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翁郁华 副研究员,博士生导师    

翁郁华 中国民盟盟员,北京理工大学生命学院特别副研究员、博士研究生导师。

研究方向:

  (1)器官靶向型核酸纳米递送载体研究,优化设计脂质纳米颗粒、可降解聚合物等用于核酸药物的器官靶向递送。

  (2)眼科疾病核酸疗法,优化设计小干扰RNA、mRNA、ASO、CRISPR/Cas基因编辑系统等核酸药物用于眼科疾病的治疗。

学术成果:

  截至2024年6月,以第一/通讯作者发表SCI论文二十余篇,其中ESI高被引论文3篇,影响因子IF>10分的论文10篇;先后主持国家自然科学基金、北京市自然科学基金,国家重点研发项目子课题等8项项目;获得授权发明专利3项;是Wiley出版社期刊Exploration的学术编辑,iLiver期刊青年编委,中国抗癌协会纳米肿瘤学专业委员会青年委员会委员,中国生物物理学会纳米生物学分会秘书组成员。

教育及工作经历

  2019.10-至今 北京理工大学 副研究员、助理教授

  2022.2-2023.2 新加坡南洋理工大学 SPMS学院 访问学者

  2017.9-2019.9 北京理工大学 化学工程与技术 博士后

  2014.9-2017.6 中国科学院大学&国家纳米科学中心,材料学,工学博士

  2011.8-2014.8 温州医科大学 眼视光学院、医院 科研人员

  2007.9-2010.7 上海师范大学,微生物学,理学硕士

学术任职

  1. Exploration期刊学术编辑

  2. iLiver期刊青年编委

  3. 中国抗癌协会纳米肿瘤学专业委员会青年委员会委员

  4. 中国生物物理学会纳米生物学分会秘书组成员

所获奖励/荣誉

  1. 2023年参与指导“互联网+”大学生创业创业大赛获校级初赛银奖;

  2. 2023年获得学科交叉人才培养教育教学成果奖校级特等奖;

  3. 2023年获评Exploration期刊杰出学术编辑证书;

  4. 2021年获得北理工统战部“同心先进个人”荣誉称号。

讲授课程

  1. 研究生课程《分子诊断学》

  2. 本科生课程《生物化学与分子生物学》、《生物技术制药》

主持及参与项目

  1. 2024.1-2027.12 国家自然科学基金联合基金,参与单位负责人,在研;

  2. 2021.11-2026.11 国家重点研发计划,2021YFA1201000,子课题负责人,在研;

  3. 2020.1-2023.12 国家自然科学基金青年基金,主持,结题;

  4. 2020.1-2022.12 北京市自然科学基金,主持,结题;

  5. 2022-至今 制药企业横向项目两项,主持,在研;

  6. 北理工学术启动计划,主持,在研;

  7. 中国博士后科学基金面上项目,主持,结题;

代表性一作及通讯论文

 1. Tian Zhang, Han Yin, Yu Li, Haiyin Yang, Kun Ge, Jinchao Zhang, Qing Yuan, Xuyan Dai, Abid Naeem, Yuhua Weng*, Yuanyu Huang,* Xing-Jie Liang*. Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo. iScience 27, 109804, 2024.(Q1区, IF=5.8)

  2. Jun Yang, Yong Li, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianna Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng*, Shaobo Ruan*. Engineered Brain-Targeting Exosome for Reprogramming Immunosuppressive Microenvironment of Glioblastoma. Exploration, 2024.

  3. Guo S, Li C, Wang C, Cao X, Liu X, Liang XJ, Huang Y, Weng Y*. pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy. Acta Pharm Sin B. 2024,14(2):781-794. (Q1区, IF=14.5)

  4. Huang Z, Yang T, Yu J, Gao Y, Weng Y*, Huang Y, Li S*. Ultra-efficient delivery of CRISPR/Cas9 using ionic liquid conjugated polymers for genome editing-based tumor therapy. Biomater Sci. 2024,12(7):1716-1725.

  5. Yuquan Zhang, Ziyue Li, Julien Milon Essola, Kun Ge, Xuyan Dai, Huining He, Haihua Xiao, Yuhua Weng*, Yuanyu Huang*. Biosafety materials: Ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system. Biosafety and Health. 2022, 4(2):70-78.

  6. Kun Li, Yuquan Zhang, Abid Hussain*, Yuhua Weng*, Yuanyu Huang*. Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment. ACS Biomaterials Science and Engineering. 2021, 7(9): 4420–4429. (Q2区,IF=5.8)

  7. Chunhui Li#, Tongren Yang#, Yuhua Weng#(equal contribution), Mengjie Zhang, Deyao Zhao, Shuai Guo, Bo Hu, Wanxuan Shao, Xiaoxia Wang, Abid Hussain, Xing-Jie Liang, Yuanyu Huang*. Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy. Bioactive Materials. 2021, 9:590-601.(Q1区,IF=16.874)

  8. Yuhua Weng, Yuanyu Huang*. Advances of mRNA vaccines for COVID-19: a new prophylactic revolution begins. Asian Journal of Pharmaceutical Sciences. 2021, 16(3): 263-264.(Q1区,IF=10.2)

  9. Tongren Yang#, Chunhui Li#, Xiaoxia Wang#, Deyao Zhao, Mengjie Zhang, Huiqing Cao, Zicai Liang, Haihua Xiao, Xing-Jie Liang, Yuhua Weng*, Yuanyu Huang*. Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle. Bioactive Materials. 2020, 5 (4): 1053-1061.(Q1区,IF=16.874)

  10. Yuhua Weng, Chunhui Li, Tongren Yang, Bo Hu, Mengjie Zhang, Shuai Guo, Haihua Xiao, Xing-Jie Liang, Yuanyu Huang*. The challenge and prospect of mRNA therapeutics landscape. Biotechnology Advances. 2020, 40: 107534.(Q1区,IF=17.681, ESI高被引论文)

  11. Yuhua Weng, Qianqian Huang, Chunhui Li, Yongfeng Yang, Xiaoxia Wang, Jie Yu, Yuanyu Huang*, Xing-Jie Liang*. Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology. Molecular Therapy - Nucleic Acids.   2020. 19: 581-601. (Q1区,IF=10.183)

  12. Bo Hu#, Yuhua Weng#(equal contribution), Xin Hua Xia, Xing‐jie Liang, Yuanyu Huang*. Clinical advances of siRNA therapeutics. J Gene Med. 2019, 21 (7): e3097. (Q2区,IF=3.5)

  13. Yuhua Weng, Haihua Xiao, Jinchao Zhang, Xing-Jie Liang, Yuanyu Huang*. RNAi therapeutic and its innovative biotechnological evolution. Biotechnology Advances. 2019, 37 (5): 801-825.(Q1区,IF=17.681, ESI高被引论文)

  14. Shuquan Zheng#, Xiaoxia Wang#, YuHua Weng#, Xingyu Jin, Jia-Li Ji, Liangxia Guo, Bo Hu, Nan Liu, Qiang Cheng, Jianqi Zhang, Huicheng Bai, Tongren Yang, Xin-Hua Xia, Hong-Yan Zhang, Shan Gao, Yuanyu Huang*. siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin. Molecular Therapy - Nucleic Acids. 2018, 12: 805-816. (Q1区,IF=10.183)

  15. Yuhua Weng#, Xiaowei Ma#, Jing Che, Chan Li, Juan Liu, Shizhu Chen, Yuqin Wang, Yaling Gan, Hao Chen, Zhongbo Hu*, Kaihui Nan*, Xing-jie Liang*. Nanomicelle-assisted targeted ocular delivery with enhanced anti-inflammatory efficacy in vivo. Advanced Science. 2018,5(1):1700455. 18(Q1区,IF=17.521)

  16. Yuhua Weng, Juan Liu, Shubin Jin, Weisheng Guo*, Xing-jie Liang*, Zhongbo Hu*. Nanotechnology-based strategies for treatment of ocular disease. Acta pharmaceutica Sinica B, 2017, 7(3):281-291. (Q1区,IF=14.5, ESI高被引论文)

  17. Yuhua Weng, Jing Che, Xiaowei Ma1, Hongbo Guo, Xiangdong Xue, Shizhu Chen, Xu Zhang, Tingbin Zhang, Chan Li, Jing Xu, Yaling Gan, Zhongbo Hu*, Xing-jie Liang*. Contrast enhancement method of TEM visualization for polymeric micelles by fluoride addition and staining. Journal of biomedical nanotechnology. 2017,13, 534–543.