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成果及论文

代表性研究成果：  

  1. Wang S#, Han H#, Qian Y, Ruan X, Lin Z, Li J, Chen B, Lai Y, Wang Z, Li M, Wen J, Yin X, Yang N, Lin S, Zhang H*. Aberrant METTL1-mediated tRNA m7G modification alters B-cell responses in systemic autoimmunity in humans and mice. Nature Communications. 2024,15(1):10599.
  2. Ye B#, Chen B#, Guo C#, Xiong N, Huang Y, Li M, Lai Y, Li J, Zhou M, Wang S, Wang S, Yang N*, Zhang H*. C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis. Molecular Therapy. 2024: S1525-0016(24)00144-8.
  3. Wang S, Yang N, Zhang H*. Metabolic dysregulation of lymphocytes in autoimmune diseases. Trends in Endocrinology & Metabolism. 2024, S1043-2760(24)00019-5.
  4. Zeng Q#, Wang S#, Li M#, Wang S#, Guo C, Ruan X, Watanabe R, Lai Y, Huang Y, Yin X, Zhang C, Chen B, Yang N*, Zhang H*. Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses. Cell Metabolism 2023, 35(5):837-854.e8.
  5. Li M#, Lai Y#, Chen B#, Guo C#, Zhou M, Zhao S, Wang S, Li J, Yang N, Zhang H*. NAMPT is a metabolic checkpoint of IFNγ-producing CD4(+) T cells in lupus nephritis. Molecular Therapy 2023, 31(1): 193-210.
  6. Zhou M#, Guo C#, Li X, Huang Y, Li M, Zhang T, Zhao S, Wang S, Zhang H*, Yang N*. JAK/STAT signaling controls the fate of CD8(+)CD103(+) tissue-resident memory T cell in lupus nephritis. Journal of Autoimmunity 2020, 109: 102424. （共同通讯）
  7. Liu Y#, Zeng Q#, Deng C#, Li M#, Li L#, Liu D#, Liu M, Ruan X, Mei J, Mo R, Zhou Q, Liu M, Peng S, Wang J*, Zhang H*, Xiao H*. Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine. Cell Discovery 2022, 8(1): 10. （共同通讯）
  8. Lai Y#, Zhao S#, Chen B#, Huang Y, Guo C, Li M, Ye B, Wang S, Zhang H*, Yang N*. Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy. Clinical and Translational Medicine 2022, 12(8): e999. （共同通讯）
  9. Chen B#, Ye B#, Li M#, Wang S, Li J, Lai Y, Yang N, Ke Z, Zhang H*. TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A-Producing CD4(+) Tissue-Resident Memory T Cells. Frontiers in Immunology 2022, 13: 931761.
  10. Wang S#, Li J#, Wang S#, Ye Y, Li M, Liu Y, Chen B, Lai Y, Li L, Zhuang L, Peng S, Yang N*, Zhang H*, Xiao H*. Impacts of delta and omicron variants on inactivated SARS-CoV-2 vaccine-induced T cell responses in patients with autoimmune diseases and healthy controls. Clinical and Translational Medicine 2023, 13(1): e1171. （共同通讯）
  11. Zhang H#, Liu Y#, Liu D#, Zeng Q#, Li L#, Zhou Q#, Li M#, Mei J, Yang N, Mo S, Liu Q, Liu M, Peng S#, Xiao H*. Time of day influences immune response to an inactivated vaccine against SARS-CoV-2. Cell Research 2021, 31(11): 1215-1217.
  12. Zhang H#, Watanabe R#, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, Goronzy JJ, Weyand CM*. Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Proc Natl Acad Sci U S A 2017, 114(6): E970-E979.
  13.  Zhang H, Watanabe R, Berry GJ, Tian L, Goronzy JJ, Weyand CM*. Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis. Circulation 2018, 137(18): 1934-1948.
  14.  Zhang H, Watanabe R, Berry GJ, Nadler SG, Goronzy JJ, Weyand CM*. CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis. Journal of the American College of Cardiology 2019, 73(14): 1811-1823.
  15. Zhang H#, Huang Y#, Wang S, Fu R, Guo C, Wang H, Zhao J, Gaskin F, Chen J, Yang N*, Fu SM. Myeloid-derived suppressor cells contribute to bone erosion in collagen-induced arthritis by differentiating to osteoclasts. Journal of Autoimmunity 2015, 65: 82-89.
  16. Zhang H#, Fu R#, Guo C, Huang Y, Wang H, Wang S, Zhao J, Yang N. Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages. Journal of Translational Medicine 2016, 14(1): 156.
  17. Zhang H#, Zhao C#, Wang S, Huang Y, Wang H, Zhao J, Yang N*. Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells. Journal of Translational Medicine 2015, 13: 178.
  18. Zhang H#, Wang S#, Huang Y, Wang H, Zhao J, Gaskin F, Yang N*, Fu SM. Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation. Clinical Immunology 2015, 157(2): 175-186.
  19. Li X#, Zeng Q#, Wang S#, Li M, Chen X, Huang Y, Chen B, Zhou M, Lai Y, Guo C, Zhao S, Zhang H*, Yang N*. CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis. Frontiers in Immunology 2021, 12: 779560. (共同通讯)