17. Craven, G. B.; Chu, H.; Sun, J. D.; Carelli, J. D.; Coyne, B.; Chen, H.; Chen, Y.; Ma, X.; Das, S.; Kong, W.; Zajdlik, A. D.; Yang, K. S.; Reisberg, S. H.; Thompson, P. A.; Lipford, J. R.; Taunton, J. Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation. Nature 2024.
https://pubmed.ncbi.nlm.nih.gov/39506119/
16. Sun, X.#; Chen, Y.#; Yang, C.; Yang, S.; Lin, W.; Quan, B.; Pan, X.; Ding, Q.; Chen, X.; Wang, C.; Qin, W., Chemical recording of pump-specific drug efflux in living cells. Angew Chem Int Ed Engl. 2024 Sep 26:e202409282.
https://pubmed.ncbi.nlm.nih.gov/39324755/
15. Chen, Y.; Craven, GB; Kamber RA; Cuesta, A.; Zhersh, S.; Moroz YS; Bassik MC; Taunton, J. Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat. Chem. 2023.15(11),1616-1625.
https://www.nature.com/articles/s41557-023-01281-3
14. Chen, Y.; Liu, Y.; Lan, T.; Qin, W.; Zhu, Y.; Qin, K.; Gao, J.; Wang, H.; Hou, X.; Chen, N.; Friedmann Angeli, J. P.; Conrad, M.; Wang, C., Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe. J.Am. Chem. Soc. 2018,140(13), 4712-4720.
https://pubmed.ncbi.nlm.nih.gov/29569437/
13. Li, X.#; Xiong, X.#; Zhang, M.#; Wang, K.#; Chen, Y.#; Zhou, J.; Mao, Y.; Lv, J.; Yi, D.; Chen, X. W.;Wang, C. ; Qian, S. B.; Yi, C., Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol. Cell 2017, 68 (5), 993–1005. (# Equal Contribution)
https://pubmed.ncbi.nlm.nih.gov/29107537/
12. Chen, Y.; Cong, Y.; Quan, B.; Lan, T.; Chu, X.; Ye, Z.; Hou, X.; Wang, C., Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017, 12, 712-718.
https://pubmed.ncbi.nlm.nih.gov/28411555/
11. Chen, Y. #; Quan, B. #; Li, Y. #; Liu Y.; Qin, W.; Wang, C., Quantitative profiling of PTM stiochiometry by resolvable mass tags. RSC Chem. Biol. 2022, 3 (11), 1320-1324. (# Equal Contribution)
https://pubmed.ncbi.nlm.nih.gov/36349223/
10. Chen, Y.; Qin, W.; Li, Z.; Guo, Z.; Liu, Y.; Lan, T.; Wang, C., Site-specific chemoproteomic profiling of targets of glyoxal. Future Med. Chem. 2019, 11 (23), 2979-2987.
https://pubmed.ncbi.nlm.nih.gov/31663776/
9. Chen, Y.; Liu, Y.; Hou, X.; Ye, Z.; Wang, C., Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem. Res. Toxicol. 2019, 32 (3), 467-473.
https://pubmed.ncbi.nlm.nih.gov/30604966/
8. Chen, Y. #; Qin, W. #; Wang, C., Functional proteomics driven by chemical and computational approaches. Chin. J. Chem. 2022, 40, 628-634. (# Equal Contribution)
https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.202100785
7. Chen, Y.; Wang, C., Profiling of Protein Carbonylations in Ferroptosis by Chemical Proteomics. Methods Mol. Biol. 2022, 2543, 141-153.
https://pubmed.ncbi.nlm.nih.gov/36087265/
6. Chen, Y.; Qin, W.; Wang, C., Chemoproteomic profiling of protein modifications by lipid-derived electrophiles. Curr. Opin. Chem. Biol. 2016, 30, 37-45.
https://pubmed.ncbi.nlm.nih.gov/26625013/
5. Chen, C. #; Chen, Y. #; Lu, J. #; Chen, Z.; Wang, C.; Pi, R., Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice. Toxicol. Lett. 2021, 344, 11–17. (# Equal Contribution)
https://pubmed.ncbi.nlm.nih.gov/33675918/
4. Dubiella, C.; Pinch, B. J.; Koikawa, K.; Zaidman, D.; Poon, E.; Manz, T. D.; Nabet, B.; He, S.; Resnick, E.; Rogel, A.; Langer, E. M.; Daniel, C. J.; Seo, H. S.; Chen, Y.; Adelmant, G.; Sharifzadeh, S.; Ficarro, S. B.; Jamin, Y.; Martins da Costa, B.; Zimmerman, M. W.; Lian, X.; Kibe, S.; Kozono, S.; Doctor, Z. M.; Browne, C. M.; Yang, A.; Stoler-Barak, L.; Shah, R. B.; Vangos, N. E.; Geffken, E. A.; Oren, R.; Koide, E.; Sidi, S.; Shulman, Z.; Wang, C.; Marto, J. A.; Dhe-Paganon, S.; Look, T.; Zhou, X. Z.; Lu, K. P.; Sears, R. C.; Chesler, L.; Gray, N. S.; London, N., Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat. Chem. Biol. 2021, 17 (9), 954-963.
https://pubmed.ncbi.nlm.nih.gov/33972797/
3. Qin, W.; Zhang, Y.; Tang, H.; Liu, D.; Chen, Y.; Liu, Y.; Wang, C., Chemoproteomic profiling of itaconation by bioorthogonal probes in inflammatory macrophages. J. Am. Chem. Soc. 2020, 142 (25), 10894-10898.
https://pubmed.ncbi.nlm.nih.gov/32496768/
2. Qin, W.; Qin, K.; Zhang, Y.; Jia, W.; Chen, Y.; Cheng, B.; Peng, L.; Chen, N.; Liu, Y.; Zhou, W.; Wang, YL.; Chen, X.; Wang, C., S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate. Nat. Chem. Biol. 2019, 15 (10), 983-991.
https://pubmed.ncbi.nlm.nih.gov/31332308/
1. Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.; Chen, X., Quantitative Time-resolved Chemoproteomics Reveals that Stable O-GlcNAc Regulates Box C/D snoRNP Biogenesis. Proc. Natl. Acad. Sci. USA 2017, 114 (33), E6749-e6758.
https://pubmed.ncbi.nlm.nih.gov/28760965/