Independent Research

2024

(30) Sun, Y.-W.⁺; Zhao, J.-H.⁺; Yan, X.-Y.; Ji, C.-L.; Feng, H.*; Gao, D.-W.* Asymmetric Synthesis of Atropisomers Featuring Cyclobutane Boronic Esters Facilitated by Ring-Strained B-ate Complexes. Nat. Commun. 2024, 15, 10.1038/S41467-024-55161-6.

(29) Zhao, J.-H.†; Chen, A.†; Zou, X.-Z.†; Ji, C.-L.*; Feng, H.*; Gao, D.-W.* Catalytic Selective Functionalization of Poly(organoborons). Chin. J. Chem. 2024, 42, 3484-3498 (Invited review).

(28) Zou, X.-Z.^†; Ge, J.-F.^†; Yang, Y.-X.; Huang, Y.-F.; Gao, D.-W.* Regioselective Alkynylation and Alkenylation at the More Hindered C–B Bond of 1,2-Bis(Boronic) Esters. Org. Lett. 2024, 26, 1595-1600 (Featured in Org. Chem. Highlights; Published as part of Organic Letters virtual special issue “Radical Reactions for the Construction and Transformation of Complex Molecules”).

(27) Ji, C.-L.; Gao, D.-W.* Stereoselective Synthesis of 1,2-Bis(Boronates). Trends Chem. 2024, 6, 211-212.

(26) Ji, C.-L.; Gao, D.-W.* Recent Advances in Catalytic Asymmetric Synthesis of 1,2-Bis(Boronic) Esters. Chin. J. Org. Chem. 2024, 44, 1385-1402 (Invited review).

(25) Sun, Y.-W.; Gao, D.-W.* Asymmetric Synthesis of Organoborons via Ir-Catalyzed Stereoconvergent Reactions. Chem Catal. 2024, 4, 100896 (Invited preview).

(24) Chen, A.^†; Ji, C.-L.^†; Gao, D.-W.* Precision Alkynylation of 1,3-Bis(Boronates) Utilizing Distinct Organometallic Reagents for Regioselective Synthesis. Synlett 2024, 35, 1839-1843 (Invited Synpacts, selected as the cover of Synlett).

(23) Jiang, X.-M.; Ji, C.-L.; Ge, J.-F.; Zhao, J.-H.; Zhu, X.-Y.; Gao, D.-W.* Asymmetric Synthesis of Chiral 1,2-Bis(Boronic) Esters Featuring Acyclic, Non-Adjacent 1,3-Stereocenters. Angew. Chem. Int. Ed. 2024, 63, e202318441. (Highlighted in "Mechanism of the Month" of Trends in Chemistry.)

2023

(22) Chen, A; Qiao, Y.; Gao, D.-W.* Controllable Regiodivergent Alkynylation of 1,3-Bis(Boronic) Esters Activated by Distinct Organometallic Reagents. Angew. Chem. Int. Ed. 2023, 62, e202312605. (Selected as "Very Important Paper"; highlighted in Chin. J. Org. Chem. 2023, 43, 4311-4313.)

(21) Gao, D.-W. Angew. Chem. Int. Ed. 2023, 62, e202309675 (Introducing...).

(20) Ge, J.-F.^†; Zou, X.-Z.^†; Liu, X.-R.^†; Ji, C.-L.; Zhu, X.-Y.; Gao, D.-W.* Ir-Catalyzed Enantioselective Synthesis of gem-Diborylalkenes Enabled by 1,2-Boron Shift. Angew. Chem. Int. Ed. 2023, 62, e202307447. (Highlighted in Synfacts 2023, 19, 995.; Featured in Organic Chemistry Highlights in July 2024).

2022

(19) Jiang, X.-M.; Liu, X.-R.; Chen, A.; Zou, X.-Z.; Ge, J.-F.; Gao. D.-W.* 1,2-Boryl Migration Enables Efficient Access to Versatile Functionalized Boronates. Eur. J. Org. Chem. 2022, e202101463. (Invited review for the #NextGenOrgChem special collection.)

Prior to ShanghaiTech University

(18)   Gao, D.-W.^†; Jamieson, C. S.^†; Wang, G.^†; Yan, Y.; Zhou, J.; Houk, K. N.; Tang, Y. A Polyketide Cyclase That Forms Medium-Ring Lactones. J. Am. Chem. Soc. 2021, 143, 80–84.

(17)   Gao, D.-W.^†; Gao, Y.^†; Shao, H.; Qiao, T.-Z.; Wang, X.; Sanchez, B.; Chen, J. S.; Liu, P.; Engle, K. M. Cascade CuH-Catalyzed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products. Nat. Catal. 2020, 3, 23–29. 

(16)   Gao, D.-W.; Vinogradova, E. V.; Nimmagadda, S. K.; Medina, J. M.; Xiao, Y.; Suciu, R. M.; Cravatt, B. M.; Engle, K. M. Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes. J. Am. Chem. Soc. 2018, 140, 8069–8073. (Top 1“Most Read Article”in June 2018.; Featured in Organic Chemistry Highlights.)

(15)   Gao, D.-W.; Xiao, Y.; Liu, M.; Liu, Z.; Karunananda, M. K.; Chen, J. S.; Engle, K. M. Catalytic, Enantioselective Synthesis of Allenyl Boronates. ACS Catal. 2018, 8, 3650–3654. (Highlighted in the Jan/Feb ChemRxiv Round-up; Highlighted in Synfacts 2018, 14, 734.; Featured in Organic Chemistry Highlights on October 22, 2018.; One of the “Most Read Articles” in March 2018.)

(14)   Gao, D.-W.; Gu, Q.; Zheng, C.; You, S.-L. Synthesis of Planar Chiral Ferrocenes via Transition-Metal-Catalyzed Direct C–H Bond Functionalization. Acc. Chem. Res. 2017, 50, 351–365.

(13)   Gao, D.-W.; Gu, Y.; Wang, S.-B.; Gu, Q.; You, S.-L. Pd(0)-Catalyzed Asymmetric C–H Alkenylation for Efficient Synthesis of Planar Chiral Ferrocenes. Organometallics 2016, 35, 3227–3233.

(12)   Gao, D.-W.; Gu, Q.; You, S.-L. An Enantioselective Oxidative C−H/C−H Cross-Coupling Reaction: Highly Efficient Method To Prepare Planar Chiral Ferrocenes. J. Am. Chem. Soc. 2016, 138, 2544–2547. (Highlighted by Chemical & Engineering News on March 14, 2016.)

(11)   Gao, D.-W.; Zheng, C.; Gu, Q.; You, S.-L. Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives. Organometallics 2015, 34, 4618–4625.

(10)   Gao, D.-W.; Gu, Q.; You, S.-L. Pd(II)-Catalyzed Intermolecular Direct C−H Bond Iodination: An Efficient Approach toward the Synthesis of Axially Chiral Compounds via Kinetic Resolution. ACS Catal. 2014, 4, 2741–2745. (One of the “Most Read Articles”in July 2014.; Highlighted in ACS Catal. Spotlights.)

(9)  Gao, D.-W.; Yin, Q.; Gu, Q.; You, S.-L. Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C−H Bond Arylation. J. Am. Chem. Soc. 2014, 136, 4841–4844. (Highlighted by Synfacts 2014, 10, 597.)

(8)  Gao, D.-W.; Shi, Y.-C.; Gu, Q.; Zhao, Z.-L.; You, S.-L. Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium-Catalyzed Direct Coupling with Arylboronic Acids. J. Am. Chem. Soc. 2013, 135, 86–89. (Highlighted by Synfacts 2013, 9, 0417.; Highlighted by Chin. J. Org. Chem. 2013, 33, 654.)

(7) Song, Y.; Wang, W.; Yang, J.; Gao, D.-W.; Billingsley, J. M.; Wang, S.; Zhu, Y.; Wang, J.; Ju, J.; Yan, Y.; Tang, Y. β-Terrecyclene synthase constructs the quadrane backbone in terrecyclic acid biosynthesis. Chem. Sci. 2024, 15, 8750–8755.

(6)   Nimmagadda, S. K.; Liu, M.; Karunananda, M. K.; Gao, D.-W.; Apolinar, O.; Chen, J. S.; Liu, P.; Engle, K. M. Catalytic, Enantioselective α-Alkylation of Azlactones with Non-Conjugated Alkenes via Directed Nucleopalladation. Angew. Chem. Int. Ed. 2019, 58, 3923–3927.

(5)   O’Duill, M. L.; Matsuura, R.; Wang, Y.; Turnbull, J. L.; Gurak Jr, J. A.; Gao, D.-W.; Lu, G.; Liu, P.; Engle, K. M. Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization. J. Am. Chem. Soc. 2017, 139, 15576–15579.

(4)   Wang, J.; Gao, D.-W.; Huang, J.; Tang, S.; Xiong, Z.; Hu, H.; You, S.-L.; Zhu, Q. Palladium-Catalyzed Enantioselective C(sp²)–H Imidoylation by Desymmetrization. ACS Catal. 2017, 7, 3832–3836.

(3)   Yin, Q.; Wang, S.-G.; Liang, X.-W.; Gao, D.-W.; Zheng, J.; You, S.-L. Asymmetric Dearomative Chlorination of β-Naphthols. Chem. Sci. 2015, 6, 4179–4183.

(2)   Shi, Y.-C.; Yang, R.-F.; Gao, D.-W.; You, S.-L. Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium-Catalyzed Annulations with Diarylethynes. Beilstein J. Org. Chem. 2013, 9, 1891–1896.

(1)   Peng, J.; Zong, C.; Ye, M.; Chen, T.; Gao, D.-W.; Wang, Y.; Chen, C. Direct Transition-Metal-Free Intramolecular C–O Bond Formation: Synthesis of Benzoxazole Derivatives. Org. Biomol. Chem. 2011, 9, 1225–1230.

 BOOK CHAPTER

(1)   Gao, D.-W.; Zheng, J.; Ye. K.-Y.; Zheng. C.; You, S.-L. Asymmetric Functionalization of C–H Bonds via a Transient Carbon-Metal (C–M) Species. in Asymmetric Functionalization of C–H Bonds, You, S.-L., Ed., Royal Society of Chemistry 2015, pp. 141–213.

 

PATENTS

(1) You, S.-L.; Gao, D.-W.; Gu, Q. A Kind of Planar Chiral Ferrocene Compounds, Synthetic Methods and Their Applications. The Number of Patent (ZL201510757648.8).

(1)   You, S.-L.; Gao, D.-W.; Yin, Q.; Gu, Q. The Preparation of Planar Chiral Ferrocene Derivatives and Their Applications. The Number of Patent (ZL201410040306.X).

(2)   You, S.-L.; Gu, Q.; Gao, D.-W.; Shi, Y.-C.; Zhao, Z.-L. The Synthesis of New Kind of Planar Chiral Ferrocene Compounds and Their Applications. The Number of Patent (ZL201210489246.0).