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成果及论文

代表论著

1. Jianwei Chen, Peng Gao, Fangmiao Yu, Yang Yang, Shizheng Zhu, Hongbin Zhai*, “Total Synthesis of (+/-)-Merrilactone A”, Angewandte Chemie International Edition201251, 5897-5899. (IF: 16.823)

2. Jianwei Chen, Mingkun Zhao, Fude Feng, Antons Sizovs, and Jin Wang*, “Tunable Thioesters as “Reduction” Responsive Functionality for Traceless Reversible Protein PEGylation”, Journal of the American Chemical Society2013135, 10938-10941. (IF: 16.383)

3. Jianwei Chen, Xiqian Jiang, Shaina L. Carroll, Jia Huang, Jin Wang*, "Theoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells", Organic Letters201517, 5978-5981.  contributed equally. (IF: 6.072)

4. Xianzhou SongJianwei Chen, Mingkun Zhao, Chengwei Zhang, Yang Yu, David M. Lonard, Dar-Chone Chow, Timothy Palzkill, Jianming Xu, Bert W. O’Malley*, Jin Wang*, “Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3”, Proceedings of the National Academy of Sciences2016113, 4970-4975. † contributed equally. (IF: 12.779)

5. Jianwei Chen, Mingkun Zhao, Xiqian Jiang, Antons Sizovs, Meng C Wang, Christopher R Provost, Jia Huang, Jin Wang, “Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide”, Analyst2016141, 1209-1213. † contributed equally. (IF: 5.227)

6. Xiqian JiangJianwei Chen, Aleksandar Bajić, Chengwei Zhang, Xianzhou Song, Shaina L. Carroll, Zhao-Lin Cai, Meiling Tang, Mingshan Xue, Ninghui Cheng, Christian P. Schaaf, Meng C. Wang, Mirjana Maletić-Savatić, Jin Wang*, “Quantitative Real-Time Imaging of Glutathione”, Nature Communications2017, 8, 16087.  contributed equally. (IF: 17.694)

7. Jianwei Chen, Xiqian Jiang, Chengwei Zhang, Kevin MacKenzie, Fabio Stossi, Timothy Palzkill, Meng Wang, Jin Wang*, “A Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria”, ACS Sensors, 2017, 2, 1257-1261. † contributed equally. (IF: 9.618)

8. JiangXiqian Jiang, Chengwei ZhangJianwei Chen, Sungwoo Choi, Ying Zhou, Mingkun Zhao, Xianzhou Song, Xi Chen, Mirjana Maletić-Savatić, Timothy Palzkill, David Moore, Meng C. Wang, and Jin Wang*, “Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution”, Antioxidants & Redox Signaling, 2018doi.org/10.1089/ars.2018.7605. † contributed equally. (IF: 7.468)

9. Li QinJianwei Chen, Dong Lu, Prashi Jain, Yang Yu, David Cardenas, Xiaohui Peng, Xiaobin Yu, Jianming Xu, Jin Wang*, Bert W O’Malley*, David M Lonard*, “Development of improved SRC-3 inhibitors as breast cancer therapeutic agents”, Endocrine-Related Cancer, 202128, 657-670. † contributed equally. (IF: 5.900)

 

10. Yang Yang, Xingnian Fu, Jianwei Chen, Hongbin Zhai*, “Total Synthesis of (-)-Jiadifenin”, Angewandte Chemie International Edition, 201251, 9825-9828. (IF: 16.823)

11. Antons Sizovs, Xianzhou Song, M. Neal Waxham, Yilong Jia, Fude Feng, Jianwei Chen, Amanda Wicker, Yan Yu, and Jin Wang*, “Precisely Tunable Engineering of Sub-30 nm Monodisperse Oligonucleotide Nanoparticles”, Journal of the American Chemical Society2014136, 234-240. (IF: 16.383)

12. Xiqian Jiang, Yong Yu, Jianwei Chen, Mingkun Zhao, Hui Chen, Xianzhou Song, Alexander J. Matzuk, Shaina L. Carroll, Xiao Tan, Antons Sizovs, Ninghui Cheng, Meng C. Wang, and Jin Wang*, “Quantitative Imaging of Glutathione in Live Cells Using a Reversible Reaction-Based Ratiometric Fluorescent Probe”, ACS Chemical Biology201510, 864-874. (IF: 4.634)

13. Xianzhou Song, Chengwei Zhang, Mingkun Zhao, Hui Chen, Xing Liu, Jianwei Chen, David M. Lonard, Li Qin, Jianming Xu, Xiaosong Wang, Feng Li, Bert W. O’Malley*, Jin Wang*, "Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug", PLoS ONE201510, e0140011. (IF: 3.752)

14. Xiqian Jiang, Lingfei Wang, Shaina Laufer Carroll, Jianwei Chen, Meng C Wang, Jin Wang*, “Challenges and Opportunities for Small Molecule Fluorescent Probes in Redox Biology Applications”, Antioxidants and Redox Signaling2018, doi.org/10.1089/ars.2017.7491. (IF: 7.468)

15. Wen-Hao Guo, Xiaoli Qi, Xin Yu, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Dong Lu, Lingfei Wang, Jianwei Chen, Lynn Hsiao Su, Krystle J Nomie, Feng Li, Meng C Wang, Xiaokun Shu, José N Onuchic, Jennifer A Woyach, Michael L Wang, Jin Wang*, “Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry”, Nature communications, 202011, 4268. † contributed equally. (IF: 17.694)

16. Xiqian Jiang, Jianwei Chen, Meng C Wang, Jin Wang*, “Glutathione quantification in live cells with real-time imaging and flow cytometry”, STAR protocols, 20201, 100170. (IF: 7.468)

17. Lingfei Wang, Feng Jin, Xiqian Jiang, Jianwei Chen, Meng C Wang, Jin Wang*, “Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems”, Antioxidants and Redox Signaling202236, 354-365. (IF: 7.468)

 

会议墙报及演讲

1. The 11th Annual Dan L. Duncan Cancer Center Symposium, Houston,TX, November 12, 2015. Poster: Tunable Thioesters as “Reduction” Responsive Functionality for Traceless Reversible Protein PEGylation

 

2. The 25th Anniversary of the Bioorganic Chemistry Gordon Research Conference, Andover, NH, June 5–10, 2016.

Poster: Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

 

3. The 2017 High-Throughput Chemistry and Chemical Biology (HTCCB) Gordon Research Conference,Andover, NH, June 25–30, 2017.

Poster: Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

 

4. 中国化学会第十一届全国有机化学学术会议,上海,2019831–201993日。

口头报告:Quantitative Real-Time Imaging of Glutathione