代表性成果：
1）世界首个亚型选择性ERRa激动剂（国际同行评价）作为新型抗代谢性疾病药物候选物（转让CASIGEN Pharma Inc.）；
2）可克服慢性粒性白血病（CML）临床耐药的新一代Bcr-AblT315I突变体抑制剂（转让广州顺健，II期临床研究）；
3）可克服非小细胞肺癌（NSCLC）对Gefitinib等临床耐药的全新特异性EGFRT790M突变抑制剂（转让南京奥赛康药业，II期临床研究）；
4）具有治疗肿瘤和肺纤维化良好潜力的世界首个选择性DDR1抑制剂（国际同行评价，转让美国Touvel Therapeutics Inc.）；
5）具有治疗心肌肥大潜力的世界首个选择性ZAK抑制剂；
6）可克服耐药结核菌的新型抗结核分子（转让广州艾格药业）;
7）新型药物候选物Axl/Flt3双重抑制剂（转让上海海和药业）等成药性先导化合物100余个。
8）早期（在美国）还设计和合成了Spirooxindole类p53-MDM2相互作用阻断剂转让法国Sanofi（美国临床研究）。
代表性论文：
1）Cell- and Tissue-Based Proteome Profiling and Dual Imaging ofApoptosis Markers with Probes Derived from Venetoclax and Idasanutlin. Dongsheng Zhu+, Haijun Guo+, Yu Chang+, Yun Ni, Lin Li, Zhi-Min Zhang, Piliang Hao,*Yong Xu, Ke Ding,* and Zhengqiu Li* Angew. Chem. Int. Ed. 2018, 57, 9284 –9289
2）Xun Q, Zhang Z, Luo J, Tong L, Huang M, Wang Z, Zou J, Liu Y, Xu Y, Xie H, Tu ZC, Lu X, Ding K. Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5- d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors.J Med Chem. 2018 Mar 22;61(6):2353-2371。
3）Wang, Z ; Zhang, YL; Pinkas, DM ; Fox, AE ; Luo, JF; Huang, HC; Cui, SY; Xiang, QP; Xu, TT ; Xun, QJ ; Zhu, DS; Tu, ZC; Ren, XM; Brekken, RA; Bullock, AN ; Liang, G; Ding, K; Lu, XY .Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem. 2018 Sep 13;61(17):7977-7990.
4）Lu, XY ; Yu, L; Zhang, Z ; Ren, XM ; Smaill, JB; Ding, K. Targeting EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) resistance mutations in NSCLC: Current developments in medicinal chemistry . Med Res Rev. 2018 Sep 38(5):1550-1581.
5）Cheng K, Lee JS, Hao P, Yao SQ, Ding K, Li Z.Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.Angew Chem Int Ed Engl. 2017 Nov 20;56(47):15044-15048
6）Chang, Y.; Lu, X.; Shibu, M. A.; Dai, Y.-B.; Luo, J.; Zhang, Y.; Li, Y.; Zhao, P.; Zhang, Z.; Xu, Y.; Tu, Z.-C.; Zhang, Q.*; Yun, C.-H.*; Huang, C.-Y.*; and Ding, K.* Structure-Based Design of N-(3-((1H-pyrazolo[3, 4-b]pyridin-5-yl)ethynyl) Benzenesulfonamides as Selective Leucine- Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors. J. Med. Chem. 2017, 60 (13) :5927-5932.