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成果及论文

Changmai Chen(#), Maocheng Yu(#), Qing Li, Ying Zhou, Mengting Zhang, Shanyu Cai, Jiaojiao Yu, Zhongnan Huang, Jiaan Liu, Ye Kuang, Xinjing Tang, Wei Chen*. Programmable Tetrahedral DNA-RNA Nanocages Woven with Stimuli-Responsive siRNA for Enhancing Therapeutic Efficacy of Multidrug-Resistant Tumors. Advanced Science, 2024, 11(32), 2404112. IF=14.3


虞娇娇(#), 蔡栅愉(#), 俞茂承, 张媛媛, 罗云, 陈昌买*. 小干扰RNA药物在慢性病领域的研究新进展:从临床前到临床[J]. 药学进展2024, 48(8): 579-591.


Changmai Chen, Zhongyu Wang, Nannan Jing, Wei Chen, Xinjing Tang*, Photomodulation of caged RNA oligonucleotide functions in living systems. ChemPhotoChem, 2021, 5, 12-21.


Changmai Chen, Nannan Jing, Zhongyu Wang, Yu Zhang, Wei Chen, Xingjing Tang*, Multimerized Self-assembled Caged Two-in-One siRNA Nanoparticles for Photomodulation of RNAi-Induced Gene Silencing. Chemical Science, 2020, 11, 12289–12297. IF=9.825 被选为期刊封面文章,入选Chemical Science 2020 HOT Article Collection。



Wei Zhang, Zhou Sha, Yunzhe Tang, Cuiyuan Jin, Wenhua Gao, Changmai Chen, Lang Yu, Nianyin Lv, Shijia Liu, Feng Xu*, Dandan Wang*, Liyun Shi*. Defective Lamtor5 Leads to Autoimmunity by Deregulating v‐ATPase and Lysosomal Acidification. Advanced Science, 2024, 11(22), 2400446. 


Wei Zhang, Cheng Cheng, Zhou Sha, Changmai Chen, Chengtao Yu, Nianyin Lv, Peng Ji, Xiaohui Wu, Tonghui Ma, Haibo Cheng*, Liyun Shi*, Rosmarinic acid prevents refractory bacterial pneumonia through regulating Keap1/Nrf2-mediated autophagic pathway and mitochondrial oxidative stress. Free Radic Biol Med, 2021. 168: 247-257.

 

Jingjing Li, Changmai Chen, Wei Zhang, Jing'ai Bi, Guang Yang*, Erguang Li*. Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition. Basic Clin Pharmacol Toxicol, 2021. 128(3):394-409.

 

Quanquan Zhuang, Shaobin He, Kaiyuan Huang, Huaping Peng, Changmai Chen, Haohua Deng*, Xinghua Xia, Wei Chen*, Guolin Hong*. Decisive role of pH in synthesis of high purity fluorescent BSA-Au20 nanoclusters. Spectrochim Acta A Mol Biomol Spectrosc, 2020. 239:118520.

 

Lijia Yu, Duanwei Liang, Nannan Jing, Changmai Chen, Xinjing Tang*. Synthesis and Evaluation of Caged siRNAs with Single cRGD Modification for Photoregulating RNA Interference. Methods Mol Biol2020. 2115:133-161.

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Changmai Chen(#), Zhongyu Wang(#), Jinhao Zhang, Xinli Fan, Luzheng Xu, Xinjing Tang*, Dextran-conjugated caged siRNA nanoparticles for photochemical regulation of RNAi-induced gene silencing in cells and mice. Bioconjugate Chemistry, 2019. 30, 1459-1465. 被选为期刊封面文章

 


Changmai Chen, Zhenjun Yang, Xinjing Tang*, Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy. Medicinal Research Reviews, 2018. 38(3), 829-869. IF=9.791 被选为期刊封面文章

                     

Jiali Yang(#)Changmai Chen(#), Xinjing Tang*, Cholesterol-Modified Caged siRNAs for Photoregulating Exogenous and Endogenous Gene Expression. Bioconjugate Chemistry, 2018. 29(4), 1010-1015. 共同第一作者

             

Liangliang Zhang(#)Changmai Chen(#), Xinli Fan, Xinjing Tang*, Photomodulating Gene Expression by Using Caged siRNAs with Single-Aptamer Modification. ChemBioChem, 2018. 19, 1259-1263. 共同第一作者

 

Changmai Chen, Wei Zhang, Hengfei Shi, Yujie Zhuo, Guang Yang, Aihua Zhang, Yayi Hou, Ren Xiang Tan, Erguang Li*, A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation. European Journal of Pharmacology, 2015. 761, 298-308.