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成果及论文

代表性论文: 

1、Tao Liu, Wangqin Zhang, Chao Xu, Zhenhui Xu, Dingguo Song, Wei Qian, Gang Lu, Chang-Jun Zhang, Weihui ZhongFei Ling,* Synthesis of P-stereogenic cyclicphosphinic amide via electrochemical enabled cobalt-catalyzed enantioselective C–H annulation. Green. Chem.2023, 25, 3606-3614.

  

2、Shiliang Wang, Dingguo Song, Feiyang Shen, Rong Chen, Yuqi Cheng, Chuhan Zhao, Qilei Shen, Shuxin Yin, Fei Ling* and Weihui Zhong,* Manganese Catalyzed Cross-Coupling of Allylic Alcohols and Nitriles: An Elegant Route for Access of δ-Hydroxynitriles, Green. Chem.202325, 357-364.

  

3Hanbing Li,* Gaohang Fu and Weihui Zhong,* Natural quinazolinones: From a treasure house to promising anticancer leads, Eur. J. Med. Chem., 2023, 245, 114915.

4、Yan Mao, Wenxi Chen, Changchang Li, Lin Miao, Yanfei Lin, Fei Ling,* Zhangpei Chen* and Jinzhong Yao,* Synthesis of 3,4,5-trisubstituted phenols via Rh(iii)-catalyzed alkenyl C–H activation assisted by phosphonium cations, Chem. Commun.2023, 59, 3775-3778.


5、Wenxi Chen, Yan Mao, Min Wang, Fei Ling,* Changchang Li, Zhangpei Chen* and Jinzhong Yao,* Rh(III)-catalyzed [4 + 1] cyclization of aryl substituted pyrazoles with cyclopropanols via C–H activation. Org. Biomol. Chem.202321, 775-782.

6、Lei Liu, Wangqin Zhang, Chao Xu, Jiaying He, Zhenhui Xu, Zehui Yang, Chuhan Zhao, Fei Ling* and Weihui Zhong,* Electrosynthesis of CF3-Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated AlkeneAdv. Synth. Catal., 2022, 364, 1319-1325. 

7Fei Ling,* Tao Liu, Chao Xu, Jiaying He, Wangqin Zhang, Changwu Ling, Lei Liu and Weihui Zhong,* Divergent Electrolysis for the Controllable Coupling of Thiols with 1,2-Dichloroethane: a Mild Approach to Sulfide and Sulfoxide, Green Chem.,2022, 24, 1342-1349.

8、Xianghua Zhao, Zehui Yang, Yuqi Cheng, An Huang, Fangyuan Hu, Fei Ling,* and Weihui Zhong,* Divergent Synthesis of β-Hydroxy Amides (Esters) and γ-Amino Alcohols via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation, Adv. Synth. Catal.2022, 364, 3074-3080.

9、Lei Liu, Zhenhui Xu, Tao Liu, Chao Xu, Wangqin Zhang, Xiangqi Hua, Fei Ling,* and Weihui Zhong,* Electrosynthesis of 2-Substituted Benzoxazoles via Intramolecular Shono-Type Oxidative Coupling of Glycine Derivatives, J. Org. Chem., 202287, 11379-11386.

10、Chao Xu, Zhensheng Zhang, Tao Liu, Wangqin Zhang, Weihui Zhong, Fei Ling,* Hydrogen evolution-enabled rhodaelectro-catalyzed [4+2] annulations of purines and 7-deazapurines with alkynes, Chem. Commun.202258, 9508-9511.

11、Yirui Chen, Xiao Yi, Yuqi Cheng, An Huang, Zehui Yang, Xianghua Zhao, Fei Ling,* and Weihui Zhong,* Rh-Catalyzed Highly Enantioselective Hydrogenation of Functionalized Olefins with Chiral Ferrocenylphosphine-Spiro Phosphonamidite Ligands, J. Org. Chem. 202287, 7864-7874. (Highlighted by Organic Chemistry Portal)


12、Xiao Yi, Yirui Chen, An Huang, Dingguo Song, Jiaying He, Fei Ling* and Weihui Zhong,* Design of Chiral Ferrocenylphosphine-spiro Phosphonamidite Ligands for Ruthenium-Catalysed Highly Enantioselective Coupling of 1,2-Diols with Amines, Org. Chem. Front.202186830–6836.
13、Ze Wang, Xianghua Zhao, Shiliang Wang, An Huang, Yifan Wang, Jiaying He, Fei Ling* and Weihui Zhong,* Iridium/f-Diaphos Catalyzed Asymmetric Hydrogenation of 2-Imidazolyl Aryl Ketones, Org. Biomol. Chem.202119, 9746-9751.

14、Fei Ling,* Yifan Wang, An Huang, Ze Wang, Shiliang Wang, Jiayin He, Xianghua Zhao, Weihui Zhong,* Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of Racemic β'-Keto-β-amino Esters via Dynamic Kinetic Resolution, Adv. Synth. Catal., 2021363, 4714-4719

  •    
    15、             Ze Wang, Xianghua Zhao, An Huang, Zehui Yang, Yuqi Cheng, Jiachen Chen, Fei Ling* and Weihui Zhong*             Manganese catalyzed enantio- and regioselective hydrogenation of a,ß-unsaturated ketones using an imidazole-based chiral PNN tridentate ligand                         Tetrahedron Lett., 2021             82, 153389;    

    16、Xiao Xiao, Bingxuan Shao, Jingyi Li, Zehui Yang, Yin-Jie Lu, and Fei Ling and Weihui Zhong*, Enantioselective synthesis of functionalized 1,4-dihydropyrazolo-[4',3':5,6]- pyrano[2,3-b]quinolines through ferrocenyl-phosphine-catalyzed annulation of modified MBH carbonates and pyrazolones, Chem. Commun., 2021, 57, 4690-4693;

    17、Fei Ling,* Didi Cheng, Tao Liu, Ze Wang, Chao Xu, Lei Liu, Yujin Li and Weihui Zhong*, Recyclable and Reusable n-Bu4NBF4/PEG-400/H2O System for Electrochemical C-3 Formylation of Indoles with Me3N as a Novel Carbonyl Source, Green Chem.2021, 23, 4107-4113;

    18、Dingguo Song, Linlin Chen, Tao Liu, Jiayin He, Chao Xu, Jingyi Li, Fei Ling* and Weihui Zhong*, Ruthenium Catalyzed α-Methylation of Sulfones with Methanol as a Sustainable C1 Source, Org. Chem. Front.2021, 8, 120-126;

    19、Haiwei Shen, Didi Cheng, Yujin Li, Tao Liu, Xiao Yi, Lei Liu, Fei Ling*and Weihui Zhong*, Late-Stage Diversification by Rutheniumelectro-Catalyzed CH mono- and di-Acyloxylation, Green Synth. Catal.2020, 1(2), 178-182

    20、Haiwei Shen, Tao Liu, Didi Cheng, Xiao Yi, Ze Wang, Lei Liu, Dingguo Song, Fei Ling* and Weihui Zhong,* Ruthenium-Catalyzed Electrochemical Synthesis of Indolines through Dehydrogenative [3+2] Annulation with H2 Evolution, J. Org. Chem.2020, 85(21), 13735-13746

    21、Wenjun Luo, BingXuan Shao, Jingyi Li, Xiao Xiao,Dingguo Song, Fei Ling and Weihui Zhong*, Construction of Spirooxindole-Fused Spiropyrazolones Containing Contiguous Three Stereogenic Centres via [3+2] Annulation Utilizing Ferrocene Derived Bifunctional Phosphine-Catalyst, Org. Chem. Front.2020, 7, 1016-1021;

    22、Fei Ling,* Dingguo Song; Linlin Chen, Tao Liu, Mengyao Yu, Yan Ma, Lian Xiao, Min Xu and Weihui Zhong*, Synthesis of N-Alkyl 2-Arylindole from Saturated Ketones and 2-Alkynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation CascadeJ. Org. Chem.2020, 85(5), 3224-3233

    23、Fei Ling             Jiachen Chen     
       
    Sanfei Nian
    Huacui Hou
    Xiao Yi
    Feifei Wu
    Min Xu and 
    Weihui Zhong, Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand,Synlett, 202031(03), 285-289; 
     

     
    24、Chongren Ai, Haiwei Shen, Dingguo Song, Yujin Li, Xiao Yi, Ze Wang, Fei Ling,*  Weihui Zhong,* Metal- and Oxidant-Free Electrochemical Synthesis of Sulfinic Ester via Sequential Oxidative SH Bond Cleavage and Double S             O Bond Formation, Green Chem. 201921(20), 5528-5531  


    25、Sanfei Nian,# Fei Ling,# Jiachen Chen, Ze Wang, Haiwei Shen, Xiao Yi, Yun-Fang Yang, Yuanbin She and Weihui Zhong,* Highly Enantioselective Hydrogenation of Non-ortho-Substituted 2-Pyridyl Aryl Ketones via Iridium-f-Diaphos Catalysis, Org. Lett., 201921(14), 5392-5396;

    26、Fei Ling, Huacui Hou, Jiachen Chen, Sanfei Nian, Xiao Yi, Ze Wang, Dingguo Song and Weihui Zhong*, Highly Enantioselective Synthesis of Chiral Benzhydrols via Manganese Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones using an Imidazole-Based Chiral PNN Tridentate Ligand, Org. Lett.201921(11), 3937-3941;

    27、Fei Ling, Zhen Xie, Jiachen Chen, Chongren Ai, Ze Wang, Haiwei Shen, Xiao Yi and Weihui Zhong*Co balt(II)-Catalyzed [5+2] C-H Annulation of o-Arylanilines with Alkynes: An Expedient Route to Dibenzo-[b,d]azepinesAdv. Synth. Catal., 2019361(13), 3094-3101;

    28、Wenjun Luo, Bingxuan Shao, Jingyi Li, Dingguo Song, Xiao Yi, Fei Ling and Weihui Zhong*Divergent synthesis of spirocyclopentene-pyrazolones and pyrano[2,3-c]-pyrazoles via Lewis base controlled annulation reactions, Tetrahedron Lett.201960(44)151206

    29、Fei Ling, Jiachen Chen, Zhen Xie, Huacui Hou, Zhentao Pan, Cong Feng, Haiwei Shen and Weihui Zhong*, Synthesis of substituted quinolines via B(C6F5)3-catalyzed aniline-aldehyde-pyruvate oxidative annulation, J. Heterocyclic Chem.201956, 3333-3342;

    30、Zhentao Pan, Hui Wang, Fei Ling, Lian Xiao, Dingguo Song and Weihui Zhong*, Development of [3]ferrocenophane-derived N/B frustrated Lewis pairs for the metal-free catalytic hydrogenation of imines, Syn. Commun.201949522-528 ;

    31、Fei Ling, Lian Xiao, Lu Fang, Cong Feng, Zhen Xie, Yaping Lv and Weihui Zhong*, Metal Free B(C6F5)3-Catalyzed Markovnikov Addition of Indoles to Unactivated Alkynes, Org. Biomol. Chem.201816, 9274-9278;

    32、Fei Ling, Sanfei Nian, Jiachen Chen, Wenjun Luo, Ze Wang, Yaping Lv and Weihui Zhong*, Development of Ferrocene-Based Diamine-Phosphine-Sulfonamide (f-Diaphos) Ligands for Iridium Catalyzed Asymmetric Hydrogenation of Ketones, J. Org. Chem., 201883(18), 10749-10761;

    33、Fei Ling, Chaowei Zhang, Chongren Ai, Yaping Lv and Weihui Zhong*, Metal Oxidant Free Cobalt Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines:An Approach Towards Free (NH)-Phenanthridinones, J. Org. Chem., 2018, 83, 5698-5706;

    34、Zhentao Pan, Leixin Shen, Fei Ling, and Weihui Zhong*, B(C6F5)3-catalyzed asymmetric reductive amination using NH3-BH3, J. Org. Chem.201883(19), 11502-11509

    35、Fei Ling, Lian Xiao, Lu Fang, Yaping Lv and Weihui Zhong*, Copper Catalysis for Nicotinate Synthesis through β-Alkenylation/Cyclization of Saturated Ketones with β-Enamino Esters, Adv. Synth. Catal., 2018360(3), 444-448

    36、Wenjun Luo, Dingguo Song, Lu Fang, Sanfei Nian, Huacui Hou, Fei Ling and Weihui Zhong*, Chiral Bifunctional Ferrocenylphosphine-Catalyzed Enantioselective Allylic Alkylation of Morita−Baylis−Hillman Carbonates with Pyrazolin-5-ones, Asian J. Org. Chem., 2018, 7, 2417-2421;

    37、Liang Qi, Huacui Hou, Fei Ling and Weihui Zhong*, The cinchona alkaloid squaramide catalyzed asymmetric Pictet–Spengler reaction and related theoretical studies, Org. Biomol. Chem.2018,16, 566-574;

    38、Fei Ling, Leixin Shen, Zhentao Pan, Lu Fang, Dingguo Song, Zhen Xie and Weihui Zhong*, B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the synthesis of 2,4,6-triarylpyridines, Tetrahedron Lett., 201859, 3678–3682

    39、Lu FangLiang QiLongfei Ye,  Zhentao PanWenjun LuoFei Ling and Weihui Zhong*, Dimethyl Sulfoxide-Accelerated Reductive Deamination of Aromatic Amines with T-BuONO in Tetrahydrofuran, J. Chem. Res., 2018, 42, 579-583; 

    40、Fei Ling, Chongren Ai, Lv, Yaping and Weihui Zhong*, Traceless Directing Group Assisted Cobalt-Catalyzed C-H Carbonylation of Benzylamines, Adv. Synth. Catal.2017359, 3707–3712;

    41、Fei Ling, Chongren AiLv, Yaping, Weihui Zhong*, Formation of N-Unprotected Isoindolinones From Benzylamines via Cobalt-Catalyzed Traceless Directing Group-Assisted C(sp2)-H Carbonylation, Adv. Synth. Catal., 2017359(21), 3675; 

    42、Wenjun Luo, Haiwen Hu, Sanfei Nian, Liang Qi, Fei Ling and Weihui Zhong*, Phosphine-catalyzed [3+2] annulation reaction: highly regio- and diastereoselective synthesis of 2-azaspiro[4.4]nonenes-1,3-dione, Org. Biomol. Chem.201715(36), 7523-7526;

    • 43、王 辉,郑 亿,潘振涛,傅鸿樑,凌飞钟为慧*受阻路易斯酸碱对催化氢化反应的研究进展有机化学2017, 37(2), 301-313

    • Before 2017

    • Haiwen Hu, Shuxian Yu, Linglong Zhu, Linxiu Zhou and Weihui Zhong* Chiral Bifunctional Ferrocenylphosphines Catalyzed highly Enantioselective [3+2] Cycloaddition Reaction, Org. Biomol. Chem. 201614(2), 752-760.

    • Guan Wang, Cheng Chen, Tieqi Du and Weihui Zhong*, Metal-free catalytic hydrogenation of imines with a recyclable [2.2]paracyclophane-derived frustrated Lewis pairs catalysts, Adv. Synth. Catal.2014, 356, 1747-1752.

    • 唐谦涂爱平邓真真胡梦莹钟为慧*手性膦小分子催化不对称反应的研究进展有机化学201333954-970.

    • 李振华,司禹,钟为慧*2-氧代-5,6,7,7a-四氢噻吩并[3,2-c]吡啶的合成研究,中国医药工业杂志201344(1), 13-16

    • Weihui Zhong*, Wang Ma and Yanbin Liu, First construction of 12H-thiochromeno[2,3-b]quinolines and 5H-benzo[7,8]thiocino[2,3-b]quinolines via intramolecular Friedel-Crafts reaction of Morita-Baylis-Hillman adducts, Tetrahedron2011, 67, 3509-3518.

    • Weihui Zhong*, Wendong Zhang, Yanhui Chen, Yanbin Liu and Yi Yao, New Procedure for the Preparation of (Z)-2-(5-Amino-1,2,4-thiadiazole-3-yl)- 2-trityloxyiminoacetic Acid, Org. Proc. Res. Dev.2011, 15, 698-703.

    • Weihui Zhong*, Yongliang Liu, Guan Wang, Lingjuan Hong, Yanhui Chen, Xiao Chen, Yemin Zheng, Wendong Zhang, Wang Ma, Yanyan Shen, and Yi Yao Recent Advances in Construction of Nitrogen-containing Heterocycles from Baylis-Hillman AdductsOrg. Prep. Proced. Inter. 2011, 43(1), 1-66.

    • Weihui Zhong, Yemin Zheng, Jiadi Zhou and Yanyan Shen, First Application of Air-Stable and Reusable Phosphine Containing Calix[4]arene in Catalytic Aza-Baylis-Hillman Reaction, Synlett 2010, (20), 3057-3060.

    • Weihui Zhong, Fuliang Lin, Ren’er Chen, Weike Su, A novel procedure for the synthesis of benzo[b][1,8]naphthyridine-3-carboxylate derivatives from Morita-Baylis-Hillman adduct acetates, Synthesis2009, (14), 2333-2340.

    • 钟为慧郭宝铭赵永志孙秀玲苏为科,4-甲基-5-甲酰基噻唑的合成工艺研究,高校化学工程学报200923(3)486-490

    • Weihui Zhong, Yongzhi Zhao, Weike Su, An efficient synthesis of 3-arylmethyl-7,8-dihydro-6H-chromene-2,5-diones from Baylis-Hillman adduct acetates under solvent-free conditions, Tetrahedron200864(23), 5491-5496.

    • Weihui Zhong, Fuliang Lin, Ren’er Chen, Weike Su, An efficient Synthesis of 2-hydroxy-7,8-dihydroquinolin-5(6H)-ones and 7,8- dihydroquinoline-2,5(1H,6H)- diones from Baylis-Hillman adduct acetates, Synthesis2008(18), 2561-2568.

    • Weihui Zhong, Zhenyu Liu, Chuanming Yu, Weike Su, Cu(OAc)2 catalyzed cross-coupling of pentafluorophenylboronic acid with amines under an atmosphere of oxygen, Synlett2008, 2888-2892.

    • Hisao Nemoto; Weihui Zhong; Tomoyuki Kawamura; Masaki Kamiya,; Yasushi Nakano; Kei Sakamoto, Synthesis of optically active d -dodecalactone via chiral resolution using CPF, Synlett2007, 2343-2346.

    • Weihui Zhong, Xian Peng, Jun Xie, Tomoyuki Kawamura and Hisao Nemoto, An efficient method for the synthesis of hydrocyclopenta[1,2-b]furan with various side chains at 3a-position, Tetrahedron Lett., 200546, 7451-7454.

    • Hisao Nemoto, Xian, Peng, Weihui Zhong, Jun Xie, Tomoyuki Kawamura, M. Nishida, A method for the synthesis of 3a-aryl-substituted cyclopenta[1,2-b]furan derivatives, Synlett2005, (20), 3103-06.

    • Motoo Tori, Masakazu Sono, Weihui Zhong, Sachiko Onishi, Atsuko Hashimoto, Yasuyo Nakashiba, Carbon-carbon bond formation reactions in the preparation of hydrindanones. Fudan Xuebao, Ziran Kexueban200544(5), 811-812.

    • Weike Su, Weihui Zhong, Gaofeng Bian, Xiangjun Shi and Jianping Zhang, Recent advances in chemistry of substitutes for phosgene: trichloromethyl chloroformate and bis(trichloromethyl)carbonate, Org. Prep. Proce. Inter., 200436, 499-547.

    • Hisao Nemoto, Hiroe Tsutsumi, Satomi Yuzawa, Xian Peng, Weihui Zhong, Jun Xie, Norikazu, Miyoshi, Ichiro Suzuki and Masayuki Shibuya, Highly Efficient Chiral Resolution and Determination of Absolute Configuration of 2-Alkanols by Using a Cyclopenta[b]furan Derivative, Tetrahedron Lett200445, 1667.

主要的授权发明专利

1一种盐酸曲马多的合成方法,发明人:钟为慧,吴窈窕,苏为科,专利号:ZL200810060734.3,授权日:2011.11.232017.10.03成果转化

2一种从Wittig反应废渣中再生三苯基膦的方法发明人:钟为慧,马旺,苏为科,专利号:ZL200910152435.7,授权日:2012.02.292021.4.03成果转化

3一种多取代烯丙基氯衍生物的合成方法发明人:钟为慧,洪玲娟,苏为科,专利号:ZL200910152437.6,授权日:2012.6.272021.4.03成果转化

45-氨基-1,2,4-噻二唑-3-乙酰胺衍生物的制备方法,发明人:钟为慧,苏为科,陈燕慧,张文栋,顾士崇,王光明,专利号:ZL200910155299.7,授权日:2012.7.25

5一种头孢洛林侧链酸的制备方法,发明人:钟为慧、苏为科、姚  奕、王光明、顾士崇,专利号:ZL201110389247.3,授权日:2013.11.13

6一种噻吩酰胺取代的手性膦二茂铁催化剂的合成方法及应用,发明人:钟为慧,胡海文,苏为科,专利号:ZL201510305448.9,授权日:2017.06.03

7一种帕泊昔布中间体的制备方法(专利号:ZL201711001007.5),发明人:钟为慧,凌飞,肖莲, 授权日:2020.3.17

8一种基于二茂铁骨架的手性氮氮膦三齿配体及其应用(专利号:ZL201810129246.7),发明人:钟为慧,凌飞,年三飞,授权日:2020.5.12

9一种(S)-1-二茂铁乙基二甲胺的制备工艺(专利号:ZL201810128676.7),发明人:钟为慧,凌飞,年三飞, 授权日:2020.08.25

10一种贝他斯汀中间体的制备工艺(专利号:ZL201910181656.0),发明人:钟为慧,年三飞,凌飞,授权日:2021.02.09


 

参编教材:

1《医药文献检索与专利》,主编:赵应征,浙江大学出版社,201112月;

2《制药工艺学》,普通高等教育十一五国家级规划教材(第二版),主编:元英进,副主编:赵广荣,孙铁民,化学工业出版社,201710月;

3《制药工程》,主编:王沛,副主编:钟为慧,人民卫生出版社,20184;

4《制药原理与设备》,普通高等教育中医药类十三五规划教材,全国普通高等教育中医药类精编教材(第二版),主编:王沛,上海科学技术出版社,20191月。