（1）新质合成方法学：基于新型合成方法、合成设备、催化剂的分子精准合成

（2）功能分子设计与合成：生物活性分子、药物中间体和天然产物以及电解液添加剂等稀缺资源型分子的高效合成

（3）药物研发：候选药物(医药、农药)分子的合成与成药性优化、药用生物资源与先导化合物发现

代表性论文：

1.

    Metal-Free Photoinduced C(sp3)–H Borylations of Alkanes

Chao Shu, Adam Noble, * Varinder K. Aggarwal, * Nature, 2020, 586, 714. (Highlighted by: C&EN news、 ChemBeanGo.com 、 Rationalscience 、 icat2019 、 icailiaoren、科学网、PHYS.org、News Break、Chem-Station )

2.

Synthesis of Multifluoromethylated γ-Sultines by a Photoinduced Radical Addition–Polar Cyclization

Helian Li, Yongxin Zhang, Xiaoxiao Yang, Zhenxi Deng, Zhimin Zhu, Pan Zhou, Xinke Ouyang, Yuting Yuan, Xi Chen, Lingyue Yang, Meng Liu, Chao shu*, Angew. Chem. Int. Ed. 2023, 62, e202300159. (Highlighted by: X-mol. com、 ChemBeanGo.com 、 Chem-Station )

3.

Synthesis of Functionalized Cyclopropanes from Carboxylic Acids via a Radical Addition-Polar Cyclization Cascade.

Chao Shu, † Riccardo S. Mega, † Björn J. Andreassen, Adam Noble, Varinder K. Aggarwal, * Angew. Chem. Int. Ed. 2018, 57, 15430. († Shu and Mega have an equal contribution to this work) (Highlighted by: Synfacts, 2018, 14, 1298)

4.

Photoredox-Catalyzed Cyclobutane Synthesis via a Deboronative Radical Addition–Polar Cyclization Cascade.

Chao Shu, Adam Noble, Varinder K. Aggarwal, * Angew. Chem. Int. Ed. 2019, 58, 3870.

5. 

Generation of α-Imino Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides.

Chao Shu, Yong-Heng Wang, Bo Zhou, Xin-Ling Li, Yi-Fan Ping, Xin Lu,* Long-Wu Ye,* J. Am. Chem. Soc. 2015, 137, 9567.  (ESI high cited paper)