许维国，博士，项目研究员。2010年和2013年分别取得吉林大学医学学士和硕士学位。2013年正式入职中国科学院长春应用化学研究所中国科学院生态环境高分子材料重点实验室，2013−2021年历任研究实习员和助理研究员，2019−2023年攻读工程博士学位，师从陈学思院士，2022年至今任副研究员，2023年至今任项目研究员。荣获中华医学科技奖三等奖（2020）、吉林省科学技术进步奖二等奖（2019，2022）、吉林省自然科学学术成果奖三等奖（2018）等奖励。应邀担任Chinese Chemical Letters期刊青年编委和Frontiers in Bioengineering and Biotechnology期刊副主编。至今，在Advanced Materials、Matter、Nano Letters、Theranostics、Biomaterials、Journal of Controlled Release、Nature Communications等学术期刊发表研究论文90余篇，其中第一作者或通讯作者30余篇，他引4900余次，H因子为41。申请中国发明专利17项，PCT国际专利1项，其中已授权6项。主持国家自然科学基金委员会面上项目（2021，2023）2项和青年科学基金（2017）1项，作为子课题负责人参与项目6项。
研究方向：高分子疫苗佐剂、组织工程修复以及聚氨基酸纳米药物和创面敷料的基础和临床转化研究
代表论文
1. Zheng, P.; Ding, B.; Shi, R.; Jiang, Z.; Xu, W.; Li, G.; Ding, J.; Chen, X., A Multichannel Ca2+ Nanomodulator for Multilevel Mitochondrial Destruction‐Mediated Cancer Therapy. Advanced Materials 2021, 33 (15), 2007426.
2. Zheng, P.; Ding, B.; Jiang, Z.; Xu, W.; Li, G.; Ding, J.; Chen, X., Ultrasound-augmented mitochondrial calcium ion overload by calcium nanomodulator to induce immunogenic cell death. Nano Letters 2021, 21 (5), 2088−2093.
3. Wang, J.; Xu, W. G.; Zhang, N.; Yang, C. S.; Xu, H. W.; Wang, Z. T.; Li, B. S.; Ding, J. X.; Chen, X. S., X-ray-responsive polypeptide nanogel for concurrent chemoradiotherapy. Journal of Controlled Release 2021, 332, 1−9.
4. Ma, W.; Chen, Q.; Xu, W.; Yu, M.; Yang, Y.; Zou, B.; Zhang, Y. S.; Ding, J.; Yu, Z., Self-targeting visualizable hyaluronate nanogel for synchronized intracellular release of doxorubicin and cisplatin in combating multidrug-resistant breast cancer. Nano Research 2021, 14 (3), 846−857.
5. Jiang, Z.; Feng, X.; Zou, H.; Xu, W.; Zhuang, X., Poly (l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization. Bioactive Materials 2021, 6 (9), 2688−2697.
6. Huang, X.; Xu, W.; Li, M.; Zhang, P.; Zhang, Y. S.; Ding, J.; Chen, X., Antiviral biomaterials. Matter 2021, 4 (6), 1892−1918.
7. Gao, Q.; Duan, L.; Feng, X.; Xu, W., Superiority of poly(l-lactic acid) microspheres as dermal fillers. Chinese Chemical Letters 2021, 32 (1), 577−582.
8. Feng, X. R.; Xu, W. G.; Xu, X. R.; Li, G.; Ding, J. X.; Chen, X. S., Cystine proportion regulates fate of polypeptide nanogel as nanocarrier for chemotherapeutics. Science China-Chemistry 2021, 64 (2), 293−301.
9. Feng, X. R.; Xu, W. G.; Liu, J. H.; Li, D.; Li, G.; Ding, J. X.; Chen, X. S., Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy. Science Bulletin 2021, 66 (4), 362−373.
10. Zheng, P.; Liu, Y.; Chen, J.; Xu, W.; Li, G.; Ding, J., Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery. Chinese Chemical Letters 2020, 31 (5), 1178−1182.
11. Zhang, H. Y.; Dong, S. J.; Li, Z. M.; Feng, X. R.; Xu, W. G.; Tulinao, C. M. S.; Jiang, Y.; Ding, J. X., Biointerface engineering nanoplatforms for cancer-targeted drug delivery. Asian Journal of Pharmaceutical Sciences 2020, 15 (4), 397−415.
12. Yin, F.; Wang, Z.; Jiang, Y.; Zhang, T.; Wang, Z.; Hua, Y.; Song, Z.; Liu, J.; Xu, W.; Xu, J.; Cai, Z.; Ding, J., Reduction-responsive polypeptide nanomedicines significantly inhibit progression of orthotopic osteosarcoma. Nanomedicine: Nanotechnology, Biology and Medicine 2020, 23, 102085.
13. Li, S.; Dong, S.; Xu, W.; Jiang, Y.; Li, Z., Polymer Nanoformulation of Sorafenib and All-Trans Retinoic Acid for Synergistic Inhibition of Thyroid Cancer. Frontiers in Pharmacology 2020, 10 (1676).
14. Li, D.; Su, T.; Ma, L.; Yin, F.; Xu, W.; Ding, J.; Li, Z., Dual-acidity-labile polysaccharide-di-drugs conjugate for targeted cancer chemotherapy. European Journal of Medicinal Chemistry 2020, 112367.
15. Le, H.; Xu, W.; Zhuang, X.; Chang, F.; Wang, Y.; Ding, J., Mesenchymal stem cells for cartilage regeneration. Journal of Tissue Engineering 2020, 11, 1−22.
16. Jia, X.; Xu, W.; Ye, Z.; Wang, Y.; Dong, Q.; Wang, E.; Li, D.; Wang, J., Functionalized Graphene@ Gold Nanostar/Lipid for Pancreatic Cancer Gene and Photothermal Synergistic Therapy under Photoacoustic/Photothermal Imaging Dual‐Modal Guidance. Small 2020, 16 (39), 2003707.
17. Guo, H.; Li, F.; Qiu, H.; Xu, W.; Li, P.; Hou, Y.; Ding, J.; Chen, X., Synergistically enhanced mucoadhesive and penetrable polypeptide nanogel for efficient drug delivery to orthotopic bladder cancer. Research 2020, 8970135.
18. Feng, X.; Liu, J.; Xu, W.; Li, G.; Ding, J., Tackling autoimmunity with nanomedicines. Nanomedicine 2020, 15 (16), 1585−1597.
19. Chen, J.; Jiang, Z.; Xu, W.; Sun, T.; Zhuang, X.; Ding, J.; Chen, X., Spatiotemporally targeted nanomedicine overcomes hypoxia-induced drug resistance of tumor cells after disrupting Neovasculature. Nano Letters 2020, 20 (8), 6191−6198.
20. Bao, Y.; Zhang, S.; Chen, Z.; Chen, A. T.; Ma, J.; Deng, G.; Xu, W.; Zhou, J.; Yu, Z.-Q.; Yao, G., Synergistic chemotherapy for breast cancer and breast cancer brain metastases via paclitaxel-loaded oleanolic acid nanoparticles. Molecular pharmaceutics 2020, 17 (4), 1343−1351.
21. Zhu, B.; Xu, W.; Liu, J.; Ding, J.; Chen, X., Osteoinductive Agents-Incorporated Three-Dimensional Biphasic Polymer Scaffold for Synergistic Bone Regeneration. Acs Biomaterials Science & Engineering 2019, 5 (2), 986−995.
22. Yu, Y.; Xu, Q.; He, S.; Xiong, H.; Zhang, Q.; Xu, W.; Ricotta, V.; Bai, L.; Zhang, Q.; Yu, Z., Recent advances in delivery of photosensitive metal-based drugs. Coordination Chemistry Reviews 2019, 387, 154−179.
23. Wang, Y.; Jiang, Z.; Xu, W.; Yang, Y.; Zhuang, X.; Ding, J.; Chen, X., Chiral Polypeptide Thermogels Induce Controlled Inflammatory Response as Potential Immunoadjuvants. ACS Applied Materials & Interfaces 2019, 11 (9), 8725−8730.
24. Li, S. X.; Feng, X. R.; Wang, J. X.; Xu, W. G.; Islam, M. A.; Sun, T. M.; Xie, Z. G.; Wang, C. X.; Ding, J. X.; Chen, X. S., Multiantigenic Nanoformulations Activate Anticancer Immunity Depending on Size. Advanced Functional Materials 2019, 29 (49)，1903391.
25. Feng, X.; Xu, W.; Li, Z.; Song, W.; Ding, J.; Chen, X., Immunomodulatory Nanosystems. Advanced Science 2019, 1900101.
26. Ding, J. X.; Feng, X. R.; Jiang, Z. Y.; Xu, W. G.; Guo, H.; Zhuang, X. L.; Chen, X. S., Polymer-Mediated Penetration-Independent Cancer Therapy. Biomacromolecules 2019, 20 (12), 4258−4271.
27. Chen, M.; Feng, X.; Xu, W.; Wang, Y.; Yang, Y.; Jiang, Z.; Ding, J., PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery. Molecules 2019, 24 (8), 1538.
28. Zhu, B.; Xu, W.; Liu, J.; Ding, J.; Chen, X., Osteoinductive agents-incorporated three-dimensional biphasic polymer scaffold for synergistic bone regeneration. ACS biomaterials science & engineering 2018, 5 (2), 986−995.
29. Zhang, Y.; Zhang, J.; Xu, W.; Xiao, G.; Ding, J.; Chen, X., Tumor microenvironment-labile polymer-doxorubicin conjugate thermogel combined with docetaxel for in situ synergistic chemotherapy of hepatoma. Acta Biomaterialia 2018, 77, 63−73.
30. Zhang, Y.; Zhang, J.; Chang, F.; Xu, W.; Ding, J., Repair of full-thickness articular cartilage defect using stem cell encapsulated thermogel. Materials Science & Engineering C: Materials for Biological Applications 2018, 88, 79−87.
31. Zhang, Y.; Sha, R.; Zhang, L.; Zhang, W.; Jin, P.; Xu, W.; Ding, J.; Lin, J.; Qian, J.; Yao, G.; Zhang, R.; Luo, F.; Zeng, J.; Cao, J.; Wen, L.-p., Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer. Nature Communications 2018, 9, 4236.
32. Zhang, W.; Xu, W.; Ning, C.; Li, M.; Zhao, G.; Jiang, W.; Ding, J.; Chen, X., Long-acting hydrogel/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia. Biomaterials 2018, 181, 378−391.
33. Zhang, W.; Ning, C.; Xu, W.; Hu, H.; Li, M.; Zhao, G.; Ding, J.; Chen, X., Precision-guided long-acting analgesia by Gel-immobilized bupivacaine-loaded microsphere. Theranostics 2018, 8 (12), 3331−3347.
34. Xu, W.; Dong, S.; Han, Y.; Li, S.; Liu, Y., Hydrogels as Antibacterial Biomaterials. Current Pharmaceutical Design 2018, 24 (8), 843−854.
35. Xu, W.; Ding, J.; Xiao, C.; Li, L.; Zhuang, X.; Chen, X., Versatile preparation of intracellular-acidity sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic. Biomaterials 2018, 163, 88.
36. Wang, J.; Xu, W.; Li, S.; Qiu, H.; Li, Z.; Wang, C.; Wang, X.; Ding, J., Polylactide-Cholesterol Stereocomplex Micelle Encapsulating Chemotherapeutic Agent for Improved Antitumor Efficacy and Safety. Journal of Biomedical Nanotechnology 2018, 14 (12), 2102−2113.
37. Ma, H.; Zhuang, X.; Ning, C.; Xu, W.; Liu, Y.; Fu, C., Synergistic treatment of spinal metastasis. Nanomedicine: Nanotechnology, Biology and Medicine 2018, 14 (5), 1852−1853.
38. Li, S.; Zhang, T.; Xu, W.; Ding, J.; Yin, F.; Xu, J.; Sun, W.; Wang, H.; Sun, M.; Cai, Z.; Hua, Y., Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis. Theranostics 2018, 8 (5), 1361−1375.
39. Li, S.; Dong, S.; Xu, W.; Tu, S.; Yan, L.; Zhao, C.; Ding, J.; Chen, X., Antibacterial Hydrogels. Advanced Science 2018, 5 (5), 1700527.
40. Li, P.; Han, J.; Li, D.; Chen, J.; Wang, W.; Xu, W., Synthetic Glycopolypeptide Micelle for Targeted Drug Delivery to Hepatic Carcinoma. Polymers 2018, 10 (6), 611.
41. Li, J.; Xu, W.; Li, D.; Liu, T.; Zhang, Y. S.; Ding, J.; Chen, X., Locally Deployable Nanofiber Patch for Sequential Drug Delivery in Treatment of Primary and Advanced Orthotopic Hepatomas. Acs Nano 2018, 12 (7), 6685−6699.
42. Li, J.; Xu, W.; Chen, J.; Li, D.; Zhang, K.; Liu, T.; Ding, J.; Chen, X., Highly Bioadhesive Polymer Membrane Continuously Releases Cytostatic and Anti-Inflammatory Drugs for Peritoneal Adhesion Prevention. Acs Biomaterials Science & Engineering 2018, 4 (6), 2026−2036.
43. Jia, M.; Liu, G.; Sun, Z.; Fu, Z.; Xu, W., Investigation on Two Forms of Temperature-Sensing Parameters for Fluorescence Intensity Ratio Thermometry Based on Thermal Coupled Theory. Inorganic Chemistry 2018, 57 (3), 1213−1219.
44. He, L.; Xu, W.; Wang, X.; Wang, C.; Ding, J.; Chen, X., Polymer micro/nanocarrier-assisted synergistic chemohormonal therapy for prostate cancer. Biomaterials Science 2018, 6 (6), 1433−1444.
45. Han, J.; Zhao, X.; Xu, W.; Wang, W.; Han, Y.; Feng, X., Effect of hydrophobic polypeptide length on performances of thermo-sensitive hydrogels. Molecules 2018, 23 (5), 1017.
46. Guo, H.; Li, F.; Xu, W.; Chen, J.; Hou, Y.; Wang, C.; Ding, J.; Chen, X., Mucoadhesive Cationic Polypeptide Nanogel with Enhanced Penetration for Efficient Intravesical Chemotherapy of Bladder Cancer. Advanced Science 2018, 5 (6), 1800004.
47. Bi, M.; Han, H.; Dong, S.; Zhang, Y.; Xu, W.; Zhu, B.; Wang, J.; Zhou, Y.; Ding, J., Collagen-Coated 2 Poly (lactide-co-glycolide)/Hydroxyapatite Scaffold 3 Incorporated with DGEA Peptide for Synergistic 4 Repair of Skull Defect. Polymers 2018, 10 (2) 109.
48. Zhao, K.; Li, D.; Xu, W.; Ding, J.; Jiang, W.; Li, M.; Wang, C.; Chen, X., Targeted hydroxyethyl starch prodrug for inhibiting the growth and metastasis of prostate cancer. Biomaterials 2017, 116, 82−94.
49. Xu, W.; Ding, J.; Zhuang, X.; Chen, X., Regular sleep and cytotoxic nanomedicine targeting tumor-associated macrophages for synergistic immunotherapy of breast cancer. Journal of Controlled Release 2017, 259, E137−E138.
50. Xu, W.; Ding, J.; Chen, X., Reduction-Responsive Polypeptide Micelles for Intracellular Delivery of Antineoplastic Agent. Biomacromolecules 2017, 18 (10), 3291−3301.
51. Shi, B.; Huang, K.; Ding, J.; Xu, W.; Yang, Y.; Liu, H.; Yan, L.; Chen, X., Intracellularly Swollen Polypeptide Nanogel Assists Hepatoma Chemotherapy. Theranostics 2017, 7 (3), 703−716.
52. Ma, H.; Zhang, Q.; Liu, Y.; Xu, W.; Fu, C., Chemo-immunotherapy of spinal malignancy: paratumor injection of PTX/1MT-incorporated thermogel. Journal of Controlled Release 2017, 259, e46.
53. Li, S.; Xu, W.; Ding, J.; Cai, Z.; Hua, Y.; Chen, X., Targeted intracellular delivery of shikonin effectively induces osteosarcoma necroptosis with downward lung metastasis. Journal of Controlled Release 2017, 259, e125.
54. Li, L.; Xu, W.; Ding, J.; Zhuang, X.; Chen, X., Systemically administered targeted nanomedicine combined with locally granted nitric oxide suppresses drug-resistance of hepatoma. Journal of Controlled Release 2017, 259, e84.
55. Li, J.; Xu, W.; Chen, J.; Li, D.; Zhang, K.; Liu, T.; Ding, J.; Chen, X., Highly bioadhesive polymer membrane continuously releases cytostatic and anti-inflammatory drugs for peritoneal adhesion prevention. ACS Biomaterials Science & Engineering 2017, 4 (6), 2026−2036.
56. Li, J.; Gong, Q.; Xu, W.; Zhang, K.; Liu, T., Sequential release of tea polyphenols and mitoxantrone from emulsion electrospun nanofibers against malignant ascites and peritoneal adhesion. Journal of Controlled Release 2017, 259, e59.
57. Li, D. D.; Zhang, G. B.; Xu, W. G.; Wang, J. X.; Wang, Y. C.; Qiu, L. Z.; Ding, J. X.; Yang, X. Z., Investigating the Effect of Chemical Structure of Semiconducting Polymer Nanoparticle on Photothermal Therapy and Photoacoustic Imaging. Theranostics 2017, 7 (16), 4029−4040.
58. Guo, H.; Xu, W.; Wang, J.; He, L.; Hou, Y.; Ding, J., Engineered nanogel with superior tissue affinity and cell targeting toward orthotopic bladder cancer. Journal of Controlled Release 2017, 259, E48−E49.
59. Guo, H.; Xu, W.; Chen, J.; Yan, L.; Ding, J.; Hou, Y.; Chen, X., Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma. Journal of Controlled Release 2017, 259, 136−148.
60. Chen, J.; Ding, J.; Xu, W.; Zhuang, X.; Chen, X., Surface dual-targeting equipped nanogels intracellularly deliver cytotoxic agent to suppress highly metastatic malignancy. Journal of Controlled Release 2017, 259, E69−E69.
61. Chen, J.; Ding, J.; Xu, W.; Sun, T.; Xiao, H.; Zhuang, X.; Chen, X., Receptor and Microenvironment Dual-Recognizable Nanogel for Targeted Chemotherapy of Highly Metastatic Malignancy. Nano Letters 2017, 17 (7), 4526−4533.
62. Li, D.; Xu, W.; Li, P.; Ding, J.; Cheng, Z.; Chen, L.; Yan, L.; Chen, X., Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma. Molecular Pharmaceutics 2016, 13 (12), 4231−4235.
63. He, L.; Li, D.; Wang, Z.; Xu, W.; Wang, J.; Guo, H.; Wang, C.; Ding, J., L-cystine-crosslinked polypeptide nanogel as a reduction-responsive excipient for prostate cancer chemotherapy. Polymers 2016, 8 (2), 36.
64. Zhang, Q.; Ding, J.; Lv, C.; Xu, W.; Sun, X.; Meng, X., Epirubicin-complexed polypeptide micelle effectively and safely treats hepatocellular carcinoma. Polymers 2015, 7 (11), 2410−2430.
65. Xu, W.; Li, L.; Lu, S.; Ding, J.; Xiao, C.; Zhuang, X.; Chen, X., Two-way combination chemotherapy for synergistic tumor capture. Journal of Controlled Release 2015, 213, E113−E114.
66. Xu, W.; Ding, J.; Xiao, C.; Li, L.; Zhuang, X.; Chen, X., Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic. Biomaterials 2015, 54, 72−86.
67. Xu, W.; Ding, J.; Li, L.; Xiao, C.; Zhuang, X.; Chen, X., Acid-labile boronate-bridged dextran-bortezomib conjugate with up-regulated hypoxic tumor suppression. Chemical Communications 2015, 51 (31), 6812−6815.
68. Wang, J.; Xu, W.; Guo, H.; Ding, J.; Chen, J.; Guan, J.; Wang, C., Selective intracellular drug delivery from pH-responsive polyion complex micelle for enhanced malignancy suppression in vivo. Colloids and Surfaces B-Biointerfaces 2015, 135, 283−290.
69. Wang, J.; Xu, W.; Ding, J.; Lu, S.; Wang, X.; Wang, C.; Chen, X., Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin. Materials 2015, 8 (1), 216−230.
70. Wang, J.; Shen, K.; Xu, W.; Ding, J.; Wang, X.; Liu, T.; Wang, C.; Chen, X., Stereocomplex micelle from nonlinear enantiomeric copolymers efficiently transports antineoplastic drug. Nanoscale Research Letters 2015, 10, 1−11.
71. Liu, X. G.; Wang, J. M.; Xu, W. G.; Ding, J. X.; Shi, B.; Huang, K. X.; Zhuang, X. L.; Chen, X. S., Glutathione-degradable drug-loaded nanogel effectively and securely suppresses hepatoma in mouse model. International journal of nanomedicine 2015, 10, 6587−6602.
72. Li, C.; Xu, W.; Ding, J.; Zhang, Y.; Wang, J.; Zhuang, X.; Chen, X., Micellization of Antineoplastic Agent to Significantly Upregulate Efficacy and Security. Macromolecular Bioscience 2015, 15 (3), 328−341.
73. Huang, K.; Shi, B.; Xu, W.; Ding, J.; Yang, Y.; Liu, H.; Zhuang, X.; Chen, X., Reduction-responsive polypeptide nanogel delivers antitumor drug for improved efficacy and safety. Acta Biomaterialia 2015, 27, 179−193.
74. Ding, J.; Li, C.; Zhang, Y.; Xu, W.; Wang, J.; Chen, X., Chirality-mediated polypeptide micelles for regulated drug delivery. Acta Biomaterialia 2015, 11, 346−355.
75. Zhang, Y..; Ding, J..; Xu, W.; Wu, J.; Chang, F.; Zhuang, X.; Chen, X.; Wang, J., Biodegradable thermogel as culture matrix of bone marrow mesenchymal stem cells for potential cartilage tissue engineering. Chinese Journal of Polymer Science 2014, 32 (12), 1590−1601.
76. Yu, S.; Ding, J.; He, C.; Cao, Y.; Xu, W.; Chen, X., Disulfide Cross-Linked Polyurethane Micelles as a Reduction-Triggered Drug Delivery System for Cancer Therapy. Advanced Healthcare Materials 2014, 3 (5), 752−760.
77. Liu, D.; Ding, J.; Xu, W.; Song, X.; Zhuang, X.; Chen, X., Stereocomplex Micelles Based on 4-Armed Poly ( ethylene glycol ) -Polylactide Enantiomeric Copolymers for Drug Delivery. Acta Polymerica Sinica 2014, (9), 1265−1273.
78. Li, D.; Sun, H.; Ding, J.; Tang, Z.; Zhang, Y.; Xu, W.; Zhuang, X.; Chen, X., Polymeric topology and composition constrained polyether-polyester micelles for directional antitumor drug delivery. Acta Biomaterialia 2013, 9 (11), 8875−8884.
89. Ding, J.; Xu, W.; Zhang, Y.; Sun, D.; Xiao, C.; Liu, D.; Zhu, X.; Chen, X., Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery. Journal of Controlled Release 2013, 172 (2), 444−455.