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杨冠青 特别研究助理     进组时间: 2021.07

杨冠青于2021年在安徽大学获得化学博士学位。2021年作为特别研究助理加入中国科学院长春应用化学研究所陈学思院士课题组。已在Angewandte Chemie International EditionActa BiomaterialiaJournal of Colloid and Interface ScienceChemical CommunicationsBiosensors and Bioelectronics等国际高影响力学术期刊上发表多篇研究论文,申请国家发明专利2 项。

研究方向:高分子抗肿瘤纳米药物、分子/纳米探针荧光成像、纳米诊疗一体化


代表论文

1. Guanqing Yang, Zhengjie Liu, Ruilong Zhang*, Xiaohe Tian, Juan Chen, Guangmei Han, Bianhua Liu, Xinya Han, Yao Fu, Zhangjun Hu, Zhongping Zhang*, A multi-responsive fluorescent probe reveals mitochondrial nucleoprotein dynamics with reactive oxygen species regulation through super-resolution imaging. Angewandte Chemie International Edition, 2020, 59, 16154–16160. 

2. Tong Zhu#, Guanqing Yang#, Xiaolu Liu, Pan Xiang, Zhenghui Yang , Sijing Zhang, Juan Chen, Hong Wang, Senio Campos de Souza, Zhongping Zhang , Ruilong Zhang, Yupeng Tian, Jieying Wu, Xiaohe Tian*, Live cell mitochondrial 3-dimentional dynamic ultrastructures under oxidative phosphorylation revealed by a pyridine-BODIPY probe. Biosensors and Bioelectronics, 2021, 178, 113036.

3. Guanqing Yang#, Tong Zhu#, Dong Wang, Zhengjie Liu, Ruilong Zhang, Guangmei Han*, Xiaohe Tian, Bianhua Liu, Ming-yong Han, Zhongping Zhang, Revealing the signaling regulation of hydrogen peroxide to cell pyroptosis by a ratiometric fluorescent probe in living cells. Chemical Communications, 2021,57, 6628–6631. 

4. Guanqing Yang, Xin Wang, Shengxiang Fu, Rupei Tang*, Jun Wang, pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy. Acta Biomaterialia, 2017, 60, 232–243.

5. Guanqing Yang, Shengxiang Fu, Weijing Yao, Xin Wang, Qian Zha, Rupei Tang*, Hyaluronic acid nanogels prepared via ortho ester linkages show pH-triggered behavior, enhanced penetration and antitumor efficacy in 3-D tumor spheroids. Journal of Colloid and Interface Science, 2017, 504, 25–38. 

6. Guanqing Yang, Shengxiang Fu, Xin Wang, Jun Wang, Rupei Tang*, pH-triggered poly(ethylene glycol) nanogels prepared via ortho ester linkages as potential drug carriers. International Journal of Polymeric Materials and Polymeric Biomaterials, 2018, 67, 1059–1068. 

7. Zhangjun Hu, Guanqing Yang, Jiwen Hu, Hui Wang, Peter Eriksson, Ruilong Zhang*, Zhongping Zhang, Kajsa Uvdal, Real-time visualizing the regulation of reactive oxygen species on Zn2+ release in cellular lysosome by a specific fluorescent probe. Sensors and Actuators B: Chemical, 2018, 264, 419–425.

8. Shengxiang Fu, Guanqing Yang, Jun Wang, Xin Wang, Xu Cheng, Rupei Tang*, Acid-degradable poly(ortho ester urethanes) copolymers for potential drug carriers: preparation, characterization, in vitro and in vivo evaluation, Polymer, 2017, 114, 1–14. 

9. Shengxiang Fu, Guanqing Yang, Jun Wang, Xin Wang, Xu Cheng, Qian Zha, Rupei Tang*, pH-sensitive poly(ortho ester urethanes) copolymers with controlled degradation kinetic: Synthesis, characterization, and in vitro evaluation as drug carriers. European Polymer Journal, 2017, 95, 275–288. 

10. Hong Wang, Jiwen Hu, Guanqing Yang, Xin Zhang, Ruilong Zhang*, Kajsa Uvdal, Zhongping Zhanga, Xiongyu Wu, Zhangjun Hu*, Real-time tracking of mitochondrial dynamics by a dual-sensitive probe. Sensors and Actuators B: Chemical, 2020, 128418. 

11. Weijing Yao, Shengxiang Fu, Guanqing Yang, Jun Wang, Xin Wang, Rupei Tang*, Low molecular weight PEI-grafted carboxyl-modified soybean protein as gene carriers with reduced cytotoxicity and greatly improved transfection in vitro. International Journal of Polymeric Materials and Polymeric Biomaterials, 2019, 68, 617–627.