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成果及论文

30. Wei, C.; Li, Y.; Yao, X.; Zhang, K.*; Cai, L.* "TFE-Facilitated Synthesis of Tetrahydropyridino[2,3-d]pyrimidine via Cascade [1,5]-Hydride Transfer/Cyclization" , J. Org. Chem. 2023, 88, 17144-17154.

29. Hao, Y.;  Wang,  X.; Wu, Y.; Song, L.; Zhang, K.; Cai, L.* "Nickel-Catalyzed Enantioconvergent Reductive Hydroalkylation of Unactivated alkenes with α-Pyridyl Alkyl Electrophiles", ACS Catal. 2023, 13, 15633.

28. Zhang, Z.; Cai, L.* ; Song, L.* "Peptide Diversification through Addition Reaction of Free Carboxylic Acids to Ynamides", Processes 202311, 2262.

27. Lv, Z.; Li, Y.; Van der Eycken, E. V.* ; Cai, L.* ; Song, L.*  "6-Exo-dig cyclization/dearomatization cascade towards N–O fused spiro polyheterocycles", Org. Chem. Front., 2023,10, 4912.

26. Song, L.*; Zhang, Z.; Lv, Z.; Xu, J.; Zhan, M.; Tang, S.; Li. H.; Wang, N.*; Cai, L.* "In Situ Generation of Fluorescent Amino Acids and Peptides via Double C–H Activation/Annulation", ACS Catal. 2023, 13, 13569.

25.  Liu, J.; Jin, J.; Zhang, K.; Cai, L. "Alkoxy Radical Induced Transformations from N-Alkoxyphthalimides Under the Photoredox Catalysis", Asian J. Org. Chem. 2023, 12, e202300160.

24.  Lv, Z.; Li, Y.; Cai, L.; Song, L. "Metal-Free Bicyclization for the Construction of N−O Fused Tetracyclic Isoquinolones",  Asian J. Org. Chem. 2023, 12, e202300393.

23.  Song, L.*; Lv, Z.; Li, Y.; Zhang, K.; Van der Eycken, E. V.*; Cai, L.* "Construction of Peptide-Isoquinolone Conjugates via Rh(III)-Catalyzed C-H Activation/Annulation", Org. Lett. 2023, 25, 2996.  

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c00766

 

22. Li, H.; Lv, L.; Tang, S.; Zhang, Y.; Wan, T.; Wang, D.; Cai, L.*; Ye, H.*; Tan, R.*; Wang, N.* "Oxidation-Induced Protein Cross-Linking in Mammalian Cells", ACS Synth. Biol. 2023, 12, 984. 

https://doi.org/10.1021/acssynbio.3c00052

      

21. Song, L.; Cai, L.; Gong, L.*; Van der Eycken, E. V.* "Photoinduced Copper-Catalyzed Enantioselective Coupling Reaction", Chem. Soc. Rev. 2023, 52, 2358.

https://doi.org/10.1039/D2CS00734G

 

20. Zhang, K.*; Cai, L.* "Enantioselective Hydroamination of Arylalkenes with Secondary Amines Via Cobalt Catalysis", Chem Catalysis 2023, 3, 100553. (Invited Paper) 

https://authors.elsevier.com/a/1glnj9URZ7naiZ

19. Zhang, K.; Chen, Y.; Song, L.; Cai, L.*"Progress of Catalytic Mitsunobu Reaction in the Two Decades", Asian J. Org. Chem. 2023, 12, e20200707. 

https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.202200707

18. Zhang, K.; Wei, C.; Li, Y.; Yao, Y.(本科生); Song, L.; Jin, J.; Cai, L.* "Cu(OAc)2-Catalyzed Hydrazination of Cyclopropanols and Later-Stage Transformation to 4,5-Dihydropyrazoles", New J. Chem. 2023, 47, 3653.

https://pubs.rsc.org/en/content/articlepdf/2023/NJ/D2NJ05989D?page=search

17. Gao, Y.; Liu, J.; Wei, C.; Li, Y.; Zhang, K.; Song, L.; Cai, L."Photoinduced β-fragmentation of aliphatic alcohol derivatives for forging C–C bonds", Nat. Commun. 2022, 13, 7450.

https://www.nature.com/articles/s41467-022-35249-7

Highlight by: https://mp.weixin.qq.com/s/ReuuhcpneQWWkQcABmNzAQ

16. Song, L.*; Lv, Z.; Zhang, K.; Wu, Y.; Van der Eycken, E.; Cai, L.* " Recent Advances in the Asymmetric Total Synthesis of Camptothecin", Asian J. Org. Chem. 2022, 11e202200515.

 https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.202200515

15. Cai, L.; Seiple, I. B.*; Li, Q.* “Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics”Acc. Chem. Res. 2021, 54,  1891. 

https://pubs.acs.org/doi/pdf/10.1021/acs.accounts.0c00894

14. Cai, L.; Yao, Y.; Yeon, S. K.; Seiple, I.* “Modular approaches to lankacidin antibiotics,”J. Am. Chem. Soc. 2020,  14215116 

 https://pubs.acs.org/doi/pdf/10.1021/jacs.0c06648

Before NJFU

13. Cai, L.; Zhang, K.; Chen, S.; Lepage, R. J.; Houk, K. N.; Krenske, E. H.; Kwon, O.*Catalytic Asymmetric Staudinger-aza-Wittig reaction for the synthesis of heterocyclic amines,” J. Am. Chem. Soc. 2019141, 9537.

12. Liu, J.#; Cai, L.#; Sun, W.; Cheng, R.; Chen, W.; Rozovsky, S.; Seiple, I. B.; Wang, L.*Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein–Protein and Protein–DNA Complexes,” Angew. Chem. Int. Ed., 201958, 18839. (共同一作)

11. Zhang, K.; Cai, L.; Hong, S.; Kwon, O.* “Phosphine-Catalyzed a-Umpolung-Aldol Reaction for the Synthesis of Benzo[b]azapin-3-ones,” Org. Lett. 201921, 5143. 

10. Zhang, K.#Cai, L.#; Yang, Z.; Houk, K. H.; Kwon, O.* "Bridged [2.2.1] Bicyclic Phosphine Oxide Facilitates Catalytic γ-Umpolung-Wittig Olefination,”Chem. Sci. 2018, 9, 1867(共同一作 ).

9. Yao, Y.; Cai, L.; Seiple, I.* “Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B,” Angew. Chem. Int. Ed. 201857, 13551.

8. Xu, Q.; Dupper, N.; Smaligo, A.; Fan, Y.; Cai, L.; Wang, Z.; Langenbacher, A.; Chen, J.; Kwon, O.* “Catalytic Enantioselective Synthesis of Guvacine Derivatives through [4+2] Annulations of Imines with α‑Methylallenoates,” Org. Lett. 201820, 6089. 

7. Cai, L.; Zhang, K.; Kwon, O.* “Catalytic Asymmetric Total Synthesis of (–)-Actinophyllic acid,” J. Am. Chem. Soc. 2016138, 3298. 

6. Zhou, Q.; Zhang, K.; Cai, L.; Kwon, O.* “Phosphine-Catalyzed Intramolecular Cyclizations of α-Nitroethylallenoates Forming (Z)-Furanone Oximes,” Org. Lett. 201618, 2954. 

5. Zhang, K.; Cai, L.; Jiang, X.; Garcia-Garibay, M. A.; Kwon, O.* “Phosphine-Mediated Iterative Arene Homologation Using Allenes,” J. Am. Chem. Soc. 2015, 137, 11258. 

4. CaiL.; Zhang, B.; Wu, G.; Song, H.; He, Z.* “Chemoselective Phosphine-catalyzed Cascade Annulations between Two Different Activated Alkenes: Highly Diastereoselective Syntheses of Polysubstituted Cyclohexanes and Cyclopentenes,” Chem. Commun. 2011, 47, 1045

3. Zhang, B.; CaiL.; Song, H.; Wang, Z.; He, Z.* A Highly Diastereoselective Tertiary Amine-Catalyzed Cascade Michael–Michael–Henry Reaction between Nitromethane, Activated Alkenes and α,β-Unsaturated Carbonyl Compounds,” Adv. Synth. Catal. 2010352, 97. 
2Wang, F.; Wang, Y.; CaiL.; Miao, Z.*; Chen, R.*“Progress in the Synthesis of Isobenzopyran and Isobenzofuran Derivatives,”Chin. J. Org. Chem. 200828, 1523.
1. Wang, F.; Wang, Y.; CaiL.; Miao, Z.*; Chen, R.* “Efficient Syntheses of (Thio)phosphonylated Isobenzofurans by Tandem Nucleophilic Addition and Regioselective 5-exo-dig Addition to Carbon-Carbon Triple Bond: Cooperative Effect to 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU),”Adv. Synth Catal. 2008350, 2733.