Guo ZX^#, Zhang Z^#, Yan JF, Xu HQ, Wang SY, Ye T, Han XX, Wang WR, Wang Y, Gao JL, Niu LN^*, Chang J^*, Jiao K^*. A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis. Acta biomaterialia. 2023;157:639-654

Feng Y^#, Su L, Zhang Z, Chen Y, Younis MR, Chen D, Xu J, Dong C, Que Y, Fan C, Jiao Y, Zhu H, Chang J^*, Dong Z^*, Yang C^*. pH-Responsive Wound Dressing Based on Biodegradable CuP Nanozymes for Treating Infected and Diabetic Wounds. ACS applied materials & interfaces. 2024;16(1):95-110

Yiren Jiao^#, Yongxia Niu, Mingxun Luo, Yanling Qiu, Min Gao, Xiaolin Chen, Sunxing Huang, Jing Zhu, Lin Xiao, Haiying Liu, Junjiu Huang^*. Chitosan microspheres loaded with WJMSCs facilitate the restoration of ovarian function in CTX-induced premature ovarian failure mice. MedComm – Biomaterials and Applications. 2023;2(4):e66

Yin H^#, Zhang Z^#, Zhang D, Peng L, Xia C, Yang X, Wang X, Li Z, Chang J^*, Huang H^*. A new method for treating chronic pancreatitis and preventing fibrosis using bioactive calcium silicate ion solution. Journal of materials chemistry. 2023;11(38):9163-9178

Wang Yu^#, Jiao Yiren, Zeng Zhen, Chang Jiang, Yang Chen^*, Dong Zhihong^*. Three-dimensional printed Zn2SiO4/sodium alginate composite scaffold with multiple biological functions for tendon-to-bone repair. MedComm – Biomaterials and Applications. 2023;2(4):e61

Que Yumei^#, Shi Jiaxin^#, Zhang Zhaowenbin^#, Sun Lu, Li Hairu, Qin Xionghai, Zeng Zhen, Yang Xiao, Chen Yanxin, Liu Chong, Liu Chang, Sun Shijie, Jin Qishu, Zhang Yanxin, Li Xin, Lei Ming, Yang Chen^*, Tian Hai^*, Tian Jiawei^*, Chang Jiang^*. Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling. Exploration. 2023, 2766-8509.

Chen X^#, Huang S, Niu Y, Luo M, Liu H, Jiao Y^*, Huang J^*. Transplantation of Gelatin Microspheres Loaded with Wharton's Jelly Derived Mesenchymal Stem Cells Facilitates Cartilage Repair in Mice. Tissue Eng Regen Med. 2024;21(1):171-183.

Jing Yu^#, Yuze Xu^#, Zhaowenbin Zhang^#, Zhen Zeng, Dongmin Chen, Ziqin Wei, Endian Wang, Yanling Zhou, Chen Yang^*, Jiang Chang^* : Strontium zinc silicate bioceramic composite electrospun fiber membrane for hair follicle regeneration in burn wounds. Composites Part B-Engineering, 2023, 110953.

Yanxin Zhang^#, Xin Li, Zhaowenbin Zhang, Huili Li, Dongmin Chen, Yiren Jiao, Chen Fan, Zhen Zeng, Jiang Chang, Yuhong Xu, Baowei Peng^*, Chen Yang^*, Yumei Que^* : Zn₂SiO₄ Bioceramic Attenuates Cardiac Remodeling after Myocardial Infarction. Advanced healthcare materials, 2023;e2203365.

Jupei Zhang^#, Zhen Zeng^#, Yanxin Chen, Li Deng, Yanxin Zhang, Yumei Que, Yiren Jiao, Jiang Chang^*, Zhihong Dong^*, Chen Yang^* : 3D-printed GelMA/CaSiO₃ composite hydrogel scaffold for vascularized adipose tissue restoration. Regenerative Biomaterials ,2023;10:rbad049.

Wenjuan Liu^#, Zhiguang Huan^#, Chengtie Wu, Zhihua Zhou^*, Jiang Chang^* : High-strength calcium silicate-incorporated magnesium phosphate bone cement with osteogenic potential for orthopedic application. Composites Part B-Engineering, 2022, 110324 

Wang C^#, Hao R, Peng B, Chang J, Chen S, Chen Y, Yin X, Que Y, Fan C^*, Xu Y^*: Dissolvable hyaluronic acid microneedles loaded with beta-Elemene for the treatment of psoriasis. Front Pharmacol, 2022, 13:1067051.

Hao RQ^#, Wang C, Yang C, Chang J, Wang X, Yuan B, Xu H, Zhou S, Fan C^*, Li Z^*. Transdermal delivery of Protocatechuic aldehyde using hyaluronic acid/gelatin-based microneedles for the prevention and treatment of hypertrophic scars. European Journal of Pharmaceutics and Biopharmaceutics, 2023, 184:202-213.

Liqin Cao^#, Huiyao Gu^#, Zhaowenbing Zhang^#, Enfan Zhang, Jiang Chang*, Zhen Cai*, Calcium Silicate/Bortezomib Combinatory Therapy for Multiple Myeloma.Journal of Materials Chemistry B, 2023;11(9):1929-1939.

Li Deng^#, Lingwei Huang^#, Hao Pan^#, Qi Zhang, Yumei Que, Chen Fan, Jiang Chang*, Siyu Ni*, Chen Yang*, 3D printed strontium-zinc-phosphate bioceramic scaffolds with multiple biological functions for bone tissue regeneration. Journal of Materials Chemistry B, 2023;11(24):5469-5482.

Fanliang Zhang^#, Zhaowenbin Zhang^#, Xianlan Duan, Wei Song, Zhao Li, Bin Yao, Yi Kong, Xing Huang, Xiaobing Fu, Jiang Chang*, Sha Huang*, Integrating Silicon/Zinc Dual Ions with 3D-printed GelMA Hydrogel Promotes In Situ Hair Follicle Regeneration. International Journal of Bioprinting, 2023;9(3):703.

Jinfeng Xu^#, Muhammad Rizwan Younis^#, Zhaowenbin Zhang^#, Yanping Feng, Lefeng Su, Yumei Que, Yiren Jiao, Chen Fan, Jiang Chang, Siyu Ni*, Chen Yang*, Mild Heat-Assisted Polydopamine/Alginate Hydrogel Containing Low-Dose Nanoselenium for Facilitating Infected Wound Healing, ACS Applied Materials & Interfaces, 2023;15(6):7841-7854.

Xin Li^#, Yanxin Zhang, Qishu Jin, Qiaoyu Song, Chen Fan, Yiren Jiao, Chen Yang, Jiang Chang, Zhihong Dong*, Yumei Que*. Silicate Ions Derived from Calcium Silicate Extract Decelerate Ang II-2 induced Cardiac Remodeling. Tissue Engineering and Regenerative Medicine, 2023;10.1007.

B. Feng^#, M. Zhang, C. Qin, D. Zhai, Y. Wang, Y. Zhou, J. Chang, Y. Zhu, C. Wu*, 3D printing of conch-like scaffolds for guiding cell migration and directional bone growth.Bioactive Materials, 2023, 22, 127-140. 

Zhaowenbin Zhang^#, Wenbo Li^#, Di Chang, Ziqin We, Endian Wang, Jing Yu, Yuze Xu, Yumei Qu, Yanxin Chen, Chen Fan, Bing Ma, Yanling Zhou, Zhiguang Huan, Chen Yang*, Feng Guo*, Jiang Chang*, A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch.Bioactive Materials, 2023, 24, 81-95.

Zhen-Xing Guo^#, Zhaowenbin Zhang^#, Jian-Fei Yan^#, Hao-Qing Xu, Shu-Yan Wang, Tao Ye, Xiao-Xiao Han, Wan-Rong Wang, Yue Wang, Jia-Lu Gao, Li-Na Niu*, Jiang Chang*, and Kai Jiao*, A biomaterial-based therapy using a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis. Acta Biomaterialia, 2023, 157, 639-654

Pan H^#, Deng L^#, Huang L, Zhang Q, Yu J, Huang Y, Chen L^*, Chang J^*, 3D-printed Sr₂ZnSi₂O₇ scaffold facilitates vascularized bone regeneration through macrophage immunomodulation. Front Bioeng Biotechnol,2022, 10:1007535.

Yumei Que^#, Zhaowenbin Zhang, Yanxin Zhang, Xin Li, Likai Chen, Peier Chen, Caiwen Ou, Chen Yang*, Jiang Chang*. Silicate ions as soluble form of bioactive ceramics alleviate aortic aneurysm and dissection. Bioactive Materials, 2022, 07, 005.

Chen Fan^#, Qing Xu, Ruiqi Hao, Chun Wang, Yumei Que, Yanxin Chen, Chen Yang*, Jiang Chang*. Multi-functional wound dressings based on silicate bioactive materials. Biomaterials 2022, 287, 121652.

Hongshi Ma^#, Chen Yang^#, Zhenjiang Ma^#, Xiaoyue Wei, Muhammad Rizwan Younis, Hanbo Wang, Wentao Li, Zhiyong Wang, Wenhao Wanga, Yongxiang Luo*, Peng Huang*, Jinwu Wang*. Multiscale hierarchical architecture-based bioactive scaffolds for versatile tissue engineering, Advanced Healthcare Materials 2022, 2102837.

Chenle Dong^#, Chen Yang^#, Muhammad Rizwan Younis, Jing Zhang, Gang He, Xingdi Qiu, Lian-Hua Fu, Dong-Yang Zhang, Hao Wang, Wenli Hong, Jing Lin, Xueqing Wu*, Peng Huang*. Bioactive NIR-II light-responsive shape memory composite based on cuprorivaite nanosheets for endometrial regeneration, Advanced Science  2022, e2102220.

Tao Chen^#, Zhaowenbin Zhang^#, Dong Weng, Liqin Lu, XiaoYa Wang, Min Xing, Hui Qiu, MengMeng Zhao, Li Shen, Ying Zhou, Jiang Chang*, Hui-Ping Li*. Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics, Bioactive Materials, 2021, 6, 3194-3206.

Qing Xu^#, Feng Jiang^#, Geyong Guo^#, Endian Wang, MR Younis, Zhaowenbin Zhang, Feiyang Zhang, Zhiguang Huan, Chen Fan, Chen Yang*, Hao Shen*, Jiang Chang*. Targeted hot ion therapy of infected wound by glycol chitosan and polydopamine grafted Cu-SiO₂ nanoparticles, Nano Today 2021, 41, 101330.

Bo Yuan^#, Zee Upton, David Leavesley, Chen Fan^#*, and Xi-Qiao Wang*. Vascular and Collagen Target: A Rational Approach to Hypertrophic Scar Management.  Advances in Wound Care 2021, 10.1089/wound.2020.1348.

Chen Yang^#, Hongshi Ma^#, Zhiyong Wang^#, MR Younis, Chunyang Liu, Chengtie Wu*, Yongxiang Luo*, Peng Huang*. 3D printed wesselsite nanosheets functionalized scaffold facilitates NIR-II photothermal therapy and vascularized bone regeneration, Advanced Science 2021, 2100894.

Chen Yang^#, Zhiwei Zheng^#, MR Younis, Chenle Dong, Yahong Chen, Shan Lei, Dongyang Zhang, Jiayingzi Wu, Xueqing Wu, Jing Lin, Xiansong Wang*, Peng Huang*. 3D printed enzyme-functionalized scaffold facilitates diabetic bone regeneration, Advanced Functional Materials 2021, 31, 2101372.

Chen Yang^#, Rui Zheng^#, MR Younis, Jundong Shao, Lianhua Fu, Dongyang Zhang, Jing Lin , Zhiming Li*, Peng Huang *. NIR-II light-responsive biodegradable shape memory composites based on cuprorivaite nanosheets for enhanced tissue reconstruction, Chemical Engineering Journal 2021, 419, 129437.

Chen Yang, Xiaoting Gao, MR Younis, TN Blum, Shan Lei, Dongyang Zhang, Yongxiang Luo, Peng Huang*, Jing Lin*. Non-invasive monitoring of in vivo bone regeneration based on alkaline phosphatase-responsive scaffolds, Chemical Engineering Journal 2021, 408, 127959.

Zhaowenbin Zhang^#, Yu Zhang^#, Wenbo Li^#, Lingling Ma, Endian Wang, Min Xing, Yanling Zhou, Zhiguang Huan, Feng Guo*, Jiang Chang*. Curcumin/Fe-SiO2 nano composites with multi-synergistic effects for scar inhibition and hair follicle regeneration during burn wound healing, Applied Materials Today 2021, 23, 101065

Zhaowenbin Zhang^#, Wenbo Li^#, Ying Liu, Zhigang Yang, Lingling Ma, Hui Zhuang, Eendian Wang, Chengtie Wu, Zhiguang Huan, Feng Guo*, Jiang Chang*. Design of a biofluid-absorbing bioactive sandwich-structured Zn-Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing, Bioactive Materials 2021, 6, 1910-1920.

Endian Wang^#, Xinfang Li^#, Yu Zhang, Lingling Ma, Qing Xu, Yuanzheng Yue, Wenzhong Wang, Qin Li*, Jianding Yu*, and Jiang Chang*. Multi‐Functional Black Bioactive Glasses Prepared via Containerless Melting Process for Tumor Therapy and Tissue Regeneration, Advanced Functional Materials 2021, 31, 2101505

Richun Liu^#, Bo Zhou^#, Hong Zhang^#, Yangwu Chen, Chunmei Fan, Tao Zhang, Tian Qin, Jie Han, Shichen Zhang, Xiao Chen, Weiliang Shen, Jiang Chang*, and Zi Yin*. Inhibition of ROS activity by controlled release of proanthocyanidins from mesoporous silica nanocomposites effectively ameliorates heterotopic tendon ossification, Chemical Engineering Journal  2021, 420, 129415

Peng Xu^#, Min Xing^#, Huizhen Huang, Ke Xue, Jiang Chang*, and Kai Liu*. Calcium Silicate-human Serum Albumin Composite Hydrogel Decreases Random Pattern Skin Flap Necrosis by Attenuating Vascular Endothelial Cell Apoptosis and Inflammation, Chemical Engineering Journal  2021, 423,130285.

Min Xing, Jiang Yun, Wei Bi, Long Gao, Yan-Ling Zhou, Sen-Le Rao, Ling-Ling Ma, Zhao-Wenbin Zhang, Huang-Tian Yang*, and Chang Jiang*. Strontium ions protect hearts against myocardial ischemia/reperfusion injury, Science Advances 2021, 7, eabe0726.

Geyong Guo^#, Qing Xu^#, Chongzun Zhu^#, Jinlong Yu, Qiaojie Wang, Jin Tang, Zhiguang Huan, Hao Shen, Jiang Chang*, and Xianlong Zhang*. Dual-Temporal Bidirectional Immunomodulation of Cu-Zn Bi-layer Nanofibrous Membranes for Sequentially Enhancing Antibacterial Activity and Osteogenesis, Applied Materials Today 2021, 22, 100888.

Chen Yang, MR Younis, Jing Zhang, Junle Qu, Jing Lin, Peng Huang*. Programmable NIR-II photothermal-enhanced starvation-primed chemodynamic therapy using glucose oxidase-functionalized ancient pigment nanosheets, Small 2020, 16, 2001518.

Chen Yang, TN Blum, Jing Lin, Junle Qu, Peng Huang*. Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy,  Science Bulletin 2020, 65(17), 1489-1504.

Long Gao, Min Yi, Min Xing, Hekai Li, Yanling Zhou, Qing Xu, Zhaowenbin Zhang, Zhanpeng Wen, Jiang Chang*. In situ activated mesenchymal stem cells (MSCs) by bioactive hydrogels for myocardial infarction treatment, Journal of Materials Chemistry B, 2020, 8, 7713-7722.

Chen Fan, Samir El Andaloussi, Taavi Lehto, Kiat Whye Kong and Yiqi Seow*. Smad‑binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts. Molecular Medicine Reports 2020, 22(6), 4589-4600.

Zheng Lu, Dongyuan Lü, Fan Zhang, Min Xing, Xiaoya Wang, Xiaohua Jia, Xinyu Shu, Peiwen Li, Shouqin Lü, Jiang Chang*, and Mian Long*. Regulation of hepatic differentiation of human embryonic stem cells by calcium silicate extracts for liver injury repairing, Applied Materials Today 2020, 20, 100730.

Lili Sheng, Zhang Zhaowenbin, Zhang Yu, Wang Endian, Ma Bing, Xu Qing, Ma Lingling, Zhang Meng, Pei Ge, and Chang Jiang*. A novel “hot spring”-mimetic hydrogel with excellent angiogenic properties for chronic wound healing, Biomaterials 2020, 264: 120414.

Zhaowenbin Zhang^#, Qiuxia Dai^#, Yu Zhang, Hui Zhuang, Endian Wang, Qing Xu, Lingling Ma, Chengtie Wu, Zhiguang Huan, Feng Guo,* and Jiang Chang*, Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin, ACS Applied Materials & Interfaces 2020, 12, 12489-12499. 

Lingling Ma, Yanling Zhou, Zhaowenbin Zhang, Yaqin Liu, Dong Zhai, Hui Zhuang, Qin Li, Jianding Yuye, Chengtie Wu, Jiang Chang*. Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair, Science Advances 2020, 6, eabb1311.  

Qing Xu^#, Mengling Chang^#, Yu Zhang, Endian Wang, Min Xing, Long Gao, Zhiguang Huan, Feng Guo*, Jiang Chang*. PDA/Cu bioactive hydrogel with “hot ions effect” for inhibition of drug-resistant bacteria and enhancement of infectious skin wound healing. ACS Applied Materials & Interfaces 2020, 28, 31255-31269.   

Feng Bao, Ge Pei, Zhongcao Wu, Hui Zhuang, Zhaowenbin Zhang, Zhiguang Huan, Chengtie Wu and Jiang Chang*, Bioactive self-pumping composite wound dressings with micropore array modified Janus membrane for enhanced diabetic wound healing,    Advanced Functional Materials, 2020, 49, 2005422.  

Aleksandra Shedoeva, David Leavesley, Zee Upton and Chen Fan*. Wound Healing and the Use of Medicinal Plants . Evidence-based Complementary and Alternative Medicine 2019, 2684108

Yanling Zhou, Chengtie Wu, Jiang Chang*, Bioceramics to regulate stem cells and their microenvironment for tissue regeneration,        Materials Today, 2019 (20), 41-56.   

Yu Zhang, Mengling Chang, Feng Bao, Min Xing, Endian Wang, Qing Xu, Zhiguang Huan, Feng Guo* and Jiang Chang*, Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing, Nanoscale, 2019, 11, 6315–6333.    

Lei Chen^#, Cuijun Deng^#, Jiayi Li, Qingqiang Yao*, Jiang Chang*, Liming Wang, Chengtie Wu*.3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction, Biomaterials 2019, 196:138-150.   

Min Yi^#, Hekai Li^#, Xiaoya Wang, Jianyun Yan, Long Gao, Yinyan He, Xinglong Zhong, Yanbin Cai, Weijing Feng, Zhanpeng Wen, Chengtie Wu, Caiwen Ou*, Jiang Chang*, Minsheng Chen*. Ion Therapy: A Novel Strategy for Acute Myocardial Infarction, Advanced Science 2019, 6, 1801260.   

Chen Yang^#, Cancan Zhao^#, Xiaoya Wang, Mengchao Shi, Yanlun Zhu, Linguo Jing, Chengtie Wu, Jiang Chang*. Stimulation of Osteogenesis and Angiogenesis by Micro/Nano Hierarchical Hydroxyapatite via Macrophage Immunomodulation, Nanoscale 2019,11, 17699–17708.   

Long Gao, Yanling Zhou, Jinliang Peng, Chen Xu, Qing Xu, Min Xing, Jiang Chang*. A Novel Dual-adhesive and Bioactive Hydrogel Activated by Bioglass for Wound Healing, NPG Asia Materials 2019,11, 66.   

Chen Xu, Bing Ma, Jinliang Peng, Long Gao, Yuhong Xu, Zhiguang Huan, Jiang Chang*. Tricalcium silicate/graphene oxide bone cement with photothermal properties for tumor ablation, Journal of Materials Chemistry B 2019, 7, 2808-2818.    

Yanlun Zhu^#, Lingzhi Kong^#, Fatemeh Farhadi, Wei Xia, Jiang Chang, Yaohua He*, Haiyan Li*. An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration, Biomaterials 2019, 192, 149–158.   

Chen Fan*, Lay Keng Priscilla Lim, See Qi Loh, Kimberley Ying Ying Lim, Zee Upton and David Leavesley. Application of “macromolecular crowding” in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars. Chemico-Biological Interactions 2019, 310, 108747.

Xiaoya Wang, Long Gao, Yan Han, Min Xing, Cancan Zhao, Jinliang Peng, and Jiang Chang*, Silicon-Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering, Advanced Science 2018, 1800776.   

Yu Zhang, Cui Huang,* and Jiang Chang,* Ca-doped mesoporous SiO2/dental resin composites with enhanced mechanical properties, bioactivity and antibacterial properties, Journal of Materials Chemistry B 2018, 6, 477-486     

Yan Huang^#, Chengtie Wu^#, Xiaoling Zhang, Jiang Chang* Kerong Dai*. Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration, Acta Biomaterialia 2018, 66, 81-92.   

Yang Zhou, Yanling Zhou, Long Gao, Chengtie Wu, Jiang Chang*, Synthesis of artificial dental enamel by an elastin-like polypeptide assisted biomimetic approach, Journal of Materials Chemistry B 2018, 6, 844-853.   

Chen Xu, XiaoYa Wang, Jie Zhou, Zhiguang Huan*, Jiang Chang*, Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties, Journal of Biomedical Materials Research: Part B-Applied Biomaterials 2018, 106B, 237-244.  

Yanling Zhou, Chen Xua, Xiaoya Wang, Yuandong Dou, Zhiguang Huan*, Jiang Chang*, Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling, Ceramics International 2018, 44, 3015-3023.   

Chen Yang, Zhiguang Huan, Xiaoya Wang, Chengtie Wu, Jiang Chang*. 3D Printed Fe Scaffolds with HA Nanocoating for Bone Regeneration, ACS Biomaterials Science & Engineering 2018, 4, 608-616.   

Cancan Zhao, Xiaoya Wang, Long Gao, Linguo Jing, Quan Zhou, Jiang Chang*. The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells, Acta Biomaterialia 2018, 73, 509–521.   

Min Xing, Xiaoya Wang, Endian Wang, Long Gao, Jiang Chang*. Bone tissue engineering strategy based on the synergistic effects of silicon and strontium ions, Acta Biomaterialia 2018, 72, 381–395.   

Yanling Zhou, Long Gao, Jinliang Peng, Min Xing, Yan Han, Xiaoya Wang, Yuhong Xu, Jiang Chang*. Bioglass Activated Albumin Hydrogels for Wound Healing, Advanced Healthcare Materials 2018, 1800144.     

Shuo Chen, Zhiguang Huan, Lin Zhang*, Jiang Chang*. The clinical application of a silicate-based wound dressing (DermFactor) for wound healing after anal surgery, A randomized study. International Journal of Surgery 2018, 52, 229–232.