2024
53. Zijin Luo, Yi Lin, Yanan Meng, Mengyao Li, Hongyu Ren, Haoping Shi, Qiang Cheng*, Tuo Wei*. Spleen-Targeted mRNA Vaccine Doped with Manganese Adjuvant for Robust Anticancer Immunity In Vivo. ACS Nano. 2024
52. Yuan Fei, Xiaolu Yu, Peiyu Liu, Hongyu Ren, Tuo Wei*, and Qiang Cheng*. Simplified Lipid Nanoparticles for Tissue- And Cell-Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model. Adv Mater. 2024 ; 2409812
2023
51. Yi Lin, Qiang Cheng, Tuo Wei. Surface engineering of lipid nanoparticles: targeted nucleic acid delivery and beyond. Biophysics Reports. 2023；doi: 10.52601/bpr.2023.230022
50. Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E. Lee, Elysha K. Rose, Xu Wang, Joshua Robinson, Sang M. Lee, Tuo Wei, William E. Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C. Wang, and Daniel J. Siegwart. In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proc Natl Acad Sci U S A. 2023; 120 (52) e2313009120
49. Zong Y, Wei T, Cheng Q*. Recent advances in strategies for developing tissue-selective mRNA-LNP technology (in Chinese). Chin Sci Bul. 2023
48. Tuo Wei, Yehui Sun, Qiang Cheng, Sumanta Chatterjee, Zachary Traylor, Lindsay T. Johnson, Melissa L. Coquelin, Jialu Wang, Michael J. Torres, Xizhen Lian, Xu Wang, Yufen Xiao, Craig A. Hodges & Daniel J. Siegwart. Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nature Communications. 2023;14,7322
47. Zhang XS, Xie G, Ma H, Ding S, Wu YX, Fei Y, Cheng Q, Huang Y, Wang Y. Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly. Biofabrication. 2023; 15(4), 045014
46. Lin Y, Zeng Q, Jia Y, Wang Z, Li L, Hsieh MH, Cheng Q, Pagani CA, Livingston N, Lee J, Zhang Y, Sharma T, Siegwart DJ, Yimlamai D, Levi B, Zhu H. In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration. Hepatology. 2023; 78(4):1133-1148
45. Lin L, Su K, Cheng Q, Liu S. Targeting materials and strategies for RNA delivery. Theranostics. 2023; 13 (13), 4667-4693.
44. Zong Y, Lin Y, Wei T*, Cheng Q*. Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy. Adv Mater. 2023. e2303261.
43. Wang X, Liu S, Sun Y, Yu X, Lee SM, Cheng Q, Wei T, Gong J, Robinson J, Zhang D, Lian X, Basak P, Siegwart DJ* . Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. Nat Protoc. 2023 ；18 (1), 265-291
2022
42. Li F*, Wang T, Cheng Q*. In vivo gene therapy with CRISPR–Cas9: A promising therapeutic strategy to cure inherited diseases. MedComm – Future Medicine. 2022 ；1 (2), e26
41. Wei T*, Tao W*, Cheng Q*. Lipid nanoparticles for mRNA therapy: recent advances in targeted delivery. Life Medicine. 2022； 1 (1), 21-23
2021
40. Dilliard SA, Cheng Q*, Siegwart DJ*. On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles. Proc Natl Acad Sci U S A. 2021;118(52):e2109256118.
39. Liu S, Wang X, Yu X, Cheng Q, Johnson LT, Chatterjee S, Zhang D, Lee SM., Sun Y, Lin T, Liu JL, Siegwart DJ*. Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes. J Am Chem Soc. 2021;143(50):21321-21330.
38. Yu X, Liu S, Cheng Q, Lee SM, Wei T, Zhang D, Farbiak L, Johnson LT, Wang X, Siegwart DJ. Hydrophobic Optimization of Functional Poly (TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration. Pharmaceutics. 2021;13(11):1914.
37. Guo S, Li K, Hu B, Li C, Zhang M, Hussain A, Wang X, Cheng Q, Yang F, Ge K, Zhang J, Chang J, Liang X-J, Weng Y, Huang Y. Membrane‐destabilizing ionizable lipid empowered imaging‐guided siRNA delivery and cancer treatment. Exploration. 2021；1(1): 35-49.
36. Fan W, Mar KB, Sari L, Gaszek IK, Cheng Q, Evers BM, Shelton JM, Wight-Carter M, Siegwart, DJ, Lin MM, Schoggins JW. TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity. Cell. 2021；184(13):3410-3425.
35. Farbiak L, Cheng Q, Wei T, Álvarez-Benedicto E, Johnson LT, Lee SM, Siegwart DJ. All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo. Adv Mater. 2021；33(30):e2006619.
34. Liu S1, Cheng Q1, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ. Membrane destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR/Cas gene editing. Nat Mater. 2021；20(5):701-710. a)Highly cited paper; b) Highlighted in News & Views of Nat Mater titled by "Overcoming delivery barriers with LNPs". Nat Mater. 2021;20(5):575-577.
33. Lee SM, Cheng Q, Yu X, Liu S, Johnson LT, Siegwart DJ. A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo. Angew Chem Int Ed Engl. 2021;60(11):5848-58532.
2020
32. Cheng Q1, Wei T1, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing. Nat Nanotechnol. 2020;15(4):313-320. a) Hot and highly cited paper; b) Highlighted in News & Views of Nat Nanotechnol titled by "Nanotechnology for organ-tunable gene editing." Nat Nanotechnol. 2020;15(4):253-255; c) ReCode Therapeutics raised $280 million in financing under the help of SORT technology ; d) Elected into seven technologies to watch in 2022 by Nature journal.
31. Wei T1, Cheng Q1, Min YL, Olson EN, Siegwart DJ. Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue-specific genome editing. Nat Commun. 2020;11(1):3232. (Highly cited paper)
30. Wei T, Cheng Q, Farbiak L, Anderson DG, Langer R, Siegwart DJ. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for in Vivo CRISPR/Cas-Based Genome Editing. ACS Nano. 2020;14(8):9243-9262.
29. Yu X, Liu S, Cheng Q, Wei T, Lee S, Zhang D, Siegwart DJ. Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver. Adv Healthc Mater. 2020;9(7):e1901487.
28. Xiong H, Liu S, Wei T, Cheng Q, Siegwart DJ. Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. J Control Release. 2020;325:198-205.
2018
27. Cheng Q, Wei T, Jia Y, Farbiak L, Zhou K, Zhang S, Wei Y, Zhu H, Siegwart DJ. Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I. Adv Mater. 2018:30(52):e1805308.
26. Du L, Wang C, Meng L, Cheng Q, Zhou J, Wang X, Zhao D, Zhang J, Deng L, Liang Z, Dong A, Cao H. The study of relationships between pKa value and siRNA delivery efficiency based on tri-block copolymers. Biomaterials. 2018; 176: 84–93.
25. Huang D, Zhao D, Wang X, Li C, Yang T, Du L, Wei Z, Cheng Q, Cao H, Liang Z, Huang Y, Li Z. Efficient delivery of nucleic acid molecules into skin by combined use of microneedle roller and flexible interdigitated electroporation array. Theranostics. 2018; 8(9): 2361-2376.
24. Zheng S, Wang X, Weng YH, Jin X, Ji JL, Guo L, Hu B, Liu N, Cheng Q, Zhang J, Bai H, Yang T, Xia XH, Zhang HY, Gao S, Huang Y. siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin. Mol Ther Nucleic Acids. 2018;12:805-816.
2017
23. Du L, Zhou J, Meng L, Wang X, Wang C, Huang Y, Zheng S, Deng L, Cao H, Liang Z, Dong A*, Cheng Q*. The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy. Theranostics. 2017;7(14):3432-3445.
22. Zhou J, Song X, Han S, Wei T, Wang X, Cao H, Liang X-J, Liang Z, Cheng Q*, Deng L*, and Dong A*. Balancing Biocompatibility, Internalization and Pharmacokinetics of Polycations/siRNA by Structuring the Weak Negative Charged Ternary Complexes with Hyaluronic Acid. J. Biomed. Nanotechnol. 2017;13(11): 1533–1544.
21. Yan Y, Xiong H, Zhang X, Cheng Q, and Siegwart DJ. Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers. Biomacromolecules. 2017;18(12):4307-4315.
20. Wang C, Du L, Zhou J, Meng L, Cheng Q, Wang C, Wang X, Zhao D, Huang Y, Zheng S, Cao H, Zhang J, Deng L, Liang Z, Dong A. Elaboration on the Distribution of Hydrophobic Segments in the Chains of Amphiphilic Cationic Polymers for Small Interfering RNA Delivery. ACS Appl Mater Interfaces. 2017;9(38):32463-32474.
2016
19. Cheng Q1*, Du L1, Meng L, Han S, Wei T, Wang X, Wu Y, Zhou J, Zheng S, Huang Y, Liang X-J, Cao H, Dong A, Liang Z. The promising nanocarrier for doxorubicin and siRNA co-delivery by PDMAEMA based amphiphilic nanomicelles. ACS Appl Mater Interfaces. 2016;8(7):4347-56.
18. Huang Y, Cheng Q, Ji J, Zheng S, Du L, Meng L, Zhao D, Wang X, Cao H, Gao S, Liang Z. Pharmacokinetic Behaviors of Intravenously Administered siRNA: Focus on Glands. Theranostics. 2016;6(10):1528-41.
17. Huang Y, Cheng Q, Jin X, Ji J, Guo S, Zheng S, Wang X, Cao H, Gao S, Liang XJ, Du Q, Liang Z. Systemic and Tumor-targeted Delivery of siRNA by Cyclic NGR Motif-containing Peptide. Biomater Sci. 2016;4(3):494-510.
16. Zhou J, Wu Y, Wang C, Cheng Q, Han S, Wang X, Zhang J, Deng L, Zhao D, Du L, Cao H, Liang Z, Huang Y, Dong A. pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release. Nano Lett. 2016;16(11):6916-23.
15. Sun Y, Zhou J, Cheng Q, Lin D, Jian Q, Dong A, Liang Z, Deng L. Fabrication of mPEGylated graphene oxide/poly(2-dimethyl aminoethyl methacrylate) nanohybrids and their primary application for small interfering RNA delivery. J Appl Polym Sci. 2016;133(16):43303.
14. Chen C, Posocco P, Liu X, Cheng Q, Laurini E, Zhou J, Liu C, Wang Y, Dal C, Yu T, Giorgio S, Fermeglia M, Qu F, Liang Z, Rossi JJ, Liu M, Rocchi P, Pricl S, Peng L. Mastering dendrimer self-assembly for efficient siRNA delivery: from conceptual design to in vivo efficient gene silencing. Small. 2016;12(27):3667-76.
13. Zhao J, Liu J, Wei T, Ma X, Cheng Q, Huo S, Zhang C, He L, Duan X, Liang X-J. Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo. Nanoscale. 2016;8(9):5126-38.
12. Zhao D, Huang D, Li Y, Wu M, Zhong W, Cheng Q, Wang X, Wu Y, Zhou X, Wei Z, Li Z, Liang Z. A Flow-Through Cell Electroporation Device for Rapidly and Efficiently Transfecting Massive Amounts of Cells in vitro and ex vivo. Sci Rep. 2016;6:18469.
2015
11. Han S1, Cheng Q1, Wu Y, Zhou J, Long X, Wei T, Huang Y, Zheng S, Zhang J, Deng L, Wang X, Liang X-J, Cao H, Liang Z, Dong A. Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery. Biomaterials. 2015;48:45-55.
10. Yang Z1, Cheng Q1, Jiang Q, Deng L, Liang Z, Dong A. Thermo-sensitive nanoparticles for triggered release of siRNA. J Biomater Sci Polym Ed. 2015;26(4):264-76.
9. Huang Y, Wang X, Huang W, Cheng Q, Zheng S, Guo S, Cao H, Liang XJ, Du Q, Liang Z. Systemic Administration of siRNA via cRGD-containing Peptide. Sci Rep. 2015;5:12458.
8. Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang X-J, Rocchi P, Peng L. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. Proc Natl Acad Sci U S A. 2015;112(10):2978-83.
2014
7. Li Y1, Cheng Q1, Jiang Q, Huang Y, Liu H, Zhao Y, Cao W, Ma G, Dai F, Liang X-J, Liang Z, Zhang X. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. J Control Release. 2014;176:104-14.
6. Liu X, Zhou J, Yu T, Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Liu C, Wang Y, Posocco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang Z, Rocchi P, Rossi JJ, Peng L. Adaptive amphiphilic dendrimer‐based nanoassemblies as robust and versatile siRNA delivery systems. Angew Chem Int Ed Engl. 2014;53(44):11822-7.
2013
5. Cheng Q1, Huang Y1, Zheng H, Wei T, Zheng S, Huo S, Wang X, Du Q, Zhang X, Zhang HY, Liang X-J, Wang C, Tang R, Liang Z. The effect of guanidinylation of PEGylated poly (2-aminoethyl methacrylate) on the systemic delivery of siRNA. Biomaterials. 2013;34(12):3120-31.
4. Zhang W1, Cheng Q1, Guo S, Lin D, Huang P, Liu J, Wei T, Deng L, Liang Z, Liang X-J, Dong A. Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid. Biomaterials. 2013;34(27):6495-503.
3. Lin D1, Cheng Q1, Jiang Q, Huang Y, Yang Z, Han S, Zhao Y, Guo S, Liang Z, Dong A. Intracellular cleavable poly (2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo. Nanoscale. 2013;5(10):4291-301.
2. Lin D, Jiang Q, Cheng Q, Huang Y, Huang P, Han S, Guo S, Liang Z, Dong A. Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery. Acta Biomater. 2013;9(8):7746-57.
1. Wei T, Liu J, Ma H, Cheng Q, Huang Y, Zhao J, Huo S, Xue X, Liang Z, Liang X-J. Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo. Nano Lett. 2013;13(6):2528-34.
