α-Diazo-1,3-indandiones. Org. Lett., 2019, 21, 4082-4086.
10). Shenghai Guo*, Yangfan Liu, Lu Zhao, Xinying Zhang and Xuesen Fan.*Rhodium-Catalyzed Selective Oxidative (Spiro)annulation of 2-Arylindoles by Using Benzoquinone as a C2 or C1 Synthon. Org. Lett., 2019, 21(16), 6437-6441.
11). Shenghai Guo,* Fang Wang, Yangfan Liu, Xuesen Fan.* Palladium-catalyzed carbonylative synthesis of indoloisoindoloquinazolinone derivatives by using CO as a carbonyl source. Tetrahedron 2019, 75 (24), 3355-3360.
12). Yan He*, Zhi Zheng, Yajie Liu, Jiajie Qiao, Xinying Zhang, and Xuesen Fan*. Selective Cleavage and Tunable Functionalization of the C–C/C–N Bonds of N-Arylpiperidines Promoted by tBuONO. Org. Lett., 2019, 21(6),1676-1680.
13). Yan He*, Tian Feng and Xuesen Fan*. Synthesis of Functionalized Indole-1-oxide Derivatives via Cascade Reactions of Allenynes and tBuONO. Org. Lett., 2019, 21(11), 3918-3922.
14). Yan He,* Zhi Zheng, Yajie Liu, Jiajie Qiao, Xinying Zhang, Xuesen Fan.* Selective synthesis of β-nitrated N-heterocycles and N-nitroso-2-alkoxyamine aldehydes from inactivated cyclic amines promoted by tBuONO and oxoammonium salt. Chem. Commun., 2019, 55 (82), 12372-12375.
15). Bin Li,* Nana Shen, Xinying Zhang and Xuesen Fan.* Synthesis of fused imidazo[1,2-a]pyridines derivatives through cascade C(sp2)–H functionalizations. Org. Biomol. Chem., 2019, 17(41), 9140-9150.
2018 Publications
1). Xiaonan Shi, Yan He, Xinying Zhang*, and Xuesen Fan*.FeCl3–catalyzed Cascade Reactions of Cyclic Amines with 2-Oxo-2-arylacetic Acids toward Furan-2(5H)-one Fused N,O-Bicyclic Compounds. Adv. Synth. Catal., 2018, 360 (2), 261-266.
2). Fang Wang, Yan He*, Miaomiao Tian, Xinying Zhang, and Xuesen Fan*. Synthesis of α-Formylated N-Heterocycles and Their 1,1-Diacetates from Inactivated Cyclic Amines Involving an Oxidative Ring Contraction. Org. Lett., 2018, 20 (3), 864-867.
3). Tian Feng, Miaomiao Tian, Xinying Zhang*, Xuesen Fan*. Tunable Synthesis of Functionalized Cyclohexa-1,3-dienes and 2-Aminobenzophenones/ Benzoate from the Cascade Reactions of Allenic Ketones/Allenoate with Amines and Enones. J. Org. Chem., 2018, 83 (7), 5313-5322.
4). Yuanshuang Xu, Bin Li, Xinying Zhang*, Xuesen Fan*. One-Pot Synthesis of Fused N,O-Heterocycles through Rh(III)-Catalyzed Cascade Reactions of Aromatic/Vinylic N-Alkoxyamides with 4-Hydroxy-2-alkynoates. Adv. Synth. Catal., 2018, 360 (14), 2613-2620.
5). Xiaonan Shi, Xi Chen, Muhua Wang, Xinying Zhang*, Xuesen Fan*. Regioselective Synthesis of Acylated N-Heterocycles via the Cascade Reactions of Saturated Cyclic Amines with 2-Oxo-2-arylacetic Acids. J. Org. Chem., 2018, 83 (12), 6524-6533.
6). Shitao Duan, Yuanshuang Xu, Xinying Zhang*, Xuesen Fan*. Facile and regioselective synthesis of functionalized benzenes via cascade reactions of 1,2-allenic ketones with 4-sulfonyl crotonates. Tetrahedron, 2018, 74 (30), 4029-4035.
7). Xia Song, Cai Gao, Bin Li, Xinying Zhang,* Xuesen Fan.* Regioselective Synthesis of 2-Alkenylindoles and 2-Alkenylindole-3-carboxylates through the Cascade Reactions of N-Nitrosoanilines with Propargyl Alcohols. J. Org. Chem., 2018, 83 (15), 8509-8521.
8). Beibei Zhang, Bin Li, Chenhao Guo, Xinying Zhang,* Xuesen Fan.* Cascade C-H bond functionalizations of benzoyl acetonitriles/methylsulfones with cyclic 2-diazo-1,3-dicarbonyl compounds: An efficient access to diversely functionalized naphtho[1,8- bc]pyrans. Tetrahedron Lett., 2018, 59, 3094-3099.
9). Guang Chen, Xinying Zhang,* Ruixue Jia, Bin Li and Xuesen Fan.* Selective Synthesis of Benzo[a]Carbazoles and Indolo[2,1-a]-Isoquinolines via Rh(III)-Catalyzed C−H Functionalizations of 2-Arylindoles with Sulfoxonium Ylides. Adv. Synth. Catal., 2018, 360(19), 3781-3787.
10). Qianqian Wang, Xinying Zhang,* Xuesen Fan.* Synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by tert-butyl nitrite. Org. Biomol. Chem., 2018, 16 (41), 7737-7747.
11). Xia Song, Cai Gao, Xinying Zhang,* and Xuesen Fan.* Synthesis of Diversely Functionalized 2H-Chromenes through Pd-Catalyzed Cascade Reactions of 1,1-Dibromoolefin Derivatives with Arylboronic Acids. J. Org. Chem., 2018, 83 (24), 15256-15267.
12). Qiang Wang,* Tao Zhang, Yunchang Fan, Xuesen Fan.* Synthesis of functionalized cyclopentenes through allenic ketone-based multicomponent reactions. Org. Biomol. Chem., 2018, 16(45), 8854-8858.
13). Shenghai Guo,* Fang Wang, Lincong Sun, Xinying Zhang, Xuesen Fan.* Palladium-Catalyzed Oxidative Cyclocarbonylation of Isoquinolones with CO via C-H/N-H Bond Cleavage: Easy Access to Isoindolo[2,1-b]isoquinoline-5,7-dione Derivatives. Adv. Synth. Catal., 2018, 360(13), 2537-2545.
14). Shenghai Guo,* Fang Wang, Li Tao, Xinying Zhang, Xuesen Fan.*Solvent-Dependent Copper-Catalyzed Indolyl C3-Oxygenation and N1-Cyclization Reactions: Selective Synthesis of 3H-Indol-3-ones and Indolo[1,2-c]quinazolines. J. Org. Chem., 2018, 83 (7), 3889-3896.
15). Shenghai Guo*, Lincong Sun, Fang Wang, Xinying Zhang, and Xuesen Fan.* Rh(III)-Catalyzed Oxidative Annulation of Isoquinolones with Diazoketoesters Featuring an in Situ Deacylation: Synthesis of Isoindoloisoquinolones and Their Transformation to Rosettacin Analogues. J. Org. Chem., 2018, 83 (19), 12034-12043.
2017 Publications
1). Bin Li, Beibei Zhang, Xinying Zhang*, Xuesen Fan*. Regio-selective synthesis of diversely substituted benzo[a]carbazoles through Rh(III)-catalyzed annulation of 2-arylindoles with α-diazo carbonyl compounds. Chem. Commun., 2017, 53, 1297-1300.
2). Beibei Zhang, Bin Li, Xinying Zhang*, Xuesen Fan*. Synthesis of Naphthoquinolizinones through Rh(III)-Catalyzed Double C(sp(2))-H Bond Carbenoid Insertion and Annulation of 2-Aryl-3-cyanopyridines with α-Diazo Carbonyl Compounds. Org. Lett., 2017, 19, 2294−2297.
3). Ze Wang, Guang Chen, Xinying Zhang,* Xuesen Fan.* Synthesis of 3-acylquinolines through Cu-catalyzed double C(sp3)–H bond functionalization of saturated ketones. Org. Chem. Front., 2017, 4, 612-616.
4). Miaomiao Tian, Xiaonan Shi, Xinying Zhang*, Xuesen Fan*. Synthesis of 4-Acylpyrazoles from Saturated Ketones and Hydrazones Featured with Multiple C(sp3)-H Bond Functionalization and C-C Bond Cleavage and Reorganization. J. Org. Chem., 2017, 82, 7363-7372.
5). Yuanshuang Xu, Bin Li, Xinying Zhang*, Xuesen Fan*. Metal-Free Synthesis of 2-Aminobenzothiazoles via Iodine-Catalyzed and Oxygen-Promoted Cascade Reactions of Isothiocyanatobenzenes with Amines. J. Org. Chem., 2017, 82, 9637−9646.
6). Xiaonan Shi, Yan He, Xinying Zhang*, Xuesen Fan*. Selective syntheses of diversely substituted 2-hydroxy-4′-hydroxybenzophenones through [4+2] or [3+3] annulation of penta-3,4-dien-2-ones with 3-formylchromones. Org. Chem. Front., 2017, 4, 1967–1971.
7). Qianqian Wang, Zhangxin Wang, Xinying Zhang*, and Xuesen Fan*. Microwave-Promoted Metal-Free -Alkylation of Ketones with Cycloalkanes through Cross-Coupling of C(sp3)-H Bonds. Asian J. Org. Chem., 2017,6, 1445–1450.
8). Qiang Wang, Xiaonan Shi, Xinying Zhang*, Xuesen Fan*. A Convenient Synthesis of 1-Aryl-1H-1,2,3-triazoles from Aliphatic Substrates. Org. Biomol. Chem., 2017, 15, 8529 - 8534.
9). Guang Chen, Ze Wang, Xinying Zhang*,and Xuesen Fan*. Synthesis of Functionalized Pyridines via Cu(II)-Catalyzed One-Pot Cascade Reactions of Inactivated Saturated Ketones with Electron-Deficient Enamines. J. Org. Chem., 2017, 82 (20), 11230–11237.
10).Yan He*, Fang Wang, Xinying Zhang, Xuesen Fan*. C(sp3)–H dehydrogenation and C(sp2)–H alkoxycarbonylation of inactivated cyclic amines towards functionalized N-heterocycles. Chem. Commun., 2017, 53, 4002-4005.
11). Shenghai Guo,* Jianhui Zhai, Xuesen Fan.* An I-2-mediated cascade reaction of 2'-bromoacetophenones with benzohydrazides/ benzamides leading to quinazolino[3,2-b]cinnoline or tryptanthrin derivatives. Org. Biomol. Chem., 2017, 15, 1521–1529.
12). Shenghai Guo,* Jianhui Zhai, Fang Wang, Xuesen Fan.*One-pot three-component selective synthesis of isoindolo[2,1-a]quinazoline derivatives via a palladium-catalyzed cascade cyclocondensation/ cyclocarbonylation sequence. Org. Biomol. Chem., 2017, 15, 3674–3680.
2016 Publications
1). Shitao Duan, Yuanshuang Xu, Xinying Zhang* and Xuesen Fan*. Synthesis of 2,2’-biphenols through direct C(sp2)–H hydroxylation of [1,1’-biphenyl]-2-ols. Chem. Commun., 2016, 52(69), 10529-10532.
2). Xuesen Fan*, Yan He, and Xinying Zhang*. Recent Advances in the Reactions of 1,2-Allenic Ketones and α-Allenic Alcohols. Chem. Rec., 2016, 16(3), 1635–1646.
3). Ju Zhang, Xinying Zhang*,and Xuesen Fan*.Synthesis of Indeno[1′,2′:4,5]imidazo[1,2-a]pyridin-11-ones and Chromeno[4′,3′:4,5]imidazo[1,2-a]pyridin- 6-ones through Palladium-Catalyzed Cascade Reactions of 2-(2-Bromophenyl)imidazo[1,2-a]pyridines. J. Org. Chem., 2016, 81(8), 3206−3213.
4). Ze Wang, Bin Li, Xinying Zhang, and Xuesen Fan*. One-Pot Cascade Reactions Leading to Pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo[1,5-a] quinolines under Bimetallic Relay Catalysis with Air as the Oxidant. J. Org. Chem., 2016, 81(15), 6357−6363.
5). Bin Li, Nana Shen, Xuesen Fan*, Xinying Zhang. Synthesis of 1-naphthaldehydes via the cascade reactions of 1-phenylpent-4-yn-2-ols promoted by iodine monochloride. Tetrahedron Lett, 2016, 57(17), 1843–1846.
6). Bin Li, Beibei Zhang, Xinying Zhang*, and Xuesen Fan*. Synthesis of 3-Cyano-1H-indoles and Their 2′-Deoxyribonucleoside Derivatives through One-Pot Cascade Reactions. J. Org. Chem., 2016, 81 (20), 9530-9538.
7). Qianqian Wang, Zhangxin Wang, Yuanshuang Xu, Xinying Zhang*, and Xuesen Fan*. Bu4NI-Catalyzed and tBuOOH-Oxidized Esterification of Aldehydes with Alkyl Halides in Water. Asian J. Org. Chem., 2016, 5(11), 1304-1308.
8). Yan He, Ningning Zhao, Liqi Qiu, Xinying Zhang*, and Xuesen Fan*. Regio- and Chemoselective Mono- and Bisnitration of 8-Aminoquinoline Amides with Fe(NO3)3·9H2O as Promoter and Nitro Source. Org. Lett., 2016, 18 (23), 6054–6057.
9). Shenghai Guo,* Li Tao, Fang Wang, Xuesen Fan.* Pd-Catalyzed Cyclocarbonylation of 2-(2-Bromoaryl)indoles with CO as a C1 Source: Selective Access to 6H-Isoindolo[2,1-a]indol-6-ones and Indeno[1,2-b]indol-10(5H)-ones. Chem. Asian J., 2016, 11, 3090-3096.
2015 Publications
1). Xinying Zhang*, Zhangxin Wang, Xuesen Fan*, and Jianji Wang. Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)−H Bond. J. Org. Chem., 2015, 80, 10660−10667.
2). Xin-Ying Zhang*,Xiao-Jie Guo, and Xue-Sen Fan*. Synthesis of 2-Aminoquinoline-3-carboamides and Pyrimido[4,5-b]quinolin-4-ones through Copper-Catalyzed One-pot Multicomponent Reactions. Chem. Asian J., 2015, 10, 106-111.
3). Yan He, Xinying Zhang*, and Xuesen Fan*. Synthesis of diversely substituted 2-(furan-3-yl)acetates from allenols through cascade carbonylations. Chem. Commun., 2015, 51, 16263-16266.
4). Xuesen Fan*, Meng Yan, Yuanyuan Wang, and Xinying Zhang*. Synthesis of pyrazolo[5,1-a]isoquinolines and 8-methylenepyrazolo[5,1-a]isoindoles via regio-selective C-C coupling and alkyne hydroamination. J. Org. Chem., 2015, 80, 10536−10547.
5). Miaomiao Tian, Yan He, Xinying Zhang*, and Xuesen Fan*. Synthesis of Pyrazolo[5,1-a]isoindoles and Pyrazolo[5,1-a]isoindole-3-carboxamides through One-Pot Cascade Reactions of 1-(2-Bromophenyl)buta-2,3-dien-1-ones with Isocyanide and Hydrazine or Acetohydrazide. J. Org. Chem., 2015, 80(15), 7447-7455.
6). Bin Li, Shenghai Guo, Ju Zhang, Xinying Zhang*, and Xuesen Fan*. Selective Access to 3-Cyano-1H-indoles, 9H-Pyrimido[4,5-b]indoles, or 9H-Pyrido[2,3-b]indoles through Copper-Catalyzed One-Pot Multicomponent Cascade Reactions. J. Org. Chem., 2015, 80, 5444−5456.
7). Xue-Sen Fan,* Ju Zhang, Bin Li, and Xin-Ying Zhang*. One-pot Sequential Reactions Featuring a Copper-catalyzed Amination Leading to Pyrido[2’,1’:2,3]imidazo[4,5-c]quinolines and Dihydropyrido[2',1':2,3]imidazo[4,5-c] quinolines. Chem. Asian J., 2015, 6, 1281-1285.
8). Yan He, Shenghai Guo, Xinying Zhang,* Chenhao Guo, and Xuesen Fan*. Synthesis of Dibenzo[b,d]furans through One-pot Cascade Reactions of 1-Arylpenta-3,4-dien-2-ones with Activated Ketones. Tetrahedron Lett., 2015, 56(12), 1513-1516.
9). Xuesen Fan*, Meng Yan, Yan He, Nana Shen, and Xinying Zhang*. Synthesis of Functionalized Phenols via the Cascade Reactions of Allenic Ketones with b-Diketones. Asian J. Org. Chem., 2015, 4, 368–376.
10). 李培源，张建瑞，郭胜海，张新迎*，范学森*，溴呋啶及其类似物的合成新方法研究. 有机化学, 2015, 35, 910-916.
11). Peiyuan Li, Xinying Zhang, and Xuesen Fan.* Synthesis of naphtho[1',2':4,5]imidazo[1,2-a]pyridines and imidazo[5,1,2-cd]indolizines through Pd-catalyzed cycloaromatization of 2-phenylimidazo[1,2-a]pyridines with alkynes. J. Org. Chem., 2015, 80, 7508-7518.
12). Shenghai Guo,* Li Tao, Wenwen Zhang, Xinying Zhang, and Xuesen Fan*. Regioselective Synthesis of Indolo[1,2-c]quinazolines and 11H-Indolo[3,2-c]quinolines via Copper-Catalyzed Cascade Reactions of 2-(2-Bromoaryl)-1H-indoles with Aldehydes and Aqueous Ammonia. J. Org. Chem., 2015, 80, 10955−10964.
13). Shenghai Guo*, Jiliang Wang, Xinying Zhang, Sandrine Cojean, Philippe M. Loiseau, and Xuesen Fan*. Synthesis of 5-isoxazol-3-yl-pyrimidine nucleosides as potential antileishmanial agents. Bioorg. Med. Chem. Lett., 2015, 25, 2617–2620.
2014 Publications
1) Xuesen Fan*, Yan He, Xinying Zhang, Jianji Wang. Sustainable and selective synthesis of 3,4-dihydro quinolizin-2-one and quinolizin-2-one derivatives via the reactions of penta-3,4-dien-2-ones. Green Chem., 2014, 16(3), 1393-1398.
2) Xuesen Fan*, Bin Li, Shenghai Guo,Yuanyuan Wang, Xinying Zhang. Synthesis of quinazolines and tetrahydroquinazolines: copper-catalyzed tandem reactions of 2-bromobenzyl bromides with aldehydes and aqueous ammonia or amines. Chem. Asian J.,2014, 9(3), 739-743.
3) Xinying Zhang*, Yunping Song, Lin Gao, Xiaojie Guo, Xuesen Fan*. Highly facile and regio-selective synthesis of pyrazolo[1,5-a]pyrimidines via reactions of 1,2-allenic ketones with amino pyrazoles. Org. Biomol. Chem., 2014, 12(13), 2099-2107.
4) Xuesen Fan*, Yuanyuan Wang, Yan He, Shenghai Guo, Xinying Zhang*.Synthesis of 1,2,3-tri-substituted indolizines, pyrrolo[1,2-a]quinolines, and pyrrolo[2,1-a]isoquinolines from 1,2-allenyl ketones. Eur. J. Org. Chem., 2014, (4), 713-717.
5) Qiang Wang, Lei Yang, Xuesen Fan*. Selective synthesis of 3-methylene-2,3-dihydrofurans or 1,2,4-tri- substituted furans via tandem reactions of allenic ketones with α-chloro β-keto Esters or ketones. Synlett, 2014, 25(5), 687-692.
6) 范学森*,李培源,李坤,张新迎,赵婉. 6-溴代呋喃[2,3-d]嘧啶双环核苷的合成新方法研究. 有机化学, 2014, 34, 999-1005.
7) Xuesen Fan*, Nana Shen, Bin Li, Shenghai Guo, and Xinying Zhang*. Synthesis of 3-(4-oxo-4H-chromen-3-yl)acrylates through the tandem reaction of 3-(2-buta-2,3-dienoylphenoxy)acrylates. RSC Adv., 2014, 4(29), 15081-15086.
8) Yan He, Xinying Zhang*, and Xuesen Fan*. One-pot cascade reactions of 1-arylpenta-3,4-dien-2-ones leading to 2-arylphenols and dibenzopyroanones. Chem. Commun., 2014, 50, 14968-14970.
9) Yan He, Xinying Zhang and Xuesen Fan*. Synthesis of naphthalene amino esters and arylnaphthalene lactone lignans through tandem reactions of 2-alkynylbenzonitriles. Chem. Commun., 2014, 50, 5641-5643.
10) Yan He, Xinying Zhang and Xuesen Fan*. Synthesis of Aminonaphthopyranones and Aminonaphthochromenones by Blaise-Reaction- Initiated Cascade Procedures. Asian J. Org. Chem., 2014, 3, 1284-1291.
11) Yan He, Shenghai Guo, Xinying Zhang, and Xuesen Fan*. Zinc-mediated one-pot tandem reaction of nitriles with propargyl bromides: an easy access to 3-alkynylpyridines and their applications. J. Org. Chem., 2014, 79, 10611-10618.
12) Bin Li, Chenhao Guo, Xuesen Fan*, Jv Zhang, Xinying Zhang. Synthesis of Substituted Quinoline via Copper-Catalyzed One-Pot Cascade Reactions of 2-Bromobenzaldehydes with Aryl Methyl Ketones and Aqueous Ammonia. Tetrahedron Lett., 2014, 55, 5944-5948.
13) Shenghai Guo*,Yan Li, Li Tao, Wenwen Zhang, Xuesen Fan*, Rapid assembly of quinazolinone scaffold via copper-catalyzed tandem reaction of 2-bromobenzamides with aldehydes and aqueous ammonia: application to the synthesis of the alkaloid tryptanthrin. RSC adv., 2014, 4, 59289-59296.
14) Shenghai Guo*, Jiliang Wang, Yan Li, Xuesen Fan*, CuCl-catalyzed one-pot synthesis of 5,6-dihydropyrazolo[1,5-c]quinazolines. Tetrahedron, 2014, 70 (14), 2383-2388.
2013 Publications
1) Yan He, Xinying Zhang, Nana Shen, Xuesen Fan*. Tunable synthesis of 3-acyl-2-naphthols and 3-substituted isocoumarins via Jones reagent promoted cascade reactions of 2-(4-hydroxy-but-1-ynyl) benzaldehydes. J. Org. Chem., 2013, 78(20), 10178-10191.
2)Yan He, Xinying Zhang, Nana Shen, Xuesen Fan*. Synthesis of α-fluoroketones and α-fluoroenones in aqueous media. J. Flu. Chem., 2013, 156(12), 9-14.
3) Yan He, Nana Shen, Xuesen Fan*, Xinying Zhang. Synthesis of β-fluoroenones and their reductive rearrangement in aqueous media. Tetrahedron, 2013, 69(41), 8818-8823.
4) Shenghai Guo*, Jiliang Wang, Xuesen Fan*, Xinying Zhang, Dongqiang Guo. Synthesis of pyrazolo [1,5-c]quinazoline derivatives through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H- pyrazoles with carbonyl compounds and aqueous ammonia. J. Org. Chem., 2013, 78(7), 3262-3270.
5) Qiang Wang, Zhouqing Xu, Xuesen Fan*. Selective synthesis of oxygen-containing heterocycles via tandem reactions of 1,2-allenic ketones with ethyl 4-chloroacetoacetate. RSC Adv., 2013, 3(13), 4156- 4160.
6) Yan He, Xinying Zhang*, Liangyan Cui, Xuesen Fan*. Iodine-initiated domino reaction of hepta-1,2- dien-6-yn-4-ols and brønsted acid promoted cyclization of hepta-1,2,6-trien-4-ols leading to functionalized benzenes. Chem. Asian J., 2013, 8(4), 717-722.
7) Xinying Zhang*, Xuefei Jia, Nan Liu, Xiaojie Guo, Yunping Song, Xuesen Fan*. 5-Hydroxypent-2-ene nitriles as precursors toward dihydropyranones, dienenitriles and functionalized naphthalenes. Tetrahedron, 2013, 69(26), 5374-5382.
8) Xinying Zhang*, Xiaojie Guo, Liangliang Fang, Yunping Song, Xuesen Fan*. Copper-catalyzed N- and O-arylation of amides: alternative approaches to 3,4-dihydroquinolin-2-ones, quinolin-2-ones, and 12H-chromeno[2,3-b]quinolin-12-ones. Eur. J. Org. Chem., 2013, (36), 8087-8093.
2012 Publications
1) Haiyun Xu, Xinying Zhang*, Yan He, Shenghai Guo, Xuesen Fan*. Tandem reaction of 3-hydroxyhexa -4,5-allenic esters: a novel access to diversely substituted 2H-pyran-2-ones and indenes. Chem. Commun., 2012, 48(25), 3121-3123.
2) Yan He, Xinying Zhang*, Liangyan Cui, Jianji Wang, Xuesen Fan*. Catalyst-free synthesis of diversely substituted 6H-benzo[c]chromenes and 6H-benzo[c]chromen-6-ones in aqueous media under MWI. Green Chem., 2012, 14(12), 3429-3435.
3) Xuesen Fan*, Yan He, Liangyan Cui, Shenghai Guo, Jianji Wang, Xinying Zhang*. Tandem reactions leading to benzo[c]chromen-6-ones and 3-substituted isocoumarins. Eur. J. Org. Chem., 2012 (4), 673-677.
4) Shenghai Guo*, Jiliang Wang, Dongqiang Guo, Xinying Zhang, Xuesen Fan*. Highly regioselective and practical synthesis of 1-acyl-5-hydroxypyrazolines and 1-acylpyrazoles from 1,2-allenic ketones and hydrazides. Tetrahedron, 2012, 68(38), 7768-7774.
5) Shenghai Guo*, Jiliang Wang, Dongqiang Guo, Xinying Zhang, Xuesen Fan*. Synthesis of 3,5-disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2'-deoxycytidine. RSC Adv., 2012, 2(9), 3772-3777.
2011 Publications
1) Xuesen Fan*, Yangyang Wang, Yingying Qu, Haiyun Xu, Yan He, Xinying Zhang*, Jianji Wang. Tandem reactions leading to bicyclic pyrimdine nucleosides and benzopyran-4-ones. J. Org. Chem., 2011, 76(3), 982-985.
2) Xuesen Fan*, Yan He, Liangyan Cui, Xinying Zhang, Jianji Wang. Tandem reaction of 1,2-allenic ketone with α-halo ketone or α-halo ester in water: an efficient and sustainable synthesis of 1,3,4'-tricarbonyl compounds. Green Chem., 2011, 13(11), 3218-3223.
3) Xinying Zhang*, Xuefei Jia, Liangliang Fang, Nan Liu, Jianji Wang, Xuesen Fan*. Tandem reactions of 1,2-allenic ketones leading to substituted benzenes and -unsaturated nitriles. Org. Lett., 2011, 13(19), 5024-5027.
4) Xinying Zhang*, Xuefei Jia, Jianji Wang, Xuesen Fan*. An economically and environmentally sustainable synthesis of 2-aminobenzothiazoles and 2-aminobenzoxazoles promoted by water. Green Chem., 2011, 13(2), 413-418.
5) Xuesen Fan*, Xinying Zhang, Jianji Wang*. Recent progress in the green and efficient synthesis of biologically privileged scaffolds in ionic liquids. Curr. Org. Synth., 2011, 8(5), 721-751.
6) Xinying Zhang*, Dongfang Li, Xuefei Jia, Jianji Wang, Xuesen Fan*. CuI/[bmim]OAc in [bmim]PF6: a highly efficient and readily recyclable catalytic system for the synthesis of 2,3-disubstituted benzo[b]furans. Catal. Commun., 2011, 12(9), 839-843.
7) Xuesen Fan*, Yan He, Xinying Zhang, Shenghai Guo. Synthesis of heteroaryl ketones via tandem reaction of 1,1-dibromoethenes. Tetrahedron, 2011, 67(34), 6369-6374.
2010 Publications
1) XuesenFan*, Dong Feng, Yingying Qu, Xinying Zhang, Jianji Wang, Philippe M. Loiseau, Graciela Andrei,Robert Snoeck, Erik De Clercq. Practical and efficient synthesis of pyrano[3,2-c]pyridone,pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents. Bioorg. Med. Chem. Lett., 2010, 20(3), 809-813.
2) XuesenFan*, Yangyang Wang,Yan He, Xinying Zhang, Jianji Wang. Ru(III)-catalyzed oxidative reactionin ionic liquid: an efficient and practical route to 2-substituted benzothiazoles and their hybrids withpyrimidine nucleoside. Tetrahedron Lett., 2010, 51(27), 3493-3496.
3) XuesenFan*, Yingying Qu, Yangyang Wang, Xinying Zhang, Jianji Wang. Ru(III)-catalyzed oxidation ofhomopropargyl alcohols in ionic liquid: an efficient and green route to 1,2-allenic ketones. TetrahedronLett., 2010, 51(16), 2123-2126.
4) Xinying Zhang, Yingying Qu, XuesenFan*, C. Bores, Dong Feng, Graciela Andrei, Robert Snoeck, Erik DeClercq, Philippe M. Loiseau, Solvent-free synthesis of pyrimidine nucleoside-aminophosphonatehybrids and their biological activity evaluation. Nucleosides Nucleotides & Nucleic Acids, 2010, 29(8), 616-627.
5) 张新迎, 王洋洋, 冯东, 范学森*. 5-取代嘧啶核苷类似物的设计、合成及生物活性研究进展. 有机化学, 2010, 30(6), 797-808.
6) Xinying Zhang, Dongfang Li,Xuesen Fan*,Xia Wang,Xiaoyan Li, Guirong Qu*, Jianji Wang. Ionic liquidpromoted multi-component reaction: noveland efficient preparation of pyrazolo[3,4-b]pyridinone,pyrazolo[3,4-b]quinolinone and their hybrids with pyrimidinenucleoside. Mol. Diver., 2010, 14(1), 159-167.
2009 Publications
1) Xinying Zhang, Xiaoyan Li, Dongfang Li, Guirong Qu*, Jianji Wang, Phillippe M. Loiseau, Xuesen Fan*. Ionic liquid mediated andpromoted eco-friendly preparation of thiazolidinone and pyrimidine nucleoside-thiazolidinone hybrids and their antiparasitic activities. Bioorg. Med. Chem. Lett., 2009, 19(22), 6280-6283.
2) Xinying Zhang*, Xiaoyan Li, Xuesen Fan*, Xia Wang, Jianji Wang, Guirong Qu, Controllable synthesis of pyrazolo[3,4-b]pyridines or substituted malononitrile derivatives through multi-component reactions in ionic liquid. Aust. J. Chem., 2009, 62(4), 382-388.
3) Xuesen Fan*, Dong Feng, Xia Wang, Yingying Qu, Xinying Zhang. A novel preparation of pyridine–urea hybridsand elucidation of their structures. Heteroatom Chem., 2009, 20(6), 362-368.
4) Xinying Zhang*, Xiaoyan Li, Xuesen Fan*, Xia Wang, Dongfang, Li, Guirong Qu, Jianji Wang. Ionic liquid promoted preparation of 4H-thiopyran and pyrimidine nucleoside-thiopyran hybrids through one-pot multi-component reaction of thioamide. Mol. Diver., 2009, 13(1), 57-61.
