代表性论文:
1、Tao Liu, Wangqin Zhang, Chao Xu, Zhenhui Xu, Dingguo Song, Wei Qian, Gang Lu, Chang-Jun Zhang, Weihui Zhong, Fei Ling,* Synthesis of P-stereogenic cyclicphosphinic amide via electrochemical enabled cobalt-catalyzed enantioselective C–H annulation. Green. Chem., 2023, 25, 3606-3614.
2、Shiliang Wang, Dingguo Song, Feiyang Shen, Rong Chen, Yuqi Cheng, Chuhan Zhao, Qilei Shen, Shuxin Yin, Fei Ling* and Weihui Zhong,* Manganese Catalyzed Cross-Coupling of Allylic Alcohols and Nitriles: An Elegant Route for Access of δ-Hydroxynitriles, Green. Chem., 2023, 25, 357-364.
3、Hanbing Li,* Gaohang Fu and Weihui Zhong,* Natural quinazolinones: From a treasure house to promising anticancer leads, Eur. J. Med. Chem., 2023, 245, 114915.
4、Yan Mao, Wenxi Chen, Changchang Li, Lin Miao, Yanfei Lin, Fei Ling,* Zhangpei Chen* and Jinzhong Yao,* Synthesis of 3,4,5-trisubstituted phenols via Rh(iii)-catalyzed alkenyl C–H activation assisted by phosphonium cations, Chem. Commun., 2023, 59, 3775-3778.
5、Wenxi Chen, Yan Mao, Min Wang, Fei Ling,* Changchang Li, Zhangpei Chen* and Jinzhong Yao,* Rh(III)-catalyzed [4 + 1] cyclization of aryl substituted pyrazoles with cyclopropanols via C–H activation. Org. Biomol. Chem., 2023, 21, 775-782.
6、Lei Liu, Wangqin Zhang, Chao Xu, Jiaying He, Zhenhui Xu, Zehui Yang, Chuhan Zhao, Fei Ling* and Weihui Zhong,* Electrosynthesis of CF3-Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene, Adv. Synth. Catal., 2022, 364, 1319-1325.
7、Fei Ling,* Tao Liu, Chao Xu, Jiaying He, Wangqin Zhang, Changwu Ling, Lei Liu and Weihui Zhong,* Divergent Electrolysis for the Controllable Coupling of Thiols with 1,2-Dichloroethane: a Mild Approach to Sulfide and Sulfoxide, Green Chem.,2022, 24, 1342-1349.
8、Xianghua Zhao, Zehui Yang, Yuqi Cheng, An Huang, Fangyuan Hu, Fei Ling,* and Weihui Zhong,* Divergent Synthesis of β-Hydroxy Amides (Esters) and γ-Amino Alcohols via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation, Adv. Synth. Catal., 2022, 364, 3074-3080.
9、Lei Liu, Zhenhui Xu, Tao Liu, Chao Xu, Wangqin Zhang, Xiangqi Hua, Fei Ling,* and Weihui Zhong,* Electrosynthesis of 2-Substituted Benzoxazoles via Intramolecular Shono-Type Oxidative Coupling of Glycine Derivatives, J. Org. Chem., 2022, 87, 11379-11386.
10、Chao Xu, Zhensheng Zhang, Tao Liu, Wangqin Zhang, Weihui Zhong, Fei Ling,* Hydrogen evolution-enabled rhodaelectro-catalyzed [4+2] annulations of purines and 7-deazapurines with alkynes, Chem. Commun., 2022, 58, 9508-9511.
11、Yirui Chen, Xiao Yi, Yuqi Cheng, An Huang, Zehui Yang, Xianghua Zhao, Fei Ling,* and Weihui Zhong,* Rh-Catalyzed Highly Enantioselective Hydrogenation of Functionalized Olefins with Chiral Ferrocenylphosphine-Spiro Phosphonamidite Ligands, J. Org. Chem. 2022, 87, 7864-7874. (Highlighted by Organic Chemistry Portal)
18、Dingguo Song, Linlin Chen, Tao Liu, Jiayin He, Chao Xu, Jingyi Li, Fei Ling* and Weihui Zhong*, Ruthenium Catalyzed α-Methylation of Sulfones with Methanol as a Sustainable C1 Source, Org. Chem. Front., 2021, 8, 120-126;
19、Haiwei Shen, Didi Cheng, Yujin Li, Tao Liu, Xiao Yi, Lei Liu, Fei Ling*and Weihui Zhong*, Late-Stage Diversification by Rutheniumelectro-Catalyzed C−H mono- and di-Acyloxylation, Green Synth. Catal., 2020, 1(2), 178-182;
20、Haiwei Shen, Tao Liu, Didi Cheng, Xiao Yi, Ze Wang, Lei Liu, Dingguo Song, Fei Ling* and Weihui Zhong,* Ruthenium-Catalyzed Electrochemical Synthesis of Indolines through Dehydrogenative [3+2] Annulation with H2 Evolution, J. Org. Chem., 2020, 85(21), 13735-13746;
21、Wenjun Luo, BingXuan Shao, Jingyi Li, Xiao Xiao,Dingguo Song, Fei Ling and Weihui Zhong*, Construction of Spirooxindole-Fused Spiropyrazolones Containing Contiguous Three Stereogenic Centres via [3+2] Annulation Utilizing Ferrocene Derived Bifunctional Phosphine-Catalyst, Org. Chem. Front., 2020, 7, 1016-1021;
22、Fei Ling,* Dingguo Song; Linlin Chen, Tao Liu, Mengyao Yu, Yan Ma, Lian Xiao, Min Xu and Weihui Zhong*, Synthesis of N-Alkyl 2-Arylindole from Saturated Ketones and 2-Alkynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation Cascade, J. Org. Chem., 2020, 85(5), 3224-3233;
25、Sanfei Nian,# Fei Ling,# Jiachen Chen, Ze Wang, Haiwei Shen, Xiao Yi, Yun-Fang Yang, Yuanbin She and Weihui Zhong,* Highly Enantioselective Hydrogenation of Non-ortho-Substituted 2-Pyridyl Aryl Ketones via Iridium-f-Diaphos Catalysis, Org. Lett., 2019, 21(14), 5392-5396;
26、Fei Ling, Huacui Hou, Jiachen Chen, Sanfei Nian, Xiao Yi, Ze Wang, Dingguo Song and Weihui Zhong*, Highly Enantioselective Synthesis of Chiral Benzhydrols via Manganese Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones using an Imidazole-Based Chiral PNN Tridentate Ligand, Org. Lett., 2019, 21(11), 3937-3941;
27、Fei Ling, Zhen Xie, Jiachen Chen, Chongren Ai, Ze Wang, Haiwei Shen, Xiao Yi and Weihui Zhong*, Co balt(II)-Catalyzed [5+2] C-H Annulation of o-Arylanilines with Alkynes: An Expedient Route to Dibenzo-[b,d]azepines, Adv. Synth. Catal., 2019, 361(13), 3094-3101;
28、Wenjun Luo, Bingxuan Shao, Jingyi Li, Dingguo Song, Xiao Yi, Fei Ling and Weihui Zhong*, Divergent synthesis of spirocyclopentene-pyrazolones and pyrano[2,3-c]-pyrazoles via Lewis base controlled annulation reactions, Tetrahedron Lett., 2019, 60(44), 151206;
29、Fei Ling, Jiachen Chen, Zhen Xie, Huacui Hou, Zhentao Pan, Cong Feng, Haiwei Shen and Weihui Zhong*, Synthesis of substituted quinolines via B(C6F5)3-catalyzed aniline-aldehyde-pyruvate oxidative annulation, J. Heterocyclic Chem., 2019, 56, 3333-3342;
30、Zhentao Pan, Hui Wang, Fei Ling, Lian Xiao, Dingguo Song and Weihui Zhong*, Development of [3]ferrocenophane-derived N/B frustrated Lewis pairs for the metal-free catalytic hydrogenation of imines, Syn. Commun., 2019, 49, 522-528 ;
31、Fei Ling, Lian Xiao, Lu Fang, Cong Feng, Zhen Xie, Yaping Lv and Weihui Zhong*, Metal Free B(C6F5)3-Catalyzed Markovnikov Addition of Indoles to Unactivated Alkynes, Org. Biomol. Chem., 2018, 16, 9274-9278;
32、Fei Ling, Sanfei Nian, Jiachen Chen, Wenjun Luo, Ze Wang, Yaping Lv and Weihui Zhong*, Development of Ferrocene-Based Diamine-Phosphine-Sulfonamide (f-Diaphos) Ligands for Iridium Catalyzed Asymmetric Hydrogenation of Ketones, J. Org. Chem., 2018, 83(18), 10749-10761;
33、Fei Ling, Chaowei Zhang, Chongren Ai, Yaping Lv and Weihui Zhong*, Metal Oxidant Free Cobalt Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines:An Approach Towards Free (NH)-Phenanthridinones, J. Org. Chem., 2018, 83, 5698-5706;
34、Zhentao Pan, Leixin Shen, Fei Ling, and Weihui Zhong*, B(C6F5)3-catalyzed asymmetric reductive amination using NH3-BH3, J. Org. Chem., 2018, 83(19), 11502-11509;
35、Fei Ling, Lian Xiao, Lu Fang, Yaping Lv and Weihui Zhong*, Copper Catalysis for Nicotinate Synthesis through β-Alkenylation/Cyclization of Saturated Ketones with β-Enamino Esters, Adv. Synth. Catal., 2018, 360(3), 444-448;
36、Wenjun Luo, Dingguo Song, Lu Fang, Sanfei Nian, Huacui Hou, Fei Ling and Weihui Zhong*, Chiral Bifunctional Ferrocenylphosphine-Catalyzed Enantioselective Allylic Alkylation of Morita−Baylis−Hillman Carbonates with Pyrazolin-5-ones, Asian J. Org. Chem., 2018, 7, 2417-2421;
37、Liang Qi, Huacui Hou, Fei Ling and Weihui Zhong*, The cinchona alkaloid squaramide catalyzed asymmetric Pictet–Spengler reaction and related theoretical studies, Org. Biomol. Chem., 2018,16, 566-574;
38、Fei Ling, Leixin Shen, Zhentao Pan, Lu Fang, Dingguo Song, Zhen Xie and Weihui Zhong*, B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the synthesis of 2,4,6-triarylpyridines, Tetrahedron Lett., 2018, 59, 3678–3682;
39、Lu Fang, Liang Qi, Longfei Ye, Zhentao Pan, Wenjun Luo, Fei Ling and Weihui Zhong*, Dimethyl Sulfoxide-Accelerated Reductive Deamination of Aromatic Amines with T-BuONO in Tetrahydrofuran, J. Chem. Res., 2018, 42, 579-583;
40、Fei Ling, Chongren Ai, Lv, Yaping and Weihui Zhong*, Traceless Directing Group Assisted Cobalt-Catalyzed C-H Carbonylation of Benzylamines, Adv. Synth. Catal., 2017, 359, 3707–3712;
41、Fei Ling, Chongren Ai, Lv, Yaping, Weihui Zhong*, Formation of N-Unprotected Isoindolinones From Benzylamines via Cobalt-Catalyzed Traceless Directing Group-Assisted C(sp2)-H Carbonylation, Adv. Synth. Catal., 2017, 359(21), 3675;
42、Wenjun Luo, Haiwen Hu, Sanfei Nian, Liang Qi, Fei Ling and Weihui Zhong*, Phosphine-catalyzed [3+2] annulation reaction: highly regio- and diastereoselective synthesis of 2-azaspiro[4.4]nonenes-1,3-dione, Org. Biomol. Chem., 2017, 15(36), 7523-7526;
43、王 辉,郑 亿,潘振涛,傅鸿樑,凌飞,钟为慧*,“受阻”路易斯酸碱对催化氢化反应的研究进展, 有机化学,2017, 37(2), 301-313。
Before 2017
Haiwen Hu, Shuxian Yu, Linglong Zhu, Linxiu Zhou and Weihui Zhong* Chiral Bifunctional Ferrocenylphosphines Catalyzed highly Enantioselective [3+2] Cycloaddition Reaction, Org. Biomol. Chem. 2016, 14(2), 752-760.
Guan Wang, Cheng Chen, Tieqi Du and Weihui Zhong*, Metal-free catalytic hydrogenation of imines with a recyclable [2.2]paracyclophane-derived frustrated Lewis pairs catalysts, Adv. Synth. Catal., 2014, 356, 1747-1752.
唐谦, 涂爱平, 邓真真, 胡梦莹, 钟为慧*, 手性膦小分子催化不对称反应的研究进展,有机化学,2013,33,954-970.
李振华,司禹,钟为慧*,2-氧代-5,6,7,7a-四氢噻吩并[3,2-c]吡啶的合成研究,中国医药工业杂志,2013,44(1), 13-16。
Weihui Zhong*, Wang Ma and Yanbin Liu, First construction of 12H-thiochromeno[2,3-b]quinolines and 5H-benzo[7,8]thiocino[2,3-b]quinolines via intramolecular Friedel-Crafts reaction of Morita-Baylis-Hillman adducts, Tetrahedron, 2011, 67, 3509-3518.
Weihui Zhong*, Wendong Zhang, Yanhui Chen, Yanbin Liu and Yi Yao, New Procedure for the Preparation of (Z)-2-(5-Amino-1,2,4-thiadiazole-3-yl)- 2-trityloxyiminoacetic Acid, Org. Proc. Res. Dev., 2011, 15, 698-703.
Weihui Zhong*, Yongliang Liu, Guan Wang, Lingjuan Hong, Yanhui Chen, Xiao Chen, Yemin Zheng, Wendong Zhang, Wang Ma, Yanyan Shen, and Yi Yao Recent Advances in Construction of Nitrogen-containing Heterocycles from Baylis-Hillman Adducts,Org. Prep. Proced. Inter. 2011, 43(1), 1-66.
Weihui Zhong, Yemin Zheng, Jiadi Zhou and Yanyan Shen, First Application of Air-Stable and Reusable Phosphine Containing Calix[4]arene in Catalytic Aza-Baylis-Hillman Reaction, Synlett 2010, (20), 3057-3060.
Weihui Zhong, Fuliang Lin, Ren’er Chen, Weike Su, A novel procedure for the synthesis of benzo[b][1,8]naphthyridine-3-carboxylate derivatives from Morita-Baylis-Hillman adduct acetates, Synthesis, 2009, (14), 2333-2340.
钟为慧, 郭宝铭, 赵永志, 孙秀玲, 苏为科,4-甲基-5-甲酰基噻唑的合成工艺研究,高校化学工程学报,2009,23(3),486-490。
Weihui Zhong, Yongzhi Zhao, Weike Su, An efficient synthesis of 3-arylmethyl-7,8-dihydro-6H-chromene-2,5-diones from Baylis-Hillman adduct acetates under solvent-free conditions, Tetrahedron, 2008, 64(23), 5491-5496.
Weihui Zhong, Fuliang Lin, Ren’er Chen, Weike Su, An efficient Synthesis of 2-hydroxy-7,8-dihydroquinolin-5(6H)-ones and 7,8- dihydroquinoline-2,5(1H,6H)- diones from Baylis-Hillman adduct acetates, Synthesis, 2008, (18), 2561-2568.
Weihui Zhong, Zhenyu Liu, Chuanming Yu, Weike Su, Cu(OAc)2 catalyzed cross-coupling of pentafluorophenylboronic acid with amines under an atmosphere of oxygen, Synlett, 2008, 2888-2892.
Hisao Nemoto; Weihui Zhong; Tomoyuki Kawamura; Masaki Kamiya,; Yasushi Nakano; Kei Sakamoto, Synthesis of optically active d -dodecalactone via chiral resolution using CPF, Synlett, 2007, 2343-2346.
Weihui Zhong, Xian Peng, Jun Xie, Tomoyuki Kawamura and Hisao Nemoto, An efficient method for the synthesis of hydrocyclopenta[1,2-b]furan with various side chains at 3a-position, Tetrahedron Lett., 2005, 46, 7451-7454.
Hisao Nemoto, Xian, Peng, Weihui Zhong, Jun Xie, Tomoyuki Kawamura, M. Nishida, A method for the synthesis of 3a-aryl-substituted cyclopenta[1,2-b]furan derivatives, Synlett, 2005, (20), 3103-06.
Motoo Tori, Masakazu Sono, Weihui Zhong, Sachiko Onishi, Atsuko Hashimoto, Yasuyo Nakashiba, Carbon-carbon bond formation reactions in the preparation of hydrindanones. Fudan Xuebao, Ziran Kexueban, 2005, 44(5), 811-812.
Weike Su, Weihui Zhong, Gaofeng Bian, Xiangjun Shi and Jianping Zhang, Recent advances in chemistry of substitutes for phosgene: trichloromethyl chloroformate and bis(trichloromethyl)carbonate, Org. Prep. Proce. Inter., 2004, 36, 499-547.
Hisao Nemoto, Hiroe Tsutsumi, Satomi Yuzawa, Xian Peng, Weihui Zhong, Jun Xie, Norikazu, Miyoshi, Ichiro Suzuki and Masayuki Shibuya, Highly Efficient Chiral Resolution and Determination of Absolute Configuration of 2-Alkanols by Using a Cyclopenta[b]furan Derivative, Tetrahedron Lett. 2004, 45, 1667.
主要的授权发明专利
1、一种盐酸曲马多的合成方法,发明人:钟为慧,吴窈窕,苏为科,专利号:ZL200810060734.3,授权日:2011.11.23;2017.10.03成果转化
2、一种从Wittig反应废渣中再生三苯基膦的方法,发明人:钟为慧,马旺,苏为科,专利号:ZL200910152435.7,授权日:2012.02.29;2021.4.03成果转化
3、一种多取代烯丙基氯衍生物的合成方法,发明人:钟为慧,洪玲娟,苏为科,专利号:ZL200910152437.6,授权日:2012.6.27;2021.4.03成果转化
4、5-氨基-1,2,4-噻二唑-3-乙酰胺衍生物的制备方法,发明人:钟为慧,苏为科,陈燕慧,张文栋,顾士崇,王光明,专利号:ZL200910155299.7,授权日:2012.7.25
5、一种头孢洛林侧链酸的制备方法,发明人:钟为慧、苏为科、姚 奕、王光明、顾士崇,专利号:ZL201110389247.3,授权日:2013.11.13
6、一种噻吩酰胺取代的手性膦二茂铁催化剂的合成方法及应用,发明人:钟为慧,胡海文,苏为科,专利号:ZL201510305448.9,授权日:2017.06.03,
7、一种帕泊昔布中间体的制备方法(专利号:ZL201711001007.5),发明人:钟为慧,凌飞,肖莲, 授权日:2020.3.17
8、一种基于二茂铁骨架的手性氮氮膦三齿配体及其应用(专利号:ZL201810129246.7),发明人:钟为慧,凌飞,年三飞,授权日:2020.5.12
9、一种(S)-1-二茂铁乙基二甲胺的制备工艺(专利号:ZL201810128676.7),发明人:钟为慧,凌飞,年三飞, 授权日:2020.08.25
10、一种贝他斯汀中间体的制备工艺(专利号:ZL201910181656.0),发明人:钟为慧,年三飞,凌飞,授权日:2021.02.09
参编教材:
1、《医药文献检索与专利》,主编:赵应征,浙江大学出版社,2011年12月;
2、《制药工艺学》,普通高等教育“十一五”国家级规划教材(第二版),主编:元英进,副主编:赵广荣,孙铁民,化学工业出版社,2017年10月;
3、《制药工程》,主编:王沛,副主编:钟为慧,人民卫生出版社,2018年4月;
4、《制药原理与设备》,普通高等教育中医药类“十三五”规划教材,全国普通高等教育中医药类精编教材(第二版),主编:王沛,上海科学技术出版社,2019年1月。