*,corresponding author, # ,first author

2024

Wang Y, Yin D, Sun X, Zhang W, Ma H, Huang J, Yang C*, Wang J*, Geng Q*. Perfluoroalkyl sulfonate induces cardiomyocyte apoptosis via endoplasmic reticulum stress activation and autophagy flux inhibition. Sci Total Environ. 2024 Apr 20;:172582. doi: 10.1016/j.scitotenv.2024.172582.

 

Chen P, Zhong X, Song Y, Zhong W, Wang S, Wang J, Huang P, Niu Y, Yang W, Ding Z, Luo* Q, Yang C*, Wang J*, Zhang W*. Triptolide induces apoptosis and cytoprotective autophagy by ROS accumulation via directly targeting peroxiredoxin 2 in gastric cancer cells. Cancer Lett. 2024 Apr 10;587:216622. doi: 10.1016/j.canlet.2024.216622.

 

Ou J, Song Y, Zhong X, Dai L, Chen J, Zhang W, Yang C*, Wang J*, Zhang W*. Perfluorooctanoic acid induces Leydig cell injury via inhibition of autophagosomes formation and activation of endoplasmic reticulum stress. Sci Total Environ. 2024 Mar 20;917:169861. doi: 10.1016/j.scitotenv.2023.169861.

 

Li G, Liu X, Sun X, Huang L, Kuang W, Ou J, Zhang J, Zhang Z, Li H, Tang H, Feng C, Gu L, Yang C*, Peili W*, Wang J*. Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway. Environ Int. 2024 Mar;185:108543. doi: 10.1016/j.envint.2024.108543. 

Bai Y, Zhu Z, Ou J, Zhang W, Iyaswamy A, Jiang Y, Wang J*, Zhang W*, Yang C*. Insight into Tetrabromobisphenol A-Associated Liver Transcriptional Landscape via Single Cell RNA Sequencing. Adv Biol (Weinh). 2024 Feb;8(2):e2300477. doi: 10.1002/adbi.202300477. Epub 2023 Oct 22. PubMed PMID: 37867281.

 

Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY. Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma. Acta Pharmacol Sin. 2024 Feb;45(2):391-404. doi: 10.1038/s41401-023-01167-7.

 

2023

Zhang W, Xia S, Xiao W, Song Y, Tang L, Cao M, Yang J, Wang S, Li Z, Xu C, Liu J*, Zhao S*, Yang C*, Wang J*. A single-cell transcriptomic landscape of mouse testicular aging. J Adv Res. 2023 Nov;53:219-234. doi: 10.1016/j.jare.2022.12.007.

 

Zhang W, Xia S, Ou J, Cao M, Cheng G, Li Z, Wang J*, Yang C*. A single-cell landscape of triptolide-associated testicular toxicity in mice. J Pharm Anal. 2023 Aug;13(8):880-893. doi: 10.1016/j.jpha.2023.04.006.

 

Yang J, Zhang W, Zhang S, Iyaswamy A, Sun J*, Wang J*, Yang C*. Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer's Disease and Parkinson's Disease. Aging Dis. 2023 Jun 1;14(3):652-669.

 

Chen P, Song Y, Tang L, Zhong W, Zhang J, Cao M, Chen J, Cheng G, Li H, Fan T, Kwok HF, Wang J, Yang C*, Xiao W*. Tributyltin chloride (TBTCL) induces cell injury via dysregulation of endoplasmic reticulum stress and autophagy in Leydig cells. J Hazard Mater. 2023 Apr 15;448:130785.

 

Iyaswamy A, Vasudevan K, Jayaraman S, Jaganathan R, Thakur A, Chang RC, Yang C. Editorial: Advances in Alzheimer's disease diagnostics, brain delivery systems, and therapeutics. Front Mol Biosci. 2023;10:1162879.

 

Yang J, Zhang W, Jia L, Shi F, Cao M, Sun J, Xu C, Li Z, Cheng Z, Zhao SC*, Wang J*, Yang C*. A novel autophagy activator ginsenoside Rh2 enhances the efficacy of immunogenic chemotherapy. Clin Transl Med. 2023 Feb;13(2):e1109.

，

Yang C#,* Xia S, Zhang W, Shen HM*, Wang J*. Modulation of Atg genes expression in aged rat liver, brain, and kidney by caloric restriction analyzed via single-nucleus/cell RNA sequencing. Autophagy. 2023 Feb;19(2):706-715.

 

2022

Luo P, Chen J, Zhang Q, Xia F, Wang C, Bai Y, Tang H, Liu D, Gu L, Du Q, Xiao W*, Yang C*, Wang J*. Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics. Precis Clin Med. 2022 Dec;5(4):pbac023. doi: 10.1093/pcmedi/pbac023.

 

Ma J, Xu X, Fu C, Xia P, Tian M, Zheng L, Chen K, Liu X, Li Y, Yu L, Zhu Q, Yu Y, Fan R, Jiang H, Li Z, Yang C, Xu C, Long Y, Wang J, Li Z. CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin. Biomater Res. 2022 Nov 26;26(1):64. doi: 10.1186/s40824-022-00312-3. PubMed PMID: 36435809; PubMed Central PMCID: PMC9701387.

 

Li M, Liu G, Yuan LX, Yang J, Liu J, Li Z, Yang C*, Wang J*. Triphenyl phosphate (TPP) promotes hepatocyte toxicity via induction of endoplasmic reticulum stress and inhibition of autophagy flux. Sci Total Environ. 2022 Sep 20;840:156461.

 

Zhang W, Xia S, Zhong X, Gao G, Yang J, Wang S, Cao M, Liang Z, Yang C*, Wang J*. Characterization of 2,2',4,4'-tetrabromodiphenyl ether (BDE47)-induced testicular toxicity via single-cell RNA-sequencing. Precis Clin Med. 2022 Sep;5(3):pbac016. doi: 10.1093/pcmedi/pbac016.

 

Chen J#, Luo P#, Wang C#, Yang C#, Bai Y, He X, Zhang Q, Zhang J, Yang J, Wang S, Wang J. Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy. JCI Insight. 2022 Aug 22;7(16).

 

Zhang Q, Luo P, Zheng L, Chen J, Zhang J, Tang H, Liu D, He X, Shi Q, Gu L, Li J, Guo Q, Yang C, Wong YK, Xia F, Wang J. 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs. J Pharm Anal. 2022 Aug;12(4):570-582.

 

Wang S, Wang G, Wu W, Xu Z, Yang J, Cao M, Wang Q, Wang J*, Yang C*, Zhang W*. Autophagy activation by dietary piceatannol enhances the efficacy of immunogenic chemotherapy. Front Immunol. 2022;13:968686.

 

Zhang W, Wang J*, Yang C*. Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease. Autophagy. 2022 Jul;18(7):1740-1742. doi: 10.1080/15548627.2022.2046437.

 

Liu D, Zhang Q, Luo P, Gu L, Shen S, Tang H, Zhang Y, Lyu M, Shi Q, Yang C*, Wang J*. Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets. Aging Dis. 2022 Jun;13(3):815-836. doi: 10.14336/AD.2021.1115.

 

Luo P, Liu D, Zhang Q, Yang F, Wong YK, Xia F, Zhang J, Chen J, Tian Y, Yang C, Dai L, Shen HM, Wang J. Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1. Acta Pharm Sin B. 2022 May;12(5):2300-2314. doi: 10.1016/j.apsb.2021.12.007.

 

Yang CB#, Liu J#, Tong BC, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi S, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH, Li M. TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2. Acta Pharmacol Sin. 2022 May;43(5):1251-1263. doi: 10.1038/s41401-021-00711-7.

 

Yang C#,*, Su C, Iyaswamy A, Krishnamoorthi SK, Zhu Z, Yang S, Tong BC, Liu J, Sreenivasmurthy SG, Guan X, Kan Y, Wu AJ, Huang AS, Tan J, Cheung K, Song J, Li M. Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy. Acta Pharm Sin B. 2022 Apr;12(4):1707-1722. doi: 10.1016/j.apsb.2022.01.017.

 

Ng L, Wang X, Yang C, Su C, Li M, Cheung AKL. Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells. Front Immunol. 2022;13:833515. doi: 10.3389/fimmu.2022.833515. eCollection 2022. PubMed PMID: 35309340; PubMed Central PMCID: PMC8926036.

 

Zhang W, Xu C, Sun J, Shen HM*, Wang J*, Yang C*. Impairment of the autophagy-lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential. Acta Pharm Sin B. 2022 Mar;12(3):1019-1040.

 

Xia S, Zhang W, Yang J, Wang S, Yang C*, Wang J*. A single-cell atlas of bisphenol A (BPA)-induced testicular injury in mice. Clin Transl Med. 2022 Mar;12(3):e789.

 

Zhang Q#, Luo P#, Chen J#, Yang C#, Xia F, Zhang J, Tang H, Liu D, Gu L, Shi Q, He X, Yang T, Wang J. Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics. Int J Biol Sci. 2022;18(5):2003-2017.

 

 

Wu MY, Cai CZ, Yang C, Yue Z, Chen Y, Bian ZX, Li M, Lu JH. Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts. Neural Regen Res. 2022 Feb;17(2):323-324. doi: 10.4103/1673-5374.317973.

 

Shen S, Liao Q, Wong YK, Chen X, Yang C, Xu C, Sun J, Wang J. The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease. Int J Biol Sci. 2022;18(3):983-994. doi: 10.7150/ijbs.66871.

 

2021

Cai CZ#, Yang C#,*, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M, Lu JH. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2021 May;17(5):1112-1130. doi: 10.1080/15548627.2020.1760623.

 

2020

Yang C, Zhang W, Dong X, Fu C, Yuan J, Xu M, Liang Z, Qiu C, Xu C. A natural product solution to aging and aging-associated diseases. Pharmacol Ther. 2020 Dec;216:107673. doi: 10.1016/j.pharmthera.2020.107673.

 

Zhang W, Yang C*. Stem Cell Modeling: A Promising New Avenue for Young-Onset PD Research. Mov Disord. 2020 May;35(5):759. doi: 10.1002/mds.28041.

 

Yang C, Zhu Z, Tong BC, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ, Li M. A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38. Redox Biol. 2020 May;32:101445. doi: 10.1016/j.redox.2020.101445.

 

Xiao Y, Zhong J, Zhong B, Huang J, Jiang L, Jiang Y, Yuan J, Sun J, Dai L, Yang C, Li Z, Wang J, Zhong T. Exosomes as potential sources of biomarkers in colorectal cancer. Cancer Lett. 2020 Apr 28;476:13-22. doi: 10.1016/j.canlet.2020.01.033. Epub 2020 Feb 7.

 

Wang Z#, Yang C#, Liu J, Chun-Kit Tong B, Zhu Z, Malampati S, Gopalkrishnashetty Sreenivasmurthy S, Cheung KH, Iyaswamy A, Su C, Lu J, Song J, Li M. A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro. Int J Mol Sci. 2020 Feb 22;21(4). doi: 10.3390/ijms21041515.

 

Song JX, Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N, Li M. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2020 Feb;19(2):e13069.

 

 Before 2020

Yang C, Cai CZ, Song JX, Tan JQ, Durairajan SSK, Iyaswamy A, Wu MY, Chen LL, Yue Z, Li M, Lu JH. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 2017;13(12):2028-2040. doi: 10.1080/15548627.2017.1379633.

Zhu Z, Yang C, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Liu J, Wang Z, Tong BC, Song J, Lu J, Cheung KH, Li M. Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease. Int J Mol Sci. 2019 Feb 8;20(3). doi: 10.3390/ijms20030728. Review. PubMed PMID: 30744070; PubMed Central PMCID: PMC6387269.

 

Chen LL, Wang YB, Song JX, Deng WK, Lu JH, Ma LL, Yang CB, Li M, Xue Y. Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy. Autophagy. 2017;13(11):1969-1980. doi: 10.1080/15548627.2017.1371393.

 

Wang ZY, Liu JY, Yang CB, Malampati S, Huang YY, Li MX, Li M, Song JX. Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review. Phytother Res. 2017 Aug;31(8):1119-1127. doi: 10.1002/ptr.5834.

 

Zhao J, Cheng Y, Yang C, Lau S, Lao L, Shuai B, Cai J, Rong J. Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2. Mol Neurobiol. 2016 May;53(4):2200-11. doi: 10.1007/s12035-015-9195-1. Epub 2015 May 8. PubMed PMID: 25952544.

 

Yang C, Cheng Y, Zhao J, Rong J. Releasing Nrf2 to promote neurite outgrowth. Neural Regen Res. 2015 Dec;10(12):1934-5. doi: 10.4103/1673-5374.169618.

 

Yang C, Zhao J, Cheng Y, Le XC, Rong J. N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway. ACS Chem Neurosci. 2015 Sep 16;6(9):1560-9. doi: 10.1021/acschemneuro.5b00115.

 

Yang C, Li X, Rong J. Amygdalin isolated from Semen Persicae (Tao Ren) extracts induces the expression of follistatin in HepG2 and C2C12 cell lines. Chin Med. 2014;9:23. doi: 10.1186/1749-8546-9-23.

 

Yang C, Zhao J, Pei W, Zheng X, Rong J. Biochemical mechanisms of bornyl caffeate induced cytotoxicity in rat pheochromocytoma PC12 cells. Chem Biol Interact. 2014 Aug 5;219:133-42. doi: 10.1016/j.cbi.2014.05.018.

 

Yang CB, Pei WJ, Zhao J, Cheng YY, Zheng XH, Rong JH. Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS- and JNK-mediated pathways. Acta Pharmacol Sin. 2014 Jan;35(1):113-23. doi: 10.1038/aps.2013.162. Epub 2013 Dec 16. PubMed PMID: 24335836; PubMed Central PMCID: PMC40