一、部分代表性论文
11. Yuanyuan You, wenxiao Jiang, Renhao Xu, junbing He, Tianfeng Chen*, Qinghua Liu*, X-Ray-Triggered CA lX lnhibition Nanoplatform Promotes intratumoral Acidosis-induced Cancer Ferroptosis, Adv. Funct. Mater., 2024, in press.
链接:https://doi.org/10.1002/adfm.202417889
10. Yuanyuan You,# Yanzhou Chang,# Shuya Pan, Qingyue Bu, Jiabao Ling, Weiling He*, Tianfeng Chen*, Cleavage of Homonuclear Chalcogen-Chalcogen Bonds in a Hybrid Platform in Response to X-Ray Radiation Potentiates Tumor Radiochemotherapy, Angew. Chem. Int. Ed., 2024, e202412922.
链接:https://doi.org/10.1002/anie.202412922
9. Yuanyuan You, Chengwei Tang, Songling Lin, Wenman Li, Yuchao Li, Dingyuan Yan, Dong Wang, Xiaohui Chen*, Activatable Fluorescent Probes for Atherosclerosis Theranostics, iScience, 2024, 27, 111009.
链接:https://doi.org/10.1016/j.isci.2024.111009
8. Yuanyuan You, Songling Lin, Chengwei Tang, Yuchao Li, Dingyuan Yan, Dong Wang, Xiaohui Chen*, Dual-/multi-organelle-targeted AIE probes associated with oxidative stress for biomedical applications, J. Mater. Chem. B, 2024, 12, 8812.
链接:https://doi.org/10.1039/D4TB01440E
7. Yuanyuan You, Chengwei Tang, Songling Lin, Delong Zeng, Yanguang Cong, Dong Wang, Xiaohui Chen*, Photoactivatable Aggregation-Induced Emission Luminogens Based on Photodehydrogenation Reactions for Biomedical Applications, Luminescence, 2024, 39, e4645.
链接: https://doi.org/10.1002/bio.4645
6. Yifan Wu,# Xiaohui Chen,# Liwei Zhu, Deliang Wang, Xue Li, Jiayi Song, Dong Wang,* Xiyong Yu, Ying Li,* Ben Zhong Tang*, Endoplasmic Reticulum-Targeted Aggregation-Induced Emission Luminogen for Synergetic Tumor Ablation with Glibenclamide, ACS Appl. Mater. Interfaces, 2023, 15, 50821.
链接:https://doi.org/10.1021/acsami.3c10940
5. Xiaohui Chen, Niu Niu, Dan Li, Zicong Zhang, Zeyan Zhuang, Dingyuan Yan, Jiangao Li, Zujin Zhao, Dong Wang,* and Ben Zhong Tang*, The Golden Touch by Light: A Finely Engineered Luminogen Em-powering High Photoactivatable and Photodynamic Efficiency for Cancer Phototheranostics, Adv. Funct. Mater., 2023, 33, 2211571.
链接: https://doi.org/10.1002/adfm.202211571
4. Xiaohui Chen, Zicong Zhang, Wenshuai Luo, Zeyan Zhuang, Zujin Zhao, Lei Wang, Dong Wang,* Ben Zhong Tang*, A Photoactivatable Theranostic Probe for Simultaneous Oxidative Stress-Triggered Multi-Color Cellular Imaging and Photodynamic Therapy, Biomaterials, 2022, 287, 121680.
链接:https://www.sciencedirect.com/science/article/pii/S0142961222003209
3. Yi Qin,# Xiaohui Chen,# Yixiong Gui, Heng Wang, Ben Zhong Tang,* and Dong Wang*, A Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics. J. Am. Chem. Soc., 2022, 144, 12825.
链接:https://doi.org/10.1021/jacs.2c03895
2. Xiaohui Chen, Letao Huang, Yongguang Jia, Rong Hu, Meng Gao,* Li Ren,* Ben Zhong Tang*, AIE-Based Theranostic Probe for Sequential Imaging and Killing of Bacteria and Cancer Cells, Adv. Optical Mater., 2020, 8, 1902191.
链接:https://doi.org/10.1002/adom.201902191
1. Xiaohui Chen, Yunxia Li, Shiwu Li, Meng Gao*, Li Ren*, Ben Zhong Tang*, Mitochondria‐and lysosomes‐targeted synergistic chemo‐photodynamic therapy associated with self‐monitoring by dual light‐up fluorescence, Adv. Funct. Mater., 2018, 28, 1804362.
链接:https://doi.org/10.1002/adfm.201804362
二、科研项目
2024年
1. 国家自然科学基金青年基金项目,22405063,级联响应二氢吲哚类激活型NIR-II探针的构建及其靶向MUC16抗卵巢癌的作用机制,30万,2025.01-2027.12。(主持人:陈晓辉)
2. 广东省普通高校特色创新类项目,2024KTSCX166,“接力”激活型NIR-IIAIE探针的构建及其在肿瘤诊疗中的应用研究,1 万,2024.07-2026.06。(主持人:陈晓辉)
3. 广东省普通高校特色创新类项目,2024KTSCX168,X射线响应型纳米前药逆转肿瘤微环境异常pH梯度促进肿瘤铁死亡,1 万,2024.07-2026.06。(主持人:尤媛媛)
2023年
1. 广东省自然科学基金面上项目,2024A1515010677,肿瘤微环境ROS指引光激活聚集诱导NIR-II荧光探针在肿瘤诊疗中的应用研究,15万,2024.01-2026.12。(主持人:陈晓辉)
2. 广东省自然科学基金面上项目,2024A1515012842,X射线触发碳酸酐酶抑制型硅碲纳米前药促进肿瘤细胞铁死亡,15万,2024.01-2026.12。(主持人:尤媛媛)
3. 广东省自然科学基金面上项目,2024A1515012577,代谢调节逆转肺炎克雷伯菌对头孢他啶-阿维巴坦耐药性的机制研究,15万,2024.01-2026.12。(主持人:李璐)
4. 广东省自然科学基金区域联合青年基金项目,2023A1515110122,集辅酶与底物为一体的激活型AIE探针的构建及其在肿瘤诊疗中的应用研究,10万,2023.11-2026.10。(主持人:陈晓辉)
5. 广东省自然科学基金区域联合青年基金项目,2023A1515110538,寨卡病毒NS1蛋白通过重塑内质网为自噬小体形成提供膜结构促进病毒复制及胞外释放的机制研究,10万,2023.11-2026.10。(主持人:陈伟杰)
6. 广东医科大学高层次人才项目,智能分子探针的构建及其在疾病诊疗中的应用研究,200万,2023.01-2028.12。(主持人:陈晓辉)
7. 广东医科大学高层次人才项目,多功能生物纳米医药的构建及其在肿瘤治疗中的应用研究,60万,2023.01-2028.12。(主持人:尤媛媛)
2022年
1. 广东省自然科学基金区域联合青年基金项目,2022A1515110158,调节脂肪酸代谢逆转高毒力耐黏菌素多重耐药肺炎克雷伯菌耐药性的机制研究及临床诊断价值,10万,2022.11-2025.10。(主持人:李璐)
2021年及之前
1. 中国博士后基金面上项目,陈晓辉;
2. 国家自然科学基金青年基金项目,中国博士后基金面上项目,中国博士后基金特别资助项目,尤媛媛。