一、学术论文（† equally contributed, * corresponding author）

56) Yue Zhang,† Tianshuai Zhu,† Yuqian Lin, Xian Wei, Xinyu Xie, Ruofan Lin, Zhijie Zhang, Weiwei Fang, Jing-Jing Zhang,* Yue Zhang,* Meng-Yang Hu, Lingchao Cai,* and Zhen Chen*. Organo-photoredox catalyzed gem-difluoroallylation of ketone derived dihydroquinazolinones via C(sp³)-C bond and C(sp³)-F bond cleavage. Org. Biomol. Chem. 2024, 22, accepted. (Invited contribution)

55)  Yue Zhang,† Jing-Jing Zhang,† Lujun Lou, Ruofan Lin, Nicolai Cramer,* Shou-Guo Wang,* Zhen Chen*. Recent advances in Rh(I)-catalyzed enantioselective C–H functionalization. Chem. Soc. Rev. 2024, 53, 3457-3484. (Highlighted by X-MOL; Highlighted by CBG)

54）Ruofan Lin,† Yujie Shan,† Yan Li, Xian Wei, Yue Zhang, Yuqian Lin, Yiman Gao, Weiwei Fang, Jing-Jing Zhang, Ting Wu,* Lingchao Cai,* Zhen Chen*. Organo-photoredox catalyzed gem-difluoroallylation of glycine and glycine residue in peptides. J. Org. Chem. 2024, 89, 4056–4066. (Highlighted by Synfacts, 2024, 20(06), 0665)

     

53) Jing-Jing Zhang,* Qi-Jie Xu, Yue Zhang, Qichen Zhou, Rui Lv, Zhen Chen,* Weijiang He*. Recent advances in nanocarriers for clinical platinum(II) anticancer drugs. Coord. Chem. Rev. 2024, 505, 215676.

52) Zhen Chen,† Jiahui Chen,† Mori Wakana,† Yongjia Yi, Jian Rong,  Yinlong Li, Erick R. Calderon Leon, Tuo Shao, Tomoteru Yamasaki, Hideki Ishii, Yiding Zhang, Tomomi Kokufuta, Kuan Hu, Lin Xie, Lee Josephson, Richard S. Van, Yihan Shao, Stewart Factor, Ming-Rong Zhang*, and Steven H. Liang*. Preclinical evaluation of novel positron emission tomography (PET) probes for imaging leucine-rich repeat kinase 2 (LRRK2). J. Med. Chem. 2024, 67, 2559–2569.

51) Ruoqian Fan, Haili Wen, Zhen Chen, Yuanzhi Xia*, Weiwei Fang*. A general protocol towards synthesis of 3-methylindoles using acenaphthoimidazolyidene-ligated oxazoline palladacycle. Org. Lett. 2024, 26, 22–28.

50) Xian Wei, Yue Zhang, Jingjing Zhang, Weiwei Fang,* and Zhen Chen*. Solvent-Controllable C−F Bond Activation for Masked Formylation of α-Trifluoromethyl Alkenes via Organo-Photoredox Catalysis. J. Org. Chem. 2024, 89, 624–632.

49) Jing-Jing Zhang,* Lujun Lou, Rui Lv, Jiahui Chen, Yinlong Li, Guangwei Wu, Lingchao Cai, Steven H. Liang,* Zhen Chen*. Recent advances in photochemistry for positron emission tomography imaging. Chin. Chem. Lett. 2024, 35, 109342. (Highlighted by X-MOL; Highlighted by CBG)

   

48) Jiahui Chen,† Wenqing Ran,† Yiman Huang,† Junjie Wei, Jian Rong, Huiyi Wei, Yinlong Li, Guocong Li, Zhen Chen, Lee Collier, Nehal H. Elghazawy, Wolfgang Sippl, Ahmed Haider, Kai Liao, Chenchen Dong, Ying Li, Hao Xu, Wenpeng He*, Lu Wang *, Steven H. Liang*. Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor. Biomed. Pharmacother. 2023, 168, 115842.

47) Jing-Jing Zhang,† Hualong Fu,† Ruofan Lin, Jingyin Zhou, Ahmed Haider, Weiwei Fang, Nehal Elghazawy, Jian Rong, Jiahui Chen, Yinlong Li, Chongzhao Ran, Thomas L. Collier, Zhen Chen*, and Steven H. Liang*. Imaging cholinergic receptors in the brain by positron emission tomography. J. Med. Chem. 2023, 66, 10889–10916. (Highlighted by X-MOL; Highlighted by CBG)

46) Chi-Hyeon Yoo,† Zhen Chen,† Nisha Rani, Jiahui Chen, Jian Rong, Laigao Chen, Lei Zhang, Steven H. Liang, Hsiao-Ying Wey*. Evaluation of [18F]PF-06455943 as a Potential LRRK2 PET Imaging Agent in the Brain of Nonhuman Primate. ACS Chem. Neurosci. 2023, 14, 370–377.

45) Zhen Chen,† Jiahui Chen,† Laigao Chen, Chi-Hyeon Yoo, Jian Rong, Hualong Fu, Tuo Shao, Karen J. Coffman, Stefanus J. Steyn, April T. Davenport, James B. Daunais, Ahmed Haider, Lee Collier, Lee Josephson, Hsiao-Ying Wey, Lei Zhang*, and Steven H. Liang*. Imaging leucine rich repeat kinase 2 (LRRK2) in vivo with 18F-labeled positron emission tomography (PET) ligand. J. Med. Chem. 2023, 66, 1712–1724.

        

44) Yue Zhang, Jun-Liang Zeng, Zhen Chen*, and Ren Wang*. Transition-metal-free [3 + 2] Cycloaddition of Trifluoroacetohydrazonoyl Chlorides with Imidates en route to Trifluoromethyl-1,2,4-triazoles. J. Org. Chem. 2022, 87, 14514–14522.

43) Ahmed Haider,† Chunyu Zhao,† Lu Wang,† Zhiwei Xiao, Jian Rong, Xiaotian Xia, Zhen Chen, Stefanie K. Pfister, Natalia Mast, Eylan Yutuc, Jiahui Chen, Yinlong Li, Tuo Shao, Geoffrey I. Warnock, Alyaa Dawoud, Theresa R. Connors, Derek H. Oakley, Huiyi Wei, Jinghao Wang, Zhihua Zheng, Hao Xu, April T. Davenport, James B. Daunais, Richard S. Van, Yihan Shao, Yuqin Wang, Ming-Rong Zhang, Catherine Gebhard, Irina Pikuleva, Allan I. Levey, William J. Griffiths, Steven H. Liang*. Assessment of cholesterol homeostasis in the living human brain. Sci. Transl. Med. 2022, 14, eadc9967.

42) Fualong Fu, Jian Rong, Zhen Chen, Jingyin Zhou, Thomas Collier, and Steven H. Liang*. Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors. J. Med. Chem. 2022, 65, 10755–10808.

41) Qingzhen Yu,† Katsushi Kumata,† Jian Rong, Zhen Chen, Tomoteru Yamasaki, Jiahui Chen, Zhiwei Xiao, Hideki Ishii, Atsuto Hiraishi, Tuo Shao, Yiding Zhang, Kuan Hu, Lin Xie, Masayuki Fujinaga, Chunyu Zhao, Wakana Mori, Thomas Collier, Ahmed Haider, Susumu Tomita,* Ming-Rong Zhang,* and Steven H. Liang*. Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography. J. Med. Chem. 2022, 65, https://doi.org/10.1021/acs.jmedchem.2c00377.

40) Ran Cheng,† Masayuki Fujinaga,† Jing Yang,† Jian Rong, Ahmed Haider, Daisuke Ogasawara, Richard S. Van, Tuo Shao, Zhen Chen, Xiaofei Zhang, Erick R. Calderon Leon, Yiding Zhang, Wakana Mori, Katsushi Kumata, Tomoteru Yamasaki, Lin Xie, Shaofa Sun, Lu Wang, Chongzhao Ran, Yihan Shao, Benjamin Cravatt, Lee Josephson, Ming-Rong Zhang*, Steven H. Liang*. A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network. Acta Pharmacologica Sinica 2022,  https://doi.org/10.1038/s41401-022-00912-8

39) Tuo Shao,† Zhen Chen,† Ran Cheng, Lee Collier, Lee Josephson, Raymond T. Chung, Steven H. Liang*. Preliminary evaluation of [11C]MAGL-0519 as a promising PET ligand for the diagnosis of hepatocellular carcinoma. Bioorg. Chem. 2022, 120, 10.1016/j.bioorg.2022.105620.

38) Zhen Chen,† Ahmed Haider,† Jiahui Chen, Zhiwei Xiao, Luca Gobbi, Michael Honer, Uwe Grether, Steven E. Arnold, Lee Josephson and Steven H. Liang*. The repertoire of small molecule PET probes for neuroinflammation imaging: challenges and opportunities beyond TSPO. J. Med. Chem. 2021, 64, 17656–17689.

37) Jian Rong,† Wakana Mori,† Xiaotian Xia, Michael A. Schafroth, Chunyu Zhao, Richard S. Van, Tomoteru Yamasaki, Jiahui Chen, Zhiwei Xiao, Ahmed Haider, Daisuke Ogasawara, Atsuto Hiraishi, Tuo Shao, Yiding Zhang, Zhen Chen, Fuwen Pang, Kuan Hu, Lin Xie, Masayuki Fujinaga, Katsushi Kumata, Yuancheng Gou, Yang Fang, Shuyin Gu, Huiyi Wei, Liang Bao, Hao Xu, Thomas L. Collier, Yihan Shao, Richard E. Carson, Benjamin F. Cravatt, Lu Wang*, Ming-Rong Zhang*, and Steven H. Liang*. Novel reversible-binding PET ligands for imaging monoacylglycerol lipase based on piperazinyl azetidine scaffold. J. Med. Chem. 2021, 64, 14283–14298.

36) Fa-Guang Zhang,*† Zhen Chen,† Xiaodong Tang, and Jun-An Ma*. Triazines: Syntheses and the applications via inverse electron-demand Diels-Alder reactions. Chem. Rev. 2021, 121, 14555-14593. (中科院一区，IF = 60.6）

Before NJFU

35) Zhen Chen†, Wakana Mori†, Jian Rong, Michael A. Schafroth, Tuo Shao, Richard S. Van, Daisuke Ogasawara, Akiko Hatori, Jiahui Chen, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Jiyun Sun, Qingzhen Yu, Thomas L. Collier, Yihan Shao, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang*, and Steven H. Liang*. Development of a highly-specific 18F-labeled irreversible MAGL PET tracer. Acta Pharmaceutica Sinica B 2021, 11, 1686-1695. (中科院一区，IF：11.413)

34) Tuo Shao†, Zhen Chen†, Jian Rong†, Vasily Belov, Hualong Fu, Qingzhen Yu, Xiaoyun Deng, Jiahui Chen, Steve H. Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T. Chung*, Steven H. Liang*. [18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models. Acta Pharmaceutica Sinica B 2022, 12, 308-315. (中科院一区，IF：11.413)

33) Tuo Shao, Zhen Chen, Vasily Belov, Xiaohong Wang, Steve H. Rwema, Viksit Kumar, Hualong Fu, Xiaoyun Deng, Jian Rong, Qingzhen Yu, Lixin Lang, Wenyu Lin, Lee Josephson, Anthony E. Samir, Xiaoyuan Chen*, Raymond T. Chung*, Steven H. Liang*. [18F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis. J. Hepatol. 2020, 73, 161-169. (中科院一区，IF：25.083)

     

                  

32) Zhen Chen, Meng-Yu Rong, Jing Nie, Xue-Feng Zhu*, Bing-Feng Shi*, and Jun-An Ma*. Catalytic alkylation of unactivated C(sp3)–H bonds for C(sp3)–C(sp3) bond formation. Chem. Soc. Rev. 2019, 48, 4921−4942. (中科院一区，IF：54.564)

31) Zhen Chen†, Nan Ren†, Xiaoxiao Ma, Jing Nie, Fa-Guang Zhang*, and Jun-An Ma*, Silver-catalyzed [3 + 3] dipolar cycloaddition of trifluorodiazoethane and glycine imines: access to highly functionalized trifluoromethyl-substituted triazines and pyridines. ACS Catal. 2019, 9, 4600−4608. (Highlighted by Synfacts: 2019, 15, 0864; Highlighted by X-mol) (中科院一区，IF：13.084)

30) Zhen Chen, Yan Zheng, and Jun-An Ma*. Use of a traceless activating and directing group for the construction of trifluoromethylpyrazoles: one-pot transformation of nitroolefins and trifluorodiazoethane. Angew. Chem. Int. Ed. 2017, 56, 4569−4574. (Highlighted by X-mol) (中科院一区，IF：15.336)

29) Zhen Chen†, Wakana Mori†, Hualong Fu, Michael A. Schafroth,, Akiko Hatori, Tuo Shao, Genwei Zhang, Richard S. Van, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Lu Wang, Vasily Belov, Daisuke Ogasawara, Pilar Giffenig, Xiaoyun Deng, Jian Rong, Qingzhen Yu, Xiaofei Zhang, Mikhail I. Papisov, Yihan Shao, Thomas L. Collier, Jun-An Ma, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang,* and Steven H. Liang*. Design, synthesis and evaluation of 18F-labeled monoacylglycerol lipase inhibitors as novel positron emission tomography probes. J. Med. Chem. 2019, 62, 8866-8872. (中科院一区，IF：7.446)

Highlighted as Journal Cover

28) Zhen Chen†, Wakana Mori†, Xiaoyun Deng, Ran Cheng, Daisuke Ogasawara, Genwei Zhang, Kenneth Dahl, Hualong Fu, Akiko Hatori, Tuo Shao, Yiding Zhang, Tomoteru Yamasaki, Xiaofei Zhang, Jian Rong, Qingzhen Yu, Kuan Hu, Masayuki Fujinaga, Lin Xie, Katsushi Kumata, Yuancheng Gou, Jingjin Chen, Liang Bao, Lu Wang, Lee Collier, Neil Vasdev, Yihan Shao, Jun-An Ma, Benjamin F. Cravatt, Christopher Fowler, Lee Josephson, Ming-Rong Zhang*, and Steven H. Liang*. Design, synthesis and evaluation of reversible and irreversible monoacylglycerol lipase positron emission tomography tracers using a ‘tail switching’ strategy on a piperazinyl azetidine skeleton. J. Med. Chem. 2019, 62, 3336−3353. (中科院一区，IF：7.446)

27) Zhen Chen†, Wakana Mori†, Xiaofei Zhang, Tomoteru Yamasaki, Genwei Zhang, Hualong Fu, Tuo Shao, Yiding Zhang, Kenneth Dahl, Akiko Hatori, Longle Ma, Masayuki Fujinaga, Lin Xie, Neil Vasdev, Lee Josephson, Yihan Shao, Lei Zhang, Jun-An Ma, Susumu Tomita, Ming-Rong Zhang*, and Steven H. Liang*. Synthesis, pharmacology and imaging evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein. Eur. J. Med. Chem. 2018, 157, 898–908. (中科院一区，IF：6.514)

26) Zhen Chen†, Yue Zhang†, Jing Nie, and Jun-An Ma*. Transition-metal-free [3 + 2] cycloaddition of nitroolefins and diazoacetonitrile: a facile access to multisubstituted cyanopyrazoles. Org. Lett. 2018, 20, 2120–2124. (中科院一区，IF：6.005)

25) Zhen Chen, Shuang-Qing Fan, Yan Zheng, and Jun-An Ma*. Silver-catalyzed regioselective [3 + 2] cycloaddition of arene-diazonium salts with 2,2,2-trifluorodiazoethane (CF3CHN2): a facile access to 2-aryl-5-trifluoromethyltetrazoles. Chem. Commun. 2015, 51, 16545–16548. (Highlighted by Synfacts: 2015, 11, 1254; Highlighted by ChemInform: 2016, DOI: 10.1002/chin.201611164) (中科院一区，IF：6.222)

24) Fa-Guang Zhang†, Zhen Chen†, Chi Wai Cheung*, Jun-An Ma*. Aryl diazonium salt-triggered cyclization and cycloaddition reactions: past, present, and future. Chin. J. Chem. 2020, 38, 1132-1152. (中科院二区，IF：6)

23) Zhen Chen†, Lu Hou†, Jiefeng Gan, Qijun Cai, Weijian Ye, Jiahui Chen, Zhiqiang Tan, Chao Zheng, Guocong Li, Hao Xu, Christopher J. Fowlerd, Steven H. Liang*, Lu Wang*. Synthesis and preliminary evaluation of a novel positron emission tomography (PET) ligand for imaging fatty acid amide hydrolase (FAAH). Bioorg. Med. Chem. Lett. 2020, 30, 127513. (中科院三区，IF：2.823)

22) Zhen Chen, Jiahui Chen, Natalia Mast, Jian Rong, Xiaoyun Deng, Tuo Shao, Hualong Fu, Qingzhen Yu, Jiyun Sun, Yihan Shao, Lee Josephson, Thomas Lee Collier, Irina Pikuleva, Steven H. Liang*. Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using ‘in-loop’ [11C]CO2 fixation method. Bioorg. Med. Chem. Lett. 2020, 30, 127068. (中科院三区，IF：2.823)

21) Mingyang Xiao†, Zhen Chen†, Fa-Guang Zhang, Jun-An Ma. Regioselective synthesis of carboxylic and fluoromethyl tetrazoles enabled by silver-catalyzed cycloaddition of diazoacetates and aryl diazonium salts. Tetrahedron 2020, 76, 131063. (中科院三区，IF：2.457)

20) Yue Zhang†, Zhen Chen†, Jing Nie, Fa-Guang Zhang*, Jun-An Ma*. Development of cyanopyrazoles as building blocks to fungicide Fluxapyroxad and analogues. J. Org. Chem. 2019, 84, 7148−7158. (中科院二区，IF：4.354)

19)  Zhen Chen†, Tuo Shao†, Wei Gao, Hualong Fu, Thomas Lee Collier, Jian Rong, Xiaoyun Deng, Qingzhen Yu, Xiaofei Zhang, April T. Davenport, James B. Daunais, Hsiao-Ying Wey, Yihan Shao, Lee Josephson, Wen-Wei Qiu*, and Steven H. Liang*. Synthesis and preliminary evaluation of [11C]GNE-1023 as a novel potent PET probe for imaging leucine-rich repeat kinase 2 (LRRK2) in Parkinson’s disease. ChemMedChem 2019, 14, 1580–1585. (中科院三区，IF：3.466)

Highlighted as Neuromedicine Hot Topics by ChemMedChem

18) Xiaofei Zhang†, Yiding Zhang†, Zhen Chen, Tuo Shao, Richard Van, Katsushi Kumata, Xiaoyun Deng, Hualong Fu, Tomoteru Yamasaki, Jian Rong, Kuan Hu, Akiko Hatori, Lin Xie, Qingzhen Yu, Weijian Ye, Hao Xu, Douglas J. Sheffler, Nicholas D. P. Cosford, Yihan Shao, Pingping Tang, Lu Wang*, Ming-Rong Zhang*, Steven H. Liang*. Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2. Theranostics 2020; 10, 11178-11196. (中科院一区，IF：11.556)

17) Ji-yun Sun†, Katsushi Kumata†, Zhen Chen, Yi-ding Zhang, Jia-hui Chen, Akiko Hatori, Hua-long Fu, Jian Rong, Xiao-yun Deng, Tomoteru Yamasaki, Lin Xie, Kuan Hu, Masayuki Fujinaga, Qing-zhen Yu, Tuo Shao, Thomas Lee Collier, Lee Josephson, Yi-han Shao, Yun-fei Du, Lu Wang, Hao Xu, Ming-Rong Zhang*, Steven H Liang*. Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators. Acta Pharmacologica Sinica 2021, 42, 491-498. (中科院一区，IF：6.150)

16) Tomoteru Yamasaki†, Xiaofei Zhang†, Katsushi Kumata†, Yiding Zhang, Xiaoyun Deng, Masayuki Fujinaga, Zhen Chen, Wakana Mori, Kuan Hu, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Masanao Ogawa, Nobuki Nengaki, Richard Van, Yihan Shao, Douglas J. Sheffler, Nicholas D. P. Cosford, Steven H. Liang*, Ming-Rong Zhang*. Identification and development of a new positron emission tomography ligand 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for imaging metabotropic glutamate receptor subtype 2 (mGlu2). J. Med. Chem. 2020, 63, 11469–11483. (中科院一区，IF：7.446)

15) Xiaoyun Deng†, Yiding Zhang†, Zhen Chen, Katsushi Kumata, Richard Van, Jian Rong, Tuo Shao, Akiko Hatori, Wakana Mori, Qingzhen Yu, Kuan Hu, Masayuki Fujinaga, Hsiao-Ying Wey, Yihan Shao, Lee Josephson, Giulia Murtas, Loredano Pollegioni, Ming-Rong Zhang*, Steven H. Liang*. Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging. Bioorg. Med. Chem. Lett. 2020, 30, 127326. (中科院三区，IF：2.572)

14) Jinhao Liang, Yi-You Huang, Qian Zhou, Yuqi Gao, Zhe Li, Deyan Wu, Si Yu, Lei Guo, Zhen Chen, Ling Huang, Steven H. Liang, Xixin He*, Ruibo Wu*, Hai-Bin Luo*. Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia. J. Med. Chem. 2020, 63, 3370–3380. (中科院一区，IF：7.446)

13) Jiahui Chen†, Jiefeng Gan†, Jiyun Sun, Zhen Chen, Hualong Fu, Jian Rong, Xiaoyun Deng, Jingjie Shang, Jian Gong, Tuo Shao, Lee Collier, Lu Wang, Hao Xu*, Steven H.Liang*. Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors. Tetrahedron 2020, 61, 151635. (中科院三区，IF：2.457)

12) Qingzhen Yu†, Katsushi Kumata†, Hua Li, Yiding Zhang, Zhen Chen, Xiaofei Zhang, Tuo Shao, Akiko Hatori, Tomoteru Yamasaki, Lin Xie, Kuan Hu, Gangqiang Wang, Lee Josephson, Shaofa Sun*, Ming-Rong Zhang*, Steven H. Liang*. Bioorg. Med. Chem. Lett. 2020, 30, 126879. (中科院三区，IF：2.823)

11) Jian Rong, Zhen Chen, Neil Vasdev, Steven H. Liang*. "Aryl-18F bond formation from nucleophilic [18F]fluoride", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2019, accepted (book chapter).

10) Hualong Fu, Zhen Chen, Lee Josephson, Zijing Li*, and Steven H. Liang*. Positron emission tomography (PET) ligand development for ionotropic glutamate receptors: challenges and opportunities for radiotracer targeting N-Methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate receptors. J. Med. Chem. 2019, 62, 403–419. (中科院一区，IF：7.446)

9)  Hualong Fu†, Weiting Tang†, Zhen Chen, Vasily V. Belov, Genwei Zhang, Tuo Shao, Xiaofei Zhang, Qingzhen Yu, Jian Rong, Xiaoyun Deng, Wei Han, Scott J. Myers, Pilar Giffenig, Lu Wang, Lee Josephson, Yihan Shao, April T. Davenport, James B. Daunais, Mikhail Papisov, Hongjie Yuan, Zijing Li*, Stephen F. Traynelis*, and Steven H. Liang*. Synthesis and preliminary evaluations of a triazole-cored antagonist as a PET imaging probe ([18F]N2B-0518) for GluN2B subunit in the brain. ACS Chem. Neurosci. 2019, 10, 2263−2275. (中科院二区，IF：4.486)

8)  Xiaoyun Deng†, Akiko Hatori†, Zhen Chen, Katsushi Kumata, Tuo Shao, Xiaofei Zhang, Tomoteru Yamasaki, Kuan Hu, Qingzhen Yu, Longle Ma, Gangqiang Wang, Lu Wang, Yihan Shao, Lee Josephson, Shaofa Sun*, Ming-Rong Zhang*, and Steven H. Liang*. Synthesis and preliminary evaluation of 11C‐labeled VU0467485/AZ13713945 and its analogues for imaging muscarinic acetylcholine receptor subtype 4. ChemMedChem 2019, 14, 303–309. (中科院三区，IF：3.446)

Highlighted as Neuromedicine Hot Topics by ChemMedChem

7)    Siyuan Cheng, Orit Jacobson, Guizhi Zhu, Zhen Chen, Steve H. Liang, Rui Tian, Zhen Yang, Gang Niu, Xiaohua Zhu, and Xiaoyuan Chen*. PET imaging of EGFR expression using an 18F-labeled RNA aptamer. Eur. J. Nucl. Med. Mol. Imaging 2019, 46, 948–956. (中科院一区，IF：9.236)

6) Bo Zhang, Benjamin H. Fraser, Mitchell A. Klenner, Zhen Chen, Steven H. Liang, Massimiliano Massi, Andrea J. Robinson, and Giancarlo Pascali*. [18F]Ethenesulfonyl fluoride as a novel radiofluoride relay reagent. Chem. Eur. J. 2019, 25, 7613–7617 . (中科院二区，IF：5.236)

5) Jun-Liang Zeng, Zhen Chen, Fa-Guang Zhang*, and Jun-An Ma*. Direct regioselective [3 + 2] cycloaddition reactions of masked difluorodiazoethane with electron-deficient alkynes and alkenes: synthesis of difluoromethyl-substituted pyrazoles. Org. Lett. 2018, 20, 4562–4565. (中科院一区，IF：6.005)

4) Chao Zheng*, Yuting Wang, Yangrui Xu, Zhen Chen, Guangying Chen*, and Steven H. Liang*. Ru-photoredox-catalyzed decarboxylative oxygenation of aliphatic carboxylic acids through N‑(acyloxy)phthalimide. Org. Lett. 2018, 20, 4824−4827. (中科院一区，IF：6.005)

3)  Ran Cheng†, Wakana Mori†, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Lu Wang, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev, Benjamin F. Cravatt, Christopher Fowler, Ming-Rong Zhang*, and Steven H. Liang*. In vitro and in vivo evaluation of 11C‑labeled azetidinecarboxylates for imaging monoacylglycerol lipase by PET imaging studies. J. Med. Chem. 2018, 61, 2278−2291. (中科院一区，IF：7.446)

2) Hema S. Krishnan, Vadim Bernard-Gauthier, Michael S. Placzek, Kenneth Dahl, Vidya Narayanaswami, Elijahu Livni, Zhen Chen, Jing Yang, Thomas L. Collier, Chongzhao Ran, Jacob M. Hooker, Steven H. Liang*, and Neil Vasdev*. Metal protein-attenuating compound for PET neuroimaging: synthesis and preclinical evaluation of [11C]PBT2. Mol. Pharmaceutics 2018, 15, 695−702. (中科院二区，IF：4.939)

1) Heng-Ying Xiong, Zhen-Yan Yang, Zhen Chen, Jun-Liang Zeng, Jing Nie, and Jun-An Ma*. Copper-catalyzed one-pot denitrogenative-dehydrogenative-decarboxylative coupling of β-ketoacids with trifluorodiazoethane: facile access to trifluoromethylated aldol products. Chem. Eur. J. 2014, 20, 8325–8329. (中科院二区，IF：5.236)

 

二、书籍与专利

1) Jian Rong, Zhen Chen, Neil Vasdev, Steven H. Liang*. "Aryl-18F bond formation from nucleophilic [18F]fluoride", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2019, accepted (book chapter).

2) 马军安，陈振，郑艳，一种3-氟烷基-1H-吡唑-4-甲酸酯的制备方法：中国，授权号：CN105461629，2016-04-06。

3) 马军安，陈振，任楠，张发光，一种5‑芳基‑6‑三氟甲基‑1,2,5,6‑四氢‑1,2,4‑三氮 嗪‑3‑甲酸酯化合物及制备方法：中国，授权号：CN107935955，2018-04-20。

4) 马军安，任楠，陈振，张发光，5-芳基-6-三氟甲基-1,2,4-三氮嗪-3-甲酸酯化合物及其制备方法：中国， 授权号：CN107827834，2018-03-23。

5) 马军安，任楠，陈振，张发光，5-芳基-1,2,4-三氮嗪-3,6-二甲酸酯的制备方法及应用：中国，授权号：CN108285434，2018-07-17。

三、代表性会议论文

Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2018 annual meeting (Philadelphia, PA, USA)

1) Zhen Chen, Ran Cheng, Jing Yang, Tuo Shao, Neil Vasdev, Chongzhao Ran, Ming-Rong Zhang and Steven H. Liang. A novel 18F-labeled MAG lipase biomarker for differentiating brown and white adipose tissue in the lipid network. J. Nucl. Med. 2018, 59, 262. (口头报告)

2) Zhen Chen, Xiaofei Zhang, Tuo Shao, Neil Vasdev, Yihan Shao, Susumu Tomita, Ming-Rong Zhang and Steven Liang. Preclinical evaluation of 11C-JNJ55511118 and 11C-JNJ56022486 for imaging subtype-selective AMPA receptor. J. Nucl. Med. 2018, 59, 1016. (美国核医学与分子影像学会(SNMMI)墙报第一名，Awarded as “First Place Poster” by SNMMI).

3) Zhen Chen, Xiaofei Zhang, Tuo Shao, Yihan Shao, Susumu Tomita, Ming-Rong Zhang and Steven Liang. Synthesis and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for development of TARP γ-8 dependent AMPAR PET tracers. J. Nucl. Med. 2018, 59, 1017. (墙报)

Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2019 annual meeting (Anaheim, CA, USA)

4) Zhen Chen, Hualong Fu, Lu Wang, Yihan Shao, Lee Josephson and Steven H. Liang. Radiosynthesis and preclinical evaluation of a novel 18F-labeled MAGL inhibitor PF-06795071 for MAGL imaging. J. Nucl. Med. 2019, 60, 131. (入选美国核医学与分子影像学会(SNMMI)放射性药物科学青年研究奖专题报告，Oral presentation in Radiopharmaceutical Sciences (RPSC) young investigator award (YIA) Symposium)

5) Zhen Chen, Lu Wang, Hideki Ishii, Tomoteru Yamasaki, Tuo Shao, Yihan Shao, Lee Josephson, Ming-Rong Zhang and Steven H. Liang. Radiosynthesis and preclinical evaluation of [11C]PF-06447475 for LRRK2 imaging. J. Nucl. Med. 2019, 60, 1609. （墙报）

6) Zhen Chen, Wakana Mori, Xiaoyun Deng, Ran Cheng, Hualong Fu, Yihan Shao, Lee Josephson, Ming-Rong Zhang and Steven H. Liang. Design, synthesis and evaluation of reversible and irreversible monoacylglycerol lipase PET tracers using a ‘tail-switching’ strategy on a piperazinyl azetidine skeleton. J. Nucl. Med. 2019, 60, 482. (口头报告)

7) Zhen Chen, Tuo Shao, Hualong Fu, Lu Wang, Yihan Shao, Hsiao-Ying Wey, Lee Collier, Lee Josephson and Steven H. Liang. Efficient radiosynthesis and preliminary autoradiography evaluation of a potent 11C-labeled LRRK2 inhibitor. J. Nucl. Med. 2019, 60, 1102. （墙报）

23rd International Symposium on Radiopharmaceutical Sciences (Beijing, China, 2019)

8) Zhen Chen, Tuo Shao, Hualong Fu, Lu Wang, Thomas Collier, Hsiao-Ying Wey, Yihan Shao, Lee Josephson, Steven Liang. Development of a novel PET ligand for imaging leucine rich repeat kinase 2. J. Label. Compd. Radiopharm. 2019, 62, S232-S233. （墙报）

Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2020 annual meeting (USA)

9) Zhen Chen, Jiahui Chen, Natalia Mast, Jian Rong, Yihan Shao, Hsiao-Ying Wey, Lee Josephson, Irina Pikuleva, and Steven Liang. ‘In-loop’ [11C]CO2fixation: Application to the synthesis of a 11C-labeled cholesterol 24-hydroxylase inhibitor. J. Nucl. Med. 2020, 61, 578. （墙报）