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成果及论文

Papers Published in 2024

1. Wen Peng, Lixiao Qin, Tianci Wang, Yangqian Sun, Zhen Li, David J. Lefer, Cheng Luo, Fei Ye, Binghe Wang*, Weiwei Guo* ,Yueqin Zheng*,  A Highly Atom-Efficient Prodrug Approach to Generate Synergy between H2S and Nonsteroidal Anti-inflammatory Drugs and Improve Safety. J. Med. Chem. 2024, 67, 19, 17350–17362. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01254.

2. Xidan Tong, Jiaxuan Chen, Maolin Wang, Jianru Liu, Jing Li, Xin Wang, Yifei Zuo, Xiaowei Xu, Yichen Wang, Binghe Wang*, Weiwei Guo*, Yueqin Zheng* Development of a Bioorthogonal Click-to-Release Reaction for Hydrogen Polysulfide (H2Sn) Detection. Anal. Chem. 2024, 96, 39, 15631–15639.  https://pubs.acs.org/doi/10.1021/acs.analchem.4c02677.

3. Wen Peng, Jianru Liu, Zhen Li, Yuanan Wang, Yangqian Sun, Yanzhao Chen, David J. Lefer*, Weiwei Guo*, Yueqin Zheng*A Bifunctional Sulfide Donor Approach for Ischemic Stroke: Leveraging Butylphthalide as a Carrier for Sulfide Prodrug, J. Med. Chem. 2024. https://doi.org/10.1021/acs.jmedchem.4c02454



Papers Published before 2024

1.        Zheng Y.;# Ji, X.;# Yu, B.; Ji, K.; Gallo, D.; Csizmadia, E.; Zhu, M.; Roy Choudhury, M.; De La Cruz, L.; Chittavong, V.; Pan, Z.; Yuan, Z.; Otterbein, L. E.; Wang, B.*, Enrichment-triggered Prodrug Activation Demonstrated through Mitochondria-targeted Delivery of Doxorubicin and Carbon Monoxide. Nature Chemistry, 2018, 10, 787-794.

2.        Zheng, Y.; # Yu, B.; # Li, Z.; # Yuan, Z.; Lefer, D.J.; Wang, S.; Organ, C.L, Trivedi, R.K.; Wang, B.*, A Novel Esterase-sensitive Prodrug Approach for Controllable Delivery of Persulfide Species. Angewandte Chemie International Edition, 2017, 56, 11749-11753.

3.        Zheng, Y.; Yu, B.; Ji, K.; Pan, Z.; Chittavong, V.; Wang, B.*, Esterase-sensitive prodrugs with tunable release rates and direct generation of hydrogen sulfide. Angewandte Chemie International Edition, 2016, 55, 4514-4518. (Cover page)

4.        Yu, B.; # Zheng, Y.; *,# Yuan, Z.; Li, S.; Zhu, H.; De La Cruz, L.; Zhang, J.; Ji, K.; Wang, S. Wang, B.*. Toward Direct Protein S-Persulfidation: A Prodrug Approach that Directly Delivers Hydrogen Persulfide. Journal of the American Chemical Society, 2017, 140, 30-33. 

5.        Yuan, Z.;# Zheng, Y.;# Yu, B.; Wang, S.; Yang, X.; Wang, B.*. Esterase-Sensitive Glutathione Persulfide Donor. Organic Letters, 2018, 20 ,63646367.

6.        Zheng, Y.; Yu, B.; De La Cruz, L.; Roy Choudhury, M.; Anifowose, A.; Wang, B.*, Toward Hydrogen Sulfide–Based Therapeutics: Critical Drug Delivery and Developability Issues. Medicinal Research Reviews, 2018, 38, 57-100.

7.        Zheng, Y.; # Duan, Y.; # Ji, K.; Wang, R.; Wang, B.*, Tuning the reaction rates of fluoride probes for detection in aqueous solution. RSC Advances, 2016, 6, 25242 -25245.

8.        Zheng, Y.; Ji, X.; Ji, K.; Wang, B.*, Hydrogen sulfide prodrugs-a review. Acta Pharmaceutica Sinica. B, 2015, 5, 367.

9.        Fang, Y.; # Zheng, Y.; # Wang, Z.*, Direct Base-Assisted C–N Bond Formation between Aryl Halides and Aliphatic Tertiary Amines under Transition-Metal-Free Conditions. European Journal of Organic Chemistry, 2012, 1495. (#These authors contributed equally. *Corresponding author)

10.    Zhang, W.; Harty, B.; Zheng, Y.; Zhang, Z.; Li, X.; Wang, D.; Kohane, D. S. *, Permeation of polyethylene glycols across the tympanic membrane. Giant, 2021, 6, 100057.

11.    Zhang, W.; Ji, T.; Li, Y.;  Zheng, Y.; Mehta, M.;  Zhao, C.; Liu, A.; Kohane, D. S. * Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nature communications, 2020, 11 (1), 1-8.

12.    Zhang, W.; Ji, T.; Lyon, S.; Mehta, M.; Zheng, Y.; Deng, X.; Liu, A.; Shagan, A.; Mizrahi, B.; Kohane, D. S. * Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives. ACS Applied Materials & Interfaces, 2020, 12, 17314-17320.

13.    Zhu, L., Huo A., Chen Y., Bai X., Cao C. *, Zheng Y. *, Guo W.*; A ROS reservoir based on a polyoxometalate and metal-organic framework hybrid for efficient bacteria eradication and wound healing. Chemical Engineering Journal, 2023, 476, 146613.

14.    Zhu, L., Huo A., Sun Y., Chen Y., Cao C. *, Zheng Y. *, Guo W.*; Enhanced Antibacterial And Wound Healing Using A MetalOrganic Cluster Inspired by Artificial Photosynthesis. Advanced Healthcare Materials, 2023, 2302087