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成果及论文

81. Tian S, Yang X, Lin Y, Li X, Zhou S, Yu P*, Zhao Y*, 2024. PDK4-mediated Nrf2 inactivation contributes to oxidative stress and diabetic kidney. Cell Signal121: 111282.

80. Li Y, Zhai W, Wang Z, Petrov AM, Zhang B*, Zhao Y*, 2024. Ultrasound-aided cellular uptake and endosomal escape of nanoparticles via the membrane surface redox reaction. Chem Res Chin Uniin press (doi: 10.7503/cjcu20240265).

79. Fan L, Du P, Li Y, Chen X, Liu F, Liu Y, Petrov AM, Li X*, Wang Z*, Zhao Y*, 2024. Targeted liposomes sensitize plastic melanoma to ferroptosis via senescence induction and coenzyme depletion. ACS Nano, 18(9): 7011-7023.

78. Song Y, Xu X, Wang Z*, Zhao Y*, 2024. Metal-organic framework-based nanomedicines for ferroptotic cancer therapy. Adv Healthc Mater, 13(11): e2303533.

77.  Gao Z, Zhang J, Hou Y, Lu J, Liang J, Gao Y, Li B, Gao S, Zhao Y*, Gao M*, Chen J*, 2024. Boosting the synergism between cancer ferroptosis and immunotherapy via targeted stimuli-responsive liposomes. Biomaterials, 305: 122442.

76.  Luo J, Li Y, Li Y, Chen X, Du P, Wang Z, Tian A,* Zhao Y*, 2023. Reversing ferroptosis resistance in breast cancer via tailored lipid and iron presentation. ACS Nano, 17(24): 25257-25268.

75.  Li Y, Wang J, Li Y, Luo J, Liu F, Chen T, Ji Y, Yang H, Wang Z, Zhao Y*, 2023. Attenuating uncontrolled inflammation by radical trapping chiral polymer micelles. ACS Nano, 17(13): 12127-12139.

74.  Meng X*, Wang L, Zhao N, Zhao D, Shen Y, Yao Y, Jing W, Man S, Dai Y*, Zhao Y*, 2023. Stimuli-responsive cancer nanomedicines inhibit glycolysis and impair redox homeostasis. Acta Biomater, 167: 374-386.

73.  Chen T, Qin Y, Li Y, Li Y, Luo J, Fan L, Feng M, Wang Z, Zhao Y*, 2023. Chiral polymer micelles alleviate adriamycin cardiotoxicity via iron chelation and ferroptosis inhibition. Adv Func Mater, 33(30): 2300689.

72.  Li Y, Feng M, Guo T, Wang Z, Zhao Y*, 2023. Tailored beta-lapachone nanomedicines for cancer-specific therapy. Adv Healthc Mater, 12(20): 2300349.

71.  Li Y, Liu M, Zheng Y, Wang Z*, Zhao Y*, 2023. Coenzyme-depleting nanocarriers for enhanced redox cancer therapy under hypoxia. J Colloid Interface Sci, 641: 135-145.

70.  Wang Z, Mu X, Yang Q, Luo J, Zhao Y*, 2022. Hypoxia-responsive nanocarriers for chemotherapy sensitization via dual-mode inhibition of hypoxia-inducible factor-1 alpha. J Colloid Interface Sci, 628: 106-115.

69.  Li Y, Qin Y, Shang Y, Li Y, Liu F, Luo J, Zhu J, Guo X, Wang Z, Zhao Y*, 2022. Mechano-responsive leapfrog micelles enable interactive apoptotic and ferroptotic cancer therapy. Adv Func Mater, 32(29): 2112000.

68. Zhu J, Guo T, Wang Z*, Zhao Y*, 2022. Triggered Azobenzene-based prodrugs and drug delivery systems. J Control Release, 345: 475-493.

67. Li Y#, Feng S#, Dai, P, Liu F, Shang Y, Yang Q, Qin J, Yuchi Z, Wang Z*, Zhao Y*, 2022. Tailored Trojan horse nanocarriers for enhanced redox-responsive drug delivery. J Control Release, 342: 201-209.

66. Ma Y, Ye Z, Zhang C, Zhao Y*, Luo H*, Xiao L*, 2022. Curved carbon photo-oxygenation catalysts for the suppression and nanoscopic imaging of β-amyloid peptides fibrillation. Nano Res, 15: 3387-3397.

65. Liu F, Zhu J, Dai P, Deng J, Qin J, Yuchi Z, Fan A, Wang Z, Zhao Y*, 2021. Double-Lock Nanomedicines Enable Tumor Microenvironment-Responsive Selective Anti-Tumor Therapy. Adv Func Mater, 31(38): 2009157.

64. Qin Y, Guo T, Wang Z, Zhao Y*, 2021. The Role of Iron in Doxorubicin-induced Cardiotoxicity: Recent Advances and Implication for Drug Delivery. J Mater Chem B, 9(24): 4793-4803.

Graphical abstract: The role of iron in doxorubicin-induced cardiotoxicity: recent advances and implication for drug delivery

63. Guo X, Liu F, Deng J, Dai P, Qin Y, Li Z, Wang B, Fan A, Wang Z*, Zhao Y*, 2020. Electron-Accepting Micelles Deplete Reduced Nicotinamide Adenine Dinucleotide Phosphate and Impair Two Antioxidant Cascades for Ferroptosis-Induced Tumor Eradication. ACS Nano, 14(11): 14715-14730.

62. Zhu J, Dai P, Liu F, Li Y, Qin Y, Yang Q, Tian R, Fan A, Medeiros SF, Wang Z*, Zhao Y*, 2020. Upconverting nanocarriers enable triggered microtubule inhibition and concurrent ferroptosis induction for selective treatment of triple-negative breast cancer. Nano Lett., 20(9): 6235-6245.

61. Mulatihan DN#, Guo T#, Zhao Y*, 2020. Azobenzene photoswitch for isomerization-dependent cancer therapy via azo-combretastatin A4 and phototrexate. Photochem. Photobiol., 96(6):1163-1168.

60.  An Y, Chen C, Zhu J, Dwivedi P, Zhao Y*, Wang Z*, 2020. Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4. Front. Chem. Sci. Eng., 14, 880-888.

59.  Guo X, Lu D, Zhang D, Deng J, Zhang X, Wang Z*, Xiao L*, Zhao Y*, 2020. Curved corannulene dually targets mitochondria and endoplasmic reticulum, and initiates apoptosis via localized ROS induction upon light triggering. Mater Sci Eng C Mater Biol Appl., 106: 110227.

 

58. Meng X, Deng J, Liu F, Guo T, Liu M, Dai P, Fan A, Wang Z, Zhao Y*, 2019. Triggered all-active metal organic framework: ferroptosis machinery contributes to the apoptotic photodynamic antitumor therapy. Nano Lett., 19(11):7866-7876.

57. Gao M#, Deng J#, Liu F, Fan A, Wang Y, Wu H, Ding D, Kong D, Wang Z, Peer D, Zhao Y*, 2019. Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy. Biomaterials, 223: 119486.

56. An Y#, Zhu J#, Liu F, Deng J, Meng X, Liu G, Wu H, Fan A, Wang Z, Zhao Y*, 2019. Boosting the ferroptotic antitumor efficacy via site-specific amplification of tailored lipid peroxidation. ACS Appl Mater Interfaces, 11(33): 29655-29666.

55. Chen Y, Deng J, Liu F, Dai P, An Y, Wang Z, Zhao Y*, 2019. Energy-free, singlet oxygen-based chemodynamic therapy for selective tumor treatment without dark toxicity. Adv Healthc Mater, 8(18): 1900366.

54. Yan Q, Guo X, Huang X, Meng X, Liu F, Dai P, Wang Z, Zhao Y*, 2019. Gated mesoporous silica nanocarriers for hypoxia-responsive cargo release. ACS Appl Mater Interfaces, 11(27): 24377-24385.

53. Deng J#, Liu F#, Wang L, An Y, Gao M, Wang Z, Zhao Y*, 2019. Hypoxia- and singlet oxygen-responsive chemo-photodynamic micelles featured with glutathione depletion and aldehyde production. Biomater Sci, 7(1):429-441.

52. Huang X#, Lu D#, Ma Y, Zhang L, Wang L, Deng J, Wang Z, Zhao Y*, 2019. From small deferiprone to macromolecular micelles: Self-assembly enhances iron chelation. J Colloid Interface Sci, 533: 375-384.

51. Gao M#, Meng X#, Guo X, Zhu J, Fan A, Wang Z, Zhao Y*, 2018. All-active anti-tumor micelles via triggered lipid peroxidation. J Control Release, 286: 381-393. 

50. Meng X#, Gao M#, Deng J, Lu D, Fan A, Ding D, Kong D, Wang Z, Zhao Y*, 2018. Self-immolative micellar drug delivery: the linker matters. Nano Res, 11(12), 6177-6189. 

49. Tao R#, Gao M#, Liu F, Guo X, Fan A, Ding D, Kong D, Wang Z, Zhao Y*, 2018. Alleviating the liver toxicity of chemotherapy via pH-responsive hepatoprotective prodrug micelles. ACS Appl Mater Interfaces, 10(26): 21836-21846. 

48. Lu D, An Y, Feng S, Li X, Fan A, Wang Z*, Zhao Y*, 2018. Imidazole-bearing polymeric micelles for enhanced cellular uptake, rapid endosomal escape and on-demand cargo release. AAPS PharmSciTech, 19(6): 2610-2619.  

47. Wang L#, Huang X#, Wang B, Zhao J, Guo X, Wang Z, Zhao Y*, 2018. Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles. Biomater Sci, 6(7):1712-1716.  

46. Li J#, Meng X#, Deng J, Lu D, Zhang X, Chen Y, Zhu J, Fan A, Ding D, Kong D, Wang Z, Zhao Y*, 2018. Multifunctional micelles dually responsive to hypoxia and singlet oxygen: enhanced photodynamic therapy via interactively triggered photosensitizer delivery. ACS Appl Mater Interfaces, 10(20): 17117–17128.   

45. Zhang X, Yan Q, Mulatihan DN, Zhu J, Fan A, Wang Z*, Zhao Y*, 2018. Pharmaceutical micelles featured with singlet oxygen-responsive cargo release and mitochondrial targeting for enhanced photodynamic therapy. Nanotechnology, 29(25): 255101. 

44. Liu G#, Deng J#, Liu F, Wang Z, Peer D, Zhao Y*, 2018. Hierarchically theranostic nanomedicine: MRI contrast agents as the physical vehicle anchor for high drug loading and triggered on-demand delivery. J Mater Chem B, 6(13): 1995-2003.  

43. Zhang D, Wang L, Zhang X, Bao D,* Zhao Y*, 2018. Polymeric micelles for pH-responsive lutein delivery. J Drug Del Sci Technol, 45: 281-286.  

42. Wang X, Li J, Yan Q, Chen Y, Fan A, Wang Z, Zhao Y*, 2018. In situ probing intracellular drug release from redox-responsive micelles by united FRET and AIE. Macromol Biosci, 18(3): 1700339.

41. Chen C, Zhao J, Gao M, Meng X, Fan A, Wang Z*, Zhao Y*, 2018. Photo-triggered micelles: Simultaneous activation and release of a microtubule inhibitors for on-demand chemotherapy. Biomater Sci, 6(3): 511-518.

40. Gu X, Zhang X, Ma H, Jia S, Zhang P, Zhao Y, Liu Q, Wang J, Zheng X, Lam JWY, Ding D*, Tang BZ*, 2018. Corannulene-incorporated AIE nanodots with highly suppressed nonradiative decay for boosted cancer phototheranostics in vivo. Adv Mater, 2018, 30(26):1801065.

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39. Gao M#, Deng J#, Chu H#, Tang Y, Wang Z, Zhao Y*, Li G*, 2017. Stereoselective stabilization of polymeric vitamin E conjugate micelles. Biomacromolecules, 18(12):4349-4356. 

38. Chen C, Tao R, Ding D, Kong D, Fan A, Wang Z*, Zhao Y*, 2017. Ratiometric co-delivery of multiple chemodrugs in a single nanocarrier. Eur J Pharm Sci, 107: 16-23. 

37. Zhang L#, Dong X#, Lu D, Liu S, Ding D, Kong D, Fan A, Wang Z*, Zhao Y*, 2017. Controlled ROS production by corannulene: The vehicle makes a difference. Biomater Sci, 5: 1236-1240. 

36.  Liu S#, Lu D#, Wang X, Ding D, Kong D, Wang Z, Zhao Y*, 2017. Topology dictates function: Controlled ROS production and mitochondria accumulation via curved carbon materials. J Mater Chem B, 5(25): 4918-4925. 

35.  Li X#, Gao M#, Xin K, Zhang L, Ding D, Kong D, Wang Z, Shi Y, Kiessling F, Lammers T, Cheng J, Zhao Y*, 2017. Singlet oxygen-responsive micelles for enhanced photodynamic therapy. J Control Release, 260: 12-21. 

34. Dong X#, Guo X#, Liu G, Fan A, Wang Z*, Zhao Y*, 2017. When self-assembly meets topology: an enhanced micellar stability. Chem Commun, 53(27): 3822-3825. 

33. Xin K#, Li M#, Lu D, Meng X, Deng J, Kong D, Ding D, Wang Z, Zhao Y*, 2017. Bioinspired coordination micelles integrating high stability, triggered cargo release, and magnetic resonance imaging. ACS Appl Mater Interfaces, 9(1):80-91.   

32. Zhang S#, Meng X#, Wang Z, Fan A, Wang G, Zhao Y,* Tang Y,* 2017. Engineering hot-melt extruded solid dispersion for controlled release of hydrophilic drugs. Eur J Pharm Sci, 100, 109-115. 

31. Li M, Gao M, Fu Y, Chen C, Meng X, Fan A, Kong D, Wang Z*, Zhao Y*, 2016. Acetal-linked polymeric prodrug micelles for enhanced curcumin. Colloids Surf B Biointerfaces, 140:11-18.

30. Gao M, Chen C, Fan A, Zhang J, Kong D, Wang Z*, Zhao Y*, 2015. Covalent and non-covalent curcumin loading in acid-responsive polymeric micellar nanocarriers. Nanotechnology, 26(27):275101.

29. Wang Z, Chen C, Zhang Q, Gao M, Zhang J, Kong D, Zhao Y*, 2015. Tuning the architecture of polymeric conjugate to mediate intracellular delivery of pleiotropic curcumin. Eur J Pharm Biopharm, 90: 53-62.

28. Li H, Li M, Chen C, Fan A, Kong D, Wang Z*, Zhao Y*, 2015. On-demand combinational delivery of curcumin and doxorubicin via a pH-labile micellar nanocarrier. Int J Pharm, 495(1):572-578. 

27. Gao M, Liu S, Fan A, Wang Z, Zhao Y*, 2015. Nitric oxide-releasing graft polymer micelles with distinct pendant amphiphiles. RSC Adv, 5(82):67041-67048.

26. Zhang Y, Gao M, Chen C, Wang Z*, Zhao Y*, 2015. Residue cytotoxicity of hydrazone-linked polymer-drug conjugate: Implication for acid-responsive micellar drug delivery. RSC Adv, 5(44):34800-34802.

25. Cao Y, Gao M, Chen C, Fan A, Zhang J, Kong D, Wang Z, Peer D, Zhao Y*, 2015. Triggered-release polymeric conjugate micelles for on-demand intracellular drug delivery. Nanotechnology, 26(11):115101.

24. Guo C, Khengar RH, Sun M, Wang Z, Fan A, Zhao Y*, 2014. Acid-responsive polymeric nanocarriers for topical adapalene delivery. Pharm Res, 31(11):3051-3059.

23. Wang Z, Chen C, Liu R, Fan A, Kong D, Zhao Y*, 2014. Two birds with one stone: dendrimer surface engineering enables tunable periphery hydrophobicity and rapid endosomal escape. Chem Commn, 50 (90): 14025-14028.

22. Guo C, Zhang Y, Sun M, Wang Z, Fan A, Zhao Y*, 2014. Modulating topical drug delivery via skin pre-treatment with low-generation poly(amidoamine) dendrimers. J Drug Deliv Sci Technol, 24(5): 555-557.

21. Fu Y, Gao X, Wan Y, Zhang J, Kong D, Wang Z*, Zhao Y*, 2014. Dendritic nanoconjugate containing optimum folic acid for targeted intracellular curcumin delivery. RSC Adv, 4(86): 46020-46023.

20. Liu R, Sun M, Liu X, Fan A, Wang Z*, Zhao Y*, 2014. Interplay of stimuli-responsiveness, drug loading and release for a surface-engineered dendrimer delivery system. Int J Pharm, 462(1-2): 103-107.

19. Zhao Y, Alas’ad MA, Jones SA*, 2014. Modifying theophylline microparticle surfaces via the sequential deposition of poly(vinyl alcohol-co-vinyl acetate) copolymers. Int J Pharm, 463(1): 27-30.

18. Song L, Sun M, Zhao Y*, Wang Z*, 2014. Tailored dual coating of magnetic nanoparticles for enhanced drug loading. RSC Adv, 4(10): 4893-4896.

17. Zhang Q, Zhu J, Song L, Zhang J, Kong D, Zhao Y*, Wang Z*, 2013. Engineering magnetic-molecular sequential targeting nanoparticles for anti-cancer therapy. J Mater Chem B, 1(46): 6402-6410.

16. Zhang J, Sun M, Fan A, Wang Z, Zhao Y*, 2013. The effect of solute-membrane interaction on solute permeation under supersaturated conditions. Int J pharm, 441(1-2):389-394.

15. Liu X, Pan D, Guo Q, Gao X, Zhao Y*, Wang Z*, 2013. The dominant role of polymer erosion in paclitaxel release from folate-modified poly(ether-anhydride) nanocarrier. J Appl Polym Sci, 129(2): 748-755.

14. Yang R, Zhang S, Kong D, Gao X, Zhao Y*, Wang Z*, 2012. Biodegradable polymer-curcumin conjugate micelles enhance the loading and delivery of low-potency curcumin. Pharm Res, 29(12): 3512-3525.

13. Zhao Y, Shen L, Wan Y, Zhu X, Wang Z*, 2012. Thermosensitivity of low generation poly(amidoamine) dendrimers with enriching peripheral functional groups. Colloid Surface A, 403:164-168.

12. Zhao Y, Brown MB, Khengar RH, Traynor MJ, Barata P, Jones SA*, 2012. Pharmacokinetic evaluation of intranasally administered vinyl polymer coated lorazepam microparticles in rabbits. AAPS J, 14(2): 218-224.

11. Zhao Y, Yang R, Liu D, Sun M, Zhou L, Wang Z*, Wan Y*, 2012. Starburst low molecular weight polyethylenimine for efficient gene delivery, J Biomed Mater Res A, 100(1):134-140.

10.  Niu Y, Zhao Y, Fan A*, 2011. Conformational switching immobilized hairpin DNA probes following subsequent expanding of gold nanoparticles enables visual detecting sequence-specific DNA, Anal Chem, 83(19):7500-7506.

09. Zhao Y, Fan X, Liu D, Wang Z*, 2011. PEGylated thermo-sensitive poly(amidoamine) dendritic drug delivery systems, Int J Pharm, 409(1-2):229-236.

08. Traynor MJ, Zhao Y, Brown MB, Jones SA*, 2011. Vinyl polymer-coated lorazepam particles for drug delivery to the airways, Int J Pharm, 410(1-2):9-16.

07. Bao D, Zhao Y*, 2010. Building membrane emulsification into pulmonary drug delivery and targeting. Pharm Res, 27(11):2505-2508.

06. Zhao Y, Jones SA, Brown MB*, 2010. Dynamic foams in topical drug delivery. J Pharm Pharmacol, 62(6):678-684.

05. Zhao Y, Brown MB, Jones SA*, 2010. Pharmaceutical foams: are they the answer to the dilemma of topical nanocarriers?  Nanomedicine NBM, 6(2):227-236.

04. Zhao Y, Brown MB, Jones SA*, 2010. The topical delivery of benzoyl peroxide using elegant dynamic hydrofluoroalkane foams. J Pharm Sci, 99(3):1384-1398.

03. Zhao Y, Brown MB, Jones SA*, 2010. The effects of particle properties on nanoparticle drug retention and release in an elegant dynamic minoxidil foams. Int J Pharm, 383(1-2):277-284.

02. Zhao Y, Moddaresi M, Jones SA, Brown MB*, 2009. A dynamic topical hydrofluoroalkane foam to induce nanoparticle modification and drug release in situ. Eur J Pharm Biopharm, 72(3):521-528.

01. Zhao Y, Brown MB, Jones SA*, 2009. Engineering novel topical foams using hydrofluoroalkane emulsions stabilised by pluronic surfactants. Eur J Pharm Sci, 37(3-4):370-377.