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成果及论文

代表论文:

1. Choy KHK, Chan SY, Lam W, Jin J, Zheng T, Law TYS, Yu SS, Wang W, Li L, Xie G, Yim HCH, Chen H*, Fok EKL*. The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis. BMC Biol. 2022 Mar 29;20(1):78 [*共同通讯作者]

2. Chen H, Shi X, Li X, Diao R, Ma Q, Jin J, Qiu Z, Li C, Yu MK, Wang C, Li X, Li F, Chan DYL, Zhao AZ, Cai Z, Sun F, Fok KL. CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia. Mol Ther Nucleic Acids. 2021 Nov 10;26:1374-1386.      

3. JW Shi#, KL Fok#, PY Dai#, F Qiao, MY Zhang, HG Liu, MM Sang, M Ye, Y Liu, YW Zhou, CN Wang, F Sun*, GC Xie*, H Chen*. Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNAseq. Cell Discovery, 2021 May 18;7(1):34. 

4. Shi J, Qiao F, Ye M, Jiang T, Liu J, Zhang M, Xie G, Fok KL, Li X, Chen H. CSE1L/CAS regulates cell proliferation through CDK signalling in mouse spermatogenesis. Cell Prolif. 2022 Sep 13:e13334. doi: 10.1111/cpr.13334.

5. Ye M, Chen Y, Liu J, Tian J, Wang X, Fok KL, Shi J, Chen H. Interfering with CSE1L/CAS inhibits tumour growth via C3 in triple-negative breast cancer. Cell Prolif. 2022 Apr 10:e13226

6. Ding N, Zhang X, Zhang XD, Jing J, Liu SS, Mu YP, Peng LL, Yan YJ, Xiao GM, Bi XY, Chen H*, Li FH*, Yao B*, Zhao AZ*. Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes. Gut. 2020 Jan 2. pii: gutjnl-2019-319127 [*共同通讯作者].

7. Wang C, Zhang J, Fok KL, Tsang LL, Ye M, Liu J, Li F, Zhao AZ, Chan HC*, Chen H*. CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/β-Catenin Complex in Human Endometriosis. American Journal of Pathology, 2018Apr 6. pii: S0002-9440(17)30969-0.

8.  Wang CQ, Jin AH, Huang WQ, Tsang LL, Cai Z, Zhou XP, Chen H*, Chan HC*. Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis. Journal of Clinical Endocrinology & Metabolism,2015,100(7):E955-63 [*共同通讯作者]

9.  DiaoR#, Fok KL#Chen H#, Yu MK, Duan YG, Chung CM, Li Z, Wu HW, Zhang H, Ji ZL, Zhen WH, Ng CF, Gui Y, Cai Z*, Chan HC*.Defective human β-defensin-1 underlies male infertility associated with poor sperm motility and genital tract infection. Science Translational Medicine,2014, 6, 249ra108. [# 共同第一作者]. 

10.  Chen H#, Fok KL#, Jiang X, Jiang J, Chen Z, Gui Y, Chan HC*, Cai Z*. CD147 regulates apoptosis in spermatocytes but not spermatogonia. Human Reproduction,2012, 27(6): 1568-1576. 

11. Chen H, Fok KL, Yu S, Jiang J, Chen Z, Gui Y, Cai Z, Chan HC*. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Molecular Human Reproduction, 2011, 17(7):405-14. 

参编专著:

《外分泌生理学:基础与临床》第二版,科学出版社,2011