主持的科研项目：
1. 国家自然科学基金项目，项目名称：N-芳基酰胺类惰性C(aryl)-N键直接活化/官能化反应研究，项目编号：21772032，执行期：2018.01-2021.12。
2. 国家自然科学基金项目，项目名称：单芳基双C-H官能化策略在苯[d]杂环衍生物合成中的应用，项目编号：21272057，执行期：2013.01-2016.12。
3. 国家自然科学基金项目，项目名称：炔丙基全碳1,3-偶极子在构建呋喃并杂环衍生物中的应用，项目编号：21002051，执行期：2011.01-2013.12。
4. 国家博士后基金面上项目，项目名称：单芳基双C-H官能化新策略制备几种苯并杂环衍生物，项目编号：2012M521397，执行期：2012.11-2014.12。
5. 国家博士后特别资助项目，项目名称：呋喃并杂环合成新策略研究，项目编号：2013T60701，执行期：2013.06-2014.12。
6. 河南省教育厅科技创新人才支持计划，项目名称：几种吡咯并杂环衍生物新合成策略研究，项目编号：17HASTIT002，执行期：2017.01-2019.12。
7. 河南省高等学校青年骨干教师资助计划，项目名称：C(sp2)-H键活化/C(sp2)-N键形成反应在合成角型的杂环并喹啉酮类化合物中的应用，项目编号：2014GGJS-049，执行期：2015.01-2018.01。
8. 河南省基础与前沿技术研究项目，项目名称：天然产物杂环母核合成新方法，项目编号：112300410312，执行期：2011.01-2013.12。
9. 河南省自然科学基金，项目名称：吡咯/呋喃/吡喃并喹啉类化合物的设计、合成与抗菌活性研究，项目编号：162300410180，执行期：2017.01-2019.12。
代表性论文（第一作者或者通讯作者）：
1. Zhang, Z.; Zhang, Q.;* Sun, S.; Xiong, T.; Liu, Q.* Domino Ring-Opening/Recyclization Reactions of Doubly Activated Cyclopropanes as a Strategy for the Synthesis of Furoquinoline Derivatives. Angew. Chem. Int. Ed., 2007, 46, 1726-1729. https://doi.org/10.1002/anie.200604276
2. Zhang, Z.; Zhang, Q.;* Yan, Z.; Liu, Q.* One-Step Synthesis of the Tricyclic Core of Martinellic Acid from 2-(Cyanomethyl)-3-oxo-N-arylbutanamides. J. Org. Chem., 2007, 72, 9808-9810. https://doi.org/10.1021/jo701551f
3. Zhang, Q.;* Zhang, Z.; Yan, Z.; Liu, Q.,* Wang, T. A New Efficient Synthesis of Pyranoquinolines from 1-Acetyl N-Aryl Cyclopentanecarboxamides. Org. Lett., 2007, 9, 3651-3653. https://doi.org/10.1021/ol701536q
4. Xiong, T.; Zhang, Q.;* Zhang, Z.; Liu, Q.* A Divergent Synthesis of γ-Iminolactones, Dihydroquinolin-2-ones and γ-Lactames from β-Hydroxymethylcyclopropanylamides. J. Org. Chem., 2007, 72, 8005-8009. https://doi.org/10.1021/jo701495s
5. Zhang, Z.; Zhang, Q.;* Ni, Z.; Liu, Q.* Ag-containing all-carbon 1,3-dipoles: generation and formal cycloaddition for furo[3,2-b]-β/γ-lactams. Chem. Commun., 2010, 46, 1269-1271 (Highlight by SYNFACTS, Synfacts, 2010, 5, 0524). https://doi.org/10.1039/b917856b
6. Zhang, Z.;* Xue, C., Liu, X.; Zhang, Q.;* Liu, Q.* Synthesis of polysubstituted 3H-pyrimidin-4-ones from cyanoacetamides under Vilsmeier conditions. Tetrahedron, 2011, 67, 7081-7084. https://doi.org/10.1016/j.tet.2011.07.006
7. Zhang, Z.;* Fang, S.; Liu, Q.; Zhang, G.,* Microwave-assisted facile synthesis of furo[3,2-b]indole derivatives via silver(I)-mediated [3+2] cycloaddition. Adv. Synth. Catal., 2012, 354 (5), 927-932. https://doi.org/10.1002/adsc.201100767
8. Zhang, Z.;* Fang, S.; Liu, Q.; Zhang, G.* Approach to polysubstituted 4-pyridones from N-aryl acetoacetamides via a N to C 1,3-acyl migration mediated by sodium persulfate. J. Org. Chem., 2012, 77 (17), 7665-7670. https://doi.org/10.1021/jo3010217
9. Bi, J.; Zhang, Z.;* Liu, Q.; Zhang, G.* Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400. Green Chem., 2012, 14 (4), 1159-1162. https://doi.org/10.1039/C2GC16661E
10. Zhang, Z.;* Bi, J.; Liu, Q.; Zhang, G.* The Synthesis of α,α-Difluoroacetamides via Electrophilic Fluorination in the Mixed-solvent of Water and PEG-400. J. Fluorine Chem., 2013, 151, 45-49. https://doi.org/10.1016/j.jfluchem.2013.03.016
11.Zhang, Z.;* Wang, D.; Wang, B.; Liu, Q.; Liu, T.; Zhang, W.; Yuan, B.; Zhao, Z.; Han, D.; Zhang, G.* SnCl4 Mediated synthesis of γ-amino ketones derivatives via the ring-opening reaction of 4,5-dihydropyrroles. Tetrahedron, 2013, 69, 9063. https://doi.org/10.1016/j.tet.2013.08.027
12. Li, Z.; Zhang, Z.;* Zhang, W.; Liu, Q.; Liu, T.; Zhang, G.* Copper-Mediated Sequential C-N and N-N Bond Formation: Facile Synthesis of Symmetrical 1,2,4-Triazoles. Synlett, 2013, 24, 2735-2739. https://doi.org/10.1055/s-0033-1338985
13. Zhang, Z.;* Qian, J.; Tain, Q.; Liu, T.; Liu, Q.; Zhang, G.* Oxidative Nuclear Bromination of Substituted 4-Pyridones Using Pyridinium Bromochromate. Synth. Commun., 2014, 44, 674-81. https://doi.org/10.1080/00397911.2013.834363
14. Zhang, Z.;* Zhang, W.; Li, J.; Liu, Q.; Liu, T.; Zhang, G.* Synthesis of Multisubstituted Pyrroles from Doubly Activated Cyclopropanes Using an Iron-Mediated Oxidation Domino Reaction. J. Org. Chem., 2014, 79, 11226–11233. https://doi.org/10.1021/jo5018487
15. Zhang, Z.;* Tian, Q.; Qian, J.; Liu, Q.; Liu, T.; Shi, L.; Zhang, G.,* Dimethyl Sulfoxide Participant Iron-Mediated Cascade Oxidation/alpha-Formylation Reaction of Substituted 2,3-Dihydropyrroles under Air and Protonic Acid Free Condition. J. Org. Chem.,2014,79, 8182-8188. https://doi.org/10.1021/jo501385w
16. Zhang, L.; Zhang, Z.;* Liu, Q.; Liu, T.; Zhang, G.* Iron-Catalyzed Vinylogous Aldol Condensation of Biginelli Products and Its Application toward Pyrido[4,3-d]pyrimidinones. J. Org. Chem., 2014, 79, 2281-2288. https://doi.org/10.1021/jo402773r
17. Qian, J.; Zhang, Z.;* Liu, Q.; Liu, T.; Zhang, G.* Dimethyl Sulfoxide Participating in Copper(I) Iodide-Catalyzed Cascade Oxidation/Formylation Reactions: The Synthesis of alpha-Formylpyrroles from 2,3-Dihydro-1H-pyrroles. Adv. Synth. Catal., 2014, 356, 3119-3124. https://doi.org/10.1002/adsc.201400332
18. Zhang, Z.;* Zhang, L.; Duan, X.; Yan, X.; Yan, Y.; Liu, Q.; Liu, T.; Zhang, G.* Iron-catalyzed four-member multicomponent reaction for assembly of (E)-6-arylvinyl-3,4-dihydropyrimidin-2(1H)-ones. Tetrahedron, 2015, 71, 7745-7751. https://doi.org/10.1016/j.tet.2015.07.039
19. Zhang, Z.;* Zhang, F.; Wang, H.; Wu, H.; Duan, X.; Liu, Q.; Liu, T.; Zhang, G.* Catalyst-Free Domino Reaction of 1-Acryloyl-1-N-arylcarbamylcyclopropanes with Amines: One-Pot Approach to 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. Adv. Synth. Catal., 2015, 357, 2681-2686. https://doi.org/10.1002/adsc.201500251
20. Zhang, Z.;* Li, J.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T. Iron-Catalyzed Intramolecular C(sp(2))-N Cyclization of 1-(N-Arylpyrrol-2-yl)ethanone O-Acetyl Oximes toward Pyrrolo[1,2-a]quinoxaline Derivatives. J. Org. Chem., 2015, 80, 6875-6884. https://doi.org/10.1021/acs.joc.5b00915
21. Zhang, Z.;* Yan, X.; Zhang, G.;* Liu, Q.; Ma, N.; Liu, T.; Shi, L. Copper(I)-catalyzed domino allylic C(sp3)–H aminative cyclization/oxidative reaction and its application toward pyrrolo[3,4-d]pyrimidinones. Tetrahedron, 2016, 72, 3077-3083. https://doi.org/10.1016/j.tet.2016.04.031
22. Zhang, Z.;* Qian, J.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T.; Sun, K.; Shi, L. Copper(I) catalyzed C(sp2)–N bond formation: synthesis of pyrrolo[3,2-c]quinolinone derivatives. Org. Chem. Front., 2016, 3, 344-348. https://doi.org/10.1039/C5QO00417A
23. Zhang, Z.;* Li, J.; Huang, G.; Sun, K.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T. Copper(I)-Catalyzed Intramolecular N-N Coupling of Cyclopropyl O-Acyl Ketoximes: Synthesis of Spiro-fused Pyrazolin-5-ones. Chin. J. Chem., 2016, 34, 1309-1320. https://doi.org/10.1002/cjoc.201600479
24. Yan, X.; Zhang, Z.;* Zhang, G.;* Ma, N.; Liu, Q.; Liu, T.; Shi, L. Copper(I)-catalysed amidation and successive oxidation of benzylic C(sp3)–H bond: synthesis of 1H-pyrrolo[3,4-b]quinoline-1,3(2H)-diones. Tetrahedron, 2016, 72, 4245-4251. https://doi.org/10.1016/j.tet.2016.05.059
25. Zhang, Z.;* Zheng, D.; Ma, N.; Bi, J. Brønsted Acid-Promoted the Synthesis of Furo[2,3-b]quinolones. Chin. J. Org. Chem., 2017, 37, 1824-1829. https://doi.org/10.6023/cjoc201612032
26. Zhang, Z.;* Zhang, Y.; Huang, G.; Zhang, G.* Organoiodine reagent-promoted intermolecular oxidative amination: synthesis of cyclopropyl spirooxindoles. Org. Chem. Front., 2017, 4, 1372-1375. https://doi.org/10.1039/C7QO00156H
27. Zhang, Z.;* Huang, Y.; Huang, G.; Zhang, G.;* Liu, Q. [Bis-(trifluoroacetoxy)iodo]benzene-Mediated Oxidative Direct Amination C-N Bond Formation: Synthesis of 1H-Indazoles. J. Heterocyclic Chem., 2017, 54, 2426. https://doi.org/10.1002/jhet.2839/full
28. Zhang, Z.;* Gao, X.; Li, Z.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T. PIFA-Mediated oxidative cyclization of 1-aroyl-N-arylcyclopropane-1-carboxamides and their application in the synthesis of pyrrolo[3,2-c]quinolinones. Org. Chem. Front., 2017, 4, 404-408. https://doi.org/10.1039/C6QO00598E
29. Liu, Y.; Zhang, Z.;* Wan, Y.; Zhang, G.;* Li, Z.; Bi, J.; Ma, N.; Liu, T.; Liu, Q. Oxidation of beta-Ketoamides: The Synthesis of Vicinal Tricarbonyl Amides. J. Org. Chem., 2017, 82, 3901-3907 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit5/816.shtm). https://doi.org/10.1021/acs.joc.6b03062
30. Yan, Y.; Zhang, Z.;* Wan, Y.; Zhang, G.;* Ma, N.; Liu, Q. Hypervalent Iodine(III)-Promoted Phenyl Transfer Reaction from Phenyl Hydrazides to Nitriles. J. Org. Chem., 2017, 82, 7957-7963. https://doi.org/10.1021/acs.joc.7b01215
31. Zhang, Z.;* Gao, X.; Wan, Y.; Huang, Y.; Huang, G.; Zhang, G.* Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. ACS Omega, 2017, 2, 6844-6851. https://doi.org/10.1021/acsomega.7b00626
32. Zhang, Z.;* Gao, X.; Yu, H.; Bi, J.; Zhang, G.* Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its Applications. ACS Omega, 2017, 2, 7746-7754. https://doi.org/10.1021/acsomega.7b01526
33. Zhang, Z.;* Zheng, D.; Wan, Y.; Zhang, G.;* Bi, J.; Liu, Q.; Liu, T.; Shi, L. Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides. J. Org. Chem.2018, 83, 1369-1376 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit6/197.shtm). https://doi.org/10.1021/acs.joc.7b02880
34. Hu, C.; Zhang, Z.;* Gao, W.; Zhang, G.;* Liu, T.; Liu, Q. PIFA-promoted intramolecular oxidative C(aryl)-H amidation reaction: Synthesis of quinolino[3,4-b]quinoxalin-6(5H)-ones. Tetrahedron, 2018, 74, 665-671. https://doi.org/10.1016/j.tet.2017.12.016
35. Wu, H.; Zhang, Z.;* Ma, N.; Liu, Q.; Liu, T.; Zhang, G.* Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions. J. Org. Chem. 2018, 83, 12880-12886 (Highlight by SYNFACTS, Synfacts, 2015, 115, 287). https://doi.org/10.1021/acs.joc.8b01828
36. Zhang, Z.;* Gao, X.; Yu, H.; Zhang, G.;* Liu, J. Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides. Adv. Synth. Catal., 2018, 360, 3406-3411. https://doi.org/10.1002/adsc.201800616
37. Wu, H.; Zhang, Z.;* Liu, Q.; Liu, T.; Ma, N.; Zhang, G.* Syntheses of Acridones via Copper(II)-Mediated Relay Reactions from o-Aminoacetophenones and Arylboronic Acids. Org. Lett., 2018, 20, 2897-2901. https://doi.org/10.1021/acs.orglett.8b00957
38. Lu, N.; Zhang, Z.;* Ma, N.; Wu, C.; Zhang, G.;* Liu, Q.; Liu, T. Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-α-Iodomethyl Vinylsulfones. Org. Lett., 2018, 20, 4318 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit6/423.shtm). https://doi.org/10.1021/acs.orglett.8b01765
39. Wan, Y.; Zhang, Z.;* Ma, N.; Bi, J.; Zhang, G.* Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation. J. Org. Chem., 2018, 84, 780-791 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/Highlights/2019/14October.shtm). https://doi.org/10.1021/acs.joc.8b02636
40. Zhang, Z.;* Wang, S.; Hu, C.; Ma, N.; Zhang, G.;* Liu, Q. Copper(I)-catalyzed benzylic C(sp3)–H geminal difunctionalization: Successive oxidative intramolecular amidation and hydroxylation. Tetrahedron, 2018, 74, 7472-7479 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit6/766.shtm). https://doi.org/10.1016/j.tet.2018.11.023
41. Zhang, Z.;* Li, X.; Song, M.; Wan, Y.; Zheng, D.; Zhang, G.;* Chen, G.* Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation. J. Org. Chem., 2019, 84, 12792-12799 (Highlight by SYNFACTS, Synfacts, 2019, 15, 1209). https://doi.org/10.1021/acs.joc.9b01362
42. Zhang, Z.;* Wang, S.; Zhang, Y.; Zhang, G.* Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors. J. Org. Chem., 2019, 84, 3919-3926. https://doi.org/10.1021/acs.joc.8b03046
43. Zhang, Z.;* Li, X.; Li, Y.; Guo, Y.; Zhao, X.; Yan, Y.; Sun, K.; Zhang, G.* Iodine-mediated aryl transfer reaction from arylhydrazine hydrochlorides to nitriles. Tetrahedron, 2019, 75, 3628-3635. https://doi.org/10.1016/j.tet.2019.05.034
专利情况：
1. 张志国，刘青锋，张贵生，田庆，高选择性地脱除2,6-二甲基-4-吡啶酮衍生物的α-单甲基的简单、有效的方法，ZL201210469746.8，授权日期：2014.08.27。
2. 张志国，刘青锋，张贵生，田庆，2,6-二甲基-4-吡啶酮衍生物的2位和6位甲基的简单、有效的脱去方法，ZL201210517552.0，授权日期：2014.08.27。
3. 张贵生，刘青锋，张志国，具有抗癌活性的3'-叠氮基表阿霉素的合成，ZL201110023054.6，授权日期：2014.06.25。
4. 张志国，郑丹，麻娜娜，张贵生，刘青锋，一种合成呋喃[2,3-b]喹啉类化合物的方法，申请号：201510195570.5，申请日期：2015.04.10。
5. 张志国，黄媛媛，麻娜娜，张贵生，刘青锋，一种合成4氢-吡咯[3,2-c]吡啶-4-酮类化合物的方法，申请号：201510195454.3，申请日期：2015.04.10。
6. 张贵生，张志国，麻娜娜，刘青锋，李忠联，一种氧化1,3-二羰基化合物的亚甲基成酮的方法，申请号：201510214235.5申请日期：2015.04.10。
7. 张贵生，张志国，麻娜娜，刘青锋，张伟，一种将2,3-二氢吡咯氧化成吡咯的方法，申请号：201510195453.9，申请日期：2015.04.10。
8. 张志国，张贵生，闫严，刘青锋，一种二级酰胺类化合物的合成方法，申请号：201611135725.7，申请日期：2016.12.18。
9. 张志国，李祥，张贵生，麻娜娜, 一种去除氨基上喹啉保护基的新方法，申请号：201811514058.2，申请日期：2018.11.29。
10. 张志国，高文婧，张贵生，麻娜娜，一种合成吡啶[1’,2’:1,5]吡唑[3,4-b]喹喔啉类化合物的方法，申请号：201811629925.7，申请日期：2018.12.20。
11. 张志国，高文婧，张贵生，麻娜娜，一种合成6氢-吡啶[1,2-c]喹唑啉-6-酮类化合物的新方法，申请号：201811630556.3，申请日期：2018.12.20。
获奖：
1. 东北师范大学，研究生学术活动先进个人，2008年。
2. 东北师范大学，优秀研究生奖学金，2008年。
3. 东北师范大学，优秀研究生奖学金，2010年。
4. 东北师范大学，研究生优秀毕业生，2010年。
5. 河南师范大学，优秀教师，2011年。
6. 吉林省优秀博士学位论文，吉林省学位委员会，2012年5月。
7. 河南省优秀博士后研究人员，河南省第二届河南省人力资源和社会保障厅，2014。
8. 河南师范大学“优秀青年科研创新人才”，2014年12月。
9. 河南省高校青年骨干教师，河南省教育厅，2014年。
10. 河南师范大学青年五四奖章，2016年5月。
11. 河南省高校科技创新人才支持计划，河南省教育厅，20
