1. Zhang XD, Jiang, LlL, Huang K, Fang CT, Li J, Yang JT, Li HT, Ruan XX, Wang PH, Mo MG, Wu P, Xu YH, Peng C, Uesugi M, Ye DY*, Yu FX*, Zhou L*. Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule.  ACS Chem. Biol. 2020, 15(3): 632-639.

2. Wen CL, Huang K, Jiang LL, Lu XX, Dai YT, Shi MM, Tang XM, Wang QB, Zhang XD, Wang PH, Li HT, Ruan XX, Wang LW, Wang XJ, Wang Q, Lu W, Xiang XQ, Sun X, Xu YH, Lai LH, Zhan Q, Li HW, Peng CH, Chen J, Huang JY, Ye DY, Chen SJ, Chen Z*, Li M*, Fang Y*, Shen BY*, Zhou L*. An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A. 2019 ;116(46):23264-23273.

3. Huang K, Liang Q, Zhou Y, Jiang LL, Gu WM, Luo MY, Tang YB, Wang Y, Lu W, Huang M, Zhang SZ, Zhuang GL, Dai Q, Shen QC, Zhang J, Lei HM, Zhu L, Ye DY, Chen HZ*, Zhou L*, Shen Y*. A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. Cell Metab. 2019. 30(6):1107-1119.

4. Huang K, Jiang L, Li H, Ye D*, Zhou L*. Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors. Molecules. 2019; 24(5). pii: E845.

5. Huang K, Jiang L, Liang R, Li H, Ruan X, Shan C, Ye D*, Zhou L*. Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment. Eur. J. Med. Chem. 2019;168:45-57.

6. Li Y, Huang T, Lou B, Ye D, Qi X, Li X, Hu S, Ding T, Chen Y, Cao Y, Mo M, Dong J, Wei M, Chu Y, Li H, Jiang XC*, Cheng N*, Zhou L*. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur. J. Med. Chem. 2019; 163:864-882.

7. Yang X, Shen J, Jiang L, Li W, Yu M, Pan G, Yan Y, Zhang C, Jia W, Xiao L, Yu H, Chen H, Zheng Y, Yu L, Xie Q*, Zhou L*, Shao L*. Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities. Eur J Med Chem. 2018;160:37-48.

8. Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L*, Ye D*. Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J. Med. Chem. 2018; 61(18):8241-8254.

9. Wang P, Jiang L, Cao Y, Ye D*, Zhou L*. The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors. Molecules. 2018; 23(6). pii: E1396.

10. Wang P, Jiang L, Cao Y, Zhang X, Chen B, Zhang S, Huang K, Ye D*, Zhou L*. Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation. Bioorg. Med. Chem. 2018; 26(8):1961-1970.

11. Liu SE, Hu JC, Zhang H, Xu P, Wan W, Zheng MY, Yu KQ, Ding H, Jiang HL, Zhou L*, Luo C*. Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1. Acta Pharmacol Sin. 2017 Jul 27.

12. Song J, Peng P, Chang J, Liu MM, Yu JM, Zhou L*, Sun X*. Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis. Bioorg Med Chem Lett. 2016; 26(9):2174-8.

13. Zhou L#, Bosscher M#, Zhang C#, Oz?ubuk?u S, Zhang L, Zhang W, Li CJ, Liu J, Jensen MP, Lai L, He C. A protein engineered to bind uranyl selectively and with femtomolar affinity. Nat Chem. 2014;6(3):236-41.

14. Hitosugi T#, Zhou L#, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu TL, Ale?kovi? M, LeRoy G, Kang Y, Kang HB, Seo JH, Shan C, Jin P, Gong W, Lonial S, Arellano ML, Khoury HJ, Chen GZ, Shin DM, Khuri FR, Boggon TJ, Kang S, He C, Chen J. Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun. 2013;4:1790. (#contribute equally)

15. Hitosugi T#, Zhou L#, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Ale?kovi? M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, Chen J. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012;22(5):585-600. (#contribute equally)