迄今已在Cancer Cell、Nature Immunology、Journal of Experimental Medicine、Nature Communications、EMBO Journal、Cell Research、Proceedings of National Academy of Sciences等发表研究论文60余篇，被引用1300余次，单篇引用最高200余次，参与编写英文专著1部，申请发明专利8项。近五年来，重点研究了Hippo信号通路及相关分子网络调控胃肠道肿瘤发生及免疫应答的机制与功能，取得了一系列重要突破，发现了多个可用于胃癌、结肠癌等恶性肿瘤以及感染性疾病的诊断标志物和潜在药物，成果被Cell、Nature Reviews Cancer、Nature China、Science Signaling、F1000Prime评价和推荐，多次应邀为Oncogene等学术期刊撰写综述，为国际学术会议做大会及分会报告，为Nature Cell Biology、Nano Letter、ACS Nano、Cell Research等国际知名学术期刊审稿。
近期代表性工作
1) S Jiao, J Guan, M Chen, W Wang, C Li, Y Wang, Y Cheng, Z Zhou. Targeting IRF3 as a YAP agonist therapy against gastric cancer. Journal of Experimental Medicine, 2018, 215:699
2) S Jiao, C Li, Q Hao, H Miao, L Zhang, L Li, Z Zhou. VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nature Communications, 2017, 8:14058
3) S Jiao, Z Zhang, C Li, M Huang, Z Shi, Y Wang, X Song, H Liu, C Li, M Chen, W Wang, Y Zhao, Z Jiang, H Wang, C Wong, C Wang, Z Zhou. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor molecule TRAF6. Nature Immunology, 2015, 16: 246
4) Q Hao, S Jiao, Z Shi, C Li, X Meng, Z Zhang, Y Wang, X Song, W Wang, R Zhang, Y Zhao, C Wong, Z Zhou. A Non-canonical Role of the p97 Complex in RIG-I Antiviral Signaling. The EMBO Journal, 2015, 34: 2903
5) S Jiao, H Wang, Z Shi, A Dong, W Zhang, X Song, F He, Y Wang, Z Zhang, W Wang, X Wang, T Guo, P Li, Y Zhao, H Ji, L Zhang, Z Zhou. Gastric cancer therapy by a peptide mimicking VGLL4 function as a YAP antagonist. Cancer Cell, 2014, 25: 166
发表论文列表(1-65)
1. Liu, C. X., Li, X., Nan, F., Jiang, S., Gao, X., Guo, S. K., Xue, W., Cui, Y., Dong, K., Ding, H., Qu, B., Zhou, Z., Shen, N., Yang, L., and Chen, L. L. (2019) Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Cell 177, 865-880 e821
2. Tang, Y., Chen, M., Zhou, L., Ma, J., Li, Y., Zhang, H., Shi, Z., Xu, Q., Zhang, X., Gao, Z., Zhao, Y., Cheng, Y., Jiao, S., and Zhou, Z. (2019) Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell discovery 5, 3
3. Li, Y., Guan, J., Wang, W., Hou, C., Zhou, L., Ma, J., Cheng, Y., Jiao, S., and Zhou, Z. (2019) TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. The Journal of biological chemistry 294, 2744-2756
4. Sun, W. W., Jiao, S., Sun, L., Zhou, Z., Jin, X., and Wang, J. H. (2018) SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin. mBio 9
5. Jiao, S., Guan, J., Chen, M., Wang, W., Li, C., Wang, Y., Cheng, Y., and Zhou, Z. (2018) Targeting IRF3 as a YAP agonist therapy against gastric cancer. The Journal of experimental medicine 215, 699-718
6. Chen, M., Zhang, H., Shi, Z., Li, Y., Zhang, X., Gao, Z., Zhou, L., Ma, J., Xu, Q., Guan, J., Cheng, Y., Jiao, S., and Zhou, Z. (2018) The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. The Journal of biological chemistry 293, 14455-14469
7. Shi, Z., He, F., Chen, M., Hua, L., Wang, W., Jiao, S., and Zhou, Z. (2017) DNA-binding mechanism of the Hippo pathway transcription factor TEAD4. Oncogene 36, 4362-4369
8. Pan, C., Xiong, Y., Lv, X., Xia, Y., Zhang, S., Chen, H., Fan, J., Wu, W., Liu, F., Wu, H., Zhou, Z., Zhang, L., and Zhao, Y. (2017) UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO reports 18, 1922-1934
9. Lv, X., Han, Z., Chen, H., Yang, B., Yang, X., Xia, Y., Pan, C., Fu, L., Zhang, S., Han, H., Wu, M., Zhou, Z., Zhang, L., Li, L., Wei, G., and Zhao, Y. (2017) A positive role for polycomb in transcriptional regulation via H4K20me1. Cell research 27, 594
10. Jiao, S., Li, C., Hao, Q., Miao, H., Zhang, L., Li, L., and Zhou, Z. (2017) VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nature communications 8, 14058
11. Fan, J., Kuai, B., Wu, G., Wu, X., Chi, B., Wang, L., Wang, K., Shi, Z., Zhang, H., Chen, S., He, Z., Wang, S., Zhou, Z., Li, G., and Cheng, H. (2017) Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export. The EMBO journal 36, 2870-2886
12. Xu, K., Liu, H., Shi, Z., Song, G., Zhu, X., Jiang, Y., Zhou, Z., and Liu, X. (2016) Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency. European journal of immunology 46, 1011-1019
13. Wang, D., Wang, T., Liu, J., Yu, H., Jiao, S., Feng, B., Zhou, F., Fu, Y., Yin, Q., Zhang, P., Zhang, Z., Zhou, Z., and Li, Y. (2016) Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy. Nano letters 16, 5503-5513
14. Wang, C., Zeng, X., Zhou, Z., Zhao, J., and Pei, G. (2016) beta-arrestin-1 contributes to brown fat function and directly interacts with PPARalpha and PPARgamma. Scientific reports 6, 26999
15. Shi, Z., Jiao, S., and Zhou, Z. (2016) STRIPAK complexes in cell signaling and cancer. Oncogene 35, 4549-4557
16. Lv, X., Han, Z., Chen, H., Yang, B., Yang, X., Xia, Y., Pan, C., Fu, L., Zhang, S., Han, H., Wu, M., Zhou, Z., Zhang, L., Li, L., Wei, G., and Zhao, Y. (2016) A positive role for polycomb in transcriptional regulation via H4K20me1. Cell research 26, 529-542
17. Zhang, Z., Wang, Y., Li, C., Shi, Z., Hao, Q., Wang, W., Song, X., Zhao, Y., Jiao, S., and Zhou, Z. (2015) The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-kappaB Signaling via Partial Degradation of the NF-kappaB Subunit p100. The Journal of biological chemistry 290, 19558-19568
18. Shi, Z., Zhang, Z., Zhang, Z., Wang, Y., Li, C., Wang, X., He, F., Sun, L., Jiao, S., Shi, W., and Zhou, Z. (2015) Structural Insights into mitochondrial antiviral signaling protein (MAVS)-tumor necrosis factor receptor-associated factor 6 (TRAF6) signaling. The Journal of biological chemistry 290, 26811-26820
19. Shi, Z., Jiao, S., and Zhou, Z. (2015) Structural dissection of Hippo signaling. Acta biochimica et biophysica Sinica 47, 29-38
20. Jiao, S., Zhang, Z., Li, C., Huang, M., Shi, Z., Wang, Y., Song, X., Liu, H., Li, C., Chen, M., Wang, W., Zhao, Y., Jiang, Z., Wang, H., Wong, C. C., Wang, C., and Zhou, Z. (2015) The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nature immunology 16, 246-257
21. Hao, Q., Jiao, S., Shi, Z., Li, C., Meng, X., Zhang, Z., Wang, Y., Song, X., Wang, W., Zhang, R., Zhao, Y., Wong, C. C., and Zhou, Z. (2015) A non-canonical role of the p97 complex in RIG-I antiviral signaling. The EMBO journal 34, 2903-2920
22. Han, H., Pan, C., Liu, C., Lv, X., Yang, X., Xiong, Y., Lu, Y., Wu, W., Han, J., Zhou, Z., Jiang, H., Zhang, L., and Zhao, Y. (2015) Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. Cell discovery 1, 15006
23. Zhang, W., Gao, Y., Li, P., Shi, Z., Guo, T., Li, F., Han, X., Feng, Y., Zheng, C., Wang, Z., Li, F., Chen, H., Zhou, Z., Zhang, L., and Ji, H. (2014) VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell research 24, 331-343
24. Xiao, Y., Nagai, Y., Deng, G., Ohtani, T., Zhu, Z., Zhou, Z., Zhang, H., Ji, M. Q., Lough, J. W., Samanta, A., Hancock, W. W., and Greene, M. I. (2014) Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell reports 7, 1471-1480
25. Mao, F., Yang, X., Fu, L., Lv, X., Zhang, Z., Wu, W., Yang, S., Zhou, Z., Zhang, L., and Zhao, Y. (2014) The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. The Journal of biological chemistry 289, 22333-22341
26. Liu, G., Shi, Z., Jiao, S., Zhang, Z., Wang, W., Chen, C., Hao, Q., Zhang, M., Feng, M., Xu, L., Zhang, Z., Zhou, Z., and Zhang, M. (2014) Structure of MST2 SARAH domain provides insights into its interaction with RAPL. Journal of structural biology 185, 366-374
27. Li, C., Feng, M., Shi, Z., Hao, Q., Song, X., Wang, W., Zhao, Y., Jiao, S., and Zhou, Z. (2014) Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1. The Journal of biological chemistry 289, 35969-35978
28. Jiao, S., Wang, H., Shi, Z., Dong, A., Zhang, W., Song, X., He, F., Wang, Y., Zhang, Z., Wang, W., Wang, X., Guo, T., Li, P., Zhao, Y., Ji, H., Zhang, L., and Zhou, Z. (2014) A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer cell 25, 166-180
29. Hao, Q., Feng, M., Shi, Z., Li, C., Chen, M., Wang, W., Zhang, M., Jiao, S., and Zhou, Z. (2014) Structural insights into regulatory mechanisms of MO25-mediated kinase activation. Journal of structural biology 186, 224-233
30. Chen, C., Shi, Z., Zhang, W., Chen, M., He, F., Zhang, Z., Wang, Y., Feng, M., Wang, W., Zhao, Y., Brown, J. H., Jiao, S., and Zhou, Z. (2014) Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. The Journal of biological chemistry 289, 9651-9661
31. Zhang, Z., Feng, J., Pan, C., Lv, X., Wu, W., Zhou, Z., Liu, F., Zhang, L., and Zhao, Y. (2013) Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. The Journal of cell biology 203, 575-583
32. Zhang, M., Dong, L., Shi, Z., Jiao, S., Zhang, Z., Zhang, W., Liu, G., Chen, C., Feng, M., Hao, Q., Wang, W., Yin, M., Zhao, Y., Zhang, L., and Zhou, Z. (2013) Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure (London, England : 1993) 21, 680-688
33. Yang, X., Mao, F., Lv, X., Zhang, Z., Fu, L., Lu, Y., Wu, W., Zhou, Z., Zhang, L., and Zhao, Y. (2013) Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Journal of cell science 126, 4230-4238
34. Shi, Z., Jiao, S., Zhang, Z., Ma, M., Zhang, Z., Chen, C., Wang, K., Wang, H., Wang, W., Zhang, L., Zhao, Y., and Zhou, Z. (2013) Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure (London, England : 1993) 21, 449-461
35. Shi, D., Lv, X., Zhang, Z., Yang, X., Zhou, Z., Zhang, L., and Zhao, Y. (2013) Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction. The Journal of biological chemistry 288, 12605-12614
36. Li, B., Wang, C., Zhou, Z., Zhao, J., and Pei, G. (2013) beta-Arrestin-1 directly interacts with Galphas and regulates its function. FEBS letters 587, 410-416
37. Huang, H. L., Wang, S., Yin, M. X., Dong, L., Wang, C., Wu, W., Lu, Y., Feng, M., Dai, C., Guo, X., Li, L., Zhao, B., Zhou, Z., Ji, H., Jiang, J., Zhao, Y., Liu, X. Y., and Zhang, L. (2013) Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 11, e1001620
38. Guo, T., Lu, Y., Li, P., Yin, M. X., Lv, D., Zhang, W., Wang, H., Zhou, Z., Ji, H., Zhao, Y., and Zhang, L. (2013) A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell research 23, 1201-1214
39. Feng, M., Ding, Z., Xu, L., Kong, L., Wang, W., Jiao, S., Shi, Z., Greene, M. I., Cong, Y., and Zhou, Z. (2013) Structural and biochemical studies of RIG-I antiviral signaling. Protein & cell 4, 142-154
40. Zhou, Z., Du, X., Cai, Z., Song, X., Zhang, H., Mizuno, T., Suzuki, E., Yee, M. R., Berezov, A., Murali, R., Wu, S. L., Karger, B. L., Greene, M. I., and Wang, Q. (2012) Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. The Journal of biological chemistry 287, 5317-5326
41. Yin, H., Shi, Z., Jiao, S., Chen, C., Wang, W., Greene, M. I., and Zhou, Z. (2012) Germinal center kinases in immune regulation. Cellular & molecular immunology 9, 439-445
42. Wang, W., Shi, Z., Jiao, S., Chen, C., Wang, H., Liu, G., Wang, Q., Zhao, Y., Greene, M. I., and Zhou, Z. (2012) Structural insights into SUN-KASH complexes across the nuclear envelope. Cell research 22, 1440-1452
43. Song, X., Li, B., Xiao, Y., Chen, C., Wang, Q., Liu, Y., Berezov, A., Xu, C., Gao, Y., Li, Z., Wu, S. L., Cai, Z., Zhang, H., Karger, B. L., Hancock, W. W., Wells, A. D., Zhou, Z., and Greene, M. I. (2012) Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell reports 1, 665-675
44. Runkle, E. A., Zhang, H., Cai, Z., Zhu, Z., Karger, B. L., Wu, S. L., O'Rourke, D. M., Zhou, Z., Wang, Q., and Greene, M. I. (2012) Reversion of the ErbB malignant phenotype and the DNA damage response. Experimental and molecular pathology 93, 324-333
45. Jin, Y., Dong, L., Lu, Y., Wu, W., Hao, Q., Zhou, Z., Jiang, J., Zhao, Y., and Zhang, L. (2012) Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. The Journal of biological chemistry 287, 5784-5796
46. Deng, G., Xiao, Y., Zhou, Z., Nagai, Y., Zhang, H., Li, B., and Greene, M. I. (2012) Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells. Experimental and molecular pathology 93, 334-338
47. Song, X., Zhang, M., Zhou, Z., and Gong, W. (2011) Ultra-high resolution crystal structure of a dimeric defensin SPE10. FEBS letters 585, 300-306
48. Xiao, Y., Li, B., Zhou, Z., Hancock, W. W., Zhang, H., and Greene, M. I. (2010) Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Current opinion in immunology 22, 583-591
49. Zhou, Z., Song, X., Berezov, A., Li, B., and Greene, M. I. (2009) Structural aspects of the FOXP3 regulatory complex as an immunopharmacological target. International immunopharmacology 9, 518-520
50. Zhou, Z., Tone, Y., Song, X., Furuuchi, K., Lear, J. D., Waldmann, H., Tone, M., Greene, M. I., and Murali, R. (2008) Structural basis for ligand-mediated mouse GITR activation. Proceedings of the National Academy of Sciences of the United States of America 105, 641-645
51. Zhou, Z., Song, X., Li, B., and Greene, M. I. (2008) FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity. Immunologic research 42, 19-28
52. Zhou, Z., Song, X., Berezov, A., Zhang, G., Li, Y., Zhang, H., Murali, R., Li, B., and Greene, M. I. (2008) Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states. Proceedings of the National Academy of Sciences of the United States of America 105, 5465-5470
53. Cai, Z., Zhang, G., Zhou, Z., Bembas, K., Drebin, J. A., Greene, M. I., and Zhang, H. (2008) Differential binding patterns of monoclonal antibody 2C4 to the ErbB3-p185her2/neu and the EGFR-p185her2/neu complexes. Oncogene 27, 3870-3874
54. Zhou, Z., Song, X., and Gong, W. (2005) Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift. The Journal of biological chemistry 280, 42391-42396
55. Li, S., Zhou, Z., Chu, W., Gong, W., Benfatto, M., Hu, T., Xie, Y., Xian, D., and Wu, Z. (2005) Investigation of zinc-containing peptide deformylase from Leptospira interrogans by X-ray absorption near-edge spectroscopy. Journal of synchrotron radiation 12, 111-114
56. Brown, J. H., Zhou, Z., Reshetnikova, L., Robinson, H., Yammani, R. D., Tobacman, L. S., and Cohen, C. (2005) Structure of the mid-region of tropomyosin: bending and binding sites for actin. Proceedings of the National Academy of Sciences of the United States of America 102, 18878-18883
57. Zhou, Z., Song, X., Li, Y., and Gong, W. (2004) Unique structural characteristics of peptide deformylase from pathogenic bacterium Leptospira interrogans. Journal of molecular biology 339, 207-215
58. Zhou, Z., and Gong, W. (2004) Co-crystallization of Leptospira interrogans peptide deformylase with a potent inhibitor and molecular-replacement schemes with eight subunits in an asymmetric unit. Acta crystallographica. Section D, Biological crystallography 60, 137-139
59. Wei, Z., Zhang, P., Zhou, Z., Cheng, Z., Wan, M., and Gong, W. (2004) Crystal structure of human eIF3k, the first structure of eIF3 subunits. The Journal of biological chemistry 279, 34983-34990
60. Song, X., Zhou, Z., Wang, J., Wu, F., and Gong, W. (2004) Purification, characterization and preliminary crystallographic studies of a novel plant defensin from Pachyrrhizus erosus seeds. Acta crystallographica. Section D, Biological crystallography 60, 1121-1124
61. Liu, L., Wang, Y., Zhang, P., Cheng, Z., Wan, M., Zhou, Z., and Gong, W. (2004) Expression, purification and preliminary crystallographic studies of human coactosin-like protein. Acta crystallographica. Section D, Biological crystallography 60, 1651-1653
62. Chang, S., Song, X., Yan, M., Zhou, Z., Wu, F., and Gong, W. (2004) Purification, characterization and preliminary crystallographic studies of a cysteine protease from Pachyrrhizus erosus seeds. Acta crystallographica. Section D, Biological crystallography 60, 187-189
63. Wu, F., Yan, M., Li, Y., Chang, S., Song, X., Zhou, Z., and Gong, W. (2003) cDNA cloning, expression, and mutagenesis of a PR-10 protein SPE-16 from the seeds of Pachyrrhizus erosus. Biochemical and biophysical research communications 312, 761-766
64. Zhou, Z., Liu, H., Li, Y., and Gong, W. (2002) Purification, crystallization and preliminary crystallographic studies of a class II chitinase from kidney bean seeds. Protein and peptide letters 9, 265-268
65. Wu, F., Li, Y., Chang, S., Zhou, Z., Wang, F., Song, X., Lin, Y., and Gong, W. (2002) Purification, characterization and preliminary crystallographic studies of a PR-10 protein from Pachyrrhizus erosus seeds. Acta crystallographica. Section D, Biological crystallography 58, 2165-2167
