上世纪80年代主要从事天然药物研究，因在镇痛药物研物、抗病毒药物等的科学研究。在学术期刊上发表论文281篇，其中SCI收录论文252篇，单篇最高引用次数241。在国际学术会议上做邀请报告34次，口头报告和墙报介绍152次。在法国、中国、欧洲、美国等国家高校和研究院所做学术报告132次。获发明专利4项，主持和参与法国、中国、国际合作等项目30余项，培养博士生、博士后40余名。现任European Journal of Medicinal Chemistry, Current Medicinal Chemistry，Chinese Chemical Letters等国际学术期刊编委，担任20多个国际学术期刊的审稿人。究方面的成就，1989年在第25届国际药物化学大会上荣获“药物化学研究鼓励奖”。90年代开始从事糖化学及糖生物学研究。在选择性糖基化反应、复杂糖类的化学合成、以糖为基础的新药研究、糖与糖之间的相互作用、碳糖与氮杂糖的化学合成与生物活性评价、环糊精的化学结构修饰、水溶性富勒烯的合成与生物学研究等国际前沿领域作了一系列原创性的工作。目前致力于抗肿瘤药物、治疗糖尿病药物、抗病毒药物等的科学研究。在学术期刊上发表论文281篇，其中SCI收录论文252篇，单篇最高引用次数241。在国际学术会议上做邀请报告34次，口头报告和墙报介绍152次。在法国、中国、欧洲、美国等国家高校和研究院所做学术报告132次。获发明专利4项，主持和参与法国、中国、国际合作等项目30余项，培养博士生、博士后40余名。现任European Journal of Medicinal Chemistry, Current Medicinal Chemistry，Chinese Chemical Letters等国际学术期刊编委，担任20多个国际学术期刊的审稿人。

近期发表论文：

1- “Synthesis and cytotoxicity assay of four ganglioside GM3 analogues”. Huanhuan Qu, Jian-Miao Liu, Joanna Wdzieczak-Bakala, Dan Lu, Xianran He, Wenji Sun, Matthieu Sollogoub, Yongmin Zhang.  European Journal of Medicinal Chemistry 2014, 75, 247-257.

2-  "Gem-difluorocarbadisaccharides: restoring the exo-anomeric effect". Bixue Xu, Luca Unione, Joao Sardinha, Shaoping Wu, Mélanie Ethève-Quelquejeu, Amelia Pilar Rauter, Yves Blériot, Yongmin Zhang, Sonsoles Martín-Santamaría, Dolores Diaz, Jesus Jiménez-Barbero, Matthieu Sollogoub. Angewandte Chemie International Edition 2014, 53, 9597-9602.
3- “Site-selective hexa-hetero-functionalization of α-cyclodextrin an archetypical C6-symmetric concave cycle”. Bo Wang, Elena Zaborova, Samuel Guieu, Marta Petrillo, Maxime Guitet, Yves Blériot, Mickaël Ménand, Yongmin Zhang, Matthieu Sollogoub. Nature Communications 2014, 5, 5354.
4-   “4, 5-cis Unsaturated α-GalCer analogs distinctly led to CD1d-mediated Th1-biased NKT cell responses”. Yanli Cui, Zhiyuan Li, Zhaodong Cheng, Chengfeng Xia, Yongmin Zhang. Chemical Research in Toxicology 2015, 28, 1209-1215.
5-  “Biological applications of hydrophilic C60 derivatives (hC60s) − a structural perspective”. Xiaolei Zhu, Matthieu Sollogoub, Yongmin Zhang. European Journal of Medicinal Chemistry 2016, 115, 438-452.     
6- “Structural characterization and inhibition on alpha-D-glucosidase activity of non-starch polysaccharides from Fagopyrum tartaricum”. Xiao-Ting Wang, Zhenyuan Zhu, Liang Zhao, Hui-Qing Sun, Meng Meng, Jinyu Zhang, Yongmin Zhang. Carbohydrate Polymers 2016, 153, 679-685.
7- “Chiron approaches to the antitumor natural product Fuzanin D”. Yangguang Gao, Zhou Cao, Chengzhong Su, Zefeng Chen, Xianran He, Fei Ding, Hang Li, Yongmin Zhang. Synthesis 2016, 48, 4471-4476.
8-  “Research progress of natural product Gentiopicroside - a secoiridoid compound”. Shaoping Wu, Yaoyao Ning, Yingyong Zhao, Wenji Sun, Serge Thorimbert, Luc Dechoux, Matthieu Sollogoub, Yongmin Zhang. Mini-Reviews in Medicinal Chemistry 2017, 17, 62-77.
9- “Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors”. Shaoping Wu, Lili Yang, Wenji Sun, Longlong Si, Sulong Xiao, Qi Wang, Luc Dechoux, Serge Thorimbert, Matthieu Sollogoub, Demin Zhou, Yongmin Zhang. European Journal of Medicinal Chemistry 2017, 130, 308-319.
10- “Secondary-rim γ-cyclodextrin functionalization to conjugate with C60: improved efficacy as photosensitizer”. Xiaolei Zhu, Annamaria Quaranta, René V. Bensasson, Matthieu Sollogoub, Yongmin Zhang. Chemistry-A European Journal 2017, 23, 9462-9466.
11- “Cyclodextrin cavity-induced mechanistic switch in copper-catalyzed hydroboration”. Pinglu Zhang, Jorge Meijide Suárez, Thomas Driant, Etienne Derat, Yongmin Zhang, Mickaël Ménand, Sylvain Roland, Matthieu Sollogoub. Angewandte Chemie International Edition 2017, 56, 10821-10825.
12- “Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents”. Xiaolei Zhu, Sulong Xiao, Demin Zhou, Matthieu Sollogoub, Yongmin Zhang. European Journal of Medicinal Chemistry 2018, 146, 194-205.

13-  “Recent advances on glycosphingolipid GM3.”Liu, Fang & Liu, Haipeng & Sollogoub, Matthieu & Zhang, Yongmin. (2020). 10.1039/9781788013864-00230. 

14-   “Platinum complexes inhibit HER-2 enriched and triple-negative breast cancer cells metabolism to suppress growth, stemness and migration by targeting PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways.” Bai, X., Ali, A., Lv, Z., Wang, N., Zhao, X., Hao, H., Zhang, Y., & Rahman, F. U. (2021).  European journal of medicinal chemistry, 224, 113689. https://doi.org/10.1016/j.ejmech.2021.113689

15-   “Inhibition of SREBP-mediated lipid biosynthesis and activation of multiple anticancer mechanisms by platinum complexes: Ascribe possibilities of new antitumor strategies." Bai, X., Ali, A., Wang, N., Liu, Z., Lv, Z., Zhang, Z., Zhao, X., Hao, H., Zhang, Y., & Rahman, F. U. (2022). European journal of medicinal chemistry, 227, 113920. https://doi.org/10.1016/j.ejmech.2021.113920

16-  "Chemical synthesis of oligosaccharides and their application in new drug research." Zhimin Lv, Hongyu Liu, Huifang Hao, Faiz-Ur Rahman, Yongmin Zhang.European Journal of Medicinal Chemistry,Volume 249,2023,115164,ISSN 0223-5234,https://doi.org/10.1016/j.ejmech.2023.115164.

17-   "Research progress on polysaccharide components of Cistanche deserticola as potential pharmaceutical agents."Cheng, N., Wang, H., Hao, H., Rahman, F. U., & Zhang, Y. (2023). European journal of medicinal chemistry, 245(Pt 1), 114892. https://doi.org/10.1016/j.ejmech.2022.114892

18-   "Monofunctional dimetallic Ru(η6-arene) complexes inhibit NOTCH1 signaling pathway and synergistically enhance anticancer effect in combination with cisplatin or vitamin C." Na Wang, Amjad Ali, Zongwei Liu, Huiqin Chi, Zhimin Lv, Xing Zhao, Zeqing Zhang, Huifang Hao, Yongmin Zhang, Faiz-Ur Rahman,European Journal of Medicinal Chemistry,Volume 258,2023,115536,ISSN 0223-5234,https://doi.org/10.1016/j.ejmech.2023.115536.

19-  "Recent advances on application of polysaccharides in cosmetics." Qingyuan Wu, Na Cheng, Danjiao Fang, Hao Wang, Faiz-Ur Rahman, Huifang Hao, Yongmin Zhang,Journal of Dermatologic Science and Cosmetic Technology,Volume 1, Issue 1,2024,100004,ISSN 2950-306X,https://doi.org/10.1016/j.jdsct.2024.100004.

20-  "Research progress of fullerenes and their derivatives in the field of PDT." Xue Bai, Chungeng Dong, Xinle Shao, Faiz-Ur Rahman, Huifang Hao, Yongmin Zhang,European Journal of Medicinal Chemistry,Volume 271,2024,116398,ISSN 0223-5234,https://doi.org/10.1016/j.ejmech.2024.116398.

21-  “Antioxidant activities of sea buckthorn polysaccharides and their potential application in cosmetic industry." Hao Wang, Na Cheng, Qingyuan Wu, Danjiao Fang, Faiz-Ur Rahman, Huifang Hao, Yongmin Zhang,Journal of Dermatologic Science and Cosmetic Technology,2024,100023,ISSN 2950-306X,https://doi.org/10.1016/j.jdsct.2024.100023.

22-   专利： 一种乳糖富勒烯抗肿瘤先导化合物的合成方法   ZL 2022 1 0497230.8