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成果及论文

50 Xiaochun Hu†, Ruihao Li†, Wenjing Wu, Kang Fang, Zhounan Zhu, Yixuan Wang, Lulu Zhou, Mengyao, Chen, Chunyan Dong*, and Shuo Shi*, A Fe(III)-porphyrin-oxaliplatin(IV) nanoplatform for enhanced ferroptosis and combined therapy, Journal of Controlled Release, 2022, Accepted.

49Ruihao Li†, Xiaochun Hu†, Fangjian Shang, Wenjing Wu, Haijun Zhang, Yixuan Wang, Jiawei Pan, Shuo Shi* and Chunyan Dong*, Treatment of triple negative breast cancer by near infrared light triggered mild temperature photothermal therapy combined with oxygen-independent cytotoxic free radicals, Acta Biomaterialia, 2022, Accepted.

48Pinting Ye, Lei Feng, Shuo Shi*, Chunyan Dong*, The Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer, Cancers2022, 14(9), 2101; https://doi.org/10.3390/cancers14092101

47Jie Liu†, Xiaochun Hu†, Lei Feng, Yun Lin, Shujing Liang, Zhounan Zhu, Shuo Shi* and Chunyan Dong*Carbonic anhydrase IX-targeted H-APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF-1α-dependent tumor hypoxia adaptation, Journal of Nanobiotechnology, 2022, 20, 187https://doi.org/10.1186/s12951-022-01394-w

46Mengyao Chen†, Jingxian Yang†, Lulu Zhou, Xiaochun Hu, Chunhui Wang, Keke Chai, Ruihao Li, Lei Feng, Yanting Sun, Chunyan Dong* and Shuo Shi *, A Dual-Responsive and ROS-augmented Nanoplatform for Chemo /Photodynamic /Chemodynamic Combination Therapy of Triple Negative Breast Cancer, Acs Applied Materials & Interfaces, 2021, Accept.

 

45Lei Feng†, Mengyao Chen†, Ruihao Li, Lulu Zhou, Chunhui Wang, Pingting Ye, Xiaochun Hu, Jingxian Yang, Yanting Sun, Zhounan Zhu, Keke Chai, Kang Fang, Shuo Shi* and Chunyan Dong*, Biodegradable Oxygen-producing Manganese-chelated Metal Organic Frameworks for Tumor-targeted Synergistic Chemo/photothermal/ photodynamic Therapy,  Acta Biomaterialia, 2021, https://doi.org/10.1016/j.actbio.2021.10.032

44Pingting Ye, Lei Feng, Shuo Shi*, Chunyan Dong*, The mechanisms of lncRNA-mediated multidrug resistance and the prospects of clinical application of lncRNAs in breast cancer, Cellular and Molecular Life Sciences, 2021, In Revison.

43Lulu Zhou†, Jinjin Chen†, Ruihao Li, Lizhen Wei, Haitao Xiong, Chunhui Wang, Keke Chai, Mengyao Chen, Zhounan Zhu, Tianming Yao, Yun Lin, Chunyan Dong* and Shuo Shi*, Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferropotosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent in Situ Bleomycin Toxification, Small, 2021, Accept.

42Lulu Zhou†, Jinjin Chen†, Yunhao Sun, Keke Chai, Zhounan Zhu, Chunhui Wang,  Mengyao Chen, Wenmei Han, Xiaochun Hu, Ruihao Li,  Tianming Yao, Hui Li, Chunyan Dong* and Shuo Shi*, A Self-Amplified Nanocatalytic System for Achieving "1+1+1>3" Chemodynamic Therapy on Triple Negative Breast Cancer, Journal of Nanobiotechnology, 2021, In press.

41Yanting Sun,† Yuling Li,† Shuo Shi* and Chunyan Dong*, Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems, Molecules 2021, 26(9), 2703.n https://doi.org/10.3390/molecules26092703

40 Mengyao Chen, Chunyan Dong* and Shuo Shi *, Nanoparticle-Mediated siRNA Delivery and Multifunctional modification strategies for Effective Cancer Therapy, Advanced Materials Technologies, 2021, 202001236. n  https://doi.org/10.1002/admt.20200123

 

39Liang Shujing, Yang Jingxian,  Lin Yun,  Li Tong,  Zhao Wenrong, Zhao Jun * and Dong Chunyan* (2021) Immune Myocarditis Overlapping With Myasthenia Gravis Due to Anti-PD-1 Treatment for a Chordoma Patient: A Case Report and Literature Review.Front. Immunol. 12:682262. https://doi.org/10.3389/fimmu.2021.682262

38Xiaochun Hu#,Yonglin Lu# , Wenrong Zhao, Menglin Sun, Ruihao Li, Lei Feng, Tianming Yao,  Chunyan Dong*, Shuo Shi*, A PDA-DTC/Cu-MnO2 Nanoplatform for MR Imaging and Multi-Therapy of Triple-Negative Breast Cancer, Chem. Comm, 2021, https://doi.org/10.1039/D1CC00987G.

37 Wenrong Zhao#, Xiaochun Hu#, Wenhui Li, Ruihao Li, Jinjin Chen, Lulu Zhou, Sufeng Qiang, Wenjing Wu, Shuo Shi,* and Chunyan Dong*, M2-like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy. Small, 2021, 17, 202007051. Inside Back Cover. n  https://doi.org/10.1002/smll.202007051

36Jinjin Chen#, Lulu Zhou#, Chunhui Wang, Yunhao Sun, Yonglin Lu, Ruihao Li, Xiaochun Hu, Mengyao Chen, Tianming Yao, Shuo Shi,* and Chunyan Dong*, Multifunctional SN38-Conjugated Nanosystem for Defeating Myelosuppression and Diarrhea Induced by Irinotecan On Esophageal Cancer, Nanoscale, 2020, https://doi.org/10.1039/D0NR06266A.

 

35Yang, Jingxian, Chunhui Wang, Shuo Shi*, and Chunyan Dong*. 2020. “Nanotechnologies for Enhancing Cancer Immunotherapy.” Nano Research 12 (1). https://doi.org/10.1007/s12274-020-2904-8.

34Shujing Liang*, Menglin Sun, Yonglin Lu, Shuo Shi, Donglei Zhu, Yiting Yang, Yun Lin, Chan Feng, Jie Liu, Lv Chen,and Chunyan Dong*, Cytokine induced killed cells-assisted tumor-targeting delivery of Her-2 monoclonal antibody-conjugated gold nanostars with NIR photosentizer for enhanced tri-modal imaging and therapy integration, J. Mater. Chem. B, 2020, https://doi.org/10.1039/D0TB00544D.

33Hu, Xiaochun#, Yonglin Lu#, Lulu Zhou, Lv Chen, Tianming Yao, Shujing Liang, Junyi Han, Chunyan Dong*, and Shuo Shi*. 2020. “Post-Synthesis Strategy to Integrate Porphyrinic Metal-Organic Frameworks with CuS NPs for Synergistic Enhanced Photo-Therapy.” Journal of Materials Chemistry B 8 (5): 935–44. https://doi.org/10.1039/c9tb02597a.

32Wang, Chunhui, Jingxian Yang, Chunyan Dong*, and Shuo Shi*. 2020. “Glucose Oxidase‐Related Cancer Therapies.” Advanced Therapeutics 2000110: 2000110. https://doi.org/10.1002/adtp.202000110.

31Ruihao Li, Yabin Ma, Xiaochun Hu, Wenjing Wu, Xuewen Wu, Chunyan Dong, Shuo Shi*, and Yun Lin*. 2020. “[Ru(Phen)2podppz]2+ Significantly Inhibits Glioblastoma Growth in Vitro and Vivo with Fewer Side-Effects than Cisplatin.” Dalton Transactions. https://doi.org/10.1039/d0dt01877e.

30Lulu Zhou, Lv Chen, Xiaochun Hu, Yonglin Lu, Wenjie, Liu Yanting Sun, Tianming Yao, Chunyan Dong*, and Shuo Shi*. 2020. “A Cu9S5 Nanoparticle-Based CpG Delivery System for Synergistic Photothermal-, Photodynamic- and Immunotherapy.” Communications Biology. https://doi.org/10.1038/s42003-020-1070-6.

29Hu, Xiaochun, Yonglin Lu, Chunyan Dong, Wenrong Zhao, Xuewen Wu, Lulu Zhou, Lv Chen, Tianming Yao*, and Shuo Shi*. 2019. “A RuII Polypyridyl Alkyne Complex Based Metal-Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy.” Chemistry - A European Journal. https://doi.org/10.1002/chem.201904704.

28Xiaochun Hu#, Yonglin Lu#, Xiaoke Shi, Tianming Yao, Chunyan Dong*, and Shuo Shi*. 2019. “Integrating: In Situ Formation of Nanozymes with Mesoporous Polydopamine for Combined Chemo, Photothermal and Hypoxia-Overcoming Photodynamic Therapy.” Chemical Communications 55 (98): 14785–88. https://doi.org/10.1039/c9cc07125c.

27Chan Feng, Lv Chen, Yonglin Lu, Jie Liu, Shujing Liang, Yun Lin, Yongyong Li*, and Chunyan Dong*. 2019. “Programmable Ce6 Delivery via Cyclopamine Based Tumor Microenvironment Modulating Nano-System for Enhanced Photodynamic Therapy in Breast Cancer.” Frontiers in Chemistry 7 (December): 1–11. https://doi.org/10.3389/fchem.2019.00853.

26Lv Chen#, Lulu Zhou#, Chunhui Wang, Yi Han, Yonglin Lu, Jie Liu, Xiaochun Hu,Tianming Yao, Yun Lin, Shujing Liang, Shuo shi*, and Chunyan Dong*. 2019. “Tumor-Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel-Enhanced Immunotherapy with Polarization toward M1-Type Macrophages on Triple Negative Breast Cancers.” Advanced Materials 31 (52): 1–9. https://doi.org/10.1002/adma.201904997.

25Hu, Xiaochun, Zhenli Xu, Jiwen Hu, Chunyan Dong, Yonglin Lu, Xuewen Wu, Maierhaba Wumaier, Tianming Yao*, and Shuo Shi*. 2019. “A Redox-Activated Theranostic Nanoplatform: Toward Glutathione-Response Imaging Guided Enhanced-Photodynamic Therapy†.” Inorganic Chemistry Frontiers. https://doi.org/10.1039/c9qi00894b.

24Song, Zhiwang, Xia Zhang, Yun Lin, Youzhen Wei, Shujing Liang, and Chunyan Dong. 2019. “LINC01133 Inhibits Breast Cancer Invasion and Metastasis by Negatively Regulating SOX4 Expression through EZH2.” Journal of Cellular and Molecular Medicine 23 (11): 7554–65. https://doi.org/10.1111/jcmm.14625.

23Feng, Chan, Donglei Zhu, Lv Chen, Yonglin Lu, Jie Liu, Na Yoon Kim, Shujing Liang, et al. 2019. “Targeted Delivery of Chlorin E6 via Redox Sensitive Diselenide-Containing Micelles for Improved Photodynamic Therapy in Cluster of Differentiation 44-Overexpressing Breast Cancer.” Frontiers in Pharmacologyhttps://doi.org/10.3389/fphar.2019.00369.

22Zhu, Donglei, Xia Zhang, Yun Lin, Shujing Liang, Zhiwang Song, and Chunyan Dong. 2019. “MT1JP Inhibits Tumorigenesis and Enhances Cisplatin Sensitivity of Breast Cancer Cells through Competitively Binding to MiR-24-3p.” American Journal of Translational Research 11 (1): 245–56.

21Lu, Yong lin, Ya bin Ma, Chan Feng, Dong lei Zhu, Jie Liu, Lv Chen, Shu jing Liang, and Chun yan Dong. 2019. “Co-Delivery of Cyclopamine and Doxorubicin Mediated by Bovine Serum Albumin Nanoparticles Reverses Doxorubicin Resistance in Breast Cancer by down-Regulating p-Glycoprotein Expression.” Journal of Cancer 10 (10): 2357–68https://doi.org/10.7150/jca.30323.

20Feng, Chan, Kun Wang, Yun Lin, Zhiwang Song, Yonglin Lu, Jie Liu, Donglei Zhu, Yongyong Li, and Chunyan Dong. 2018. “Extracellular Retention of a Cyclopamine Nanoformulation Leveraging Larger Size and More Negative Charge for Improved Breast Cancer Treatment.” Journal of Materials Chemistry B 6 (12): 1834–43. https://doi.org/10.1039/c7tb02777j.

19Song, Zhiwang, Chan Feng, Yonglin Lu, Yun Lin, and Chunyan Dong. 2018. “PHGDH Is an Independent Prognosis Marker and Contributes Cell Proliferation, Migration and Invasion in Human Pancreatic Cancer.” Gene 642 (July 2017): 43-50. https://doi.org/10.1016/j.gene.2017.11.014.

18Song, Zhiwang, Xia Zhang, Xiaojuan Ye, Chan Feng, Guang Yang, Yonglin Lu, Yun Lin, and Chunyan Dong. 2017. “High Expression of Stromal Cell-Derived Factor 1 (SDF-1) and NF-ΚB Predicts Poor Prognosis in Cervical Cancer.” Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. https://doi.org/10.12659/msm.899319.

17Liu, Jie, Zhiwang Song, Chan Feng, Yonglin Lu, Yu Zhou, Yun Lin, and Chun Yan Dong. 2017. “The Long Non-Coding RNA SUMO1P3 Facilitates Breast Cancer Progression by Negatively Regulating MiR-320a.” American Journal of Translational Research 9 (12): 5594–5602.

16Song, Zhiwang, Chan Feng, Yonglin Lu, Yong Gao, Yun Lin, and Chunyan Dong. 2017. “Overexpression and Biological Function of MEF2D in Human Pancreatic Cancer.” American Journal of Translational Research.

15Song, Zhiwang, Yun Lin, Xia Zhang, Chan Feng, Yonglin Lu, Yong Gao, and Chunyan Dong. 2017. “Cyclic RGD Peptide-Modified Liposomal Drug Delivery System for Targeted Oral Apatinib Administration: Enhanced Cellular Uptake and Improved Therapeutic Effects.” International Journal of Nanomedicine 12: 1941–58. https://doi.org/10.2147/IJN.S125573.

14Song, Zhiwang, Yun Lin, Xiaojuan Ye, Chan Feng, Yonglin Lu, Guang Yang, and Chunyan Dong. 2016. “Expression of IL-1α and IL-6 Is Associated with Progression and Prognosis of Human Cervical Cancer.” Medical Science Monitor : International Medical Journal of Experimental and Clinical Researchhttps://doi.org/10.12659/msm.898569.

13Song, Zhiwang, Yonglin Lu, Xia Zhang, Haiping Wang, Junyi Han, and Chunyan Dong. 2016. “Novel Curcumin-Loaded Human Serum Albumin Nanoparticles Surface Functionalized with Folate: Characterization and in Vitro/Vivo Evaluation.” Drug Design, Development and Therapy 10: 2643–49. https://doi.org/10.2147/DDDT.S112039.  

12Song, Zhiwang, Chuan Shao, Chan Feng, Yonglin Lu, Yong Gao, and Chunyan Dong. 2016. “Association of Glutathione S-Transferase T1, M1, and P1 Polymorphisms in the Breast Cancer Risk: A Meta-Analysis.” Therapeutics and Clinical Risk Managementhttps://doi.org/10.2147/tcrm.s104339.

11Li, Yongyong, Yuqin Chen, Haiqing Dong, and Chunyan Dong. 2015. “Supramolecular, Prodrug-Based Micelles with Enzyme-Regulated Release Behavior for Controlled Drug Delivery.” MedChemComm 6 (10): 1874–81. https://doi.org/10.1039/c5md00299k.

10Feng, Chan, Xiaoyan Li, Chunyan Dong, Xuemei Zhang, Xie Zhang, and Yong Gao. 2015. “Rgd-Modified Liposomes Enhance Efficiency of Aclacinomycin a Delivery: Evaluation of Their Effect in Lung Cancer.” Drug Design, Development and Therapy 9: 4613–20. https://doi.org/10.2147/DDDT.S85993.

9Dong, Haiqing, Chunyan Dong, Tianbin Ren, Yongyong Li, and Donglu Shi. 2014. “Surface-Engineered Graphene-Based Nanomaterials for Drug Delivery.” Journal of Biomedical Nanotechnology 10 (9): 2086–2106. https://doi.org/10.1166/jbn.2014.1989.

8Zhu, Haiyan, Chunyan Dong, Haiqing Dong, Tianbin Ren, Xuejun Wen, Jiansheng Su, and Yongyong Li. 2014. “Cleavable PEGylation and Hydrophobic Histidylation of Polylysine for SiRNA Delivery and Tumor Gene Therapy.” ACS Applied Materials and Interfaces 6 (13): 10393–407. https://doi.org/10.1021/am501928p.

7Dong, Haiqing, Chunyan Dong, Wenjuan Xia, Yongyong Li, and Tianbin Ren. 2014. “Self-Assembled, Redox-Sensitive, H-Shaped Pegylated Methotrexate Conjugates with High Drug-Carrying Capability for Intracellular Drug Delivery.” MedChemComm 5 (2): 147–52. https://doi.org/10.1039/c3md00267e.

6Chu, Meng, Chunyan Dong, Haiyan Zhu, Xiaojun Cai, Haiqing Dong, Tianbin Ren, Jiansheng Su, and Yongyong Li. 2013. “Biocompatible Polyethylenimine-Graft-Dextran Catiomer for Highly Efficient Gene Delivery Assisted by a Nuclear Targeting Ligand.” Polymer Chemistry 4 (8): 2528–39. https://doi.org/10.1039/c3py21092h.

5Dong, Haiqing, Chunyan Dong, Yue Feng, Tianbin Ren, Zhonghai Zhang, Lan Li, and Yongyong Li. 2012. “Engineering of Peglayted Camptothecin into Core-Shell Nanomicelles for Improving Solubility, Stability and Combination Delivery.” MedChemComm 3 (12): 1555–61. https://doi.org/10.1039/c2md20153d.

4Jiang, Hong, Xuemei Zhang, Jinhong Luo, C. Dong, Junli Xue, Wei Wei, Jingde Chen, Jun Zhou, Yong Gao, and Changqing Yang. 2012. “Knockdown of HMex-3A by Small RNA Interference Suppresses Cell Proliferation and Migration in Human Gastric Cancer Cells.” Molecular Medicine Reports 6 (3): 575–80. https://doi.org/10.3892/mmr.2012.943.

3Shen, Ai Jun, Dong Liang Li, Xiao Jun Cai, Chun Yan Dong, Hai Qing Dong, Hui Yun Wen, Gong Hua Dai, Pei Jun Wang, and Yong Yong Li. 2012. “Multifunctional Nanocomposite Based on Graphene Oxide for in Vitro Hepatocarcinoma Diagnosis and Treatment.” Journal of Biomedical Materials Research - Part A 100 A (9): 2499–2506. https://doi.org/10.1002/jbm.a.34148.

2Wen, Huiyun, Chunyan Dong, Haiqing Dong, Aijun Shen, Wenjuan Xia, Xiaojun Cai, Yanyan Song, Xuequan Li, Yongyong Li, and Donglu Shi. 2012. “Engineered Redox-Responsive PEG Detachment Mechanism in PEGylated Nano-Graphene Oxide for Intracellular Drug Delivery.” Small 8 (5): 760–69. https://doi.org/10.1002/smll.201101613.

1Cai, X., C. Dong, H. Dong, G. Wang, G.M. Pauletti, X. Pan, H. Wen, I. Mehl, Y. Li, and D. Shi. 2012. “Effective Gene Delivery Using Stimulus-Responsive Catiomer Designed with Redox-Sensitive Disulfide and Acid-Labile Imine Linkers.” Biomacromolecules 13 (4): 1024–34. https://doi.org/10.1021/bm2017355.