(1)  教育背景

2021.07 -至今 中国科学院上海药物研究所 博士后

2016.09-2021.06 华东师范大学 博士研究生；

2012.09-2016.06 浙江工业大学 学士；

(2)  研究方向：肿瘤和神经退行性疾病相关智能药物递送平台

(3)  发表论文情况

[1] Y. Lai^#, Y. Dang^#, F. Li, C. Ding, H. Yu, W. Zhang*, Z. Xu*, Reactive Glycolysis Metabolite-Activatable Nanotheranostics for NIR-II Fluorescence Imaging-Guided Phototherapy of Cancer, Adv. Funct. Mater. 32 (2022) 2200016. https://doi.org/10.1002/ADFM.202200016.

[2]   Y. Lai^#, Y. Zhu, Z. Xu*, X. Hu, M. Saeed, H. Yu, X. Chen, J. Liu, W. Zhang*, Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid β, Adv. Funct. Mater. 30 (2020) 1908473. https://doi.org/10.1002/ADFM.201908473.

[3]   Y. Lai^#, Z. Xu*, X. Hu, L. Lei, L. Li, L. Dong, H. Yu, W. Zhang*, Peptide Nanotube-Templated Biomineralization of Cu2−xS Nanoparticles for Combination Treatment of Metastatic Tumor, Small. 15 (2019) 1904397. https://doi.org/10.1002/SMLL.201904397.

[4]   Y. Lai^#, F. Li, Z. Zou, M. Saeed, Z. Xu*, H. Yu*, Bio-inspired amyloid polypeptides: From self-assembly to nanostructure design and biotechnological applications, Appl. Mater. Today. 22 (2021) 100966. https://doi.org/10.1016/J.APMT.2021.100966.

[5]   Y. Lai^#, Y. Dang, Q. Sun, J. Pan, H. Yu, W. Zhang*, Z. Xu*, Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer’s disease-related variations in methylglyoxal concentrations, Chem. Sci. 13 (2022) 12511–12518. https://doi.org/10.1039/D2SC05242C.

[6]   F. Li^#, Y. Lai^#, J. Ye#, M. Saeed, Y. Dang, Z. Zou, F. Chen, W. Zhang, Z. Xu*, Dual-targeting prodrug nanotheranostics for NIR-Ⅱ fluorescence imaging-guided photo-immunotherapy of glioblastoma, Acta Pharm. Sin. B. 12 (2022) 3486–3497. https://doi.org/10.1016/J.APSB.2022.05.016.

[7]   Y. Dang^#, Y. Lai^#, F. Chen, Q. Sun, C. Ding, W. Zhang*, Z. Xu*, Activatable NIR-II Fluorescent Nanoprobe for Rapid Detection and Imaging of Methylglyoxal Facilitated by the Local Nonpolar Microenvironment, Anal. Chem. 94 (2022) 1076–1084. https://doi.org/10.1021/ACS.ANALCHEM.1C04076/ASSET/IMAGES/LARGE/AC1C04076_0006.JPEG.

[8]   L. Huang^#, F. Chen^#, Y. Lai*, Z. Xu, H. Yu*, Engineering Nanorobots for Tumor-Targeting Drug Delivery: From Dynamic Control to Stimuli-Responsive Strategy, ChemBioChem. 22 (2021) 1–13. https://doi.org/10.1002/cbic.202100347.

[9]   H. Zhang^#, J. Pan^#, T. Wang, Y. Lai*, X. Liu, F. Chen, L. Xu, X. Qu*, X. Hu*, H. Yu*, Sequentially Activatable Polypeptide Nanoparticles for Combinatory Photodynamic Chemotherapy of Breast Cancer, ACS Appl. Mater. Interfaces. 14 (2022) 39787–39798. https://doi.org/10.1021/ACSAMI.2C09064/ASSET/IMAGES/LARGE/AM2C09064_0006.JPEG.

[10] Y. Zhu^#, S. Zhang^#, Y. Lai*, J. Pan, F. Chen, T. Wang, F. Wang, Z. Xu, W. Yang*, H. Yu*, Self-Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer, Adv. Sci. (Weinheim, Baden-Wurttemberg, Ger. 9 (2022) 2203263. https://doi.org/10.1002/ADVS.202203263.

[11] Xingyu Jiang#, Wenzheng Xia#, Jiaxing Pan, Wenfang Yang, Shunan Zhang, Chunming Li, Yi Lai*, Zhiai Xu, Haijun Yu*. Engineered Microneedle Systems for Topical Cancer Therapy. Applied Materials Today. 2023, 31, 101774.

（4）项目及获奖情况

国家自然青年科学基金项目1项（82203041）

2022年度博士后创新人才支持计划（BX20220320）

第70批中国博士后科学基金面上资助一等资助（2021M700157）

2021年上海市“超级博士后”激励计划（2021424）

2022年度“赛诺菲优秀青年人才奖”

2022年度中科院特别研究助理

2021年度中国科学院上海药物研究所优秀员工

2020年度博士研究生国家奖学金

2022药剂学年会暨青年论文报告会二等奖

2021药剂学年会暨青年论文报告会三等奖